PDB: 5653 件ウェブページステータス検索Chemie searchBIRD

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2FWA	Structure of PurE (N5-carboxyaminoimidazole ribonucleotide mutase) H89N from the acidophilic bacterium Acetobacter aceti, at pH 7 分子名称: N5-carboxyaminoimidazole ribonucleotide mutase 著者 Starks, C.M, Kappock, T.J. 登録日 2006-02-01 公開日 2006-06-13 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Biochemical and Structural Studies of N(5)-Carboxyaminoimidazole Ribonucleotide Mutase from the Acidophilic Bacterium Acetobacter aceti. Biochemistry, 45, 2006
8HYJ	A cryo-EM structure of KTF1-bound polymerase V transcription elongation complex 分子名称: DNA (48-MER), DNA-directed RNA polymerase V subunit 1, DNA-directed RNA polymerase V subunit 5A, ... 著者 Zhang, H, Zhang, Y. 登録日 2023-01-06 公開日 2023-06-21 最終更新日 2024-05-29 実験手法 ELECTRON MICROSCOPY (4.3 Å) 主引用文献 A cryo-EM structure of KTF1-bound polymerase V transcription elongation complex. Nat Commun, 14, 2023
5WHR	Discovery of a novel and selective IDO-1 inhibitor PF-06840003 and its characterization as a potential clinical candidate. 分子名称: (3R)-3-(5-fluoro-1H-indol-3-yl)pyrrolidine-2,5-dione, Indoleamine 2,3-dioxygenase 1, PROTOPORPHYRIN IX CONTAINING FE 著者 Greasley, S.E, Kaiser, S.E, Feng, J.L, Stewart, A. 登録日 2017-07-18 公開日 2017-12-27 実験手法 X-RAY DIFFRACTION (2.28 Å) 主引用文献 Discovery of a Novel and Selective Indoleamine 2,3-Dioxygenase (IDO-1) Inhibitor 3-(5-Fluoro-1H-indol-3-yl)pyrrolidine-2,5-dione (EOS200271/PF-06840003) and Its Characterization as a Potential Clinical Candidate. J. Med. Chem., 60, 2017
5WMV	Structural Insights into Substrate and Inhibitor Binding Sites in Human Indoleamine 2,3-Dioxygenase 1 分子名称: 2-(1H-indol-3-yl)ethanol, CYANIDE ION, Indoleamine 2,3-dioxygenase 1, ... 著者 Lewis-Ballester, A, Yeh, S.R, Pham, K.N, Batabyal, D, Karkashon, S, Bonanno, J.B, Poulos, T.L. 登録日 2017-07-31 公開日 2017-12-06 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Structural insights into substrate and inhibitor binding sites in human indoleamine 2,3-dioxygenase 1. Nat Commun, 8, 2017
2GZ3	Structure of Aspartate Semialdehyde Dehydrogenase (ASADH) from Streptococcus pneumoniae complexed with NADP and aspartate-semialdehyde 分子名称: (2R)-2-AMINO-4-OXOBUTANOIC ACID, Aspartate beta-semialdehyde dehydrogenase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE 著者 Faehnle, C.R, Le Coq, J, Liu, X, Viola, R.E. 登録日 2006-05-10 公開日 2006-08-15 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Examination of key intermediates in the catalytic cycle of aspartate-beta-semialdehyde dehydrogenase from a gram-positive infectious bacteria. J.Biol.Chem., 281, 2006
4ZZ3	Human GAR transformylase in complex with GAR and pemetrexed 分子名称: GLYCINAMIDE RIBONUCLEOTIDE, N-{4-[2-(2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl}-L-glutamic acid, Trifunctional purine biosynthetic protein adenosine-3 著者 Deis, S.M, Dann III, C.E. 登録日 2015-05-22 公開日 2015-12-16 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.504 Å) 主引用文献 6-Substituted Pyrrolo[2,3-d]pyrimidine Thienoyl Regioisomers as Targeted Antifolates for Folate Receptor alpha and the Proton-Coupled Folate Transporter in Human Tumors. J.Med.Chem., 58, 2015
9BEI	Cryo-EM structure of synthetic claudin-4 complex with Clostridium perfringens enterotoxin C-terminal domain, sFab COP-2, and Nanobody 分子名称: Anti-fab nanobody, COP-2 Fab Heavy chain, COP-2 Fab Light chain, ... 著者 Vecchio, A.J. 登録日 2024-04-15 公開日 2024-04-24 最終更新日 2024-07-03 実験手法 ELECTRON MICROSCOPY (4.16 Å) 主引用文献 Computational design of soluble and functional membrane protein analogues. Nature, 2024
7D80	Molecular model of the cryo-EM structure of 70S ribosome in complex with peptide deformylase, trigger factor, and methionine aminopeptidase 分子名称: 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S10, ... 著者 Akbar, S, Bhakta, S, Sengupta, J. 登録日 2020-10-06 公開日 2021-04-07 最終更新日 2024-05-29 実験手法 ELECTRON MICROSCOPY (4.1 Å) 主引用文献 Structural insights into the interplay of protein biogenesis factors with the 70S ribosome. Structure, 29, 2021
4ZZ2	HUMAN GAR TRANSFORMYLASE IN COMPLEX WITH GAR AND (S)-2-({5-[3-(2-AMINO-4-OXO-4,7-DIHYDRO-3H-PYRROLO[2,3-D]PYRIMIDIN-6-YL)-PROPYL]-THIOPHENE-3-CARBONYL}-AMINO)-PENTANEDIOIC ACID 分子名称: (S)-2-({5-[3-(2-Amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-6-yl)-propyl]-thiophene-3-carbonyl}-amino)-pentanedioic acid, GLYCINAMIDE RIBONUCLEOTIDE, Trifunctional purine biosynthetic protein adenosine-3 著者 Deis, S.M, Dann III, C.E. 登録日 2015-05-22 公開日 2015-12-16 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.451 Å) 主引用文献 6-Substituted Pyrrolo[2,3-d]pyrimidine Thienoyl Regioisomers as Targeted Antifolates for Folate Receptor alpha and the Proton-Coupled Folate Transporter in Human Tumors. J.Med.Chem., 58, 2015
7CXT	Crystal structure of a GDP-6-OMe-4-keto-L-xylo-heptose reductase from C.jejuni 分子名称: GDP-L-fucose synthase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE 著者 Kim, J.H, Kim, J.S. 登録日 2020-09-02 公開日 2021-04-14 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2.05 Å) 主引用文献 Crystal structure of a GDP-6-OMe-4-keto-L-xylo-heptose reductase from Campylobacter jejuni. Proteins, 2021
4ZZ1	HUMAN GAR TRANSFORMYLASE IN COMPLEX WITH GAR AND (S)-2-({4-[3-(2-AMINO-4-OXO-4,7-DIHYDRO-3H-PYRROLO[2,3-D]PYRIMIDIN-6-YL)-PROPYL]-THIOPHENE-2-CARBONYL}-AMINO)-PENTANEDIOIC ACID 分子名称: (S)-2-({4-[3-(2-Amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-6-yl)-propyl]-thiophene-2-carbonyl}-amino)-pentanedioic acid, GLYCINAMIDE RIBONUCLEOTIDE, Trifunctional purine biosynthetic protein adenosine-3 著者 Deis, S.M, Dann III, C.E. 登録日 2015-05-22 公開日 2015-12-16 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.351 Å) 主引用文献 6-Substituted Pyrrolo[2,3-d]pyrimidine Thienoyl Regioisomers as Targeted Antifolates for Folate Receptor alpha and the Proton-Coupled Folate Transporter in Human Tumors. J.Med.Chem., 58, 2015
7ALE	Crystal structure of human PAICS in complex with inhibitor 69 分子名称: (2~{S})-2-[[5-azanyl-1-[(2~{R},3~{R},4~{S},5~{R})-3,4-bis(oxidanyl)-5-(phosphonooxymethyl)oxolan-2-yl]imidazol-4-yl]car bonylamino]butanedioic acid, 2-azanyl-~{N}-[2-bromanyl-5-[4-[3-(dimethylamino)propylsulfonyl]piperazin-1-yl]phenyl]-1,3-oxazole-4-carboxamide, Multifunctional protein ADE2 著者 Skerlova, J, Marttila, P, Unterlass, J, Jemth, A.-S, Henriksson, M, Wakchaure, P, Grube, M, Warpman Berglund, U, Homan, E, Helleday, T, Stenmark, P. 登録日 2020-10-06 公開日 2022-04-20 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.95 Å) 主引用文献 Cellular and biochemical validation of a potent PAICS inhibitor To Be Published
2R86	Crystal structure of PurP from Pyrococcus furiosus complexed with ATP 分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, ADENOSINE-5'-TRIPHOSPHATE, PHOSPHATE ION, ... 著者 Zhang, Y, White, R.H, Ealick, S.E. 登録日 2007-09-10 公開日 2007-12-04 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Crystal structure and function of 5-formaminoimidazole-4-carboxamide ribonucleotide synthetase from Methanocaldococcus jannaschii. Biochemistry, 47, 2008
2R7M	Crystal structure of FAICAR synthetase (PurP) from M. jannaschii complexed with AMP 分子名称: 5-formaminoimidazole-4-carboxamide-1-(beta)-D-ribofuranosyl 5'-monophosphate synthetase, ADENOSINE MONOPHOSPHATE, CHLORIDE ION, ... 著者 Zhang, Y, White, R.H, Ealick, S.E. 登録日 2007-09-09 公開日 2007-12-04 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Crystal structure and function of 5-formaminoimidazole-4-carboxamide ribonucleotide synthetase from Methanocaldococcus jannaschii. Biochemistry, 47, 2008
3W1N	Crystal structure of Trypanosoma cruzi dihydroorotate dehydrogenase in complex with 5-iodoorotate 分子名称: 5-iodo-2,6-dioxo-1,2,3,6-tetrahydropyrimidine-4-carboxylic acid, COBALT HEXAMMINE(III), Dihydroorotate dehydrogenase (fumarate), ... 著者 Inaoka, D.K, Iida, M, Tabuchi, T, Lee, N, Matsuoka, S, Shiba, T, Sakamoto, K, Suzuki, S, Balogun, E.O, Nara, T, Aoki, T, Inoue, M, Honma, T, Tanaka, A, Harada, S, Kita, K. 登録日 2012-11-19 公開日 2013-11-20 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Structure of Trypanosoma cruzi dihydroorotate dehydrogenase in complex with 5-iodoorotate To be Published
6LFG	Cryo-EM structure of the Drosophila CTP synthase product-bound filament 分子名称: CTP synthase 著者 Ji-long, L, Xian, Z, Chen-Jun, G. 登録日 2019-12-02 公開日 2020-03-18 最終更新日 2024-03-27 実験手法 ELECTRON MICROSCOPY (9.58 Å) 主引用文献 Drosophila CTP synthase can form distinct substrate- and product-bound filaments. J Genet Genomics, 46, 2019
2R84	Crystal structure of PurP from Pyrococcus furiosus complexed with AMP and AICAR 分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, ADENOSINE MONOPHOSPHATE, AMINOIMIDAZOLE 4-CARBOXAMIDE RIBONUCLEOTIDE, ... 著者 Zhang, Y, White, R.H, Ealick, S.E. 登録日 2007-09-10 公開日 2007-12-04 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Crystal structure and function of 5-formaminoimidazole-4-carboxamide ribonucleotide synthetase from Methanocaldococcus jannaschii. Biochemistry, 47, 2008
2R7L	Crystal structure of FAICAR synthetase (PurP) from M. jannaschii complexed with ATP and AICAR 分子名称: 5-formaminoimidazole-4-carboxamide-1-(beta)-D-ribofuranosyl 5'-monophosphate synthetase, ADENOSINE-5'-TRIPHOSPHATE, AMINOIMIDAZOLE 4-CARBOXAMIDE RIBONUCLEOTIDE, ... 著者 Zhang, Y, White, R.H, Ealick, S.E. 登録日 2007-09-09 公開日 2007-12-04 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Crystal structure and function of 5-formaminoimidazole-4-carboxamide ribonucleotide synthetase from Methanocaldococcus jannaschii. Biochemistry, 47, 2008
3W1L	Crystal structure of Trypanosoma cruzi dihydroorotate dehydrogenase in complex with 5-chloroorotate 分子名称: 5-chloro-2,6-dioxo-1,2,3,6-tetrahydropyrimidine-4-carboxylic acid, COBALT HEXAMMINE(III), Dihydroorotate dehydrogenase (fumarate), ... 著者 Inaoka, D.K, Iida, M, Tabuchi, T, Lee, N, Matsuoka, S, Shiba, T, Sakamoto, K, Suzuki, S, Balogun, E.O, Nara, T, Aoki, T, Inoue, M, Honma, T, Tanaka, A, Harada, S, Kita, K. 登録日 2012-11-16 公開日 2013-11-20 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Crystal structure of Trypanosoma cruzi dihydroorotate dehydrogenase in complex with 5-chloroorotate TO BE PUBLISHED
3W1X	Structure of Trypanosoma cruzi dihydroorotate dehydrogenase in complex with MII-3-121 分子名称: 5-{2-[4-(cyanomethyl)phenyl]ethyl}-2,6-dioxo-1,2,3,6-tetrahydropyrimidine-4-carboxylic acid, COBALT HEXAMMINE(III), Dihydroorotate dehydrogenase (fumarate), ... 著者 Inaoka, D.K, Iida, M, Tabuchi, T, Lee, N, Matsuoka, S, Shiba, T, Sakamoto, K, Suzuki, S, Balogun, E.O, Nara, T, Aoki, T, Inoue, M, Honma, T, Tanaka, A, Harada, S, Kita, K. 登録日 2012-11-22 公開日 2013-11-27 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (1.45 Å) 主引用文献 Structure of Trypanosoma cruzi dihydroorotate dehydrogenase in complex with MII-3-121. To be Published
2R7N	Crystal structure of FAICAR synthetase (PurP) from M. jannaschii complexed with ADP and FAICAR 分子名称: 5-(formylamino)-1-(5-O-phosphono-beta-D-ribofuranosyl)-1H-imidazole-4-carboxamide, 5-formaminoimidazole-4-carboxamide-1-(beta)-D-ribofuranosyl 5'-monophosphate synthetase, ADENOSINE-5'-DIPHOSPHATE, ... 著者 Zhang, Y, White, R.H, Ealick, S.E. 登録日 2007-09-09 公開日 2007-12-04 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Crystal structure and function of 5-formaminoimidazole-4-carboxamide ribonucleotide synthetase from Methanocaldococcus jannaschii. Biochemistry, 47, 2008
2R87	Crystal structure of PurP from Pyrococcus furiosus complexed with ADP 分子名称: ADENOSINE-5'-DIPHOSPHATE, PHOSPHATE ION, PurP protein PF1517 著者 Zhang, Y, White, R.H, Ealick, S.E. 登録日 2007-09-10 公開日 2007-12-04 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Crystal structure and function of 5-formaminoimidazole-4-carboxamide ribonucleotide synthetase from Methanocaldococcus jannaschii. Biochemistry, 47, 2008
3VIU	Crystal structure of PurL from thermus thermophilus 分子名称: ADENOSINE-5'-DIPHOSPHATE, DI(HYDROXYETHYL)ETHER, MAGNESIUM ION, ... 著者 Suzuki, S, Yanai, H, Kanagawa, M, Tamura, S, Watanabe, Y, Fuse, K, Baba, S, Sampei, G, Kawai, G, RIKEN Structural Genomics/Proteomics Initiative (RSGI) 登録日 2011-10-12 公開日 2012-01-18 最終更新日 2012-04-25 実験手法 X-RAY DIFFRACTION (2.35 Å) 主引用文献 Structure of N-formylglycinamide ribonucleotide amidotransferase II (PurL) from Thermus thermophilus HB8 Acta Crystallogr.,Sect.F, 68, 2012
4UKD	UMP/CMP KINASE FROM SLIME MOLD COMPLEXED WITH ADP, UDP, BERYLLIUM FLUORIDE 分子名称: ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM DIFLUORIDE, MAGNESIUM ION, ... 著者 Schlichting, I, Reinstein, J. 登録日 1997-05-20 公開日 1998-05-20 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Structures of active conformations of UMP kinase from Dictyostelium discoideum suggest phosphoryl transfer is associative. Biochemistry, 36, 1997
3W1A	Structure of Trypanosoma cruzi dihydroorotate dehydrogenase in complex with 5-halogenated orotate derivatives 分子名称: 5-FLUORO-2,6-DIOXO-1,2,3,6-TETRAHYDROPYRIMIDINE-4-CARBOXYLIC ACID, COBALT HEXAMMINE(III), Dihydroorotate dehydrogenase (fumarate), ... 著者 Inaoka, D.K, Iida, M, Tabuchi, T, Lee, N, Matsuoka, S, Shiba, T, Sakamoto, K, Suzuki, S, Balogun, E.O, Nara, T, Aoki, T, Inoue, M, Honma, T, Tanaka, A, Harada, S, Kita, K. 登録日 2012-11-13 公開日 2013-11-13 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (1.42 Å) 主引用文献 Structure of Trypanosoma cruzi dihydroorotate dehydrogenase in complex with 5-halogenated orotate derivatives To be Published

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