1M4A

Crystal Structure of Human Interleukin-2 Y31C Covalently Modified at C31 with (1H-Indol-3-yl)-(2-mercapto-ethoxyimino)-acetic acid

Summary for 1M4A

Related1M47 1M48 1M49 1M4B 1M4C
Descriptorinterleukin-2, (1H-INDOL-3-YL)-(2-MERCAPTO-ETHOXYIMINO)-ACETIC ACID, GLYCEROL, ... (4 entities in total)
Functional Keywordscytokine, four-helix bundle, small molecule complex
Biological sourceHomo sapiens (human)
Cellular locationSecreted P60568
Total number of polymer chains1
Total molecular weight15734.36
Authors
Arkin, M.A.,Randal, M.,DeLano, W.L.,Hyde, J.,Luong, T.N.,Oslob, J.D.,Raphael, D.R.,Taylor, L.,Wang, J.,McDowell, R.S.,Wells, J.A.,Braisted, A.C. (deposition date: 2002-07-02, release date: 2002-07-31, Last modification date: 2017-10-11)
Primary citation
Arkin, M.A.,Randal, M.,DeLano, W.L.,Hyde, J.,Luong, T.N.,Oslob, J.D.,Raphael, D.R.,Taylor, L.,Wang, J.,McDowell, R.S.,Wells, J.A.,Braisted, A.C.
Binding of small molecules to an adaptive protein-protein interface
Proc.Natl.Acad.Sci.USA, 100:1603-1608, 2003
PubMed: 12582206 (PDB entries with the same primary citation)
DOI: 10.1073/pnas.252756299
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.18 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.309193.7%5.5%8.8%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation reportDownload