4LYN

Crystal structure of cyclin-dependent kinase 2 (cdk2-wt) complex with (2s)-n-(5-(((5-tert-butyl-1,3-oxazol-2-yl)methyl)sulfanyl)-1,3-thiazol-2-yl)-2-phenylpropanamide

Summary for 4LYN

Entry DOI	10.2210/pdb4lyn/pdb
Descriptor	Cyclin-dependent kinase 2, (2S)-N-(5-{[(5-tert-butyl-1,3-oxazol-2-yl)methyl]sulfanyl}-1,3-thiazol-2-yl)-2-phenylpropanamide (3 entities in total)
Functional Keywords	kinase, mitosis, cell cycle, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm, cytoskeleton, microtubule organizing center, centrosome: P24941
Total number of polymer chains	1
Total formula weight	34378.03
Authors	Sack, J.S. (deposition date: 2013-07-31, release date: 2013-10-02, Last modification date: 2024-04-03)
Primary citation	Kim, K.S.,Kimball, S.D.,Misra, R.N.,Rawlins, D.B.,Hunt, J.T.,Xiao, H.-Y.,Lu, S.,Qian, L.,Han, W.C.,Shan, W.,Mitt, T.,Cai, Z.-W.,Poss, M.A.,Zhu, H.,Sack, J.S.,Tokarski, J.S.,Chang, C.Y.,Pavletich, N.,Kamath, A.,Humphreys, W.G.,Marathe, P.,Bursuker, I.,Kellar, K.A.,Roongta, U.,Batorsky, R.,Mulheron, J.G.,Bol, D.,Fairchild, C.R.,Lee, F.Y.,Webster, K.R. Discovery of Aminothiazole Inhibitors of Cyclin-Dependent Kinase 2: Synthesis, X-Ray Crystallographic Analysis, and Biological Activities J.Med.Chem., 45:3905-3927, 2002 Cited by PubMed: 12190313 DOI: 10.1021/jm0201520 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation