3TXO

PKC eta kinase in complex with a naphthyridine

Summary for 3TXO

Entry DOI	10.2210/pdb3txo/pdb
Descriptor	Protein kinase C eta type, 2-methyl-N~1~-[3-(pyridin-4-yl)-2,6-naphthyridin-1-yl]propane-1,2-diamine (3 entities in total)
Functional Keywords	kinase, phosphotransferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	40786.46
Authors	Stark, W.,Rummel, G.,Cowan-Jacob, S.W. (deposition date: 2011-09-23, release date: 2011-11-30, Last modification date: 2011-12-07)
Primary citation	van Eis, M.J.,Evenou, J.P.,Floersheim, P.,Gaul, C.,Cowan-Jacob, S.W.,Monovich, L.,Rummel, G.,Schuler, W.,Stark, W.,Strauss, A.,Matt, A.,Vangrevelinghe, E.,Wagner, J.,Soldermann, N. 2,6-Naphthyridines as potent and selective inhibitors of the novel protein kinase C isozymes. Bioorg.Med.Chem.Lett., 21:7367-7372, 2011 Cited by PubMed: 22078216 DOI: 10.1016/j.bmcl.2011.10.025 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.05 Å)

Structure validation