PDB: 47065 件ウェブページステータス検索Chemie searchBIRD

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4C2A	Crystal Structure of High-Affinity von Willebrand Factor A1 domain with R1306Q and I1309V Mutations in Complex with High Affinity GPIb alpha 分子名称: ACETATE ION, CACODYLATE ION, CALCIUM ION, ... 著者 Blenner, M.A, Dong, X, Springer, T.A. 登録日 2013-08-16 公開日 2014-01-08 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.081 Å) 主引用文献 Towards the Structural Basis of Regulation of Von Willebrand Factor Binding to Glycoprotein Ib J.Biol.Chem., 289, 2014
7ECH	Crystal Structure of d(G4C2)2-K in F222 space group 分子名称: DNA (5'-D(*GP*GP*GP*GP*CP*CP*GP*GP*GP*GP*CP*C)-3'), POTASSIUM ION 著者 Geng, Y, Liu, C, Cai, Q, Luo, Z, Zhu, G. 登録日 2021-03-12 公開日 2021-06-09 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2.38 Å) 主引用文献 Crystal structure of parallel G-quadruplex formed by the two-repeat ALS- and FTD-related GGGGCC sequence. Nucleic Acids Res., 49, 2021
7ECG	Crystal Structure of d(G4C2)2-Ba in F222 space group 分子名称: BARIUM ION, DNA (5'-D(*GP*GP*GP*GP*CP*CP*GP*GP*GP*GP*CP*C)-3') 著者 Geng, Y, Liu, C, Cai, Q, Luo, Z, Zhu, G. 登録日 2021-03-12 公開日 2021-06-09 最終更新日 2024-03-27 実験手法 X-RAY DIFFRACTION (1.97 Å) 主引用文献 Crystal structure of parallel G-quadruplex formed by the two-repeat ALS- and FTD-related GGGGCC sequence. Nucleic Acids Res., 49, 2021
3V6T	Crystal structure of the DNA-bound dHax3, a TAL effector, at 1.85 angstrom 分子名称: DNA (5'-D(*AP*GP*AP*GP*AP*GP*AP*TP*AP*AP*AP*GP*GP*GP*AP*CP*A)-3'), DNA (5'-D(*TP*GP*TP*CP*CP*CP*TP*TP*TP*AP*TP*CP*TP*CP*TP*CP*T)-3'), dHax3 著者 Deng, D, Yan, C.Y, Pan, X.J, Wang, J.W, Yan, N, Shi, Y.G. 登録日 2011-12-20 公開日 2012-01-18 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (1.85 Å) 主引用文献 Structural Basis for Sequence-Specific Recognition of DNA by TAL Effectors Science, 2012
6GTC	Transition state structure of Cpf1(Cas12a) I1 conformation 分子名称: CRISPR-associated endonuclease Cas12a, DNA (5'-D(P*CP*GP*AP*GP*CP*TP*CP*GP*TP*TP*AP*GP*AP*GP*AP*AP*G)-3'), DNA (5'-D(P*TP*GP*AP*CP*TP*TP*CP*TP*CP*TP*AP*AP*CP*AP*AP*GP*CP*TP*CP*G)-3'), ... 著者 Mesa, P, Montoya, G. 登録日 2018-06-18 公開日 2018-12-19 最終更新日 2024-05-15 実験手法 ELECTRON MICROSCOPY (3.91 Å) 主引用文献 Conformational Activation Promotes CRISPR-Cas12a Catalysis and Resetting of the Endonuclease Activity. Cell, 175, 2018
4C4W	Structure of a rare, non-standard sequence k-turn bound by L7Ae protein 分子名称: 50S RIBOSOMAL PROTEIN L7AE, DIHYDROGENPHOSPHATE ION, TSKT-23, ... 著者 Huang, L, Lilley, D.M.J. 登録日 2013-09-09 公開日 2014-02-12 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.95 Å) 主引用文献 Structure of a Rare, Non-Standard Sequence K-Turn Bound by L7Ae Protein Nucleic Acids Res., 42, 2014
4AQ4	substrate bound sn-glycerol-3-phosphate binding periplasmic protein ugpB from Escherichia coli 分子名称: CADMIUM ION, COBALT (II) ION, GLYCEROL, ... 著者 Wuttge, S, Bommer, M, Jaeger, F, Martins, B.M, Jacob, S, Licht, A, Scheffel, F, Dobbek, H, Schneider, E. 登録日 2012-04-13 公開日 2012-10-17 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Determinants of Substrate Specificity and Biochemical Properties of the Sn-Glycerol-3-Phosphate ATP Binding Cassette Transporter (Ugpb-Aec(2) ) of Escherichia Coli. Mol.Microbiol., 86, 2012
6GTE	Transient state structure of CRISPR-Cpf1 (Cas12a) I3 conformation 分子名称: CRISPR-associated endonuclease Cas12a, DNA (5'-D(P*AP*TP*GP*AP*CP*TP*TP*CP*TP*CP*TP*AP*AP*CP*AP*AP*GP*CP*TP*CP*G)-3'), DNA (5'-D(P*CP*GP*AP*GP*CP*TP*CP*GP*TP*TP*AP*GP*AP*GP*AP*AP*G)-3'), ... 著者 Montoya, G, Mesa, P, Stella, S. 登録日 2018-06-18 公開日 2018-12-19 最終更新日 2024-05-15 実験手法 ELECTRON MICROSCOPY (4.07 Å) 主引用文献 Conformational Activation Promotes CRISPR-Cas12a Catalysis and Resetting of the Endonuclease Activity. Cell, 175, 2018
4CCK	60S ribosomal protein L8 histidine hydroxylase (NO66) in complex with Mn(II) and N-oxalylglycine (NOG) 分子名称: 1,2-ETHANEDIOL, BIFUNCTIONAL LYSINE-SPECIFIC DEMETHYLASE AND HISTIDYL-HYDROXYLASE NO66, MANGANESE (II) ION, ... 著者 Chowdhury, R, Ge, W, Clifton, I.J, Schofield, C.J. 登録日 2013-10-23 公開日 2014-05-14 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.15 Å) 主引用文献 Ribosomal oxygenases are structurally conserved from prokaryotes to humans. Nature, 510, 2014
7E8P	Crystal structure of a Flavin-dependent Monooxygenase HadA wild type complexed with reduced FAD and 4-nitrophenol 分子名称: Chlorophenol monooxygenase, DIHYDROFLAVINE-ADENINE DINUCLEOTIDE, P-NITROPHENOL 著者 Pimviriyakul, P, Jaruwat, A, Chitnumsub, P, Chaiyen, P. 登録日 2021-03-02 公開日 2021-07-21 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Structural insights into a flavin-dependent dehalogenase HadA explain catalysis and substrate inhibition via quadruple pi-stacking. J.Biol.Chem., 297, 2021
6EPM	Ras guanine nucleotide exchange factor SOS1 (Rem-cdc25) in complex with KRAS(G12C) and fragment screening hit F1 分子名称: (1-phenyl-5,6-dihydro-4~{H}-cyclopenta[c]pyrazol-3-yl)methanamine, GLYCEROL, GTPase KRas, ... 著者 Hillig, R.C, Moosmayer, D, Hilpmann, A, Bader, B, Schroeder, J, Wortmann, L, Sautier, B, Kahmann, J, Wegener, D, Briem, H, Petersen, K, Badock, V. 登録日 2017-10-12 公開日 2019-02-06 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Discovery of potent SOS1 inhibitors that block RAS activation via disruption of the RAS-SOS1 interaction. Proc. Natl. Acad. Sci. U.S.A., 116, 2019
6E8C	Crystal structure of the double homeodomain of DUX4 in complex with DNA 分子名称: DNA (5'-D(*GP*CP*GP*TP*AP*AP*TP*CP*TP*AP*AP*TP*CP*AP*AP*CP*A)-3'), DNA (5'-D(*TP*GP*TP*TP*GP*AP*TP*TP*AP*GP*AP*TP*TP*AP*CP*GP*C)-3'), Double homeobox protein 4 著者 Lee, J.K, Bosnakovski, D, Toso, E.A, Dinh, T, Banerjee, S, Bohl, T.E, Shi, K, Kurahashi, K, Kyba, M, Aihara, H. 登録日 2018-07-27 公開日 2018-12-26 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.12 Å) 主引用文献 Crystal Structure of the Double Homeodomain of DUX4 in Complex with DNA. Cell Rep, 25, 2018
6ED1	Bacteroides dorei Beta-glucuronidase 分子名称: Glycosyl hydrolase family 2, sugar binding domain protein, SODIUM ION 著者 Biernat, K.A, Redinbo, M.R. 登録日 2018-08-08 公開日 2019-02-13 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 Structure, function, and inhibition of drug reactivating human gut microbial beta-glucuronidases. Sci Rep, 9, 2019
6EIN	Crystal structure of KDM5B in complex with S49365a. 分子名称: 1,2-ETHANEDIOL, 8-[4-[2-(4-propanoylpiperazin-1-yl)ethyl]pyrazol-1-yl]-3~{H}-pyrido[3,4-d]pyrimidin-4-one, Lysine-specific demethylase 5B,Lysine-specific demethylase 5B, ... 著者 Srikannathasan, V, Newman, J.A, Szykowska, A, Wright, M, Ruda, G.F, Vazquez-Rodriguez, S.A, Kupinska, K, Strain-Damerell, C, Burgess-Brown, N.A, Arrowsmith, C.H, Edwards, A, Bountra, C, Oppermann, U, Huber, K, von Delft, F. 登録日 2017-09-19 公開日 2018-05-02 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.11 Å) 主引用文献 Crystal structure of KDM5B in complex with S49365a. To Be Published
4F21	Crystal structure of carboxylesterase/phospholipase family protein from Francisella tularensis 分子名称: Carboxylesterase/phospholipase family protein, N-((1R,2S)-2-allyl-4-oxocyclobutyl)-4-methylbenzenesulfonamide, bound form 著者 Filippova, E.V, Minasov, G, Kuhn, M, Wawrzak, Z, Shuvalova, L, Dubrovska, I, Winsor, J.R, Kiryukhina, O, Becker, D.P, Armoush, N, Anderson, W.F, Center for Structural Genomics of Infectious Diseases (CSGID) 登録日 2012-05-07 公開日 2012-08-29 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Large scale structural rearrangement of a serine hydrolase from Francisella tularensis facilitates catalysis. J.Biol.Chem., 288, 2013
6EPN	Ras guanine exchange factor SOS1 (Rem-cdc25) in complex with KRAS(G12C) and fragment screening hit F2 分子名称: 1-(3,4-dihydro-1~{H}-isoquinolin-2-yl)-2-oxidanyl-ethanone, DIMETHYL SULFOXIDE, GLYCEROL, ... 著者 Hillig, R.C, Moosmayer, D, Hilpmann, A, Bader, B, Schroeder, J, Wortmann, L, Sautier, B, Kahmann, J, Wegener, D, Briem, H, Petersen, K, Badock, V. 登録日 2017-10-12 公開日 2019-02-06 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Discovery of potent SOS1 inhibitors that block RAS activation via disruption of the RAS-SOS1 interaction. Proc. Natl. Acad. Sci. U.S.A., 116, 2019
6GG9	Crystal structures of a short blue light photoreceptor protein PpSB1-LOV mutant (dark state) - R61H/R66I 分子名称: FLAVIN MONONUCLEOTIDE, Sensory box protein 著者 Roellen, K, Granzin, J, Batra-Safferling, R. 登録日 2018-05-03 公開日 2018-07-25 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.04 Å) 主引用文献 Small-angle X-ray scattering study of the kinetics of light-dark transition in a LOV protein. PLoS ONE, 13, 2018
4DJQ	Crystal Structure of wild-type HIV-1 Protease in Complex with MKP86 分子名称: 2-(2-oxoimidazolidin-1-yl)ethyl [(2S,3R)-3-hydroxy-4-{[(4-methoxyphenyl)sulfonyl][(2S)-2-methylbutyl]amino}-1-phenylbutan-2-yl]carbamate, PHOSPHATE ION, Pol polyprotein 著者 Schiffer, C.A, Nalam, M.N.L. 登録日 2012-02-02 公開日 2012-08-01 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.4 Å) 主引用文献 Design, synthesis, and biological and structural evaluations of novel HIV-1 protease inhibitors to combat drug resistance. J.Med.Chem., 55, 2012
6GY3	Crystal Structure of C. glutamicum AmtR bound to glnA operator DNA 分子名称: AmtR protein, DNA (5'-D(*GP*TP*CP*TP*AP*TP*AP*GP*AP*TP*CP*GP*AP*TP*AP*GP*AP*C)-3'), DNA (5'-D(*GP*TP*CP*TP*AP*TP*CP*GP*AP*TP*CP*TP*AP*TP*AP*GP*AP*C)-3') 著者 Sevvana, M, Muller, Y.A. 登録日 2018-06-28 公開日 2019-07-10 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.68 Å) 主引用文献 The role of DNA flexibility in transcription regulator AmtR-DNA interaction To be published
6GYU	Cryo-EM structure of the CBF3-msk complex of the budding yeast kinetochore 分子名称: Centromere DNA-binding protein complex CBF3 subunit A, Centromere DNA-binding protein complex CBF3 subunit B, Centromere DNA-binding protein complex CBF3 subunit C, ... 著者 Yan, K, Zhang, Z, Yang, J, McLaughlin, S.H, Barford, D. 登録日 2018-07-02 公開日 2018-12-05 最終更新日 2019-12-18 実験手法 ELECTRON MICROSCOPY (3 Å) 主引用文献 Architecture of the CBF3-centromere complex of the budding yeast kinetochore. Nat. Struct. Mol. Biol., 25, 2018
7FDE	CryoEM Structures of Reconstituted V-ATPase, Oxr1 bound V1 分子名称: Oxidation resistance protein 1, V-type proton ATPase subunit B, V-type proton ATPase subunit C, ... 著者 Khan, M.M, Lee, S, Oot, R.A, Couoh-Cardel, S, KIm, H, Wilkens, S, Roh, S.H. 登録日 2021-07-16 公開日 2021-12-29 最終更新日 2024-06-12 実験手法 ELECTRON MICROSCOPY (3.8 Å) 主引用文献 CryoEM Structures of Reconstituted V-ATPase and Oxr1-bound V1 Reveal a Novel Mechanism of Regulation. Embo J., 2021
6H3O	Alcohol oxidase from Phanerochaete chrysosporium mutant F101S 分子名称: Alcohol oxidase, FLAVIN-ADENINE DINUCLEOTIDE, GLYCEROL 著者 Nguyen, Q.-T, Romero, E, Dijkman, W.P, de Vasconcellos, S.P, Binda, C, Mattevi, A, Fraaije, M.W. 登録日 2018-07-19 公開日 2018-10-10 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Structure-Based Engineering of Phanerochaete chrysosporium Alcohol Oxidase for Enhanced Oxidative Power toward Glycerol. Biochemistry, 57, 2018
7ERE	Crystal structure of human Biliverdin IX-beta reductase B with Pyrantel Pamoate (PPA) 分子名称: 4-[(3-carboxy-2-oxidanyl-naphthalen-1-yl)methyl]-3-oxidanyl-naphthalene-2-carboxylic acid, Flavin reductase (NADPH), NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... 著者 Griesinger, C, Lee, D, Ryu, K.S, Kim, M, Ha, J.H. 登録日 2021-05-06 公開日 2022-01-19 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Repositioning Food and Drug Administration-Approved Drugs for Inhibiting Biliverdin IX beta Reductase B as a Novel Thrombocytopenia Therapeutic Target. J.Med.Chem., 65, 2022
4A7E	X-ray crystal structure of porcine insulin flash-cooled at high pressure 分子名称: INSULIN A CHAIN, INSULIN B CHAIN 著者 Burkhardt, A, Warmer, M, Panneerselvam, S, Wagner, A, Reimer, R, Hohenberg, H, Meents, A. 登録日 2011-11-14 公開日 2011-11-30 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (1.856 Å) 主引用文献 Fast High-Pressure Freezing of Protein Crystals in Their Mother Liquor Acta Crystallogr.,Sect.F, 68, 2012
4A08	Structure of hsDDB1-drDDB2 bound to a 13 bp CPD-duplex (purine at D-1 position) at 3.0 A resolution (CPD 1) 分子名称: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 5'-D(*AP*CP*GP*CP*GP*AP*(TTD)P*GP*CP*GP*CP*CP*C)-3', 5'-D(*TP*GP*GP*GP*CP*GP*CP*CP*CP*TP*CP*GP*CP*G)-3', ... 著者 Scrima, A, Fischer, E.S, Iwai, S, Gut, H, Thoma, N.H. 登録日 2011-09-08 公開日 2011-11-30 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 The Molecular Basis of Crl4(Ddb2/Csa) Ubiquitin Ligase Architecture, Targeting, and Activation Cell(Cambridge,Mass.), 147, 2011

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