PDB: 215264 件ウェブページステータス検索Chemie searchBIRD

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3I5K	Crystal structure of the NS5B polymerase from Hepatitis C Virus (HCV) strain JFH1 分子名称: PHOSPHATE ION, RNA-directed RNA polymerase 著者 Simister, P.C, Schmitt, M, Lohmann, V, Bressanelli, S. 登録日 2009-07-05 公開日 2009-09-22 最終更新日 2024-03-20 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Structural and functional analysis of hepatitis C virus strain JFH1 polymerase J.Virol., 83, 2009
1OAE	Crystal structure of the reduced form of cytochrome c" from Methylophilus methylotrophus 分子名称: CYTOCHROME C", GLYCEROL, HEME C, ... 著者 Enguita, F.J, Grenha, R, Santos, H, Carrondo, M.A. 登録日 2003-01-09 公開日 2004-03-26 最終更新日 2024-05-01 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 Structural Evidence for a Proton Transfer Pathway Coupled with Haem Reduction of Cytochrome C" from Methylophilus Methylotrophus. J.Biol.Inorg.Chem., 11, 2006
3I5N	Crystal structure of c-Met with triazolopyridazine inhibitor 13 分子名称: 7-methoxy-N-[(6-phenyl[1,2,4]triazolo[4,3-b]pyridazin-3-yl)methyl]-1,5-naphthyridin-4-amine, Hepatocyte growth factor receptor 著者 Bellon, S.F, Whittington, D.A, Long, A.M, Boezio, A.A. 登録日 2009-07-06 公開日 2010-01-12 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Discovery and optimization of potent and selective triazolopyridazine series of c-Met inhibitors Bioorg.Med.Chem.Lett., 19, 2009
6DIU	Crystal structure of HCV NS3/4A protease in complex with P4-3(AJ-74) 分子名称: 1-methylcyclopentyl [(2R,6S,12Z,13aS,14aR,16aS)-2-[(7-methoxy-3-methylquinoxalin-2-yl)oxy]-14a-{[(1-methylcyclopropyl)sulfonyl]carbamoyl}-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin-6-yl]carbamate, GLYCEROL, NS3 protease, ... 著者 Matthew, A.N, Schiffer, C.A. 登録日 2018-05-23 公開日 2019-07-31 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.868 Å) 主引用文献 Design of Hepatitis C NS3/4A Protease Inhibitors Leveraging Untapped Regions of the Substrate Envelope To Be Published
2W0I	Structure Of C-Terminal Actin Depolymerizing Factor Homology (Adf-H) Domain Of Human Twinfilin-2 分子名称: TWINFILIN-2 著者 Elkins, J.M, Pike, A.C.W, Salah, E, Savitsky, P, Murray, J.W, Roos, A, von Delft, F, Edwards, A, Arrowsmith, C.H, Wikstrom, M, Bountra, C, Knapp, S. 登録日 2008-08-18 公開日 2008-09-30 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Structure of C-Terminal Actin Depolymerizing Factor Homology (Adf-H) Domain of Human Twinfilin- 2 To be Published
6DIS	Crystal structure of HCV NS3/4A protease in complex with P4-1 (AJ-71) 分子名称: 1,1,1-trifluoro-2-methylpropan-2-yl [(2R,6S,12Z,13aS,14aR,16aS)-2-[(7-methoxy-3-methylquinoxalin-2-yl)oxy]-14a-{[(1-methylcyclopropyl)sulfonyl]carbamoyl}-5, 16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin-6- yl]carbamate, GLYCEROL, ... 著者 Matthew, A.N, Schiffer, C.A. 登録日 2018-05-23 公開日 2019-07-31 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.921 Å) 主引用文献 Design of Hepatitis C NS3/4A Protease Inhibitors Leveraging Untapped Regions of the Substrate Envelope To Be Published
5OP0	Structure of Prim-PolC from Mycobacterium smegmatis 分子名称: DNA polymerase LigD, polymerase domain 著者 Brissett, N.C, Doherty, A.J. 登録日 2017-08-09 公開日 2017-11-15 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.84 Å) 主引用文献 DNA Ligase C and Prim-PolC participate in base excision repair in mycobacteria. Nat Commun, 8, 2017
7DYV	Human JMJD5 in complex with MN and 5-(benzylamino)pyridine-2,4-dicarboxylic acid. 分子名称: 5-(benzylamino)pyridine-2,4-dicarboxylic acid, Bifunctional peptidase and arginyl-hydroxylase JMJD5, MANGANESE (II) ION 著者 Nakashima, Y, Brewitz, L, Schofield, C.J. 登録日 2021-01-23 公開日 2022-02-02 最終更新日 2023-12-06 実験手法 X-RAY DIFFRACTION (1.92 Å) 主引用文献 5-Substituted Pyridine-2,4-dicarboxylate Derivatives Have Potential for Selective Inhibition of Human Jumonji-C Domain-Containing Protein 5. J.Med.Chem., 66, 2023
6DIR	Crystal structure of HCV NS3/4A protease in complex with P4-P5-2 (AJ-67) 分子名称: (2R,6S,12Z,13aS,14aR,16aS)-6-[(N-acetyl-3-methyl-L-valyl)amino]-2-[(7-methoxy-3-methylquinoxalin-2-yl)oxy]-N-[(1-methyl cyclopropyl)sulfonyl]-5,16-dioxo-1,2,3,6,7,8,9,10,11,13a,14,15,16,16a-tetradecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diaz acyclopentadecine-14a(5H)-carboxamide, NS3 protease, SULFATE ION, ... 著者 Matthew, A.N, Schiffer, C.A. 登録日 2018-05-23 公開日 2019-07-31 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.751 Å) 主引用文献 Design of Hepatitis C NS3/4A Protease Inhibitors Leveraging Untapped Regions of the Substrate Envelope To Be Published
6DIV	Crystal structure of HCV NS3/4A D168A protease in complex with P4-P5-2 (AJ-67) 分子名称: (2R,6S,12Z,13aS,14aR,16aS)-6-[(N-acetyl-3-methyl-L-valyl)amino]-2-[(7-methoxy-3-methylquinoxalin-2-yl)oxy]-N-[(1-methyl cyclopropyl)sulfonyl]-5,16-dioxo-1,2,3,6,7,8,9,10,11,13a,14,15,16,16a-tetradecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diaz acyclopentadecine-14a(5H)-carboxamide, GLYCEROL, NS3 protease, ... 著者 Matthew, A.N, Schiffer, C.A. 登録日 2018-05-23 公開日 2019-07-31 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.83 Å) 主引用文献 Design of Hepatitis C NS3/4A Protease Inhibitors Leveraging Untapped Regions of the Substrate Envelope To Be Published
7DYW	Human JMJD5 in complex with MN and 5-((2-methoxybenzyl)amino)pyridine-2,4-dicarboxylic acid. 分子名称: 5-((2-methoxybenzyl)amino)pyridine-2,4-dicarboxylic acid, Bifunctional peptidase and arginyl-hydroxylase JMJD5, MANGANESE (II) ION 著者 Nakashima, Y, Brewitz, L, Schofield, C.J. 登録日 2021-01-23 公開日 2022-02-02 最終更新日 2023-12-06 実験手法 X-RAY DIFFRACTION (2.13 Å) 主引用文献 5-Substituted Pyridine-2,4-dicarboxylate Derivatives Have Potential for Selective Inhibition of Human Jumonji-C Domain-Containing Protein 5. J.Med.Chem., 66, 2023
7DYT	Human JMJD5 in complex with MN and 5-((4-methoxybenzyl)amino)pyridine-2,4-dicarboxylic acid. 分子名称: 5-((4-methoxybenzyl)amino)pyridine-2,4-dicarboxylic acid, Bifunctional peptidase and arginyl-hydroxylase JMJD5, MANGANESE (II) ION 著者 Nakashima, Y, Brewitz, L, Schofield, C.J. 登録日 2021-01-23 公開日 2022-02-02 最終更新日 2023-12-06 実験手法 X-RAY DIFFRACTION (1.62 Å) 主引用文献 5-Substituted Pyridine-2,4-dicarboxylate Derivatives Have Potential for Selective Inhibition of Human Jumonji-C Domain-Containing Protein 5. J.Med.Chem., 66, 2023
7DYX	Human JMJD5 in complex with MN and 5-((2-cyclopropylbenzyl)amino)pyridine-2,4-dicarboxylic acid. 分子名称: 5-((2-cyclopropylbenzyl)amino)pyridine-2,4-dicarboxylic acid, Bifunctional peptidase and arginyl-hydroxylase JMJD5, MANGANESE (II) ION 著者 Nakashima, Y, Brewitz, L, Schofield, C.J. 登録日 2021-01-23 公開日 2022-02-02 最終更新日 2023-12-06 実験手法 X-RAY DIFFRACTION (2.27 Å) 主引用文献 5-Substituted Pyridine-2,4-dicarboxylate Derivatives Have Potential for Selective Inhibition of Human Jumonji-C Domain-Containing Protein 5. J.Med.Chem., 66, 2023
7DYU	Human JMJD5 in complex with MN and 5-((4-phenylbutyl)amino)pyridine-2,4-dicarboxylic acid. 分子名称: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 5-(4-phenylbutylamino)pyridine-2,4-dicarboxylic acid, Bifunctional peptidase and arginyl-hydroxylase JMJD5, ... 著者 Nakashima, Y, Brewitz, L, Schofield, C.J. 登録日 2021-01-23 公開日 2022-02-02 最終更新日 2023-12-06 実験手法 X-RAY DIFFRACTION (1.72 Å) 主引用文献 5-Substituted Pyridine-2,4-dicarboxylate Derivatives Have Potential for Selective Inhibition of Human Jumonji-C Domain-Containing Protein 5. J.Med.Chem., 66, 2023
5VOJ	Crystal structure of HCV NS3/4A protease in complex with JZ01-15, an analogue of 5172-mcP1P3 分子名称: NS4A cofactor -- NS3 protein chimera, SULFATE ION, ZINC ION, ... 著者 Matthew, A.N, Schiffer, C.A. 登録日 2017-05-03 公開日 2017-06-21 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.799 Å) 主引用文献 Hepatitis C Virus NS3/4A Protease Inhibitors Incorporating Flexible P2 Quinoxalines Target Drug Resistant Viral Variants. J. Med. Chem., 60, 2017
3NBS	Crystal structure of dimeric cytochrome c from horse heart 分子名称: Cytochrome c, DI(HYDROXYETHYL)ETHER, HEME C, ... 著者 Taketa, M, Komori, H, Hirota, S, Higuchi, Y. 登録日 2010-06-04 公開日 2010-07-14 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Cytochrome c polymerization by successive domain swapping at the C-terminal helix Proc.Natl.Acad.Sci.USA, 107, 2010
6DIQ	Crystal structure of HCV NS3/4A protease in complex with P4-P5-1 (WK-23) 分子名称: GLYCEROL, NS3 protease, SULFATE ION, ... 著者 Matthew, A.N, Schiffer, C.A. 登録日 2018-05-23 公開日 2019-07-31 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.579 Å) 主引用文献 Design of Hepatitis C NS3/4A Protease Inhibitors Leveraging Untapped Regions of the Substrate Envelope To Be Published
6DIW	Crystal structure of HCV NS3/4A D168A protease in complex with P4-1 (AJ-71) 分子名称: 1,1,1-trifluoro-2-methylpropan-2-yl [(2R,6S,12Z,13aS,14aR,16aS)-2-[(7-methoxy-3-methylquinoxalin-2-yl)oxy]-14a-{[(1-methylcyclopropyl)sulfonyl]carbamoyl}-5, 16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin-6- yl]carbamate, GLYCEROL, ... 著者 Matthew, A.N, Schiffer, C.A. 登録日 2018-05-23 公開日 2019-07-31 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Design of Hepatitis C NS3/4A Protease Inhibitors Leveraging Untapped Regions of the Substrate Envelope To Be Published
6DL0	Crystal structure of pohlianin C, an orbitide from Jatropha pohliana 分子名称: pohlianin C 著者 Wang, C.K, King, G.J, Ramalho, S.D. 登録日 2018-05-31 公開日 2018-11-07 最終更新日 2023-07-26 実験手法 X-RAY DIFFRACTION (1.2 Å) 主引用文献 Synthesis, Racemic X-ray Crystallographic, and Permeability Studies of Bioactive Orbitides from Jatropha Species. J. Nat. Prod., 81, 2018
3ZOO	Structure of the Y46F mutant of human cytochrome c 分子名称: CYTOCHROME C, HEME C, PHOSPHATE ION 著者 Rajagopal, B.S, Worrall, J.A.R, Hough, M.A. 登録日 2013-02-22 公開日 2013-10-23 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (1.35 Å) 主引用文献 The Hydrogen Peroxide Induced Radical Behaviour in Human Cytochrome C Phospholipid Complexes: Implications for the Enhanced Pro-Apoptotic Activity of the G41S Mutant Biochem.J., 456, 2013
6KKH	Crystal structure of the oxalate bound malyl-CoA lyase from Roseiflexus castenholzii 分子名称: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, HpcH/HpaI aldolase, MAGNESIUM ION, ... 著者 Tang, W.R, Wang, Z.G, Zhang, C.Y, Wang, C. 登録日 2019-07-25 公開日 2019-09-04 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.64 Å) 主引用文献 The C-terminal domain conformational switch revealed by the crystal structure of malyl-CoA lyase from Roseiflexus castenholzii. Biochem.Biophys.Res.Commun., 518, 2019
3ZCF	Structure of recombinant human cytochrome c 分子名称: CYTOCHROME C, HEME C 著者 Rajagopal, B.S, Worrall, J.A.R, Hough, M.A. 登録日 2012-11-20 公開日 2013-10-23 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (1.65 Å) 主引用文献 The Hydrogen Peroxide Induced Radical Behaviour in Human Cytochrome C Phospholipid Complexes: Implications for the Enhanced Pro-Apoptotic Activity of the G41S Mutant Biochem.J., 456, 2013
4ZRL	Structure of the non canonical Poly(A) polymerase complex GLD-2 - GLD-3 分子名称: CHLORIDE ION, Defective in germ line development protein 3, Poly(A) RNA polymerase gld-2 著者 Nakel, K, Bonneau, F, Eckmann, C.R, Conti, E. 登録日 2015-05-12 公開日 2015-07-08 最終更新日 2017-09-06 実験手法 X-RAY DIFFRACTION (2.28 Å) 主引用文献 Structural basis for the activation of the C. elegans noncanonical cytoplasmic poly(A)-polymerase GLD-2 by GLD-3. Proc.Natl.Acad.Sci.USA, 112, 2015
6DIT	Crystal structure of HCV NS3/4A protease in complex with P4-2 (JZ01-19) 分子名称: NS3 protease, ZINC ION, pentyl [(2R,6S,12Z,13aS,14aR,16aS)-2-[(7-methoxy-3-methylquinoxalin-2-yl)oxy]-14a-{[(1-methylcyclopropyl)sulfonyl]carbamoyl}-5, ... 著者 Matthew, A.N, Schiffer, C.A. 登録日 2018-05-23 公開日 2019-07-31 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.789 Å) 主引用文献 Design of Hepatitis C NS3/4A Protease Inhibitors Leveraging Untapped Regions of the Substrate Envelope To Be Published
3ZIX	Clostridium perfringens Enterotoxin with the N-terminal 37 residues deleted 分子名称: HEAT-LABILE ENTEROTOXIN B CHAIN, HEXAETHYLENE GLYCOL 著者 Yelland, T, Naylor, C.E, Savva, C.G, Basak, A.K. 登録日 2013-01-14 公開日 2014-01-29 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Structure of a C. Perfringens Enterotoxin Mutant in Complex with a Modified Claudin-2 Extracellular Loop 2 J.Mol.Biol., 426, 2014

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