3CCN
| X-ray structure of c-Met with triazolopyridazine inhibitor. | 分子名称: | 4-[(6-phenyl[1,2,4]triazolo[4,3-b]pyridazin-3-yl)methyl]phenol, Hepatocyte growth factor receptor | 著者 | Abrecht, B.K, Harmange, J.-C, Bauer, D, Dussault, I, long, A, Bellon, S.F. | 登録日 | 2008-02-26 | 公開日 | 2008-04-29 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Discovery and Optimization of Triazolopyridazines as Potent and Selective Inhibitors of the c-Met Kinase. J.Med.Chem., 51, 2008
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5T6Y
| HLA-B*57:01 presenting TSTFEDVKILAF | 分子名称: | ACETATE ION, Beta-2-microglobulin, Decapeptide: THR-SER-THR-PHE-GLU-ASP-VAL-LYS-ILE-LEU-ALA-PHE, ... | 著者 | Pymm, P, Rossjohn, J, Vivian, J.P. | 登録日 | 2016-09-02 | 公開日 | 2017-03-01 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (1.76 Å) | 主引用文献 | MHC-I peptides get out of the groove and enable a novel mechanism of HIV-1 escape. Nat. Struct. Mol. Biol., 24, 2017
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4ZFO
| J22.9-xi: chimeric mouse/human antibody against human BCMA (CD269) | 分子名称: | 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, COPPER (II) ION, J22.9-xi Fab, ... | 著者 | Marino, S.F, Daumke, O, Olal, D. | 登録日 | 2015-04-21 | 公開日 | 2015-05-20 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (1.895 Å) | 主引用文献 | Potent anti-tumor response by targeting B cell maturation antigen (BCMA) in a mouse model of multiple myeloma. Mol Oncol, 9, 2015
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8QO9
| Cryo-EM structure of a human spliceosomal B complex protomer | 分子名称: | 116 kDa U5 small nuclear ribonucleoprotein component, MINX pre-mRNA, Microfibrillar-associated protein 1, ... | 著者 | Zhang, Z, Kumar, V, Dybkov, O, Will, C.L, Urlaub, H, Stark, H, Luehrmann, R. | 登録日 | 2023-09-28 | 公開日 | 2024-01-24 | 最終更新日 | 2024-08-07 | 実験手法 | ELECTRON MICROSCOPY (5.29 Å) | 主引用文献 | Cryo-EM analyses of dimerized spliceosomes provide new insights into the functions of B complex proteins. Embo J., 43, 2024
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5H07
| TNIP2-Ub complex, C2 form | 分子名称: | Polyubiquitin-C, TNFAIP3-interacting protein 2 | 著者 | Lo, Y.C, Lin, S.C. | 登録日 | 2016-10-04 | 公開日 | 2017-03-08 | 実験手法 | X-RAY DIFFRACTION (2.586 Å) | 主引用文献 | Structural Insights into Linear Tri-ubiquitin Recognition by A20-Binding Inhibitor of NF-kappa B, ABIN-2 Structure, 25, 2017
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8EMA
| mouse full length B cell receptor | 分子名称: | Anti-human Langerin 2G3 lambda chain, B-cell antigen receptor complex-associated protein alpha chain, B-cell antigen receptor complex-associated protein beta chain, ... | 著者 | Ying, D, Xiong, P, Michael, R. | 登録日 | 2022-09-27 | 公開日 | 2022-11-16 | 最終更新日 | 2022-12-07 | 実験手法 | ELECTRON MICROSCOPY (8.2 Å) | 主引用文献 | Structural principles of B cell antigen receptor assembly. Nature, 612, 2022
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5WJW
| Cryo-EM structure of B. subtilis flagellar filaments H84R | 分子名称: | Flagellin | 著者 | Wang, F, Burrage, A.M, Orlova, A, Kearns, D.B, Egelman, E.H. | 登録日 | 2017-07-24 | 公開日 | 2017-10-25 | 最終更新日 | 2024-03-13 | 実験手法 | ELECTRON MICROSCOPY (4.4 Å) | 主引用文献 | A structural model of flagellar filament switching across multiple bacterial species. Nat Commun, 8, 2017
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4IVA
| JAK2 kinase (JH1 domain) in complex with the inhibitor TRANS-4-[(8AS)-2-[(1R)-1-HYDROXYETHYL]IMIDAZO[4,5-D]PYRROLO[2,3-B]PYRIDIN-1(8AH)-YL]CYCLOHEXANECARBONITRILE | 分子名称: | Tyrosine-protein kinase JAK2, trans-4-{2-[(1R)-1-hydroxyethyl]imidazo[4,5-d]pyrrolo[2,3-b]pyridin-1(6H)-yl}cyclohexanecarbonitrile | 著者 | Eigenbrot, C, Shia, S. | 登録日 | 2013-01-22 | 公開日 | 2013-05-22 | 最終更新日 | 2023-12-06 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | Identification of C-2 Hydroxyethyl Imidazopyrrolopyridines as Potent JAK1 Inhibitors with Favorable Physicochemical Properties and High Selectivity over JAK2. J.Med.Chem., 56, 2013
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6N5W
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3NGS
| Structure of Leishmania nucleoside diphosphate kinase b with ordered nucleotide-binding loop | 分子名称: | 2,3-DIHYDROXY-1,4-DITHIOBUTANE, Nucleoside diphosphate kinase, PHOSPHATE ION | 著者 | Trindade, D.M, Sousa, T.A.C.B, Tonoli, C.C.C, Santos, C.R, Arni, R.K, Ward, R.J, Oliveira, A.H.C, Murakami, M.T. | 登録日 | 2010-06-13 | 公開日 | 2011-04-27 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Molecular adaptability of nucleoside diphosphate kinase b from trypanosomatid parasites: stability, oligomerization and structural determinants of nucleotide binding. Mol Biosyst, 7, 2011
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5UPJ
| HIV-2 PROTEASE/U99283 COMPLEX | 分子名称: | 5,6,7,8,9,10-HEXAHYDRO-4-HYDROXY-3-(1-PHENYLPROPYL)CYCLOOCTA[B]PYRAN-2-ONE, HIV-2 PROTEASE | 著者 | Watenpaugh, K.D, Mulichak, A.M, Finzel, B.C. | 登録日 | 1996-12-10 | 公開日 | 1997-04-21 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Use of medium-sized cycloalkyl rings to enhance secondary binding: discovery of a new class of human immunodeficiency virus (HIV) protease inhibitors. J.Med.Chem., 38, 1995
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3W32
| EGFR kinase domain complexed with compound 20a | 分子名称: | 4-({3-chloro-4-[3-(trifluoromethyl)phenoxy]phenyl}amino)-N-[2-(methylsulfonyl)ethyl]-8,9-dihydro-7H-pyrimido[4,5-b]azepine-6-carboxamide, Epidermal growth factor receptor, SULFATE ION | 著者 | Sogabe, S, Kawakita, Y. | 登録日 | 2012-12-07 | 公開日 | 2013-03-06 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Design and synthesis of novel pyrimido[4,5-b]azepine derivatives as HER2/EGFR dual inhibitors Bioorg.Med.Chem., 21, 2013
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3WC7
| Carboxypeptidase B in complex with EF6265 | 分子名称: | (2S)-7-amino-2-{[(R)-hydroxy{(1R)-2-methyl-1-[(3-phenylpropanoyl)amino]propyl}phosphoryl]methyl}heptanoic acid, Carboxypeptidase B, ZINC ION | 著者 | Yoshimoto, N, Itoh, T, Inaba, Y, Yamamoto, K. | 登録日 | 2013-05-24 | 公開日 | 2013-10-02 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Structural basis for inhibition of carboxypeptidase B by selenium-containing inhibitor: selenium coordinates to zinc in enzyme. J.Med.Chem., 56, 2013
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6M1J
| The DNA Gyrase B ATP binding domain of PSEUDOMONAS AERUGINOSA in complex with compound 12x | 分子名称: | 1-[5-[6-fluoranyl-8-(methylamino)-4-[3-(trifluoromethyl)pyrazol-1-yl]-9H-pyrido[2,3-b]indol-3-yl]pyrimidin-2-yl]cyclopropane-1-carboxylic acid, DIMETHYL SULFOXIDE, DNA gyrase subunit B, ... | 著者 | Xu, Z.H, Zhou, Z. | 登録日 | 2020-02-26 | 公開日 | 2020-09-02 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.701 Å) | 主引用文献 | Discovery of Pyrido[2,3-b]indole Derivatives with Gram-Negative Activity Targeting Both DNA Gyrase and Topoisomerase IV. J.Med.Chem., 63, 2020
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5B23
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5BQ6
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4ZV7
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6NR6
| Crystal Structure of Staphylococcus pseudintermedius SbnI in complex with ADP | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, Bifunctional transcriptional regulator/O-phospho-L-serine synthase SbnI, MAGNESIUM ION | 著者 | Verstraete, M.M, Morales, L.D, Kobylarz, M.J, Loutet, S.A, Laakso, H.A, Heinrichs, D.E, Murphy, M.E.P. | 登録日 | 2019-01-22 | 公開日 | 2019-06-19 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | The heme-sensitive regulator SbnI has a bifunctional role in staphyloferrin B production by Staphylococcus aureus . J.Biol.Chem., 294, 2019
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3WAB
| Carboxypeptidase B in complex with DD2 | 分子名称: | (2R)-7-amino-2-(sulfanylmethyl)heptanoic acid, CACODYLATE ION, Carboxypeptidase B, ... | 著者 | Yoshimoto, N, Itoh, T, Inaba, Y, Yamamoto, K. | 登録日 | 2013-05-01 | 公開日 | 2013-10-02 | 最終更新日 | 2024-10-16 | 実験手法 | X-RAY DIFFRACTION (2.154 Å) | 主引用文献 | Structural basis for inhibition of carboxypeptidase B by selenium-containing inhibitor: selenium coordinates to zinc in enzyme. J.Med.Chem., 56, 2013
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3WC5
| Carboxypeptidase B in complex with DD9 | 分子名称: | (2R)-7-amino-2-(selanylmethyl)heptanoic acid, CACODYLATE ION, Carboxypeptidase B, ... | 著者 | Yoshimoto, N, Itoh, T, Inaba, Y, Yamamoto, K. | 登録日 | 2013-05-24 | 公開日 | 2013-10-02 | 最終更新日 | 2022-08-24 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Structural basis for inhibition of carboxypeptidase B by selenium-containing inhibitor: selenium coordinates to zinc in enzyme. J.Med.Chem., 56, 2013
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1MQY
| NMR solution structure of type-B lantibiotics mersacidin in DPC micelles | 分子名称: | LANTIBIOTIC MERSACIDIN | 著者 | Hsu, S.-T, Breukink, E, Bierbaum, G, Sahl, H.-G, de Kruijff, B, Kaptein, R, van Nuland, N.A, Bonvin, A.M. | 登録日 | 2002-09-17 | 公開日 | 2003-03-11 | 最終更新日 | 2024-07-10 | 実験手法 | SOLUTION NMR | 主引用文献 | NMR Study of Mersacidin and Lipid II Interaction in Dodecylphosphocholine Micelles. Conformational Changes are a Key to Antimicrobial Activity J.Biol.Chem., 278, 2003
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1MQZ
| NMR solution structure of type-B lantibiotics mersacidin bound to lipid II in DPC micelles | 分子名称: | LANTIBIOTIC MERSACIDIN | 著者 | Hsu, S.-T, Breukink, E, Bierbaum, G, Sahl, H.-G, de Kruijff, B, Kaptein, R, van Nuland, N.A, Bonvin, A.M. | 登録日 | 2002-09-17 | 公開日 | 2003-03-11 | 最終更新日 | 2024-07-10 | 実験手法 | SOLUTION NMR | 主引用文献 | NMR Study of Mersacidin and Lipid II Interaction in Dodecylphosphocholine Micelles. Conformational Changes are a Key to Antimicrobial Activity J.Biol.Chem., 278, 2003
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5WJX
| Cryo-EM structure of B. subtilis flagellar filaments S17P | 分子名称: | Flagellin | 著者 | Wang, F, Burrage, A.M, Orlova, A, Kearns, D.B, Egelman, E.H. | 登録日 | 2017-07-24 | 公開日 | 2017-10-25 | 最終更新日 | 2024-03-13 | 実験手法 | ELECTRON MICROSCOPY (6.7 Å) | 主引用文献 | A structural model of flagellar filament switching across multiple bacterial species. Nat Commun, 8, 2017
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5CMJ
| GTA mutant with mercury - E303Q | 分子名称: | Histo-blood group ABO system transferase, MERCURY (II) ION | 著者 | Gagnon, S.M.L, Blackler, R.J. | 登録日 | 2015-07-16 | 公開日 | 2016-07-20 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (1.73 Å) | 主引用文献 | Glycosyltransfer in mutants of putative catalytic residue Glu303 of the human ABO(H) A and B blood group glycosyltransferases GTA and GTB proceeds through a labile active site. Glycobiology, 27, 2017
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3W33
| EGFR kinase domain complexed with compound 19b | 分子名称: | 4-{[4-(1-benzothiophen-4-yloxy)-3-chlorophenyl]amino}-N-(2-hydroxyethyl)-8,9-dihydro-7H-pyrimido[4,5-b]azepine-6-carboxamide, Epidermal growth factor receptor, SULFATE ION | 著者 | Sogabe, S, Kawakita, Y. | 登録日 | 2012-12-07 | 公開日 | 2013-03-06 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Design and synthesis of novel pyrimido[4,5-b]azepine derivatives as HER2/EGFR dual inhibitors Bioorg.Med.Chem., 21, 2013
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