2EA0

Crystal structure of the DNA repair enzyme endonuclease-VIII (Nei) from E. coli in complex with AP-site containing DNA substrate

Summary for 2EA0

• Entry DOI: 10.2210/pdb2ea0/pdb
• Related: 2OPF 2OQ4
• Descriptor: 5'-D(P*GP*GP*CP*TP*TP*CP*AP*TP*CP*CP*TP*G)-3', 5'-D(P*CP*AP*GP*GP*AP*(PED)P*GP*AP*AP*GP*CP*C)-3', Endonuclease VIII, ... (7 entities in total)
• Functional Keywords: endonuclease viii, oxidative damage, dna repair, base excision, covalent intermediate, reaction mechanism, hydrolase-dna complex, hydrolase/dna
• Biological source: Escherichia coli
• Total number of polymer chains: 3
• Total formula weight: 37656.53

Authors

Golan, G.,Zharov, D.O.,Grollman, A.P.,Shoham, G. (deposition date: 2007-01-29, release date: 2008-02-26, Last modification date: 2023-10-25)

• Primary citation: Golan, G.,Zharkov, D.O.,Grollman, A.P.,Shoham, G.; Active site plasticity of endonuclease VIII: Conformational changes compensating for different substrate and mutations of critical residues; To be Published,

Experimental method

X-RAY DIFFRACTION (1.4 Å)