PDB: 45953 件ウェブページステータス検索Chemie searchBIRD

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8THB	Structure of the Saccharomyces cerevisiae PCNA clamp unloader Elg1-RFC complex 分子名称: ADENOSINE-5'-DIPHOSPHATE, ELG1 isoform 1, MAGNESIUM ION, ... 著者 Zheng, F, Yao, Y.N, Georgescu, R, O'Donnell, M.E, Li, H. 登録日 2023-07-14 公開日 2024-05-22 最終更新日 2024-05-29 実験手法 ELECTRON MICROSCOPY (3.2 Å) 主引用文献 Structure of the PCNA unloader Elg1-RFC. Sci Adv, 10, 2024
5TN2	Solution Structure of the C-terminal multimerization domain of the master biofilm-regulator SinR from Bacillus subtilis 分子名称: HTH-type transcriptional regulator SinR 著者 Draughn, G.L, Bobay, B.G, Stowe, S.D, Thompson, R.J, Cavanagh, J. 登録日 2016-10-13 公開日 2017-10-25 最終更新日 2024-05-01 実験手法 SOLUTION NMR 主引用文献 The Solution Structures and Interaction of SinR and SinI: Elucidating the Mechanism of Action of the Master Regulator Switch for Biofilm Formation in Bacillus subtilis. J.Mol.Biol., 2019
6YHR	Crystal structure of Werner syndrome helicase 分子名称: ADENOSINE-5'-DIPHOSPHATE, Werner syndrome ATP-dependent helicase, ZINC ION 著者 Newman, J.A, Gavard, A.E, Savitsky, P, von Delft, F, Arrowsmith, C.H, Edwards, A, Bountra, C, Gileadi, O. 登録日 2020-03-30 公開日 2020-04-29 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Structure of the helicase core of Werner helicase, a key target in microsatellite instability cancers. Life Sci Alliance, 4, 2021
6JMI	Crystal structure of M.tuberculosis Rv0081 分子名称: SULFATE ION, Uncharacterized HTH-type transcriptional regulator Rv0081 著者 Kumar, A, Phulera, S, Mande, C.S. 登録日 2019-03-11 公開日 2019-04-10 最終更新日 2024-03-27 実験手法 X-RAY DIFFRACTION (2.896 Å) 主引用文献 Structural basis of hypoxic gene regulation by the Rv0081 transcription factor of Mycobacterium tuberculosis. Febs Lett., 593, 2019
7O5E	The structure of an i-motif/duplex junction at neutral pH 分子名称: I-motif/duplex junction (IDJ) 著者 Serrano-Chacon, I, Mir, B, Escaja, N, Gonzalez, C. 登録日 2021-04-08 公開日 2021-09-01 最終更新日 2024-06-19 実験手法 SOLUTION NMR 主引用文献 Structure of i-Motif/Duplex Junctions at Neutral pH. J.Am.Chem.Soc., 143, 2021
1RR7	Crystal structure of the Middle Operon Regulator protein of Bacteriophage Mu 分子名称: Middle operon regulator, PLATINUM (II) ION 著者 Kumaraswami, M, Howe, M.M, Park, H.W. 登録日 2003-12-08 公開日 2004-08-17 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Crystal structure of the Mor protein of bacteriophage Mu, a member of the Mor/C family of transcription activators. J.Biol.Chem., 279, 2004
2EA0	Crystal structure of the DNA repair enzyme endonuclease-VIII (Nei) from E. coli in complex with AP-site containing DNA substrate 分子名称: 5'-D(P*CP*AP*GP*GP*AP*(PED)P*GP*AP*AP*GP*CP*C)-3', 5'-D(P*GP*GP*CP*TP*TP*CP*AP*TP*CP*CP*TP*G)-3', Endonuclease VIII, ... 著者 Golan, G, Zharov, D.O, Grollman, A.P, Shoham, G. 登録日 2007-01-29 公開日 2008-02-26 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (1.4 Å) 主引用文献 Active site plasticity of endonuclease VIII: Conformational changes compensating for different substrate and mutations of critical residues To be Published
6Q0W	Structure of DDB1-DDA1-DCAF15 complex bound to Indisulam and RBM39 分子名称: DDB1- and CUL4-associated factor 15, DET1- and DDB1-associated protein 1, DNA damage-binding protein 1, ... 著者 Faust, T, Yoon, H, Nowak, R.P, Donovan, K.A, Li, Z, Cai, Q, Eleuteri, N.A, Zhang, T, Gray, N.S, Fischer, E.S. 登録日 2019-08-02 公開日 2019-11-13 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 Structural complementarity facilitates E7820-mediated degradation of RBM39 by DCAF15. Nat.Chem.Biol., 16, 2020
4LYN	Crystal structure of cyclin-dependent kinase 2 (cdk2-wt) complex with (2s)-n-(5-(((5-tert-butyl-1,3-oxazol-2-yl)methyl)sulfanyl)-1,3-thiazol-2-yl)-2-phenylpropanamide 分子名称: (2S)-N-(5-{[(5-tert-butyl-1,3-oxazol-2-yl)methyl]sulfanyl}-1,3-thiazol-2-yl)-2-phenylpropanamide, Cyclin-dependent kinase 2 著者 Sack, J.S. 登録日 2013-07-31 公開日 2013-10-02 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Discovery of Aminothiazole Inhibitors of Cyclin-Dependent Kinase 2: Synthesis, X-Ray Crystallographic Analysis, and Biological Activities J.Med.Chem., 45, 2002
6Q0R	Structure of DDB1-DDA1-DCAF15 complex bound to E7820 and RBM39 分子名称: 3-cyano-N-(3-cyano-4-methyl-1H-indol-7-yl)benzene-1-sulfonamide, DDB1- and CUL4-associated factor 15, DET1- and DDB1-associated protein 1, ... 著者 Faust, T, Yoon, H, Nowak, R.P, Donovan, K.A, Li, Z, Cai, Q, Eleuteri, N.A, Zhang, T, Gray, N.S, Fischer, E.S. 登録日 2019-08-02 公開日 2019-11-13 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 Structural complementarity facilitates E7820-mediated degradation of RBM39 by DCAF15. Nat.Chem.Biol., 16, 2020
6Q1M	Crystal structure of the wheat dwarf virus Rep domain 分子名称: GLYCEROL, Replication-associated protein 著者 Litzau, L.A, Everett, B.A, Evans III, R.L, Shi, K, Tompkins, K, Gordon, W.R. 登録日 2019-08-05 公開日 2019-12-11 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.24 Å) 主引用文献 Crystal structure of the Wheat dwarf virus Rep domain. Acta Crystallogr.,Sect.F, 75, 2019
6Q0V	Structure of DDB1-DDA1-DCAF15 complex bound to tasisulam and RBM39 分子名称: DDB1- and CUL4-associated factor 15, DET1- and DDB1-associated protein 1, DNA damage-binding protein 1, ... 著者 Faust, T, Yoon, H, Nowak, R.P, Donovan, K.A, Li, Z, Cai, Q, Eleuteri, N.A, Zhang, T, Gray, N.S, Fischer, E.S. 登録日 2019-08-02 公開日 2019-11-13 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 Structural complementarity facilitates E7820-mediated degradation of RBM39 by DCAF15. Nat.Chem.Biol., 16, 2020
6ZM6	Human mitochondrial ribosome in complex with mRNA, A/A tRNA and P/P tRNA 分子名称: 12S mitochondrial rRNA, 16S mitochondrial rRNA, 28S ribosomal protein S10, ... 著者 Itoh, Y, Andrell, J, Amunts, A. 登録日 2020-07-01 公開日 2021-01-13 最終更新日 2023-11-15 実験手法 ELECTRON MICROSCOPY (2.59 Å) 主引用文献 Mechanism of membrane-tethered mitochondrial protein synthesis. Science, 371, 2021
6CDB	Crystal Structure of V66L CzrA in the Zn(II)bound state 分子名称: ArsR family transcriptional regulator, CHLORIDE ION, SODIUM ION, ... 著者 Capdevila, D.A, Campanello, G, Gonzalez-Gutierrez, G, Giedroc, D.P. 登録日 2018-02-08 公開日 2018-07-11 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (1.99 Å) 主引用文献 Functional Role of Solvent Entropy and Conformational Entropy of Metal Binding in a Dynamically Driven Allosteric System. J. Am. Chem. Soc., 140, 2018
6ZSC	Human mitochondrial ribosome in complex with E-site tRNA 分子名称: 12S mitochondrial rRNA, 16S mitochondrial rRNA, 28S ribosomal protein S10, ... 著者 Aibara, S, Singh, V, Modelska, A, Amunts, A. 登録日 2020-07-15 公開日 2020-09-16 最終更新日 2024-07-10 実験手法 ELECTRON MICROSCOPY (3.5 Å) 主引用文献 Structural basis of mitochondrial translation. Elife, 9, 2020
7A5J	Structure of the split human mitoribosomal large subunit with P-and E-site mt-tRNAs 分子名称: 16S rRNA, 39S ribosomal protein L10, mitochondrial, ... 著者 Desai, N, Yang, H, Chandrasekaran, V, Kazi, R, Minczuk, M, Ramakrishnan, V. 登録日 2020-08-21 公開日 2020-12-23 最終更新日 2023-03-15 実験手法 ELECTRON MICROSCOPY (3.1 Å) 主引用文献 Elongational stalling activates mitoribosome-associated quality control. Science, 370, 2020
1N6J	Structural basis of sequence-specific recruitment of histone deacetylases by Myocyte Enhancer Factor-2 分子名称: 5'-D(*AP*GP*CP*TP*AP*TP*TP*TP*AP*TP*AP*AP*GP*C)-3', 5'-D(*GP*CP*TP*TP*AP*TP*AP*AP*AP*TP*AP*GP*CP*T)-3', Calcineurin-binding protein Cabin 1, ... 著者 Han, A, Pan, F, Stroud, J.C, Youn, H.D, Liu, J.O, Chen, L. 登録日 2002-11-11 公開日 2003-11-11 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Sequence-specific recruitment of transcriptional co-repressor Cabin1 by myocyte enhancer factor-2 Nature, 422, 2003
6ZSD	Human mitochondrial ribosome in complex with mRNA, P-site tRNA and E-site tRNA 分子名称: 12S mitochondrial rRNA, 16S mitochondrial rRNA, 28S ribosomal protein S10, ... 著者 Aibara, S, Singh, V, Modelska, A, Amunts, A. 登録日 2020-07-15 公開日 2020-09-16 最終更新日 2024-07-10 実験手法 ELECTRON MICROSCOPY (3.7 Å) 主引用文献 Structural basis of mitochondrial translation. Elife, 9, 2020
1H56	Structural and biochemical characterization of a new magnesium ion binding site near Tyr94 in the restriction endonuclease PvuII 分子名称: MAGNESIUM ION, TYPE II RESTRICTION ENZYME PVUII 著者 Spyrida, A, Matzen, C, Lanio, T, Jeltsch, A, Simoncsits, A, Athanasiadis, A, Scheuring-Vanamee, E, Kokkinidis, M, Pingoud, A. 登録日 2001-05-20 公開日 2003-08-07 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 Structural and Biochemical Characterization of a New Mg(2+) Binding Site Near Tyr94 in the Restriction Endonuclease PvuII. J.Mol.Biol., 331, 2003
5UOP	CRYSTAL STRUCTURE OF THE PROTOTYPE FOAMY VIRUS INTASOME WITH A 2- PYRIDINONE AMINAL INHIBITOR (COMPOUND 18) 分子名称: (1S,2S,5R)-8'-[(3-chloro-4-fluorophenyl)methyl]-2'-[2-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)ethyl]-6'-hydroxy-9',10'-dihydro-2'H-spiro[bicyclo[3.1.0]hexane-2,3'-imidazo[5,1-a][2,6]naphthyridine]-1',5',7'(8'H)-trione, GLYCEROL, INTEGRASE, ... 著者 Klein, D.J. 登録日 2017-02-01 公開日 2017-03-29 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (2.85 Å) 主引用文献 Discovery and optimization of 2-pyridinone aminal integrase strand transfer inhibitors for the treatment of HIV. Bioorg. Med. Chem. Lett., 27, 2017
6CDA	Crystal structure of L34A CzrA in the Zn(II)bound state 分子名称: ArsR family transcriptional regulator, CHLORIDE ION, GLYCEROL, ... 著者 Capdevila, D.A, Gonzalez-Gutierrez, G, Giedroc, D.P. 登録日 2018-02-08 公開日 2018-07-11 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Functional Role of Solvent Entropy and Conformational Entropy of Metal Binding in a Dynamically Driven Allosteric System. J. Am. Chem. Soc., 140, 2018
4S0R	Structure of GS-TnrA complex 分子名称: GLUTAMINE, Glutamine synthetase, MAGNESIUM ION, ... 著者 Schumacher, M.A, Chinnam, N.G, Cuthbert, B, Tonthat, N.K. 登録日 2015-01-04 公開日 2015-03-04 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (3.5 Å) 主引用文献 Structures of regulatory machinery reveal novel molecular mechanisms controlling B. subtilis nitrogen homeostasis. Genes Dev., 29, 2015
5UJ7	Structure of the active form of human Origin Recognition Complex ATPase motor module, complex subunitS 1, 4, 5 分子名称: ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, Origin recognition complex subunit 1, ... 著者 Tocilj, A, Elkayam, E, On, K.F, Joshua-Tor, L. 登録日 2017-01-17 公開日 2017-02-08 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (3.394 Å) 主引用文献 Structure of the active form of human Origin Recognition Complex and its ATPase motor module. Elife, 6, 2017
7KID	PRMT5:MEP50 Complexed with 5,5-Bicyclic Inhibitor Compound 72 分子名称: (1S,2R,3aR,4S,6aR)-4-[(2-amino-3,5-difluoroquinolin-7-yl)methyl]-2-(4-amino-5-fluoro-7H-pyrrolo[2,3-d]pyrimidin-7-yl)hexahydropentalene-1,6a(1H)-diol, 1,2-ETHANEDIOL, Methylosome protein 50, ... 著者 Palte, R.L. 登録日 2020-10-23 公開日 2021-04-21 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 The Discovery of Two Novel Classes of 5,5-Bicyclic Nucleoside-Derived PRMT5 Inhibitors for the Treatment of Cancer. J.Med.Chem., 64, 2021
7KIC	PRMT5:MEP50 Complexed with 5,5-Bicyclic Inhibitor Compound 34 分子名称: (2R,3R,3aS,6S,6aR)-6-[(2-amino-3-bromoquinolin-7-yl)oxy]-2-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)hexahydro-3aH-cyclopenta[b]furan-3,3a-diol, 1,2-ETHANEDIOL, Methylosome protein 50, ... 著者 Palte, R.L. 登録日 2020-10-23 公開日 2021-04-21 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.43 Å) 主引用文献 The Discovery of Two Novel Classes of 5,5-Bicyclic Nucleoside-Derived PRMT5 Inhibitors for the Treatment of Cancer. J.Med.Chem., 64, 2021

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