8TV7
 
 | | SARS-CoV-2 Mac1 in complex with MDOLL-0229 | | 分子名称: | (1R,2R)-2-{[3-(methoxycarbonyl)-4,5,6,7,8,9-hexahydrocycloocta[b]thiophen-2-yl]carbamoyl}cyclohexane-1-carboxylic acid, GLYCEROL, Papain-like protease nsp3 | | 著者 | Wazir, S, Maksimainen, M, Lehtio, L. | | 登録日 | 2023-08-17 | | 公開日 | 2024-04-24 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | | 主引用文献 | Discovery of 2-Amide-3-methylester Thiophenes that Target SARS-CoV-2 Mac1 and Repress Coronavirus Replication, Validating Mac1 as an Antiviral Target.
J.Med.Chem., 67, 2024
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6FU3
 | | Structure of the mixed-valence, active form, of cytochrome c peroxidase from obligate human pathogenic bacterium Neisseria gonorrhoeae | | 分子名称: | CALCIUM ION, HEME C, Protein CcpR | | 著者 | Carvalho, A.L, Romao, M.J, Pauleta, S, Nobrega, C. | | 登録日 | 2018-02-26 | | 公開日 | 2019-03-13 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Structure of the mixed-valence, active form, of cytochrome c peroxidase from obligate human pathogenic bacterium Neisseria gonorrhoeae
To Be Published
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8TED
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6HN0
 | | Complex of Ovine Serum Albumin with diclofenac | | 分子名称: | (2S)-2-hydroxybutanedioic acid, 2-[2,6-DICHLOROPHENYL)AMINO]BENZENEACETIC ACID, ACETATE ION, ... | | 著者 | Talaj, J.A, Bujacz, A, Bujacz, G. | | 登録日 | 2018-09-13 | | 公開日 | 2019-10-09 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (2.12 Å) | | 主引用文献 | Structural Investigation of Diclofenac Binding to Ovine, Caprine, and Leporine Serum Albumins.
Int J Mol Sci, 24, 2023
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8TQD
 | | NF-Kappa-B1 Bound with a Covalent Inhibitor | | 分子名称: | 1-(2-bromo-4-chlorophenyl)-N-{(3S)-1-[(E)-iminomethyl]pyrrolidin-3-yl}methanesulfonamide, Nuclear factor NF-kappa-B p105 subunit | | 著者 | Hilbert, B.J. | | 登録日 | 2023-08-07 | | 公開日 | 2024-04-24 | | 最終更新日 | 2024-05-22 | | 実験手法 | X-RAY DIFFRACTION (2.02 Å) | | 主引用文献 | DrugMap: A quantitative pan-cancer analysis of cysteine ligandability.
Cell, 187, 2024
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3AJI
 | | Structure of Gankyrin-S6ATPase photo-cross-linked site-specifically, and incoporated by genetic code expansion | | 分子名称: | 26S proteasome non-ATPase regulatory subunit 10, Proteasome (Prosome, macropain) 26S subunit, ... | | 著者 | Sato, S, Mimasu, S, Sato, A, Hino, N, Sakamoto, K, Umehara, T, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | | 登録日 | 2010-06-07 | | 公開日 | 2010-12-22 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | | 主引用文献 | Crystallographic study of a site-specifically cross-linked protein complex with a genetically incorporated photoreactive amino acid
Biochemistry, 50, 2011
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7TY2
 | | Crystal Structure of SETD2 Bound to an Indole-based Inhibitor | | 分子名称: | Histone-lysine N-methyltransferase SETD2, N-[(1R,3S)-3-(4-acetylpiperazin-1-yl)cyclohexyl]-4-fluoro-7-methyl-1H-indole-2-carboxamide, S-ADENOSYLMETHIONINE, ... | | 著者 | Farrow, N.A. | | 登録日 | 2022-02-11 | | 公開日 | 2022-08-31 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (2.438 Å) | | 主引用文献 | Conformational-Design-Driven Discovery of EZM0414: A Selective, Potent SETD2 Inhibitor for Clinical Studies.
Acs Med.Chem.Lett., 13, 2022
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6G01
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5LJ5
 | | Overall structure of the yeast spliceosome immediately after branching. | | 分子名称: | CWC15, CWC22, Exon 1 (5' exon) of UBC4 pre-mRNA, ... | | 著者 | Galej, W.P, Wilkinson, M.F, Fica, S.M, Oubridge, C, Newman, A.J, Nagai, K. | | 登録日 | 2016-07-17 | | 公開日 | 2016-08-31 | | 最終更新日 | 2019-12-11 | | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | | 主引用文献 | Cryo-EM structure of the spliceosome immediately after branching.
Nature, 537, 2016
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8TFM
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6HOZ
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6G49
 | | Crystal structure of the periplasmic domain of TgpA from Pseudomonas aeruginosa | | 分子名称: | CHLORIDE ION, PHOSPHATE ION, Protein-glutamine gamma-glutamyltransferase | | 著者 | Milani, M, Mastrangelo, E, Uruburu, M. | | 登録日 | 2018-03-27 | | 公開日 | 2019-04-10 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | | 主引用文献 | Structural and functional characterization of TgpA, a critical protein for the viability of Pseudomonas aeruginosa.
J.Struct.Biol., 205, 2019
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8TH7
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1FJU
 | | THERMOLYSIN (80% ACETONITRILE SOAKED CRYSTALS) | | 分子名称: | ACETONITRILE, CALCIUM ION, DIMETHYL SULFOXIDE, ... | | 著者 | English, A.C, Groom, C.R, Hubbard, R.E. | | 登録日 | 2000-08-08 | | 公開日 | 2001-04-18 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Experimental and computational mapping of the binding surface of a crystalline protein.
Protein Eng., 14, 2001
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6G5L
 | | Crystal structure of human carbonic anhydrase isozyme XII with 4-chloro-2-(cyclohexylamino)-N-(2-hydroxyethyl)-5-sulfamoyl-benzamide | | 分子名称: | 1,2-ETHANEDIOL, 4-chloranyl-2-(cyclohexylamino)-~{N}-(2-hydroxyethyl)-5-sulfamoyl-benzamide, Carbonic anhydrase 12, ... | | 著者 | Smirnov, A, Manakova, E, Grazulis, S. | | 登録日 | 2018-03-29 | | 公開日 | 2019-03-13 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (1.21 Å) | | 主引用文献 | Design of two-tail compounds with rotationally fixed benzenesulfonamide ring as inhibitors of carbonic anhydrases.
Eur J Med Chem, 156, 2018
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6HTL
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7U6M
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6H87
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5LTQ
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8TH6
 | | Crystal Structure of the G3BP1 NTF2-like domain bound to USP10 peptide | | 分子名称: | 1,2-ETHANEDIOL, Ras GTPase-activating protein-binding protein 1, Ubiquitin carboxyl-terminal hydrolase 10 | | 著者 | Hughes, M.P, Taylor, J.P, Yang, Z. | | 登録日 | 2023-07-14 | | 公開日 | 2024-03-20 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (2.34 Å) | | 主引用文献 | Interaction between host G3BP and viral nucleocapsid protein regulates SARS-CoV-2 replication and pathogenicity.
Cell Rep, 43, 2024
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6HB0
 | | Crystal structure of MSMEG_1712 from Mycobacterium smegmatis | | 分子名称: | ABC transporter periplasmic-binding protein YtfQ, ZINC ION | | 著者 | Li, M, Mueller, C, Einsle, O, Jessen-Trefzer, C. | | 登録日 | 2018-08-09 | | 公開日 | 2019-05-01 | | 最終更新日 | 2024-05-15 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Detection and Characterization of a Mycobacterial L-Arabinofuranose ABC Transporter Identified with a Rapid Lipoproteomics Protocol.
Cell Chem Biol, 26, 2019
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5LWQ
 | | CeuE (H227L variant) a periplasmic protein from Campylobacter jejuni | | 分子名称: | BROMIDE ION, Enterochelin uptake periplasmic binding protein, SODIUM ION | | 著者 | Wilde, E.J, Blagova, E, Hughes, A, Raines, D.J, Moroz, O.V, Turkenburg, J.P, Duhme-Klair, A.-K, Wilson, K.S. | | 登録日 | 2016-09-19 | | 公開日 | 2017-04-12 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (1.52 Å) | | 主引用文献 | Interactions of the periplasmic binding protein CeuE with Fe(III) n-LICAM(4-) siderophore analogues of varied linker length.
Sci Rep, 7, 2017
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4RKP
 | | Crystal Structure of Mevalonate-3-Kinase from Thermoplasma acidophilum (apo form) | | 分子名称: | ACETATE ION, Putative uncharacterized protein Ta1305, SULFATE ION | | 著者 | Vinokur, J.M, Cascio, D, Sawaya, M.R, Bowie, J.U. | | 登録日 | 2014-10-13 | | 公開日 | 2014-12-10 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Structural analysis of mevalonate-3-kinase provides insight into the mechanisms of isoprenoid pathway decarboxylases.
Protein Sci., 24, 2015
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5LZJ
 | | Cholera toxin El Tor B-pentamer in complex with inhibitor Laura237 | | 分子名称: | (~{Z})-~{N}-[2-[(2~{R},3~{R},4~{R},5~{R},6~{R})-6-(hydroxymethyl)-3,4,5-tris(oxidanyl)oxan-2-yl]ethyl]-3-(3,4,5-trimethoxyphenyl)prop-2-enamide, Cholera enterotoxin subunit B, DI(HYDROXYETHYL)ETHER, ... | | 著者 | Heggelund, J.E, Krengel, U. | | 登録日 | 2016-09-29 | | 公開日 | 2017-05-31 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (1.2 Å) | | 主引用文献 | Towards new cholera prophylactics and treatment: Crystal structures of bacterial enterotoxins in complex with GM1 mimics.
Sci Rep, 7, 2017
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8TH5
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