PDB: 2606 件ウェブページステータス検索Chemie searchBIRD

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5N20	Crystal structure of the BCL6 BTB domain in complex with pyrazolo-pyrimidine ligand 分子名称: B-cell lymphoma 6 protein, ~{N}-[5-[[3-cyano-7-(cyclopropylamino)pyrazolo[1,5-a]pyrimidin-5-yl]amino]-2-[(3~{R})-3-(dimethylamino)pyrrolidin-1-yl]phenyl]ethanamide 著者 Robb, G, Ferguson, A, Hargreaves, D. 登録日 2017-02-06 公開日 2017-05-17 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (1.38 Å) 主引用文献 Discovery of Pyrazolo[1,5-a]pyrimidine B-Cell Lymphoma 6 (BCL6) Binders and Optimization to High Affinity Macrocyclic Inhibitors. J. Med. Chem., 60, 2017
5N1V	Crystal structure of the protein kinase CK2 catalytic subunit in complex with pyrazolo-pyrimidine macrocyclic ligand 分子名称: 1,2-ETHANEDIOL, Casein kinase II subunit alpha, SULFATE ION, ... 著者 Robb, G, Ferguson, A, Hargreaves, D. 登録日 2017-02-06 公開日 2017-05-17 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (2.52 Å) 主引用文献 Discovery of Pyrazolo[1,5-a]pyrimidine B-Cell Lymphoma 6 (BCL6) Binders and Optimization to High Affinity Macrocyclic Inhibitors. J. Med. Chem., 60, 2017
7QTT	Structural organization of a late activated human spliceosome (Baqr, core region) 分子名称: 116 kDa U5 small nuclear ribonucleoprotein component, BUD13 homolog, Cell division cycle 5-like protein, ... 著者 Cretu, C, Pena, V. 登録日 2022-01-15 公開日 2023-05-10 最終更新日 2024-07-17 実験手法 ELECTRON MICROSCOPY (3.1 Å) 主引用文献 Structural basis of catalytic activation in human splicing. Nature, 617, 2023
2NQ3	Crystal structure of the C2 Domain of Human Itchy Homolog E3 Ubiquitin Protein Ligase 分子名称: CHLORIDE ION, Itchy homolog E3 ubiquitin protein ligase 著者 Walker, J.R, Avvakumov, G.V, Xue, S, Butler-Cole, C, Finerty Jr, P.J, Weigelt, J, Sundstrom, M, Arrowsmith, C.H, Edwards, A.M, Bochkarev, A, Dhe-Paganon, S, Structural Genomics Consortium (SGC) 登録日 2006-10-30 公開日 2006-11-14 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 The C2 Domain of Human Itchy Homolog E3 Ubiquitin Protein Ligase To be Published
3BLR	Crystal Structure of Human CDK9/cyclinT1 in complex with Flavopiridol 分子名称: 2-(2-CHLORO-PHENYL)-5,7-DIHYDROXY-8-(3-HYDROXY-1-METHYL-PIPERIDIN-4-YL)-4H-BENZOPYRAN-4-ONE, Cell division protein kinase 9, Cyclin-T1, ... 著者 Baumli, S, Lolli, G, Lowe, E.D, Johnson, L.N. 登録日 2007-12-11 公開日 2008-07-01 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 The structure of P-TEFb (CDK9/cyclin T1), its complex with flavopiridol and regulation by phosphorylation Embo J., 27, 2008
4L62	Crystal Structure of Pseudomonas aeruginosa transcriptional regulator PA2196 bound to its operator DNA 分子名称: DNA (25-MER), Transcriptional regulator 著者 Choe, J.W, Kim, Y.W. 登録日 2013-06-11 公開日 2013-10-23 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 Crystal structure of Pseudomonas aeruginosa transcriptional regulator PA2196 bound to its operator DNA. Biochem.Biophys.Res.Commun., 440, 2013
6VIL	Crystal structure of mouse BAHCC1 BAH domain in complex with H3K27me3 分子名称: BAH and coiled-coil domain-containing protein 1, Histone H3.1 著者 Song, J, Lu, J. 登録日 2020-01-13 公開日 2020-09-16 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (3.301 Å) 主引用文献 BAHCC1 binds H3K27me3 via a conserved BAH module to mediate gene silencing and oncogenesis. Nat.Genet., 52, 2020
6W4K	Crystal structure of Lysine Specific Demethylase 1 (LSD1) with CC-90011 分子名称: 4-[2-(4-aminopiperidin-1-yl)-5-(3-fluoro-4-methoxyphenyl)-1-methyl-6-oxo-1,6-dihydropyrimidin-4-yl]-2-fluorobenzonitrile, FLAVIN-ADENINE DINUCLEOTIDE, Lysine-specific histone demethylase 1A, ... 著者 Hosfield, D.J. 登録日 2020-03-11 公開日 2020-10-21 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.93 Å) 主引用文献 Discovery of CC-90011: A Potent and Selective Reversible Inhibitor of Lysine Specific Demethylase 1 (LSD1). J.Med.Chem., 63, 2020
3BLH	Crystal Structure of Human CDK9/cyclinT1 分子名称: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Cell division protein kinase 9, Cyclin-T1 著者 Baumli, S, Lolli, G, Lowe, E.D, Johnson, L.N. 登録日 2007-12-11 公開日 2008-07-01 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2.48 Å) 主引用文献 The structure of P-TEFb (CDK9/cyclin T1), its complex with flavopiridol and regulation by phosphorylation Embo J., 27, 2008
3C6O	Small molecule agonists and antagonists of F-box protein-substrate interactions in auxin perception and signaling 分子名称: (2S)-2-(1H-indol-3-yl)hexanoic acid, INOSITOL HEXAKISPHOSPHATE, SKP1-like protein 1A, ... 著者 Tan, X. 登録日 2008-02-04 公開日 2008-04-22 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Small-molecule agonists and antagonists of F-box protein-substrate interactions in auxin perception and signaling. Proc.Natl.Acad.Sci.Usa, 105, 2008
3C6N	Small molecule agonists and antagonists of F-box protein-substrate interactions in auxin perception and signaling 分子名称: (2S)-8-[(tert-butoxycarbonyl)amino]-2-(1H-indol-3-yl)octanoic acid, INOSITOL HEXAKISPHOSPHATE, SKP1-like protein 1A, ... 著者 Tan, X, Zheng, N, Hayashi, K. 登録日 2008-02-04 公開日 2008-04-22 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Small-molecule agonists and antagonists of F-box protein-substrate interactions in auxin perception and signaling. Proc.Natl.Acad.Sci.Usa, 105, 2008
4MBE	Sac3:Sus1:Cdc31:Nup1 complex 分子名称: CALCIUM ION, Cell division control protein 31, Nuclear mRNA export protein SAC3, ... 著者 Jani, D, Meineke, B, Stewart, M. 登録日 2013-08-19 公開日 2014-07-02 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.612 Å) 主引用文献 Structural basis for binding the TREX2 complex to nuclear pores, GAL1 localisation and mRNA export. Nucleic Acids Res., 42, 2014
3C6P	Small molecule agonists and antagonists of F-box protein-substrate interactions in auxin perception and signaling 分子名称: (2S)-2-(1H-indol-3-yl)pentanoic acid, INOSITOL HEXAKISPHOSPHATE, SKP1-like protein 1A, ... 著者 Tan, X. 登録日 2008-02-04 公開日 2008-04-22 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Small-molecule agonists and antagonists of F-box protein-substrate interactions in auxin perception and signaling. Proc.Natl.Acad.Sci.Usa, 105, 2008
3BLQ	Crystal Structure of Human CDK9/cyclinT1 in Complex with ATP 分子名称: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ADENOSINE-5'-TRIPHOSPHATE, Cell division protein kinase 9, ... 著者 Baumli, S, Lolli, G, Lowe, E.D, Johnson, L.N. 登録日 2007-12-11 公開日 2008-07-01 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 The structure of P-TEFb (CDK9/cyclin T1), its complex with flavopiridol and regulation by phosphorylation Embo J., 27, 2008
6I9H	Solution structure of TRIM28 RING domain 分子名称: Transcription intermediary factor 1-beta, ZINC ION 著者 Stevens, R.V, Esposito, D, Rittinger, K. 登録日 2018-11-23 公開日 2019-05-01 最終更新日 2024-06-19 実験手法 SOLUTION NMR 主引用文献 Characterisation of class VI TRIM RING domains: linking RING activity to C-terminal domain identity. Life Sci Alliance, 2, 2019
7KWM	CtBP1 (28-375) L182F/V185T - AMP 分子名称: ADENOSINE MONOPHOSPHATE, C-terminal-binding protein 1, CALCIUM ION 著者 Royer, W.E, Del Campo, M. 登録日 2020-12-01 公開日 2021-02-03 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 NAD(H) phosphates mediate tetramer assembly of human C-terminal binding protein (CtBP). J.Biol.Chem., 296, 2021
5ESC	Crystal structure of Group A Streptococcus HupZ 分子名称: HupZ 著者 Agniswamy, J, Weber, I.T. 登録日 2015-11-16 公開日 2016-05-25 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 In vitro heme biotransformation by the HupZ enzyme from Group A streptococcus. Biometals, 29, 2016
6HTS	Cryo-EM structure of the human INO80 complex bound to nucleosome 分子名称: ADENOSINE-5'-DIPHOSPHATE, Actin-related protein 5, Chromatin-remodeling ATPase INO80, ... 著者 Ayala, R, Willhoft, O, Aramayo, R.J, Wilkinson, M, McCormack, E.A, Ocloo, L, Wigley, D.B, Zhang, X. 登録日 2018-10-04 公開日 2018-11-07 最終更新日 2024-05-15 実験手法 ELECTRON MICROSCOPY (4.8 Å) 主引用文献 Structure and regulation of the human INO80-nucleosome complex. Nature, 556, 2018
1SXI	Structure of apo transcription regulator B. megaterium 分子名称: Glucose-resistance amylase regulator, MAGNESIUM ION 著者 Schumacher, M.A, Allen, G.S, Diel, M, Seidel, G, Hillen, W, Brennan, R.G. 登録日 2004-03-30 公開日 2004-10-19 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 Structural studies on the apo transcription factor form B. megaterium Cell(Cambridge,Mass.), 118, 2004
1SXG	Structural studies on the apo transcription factor form B. megaterium 分子名称: 2-PHENYLAMINO-ETHANESULFONIC ACID, Glucose-resistance amylase regulator 著者 Schumacher, M.A, Allen, G.S, Diel, M, Seidel, G, Hillen, W, Brennan, R.G. 登録日 2004-03-30 公開日 2004-10-19 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (2.75 Å) 主引用文献 Structural studies on the apo transcription factor form B. megaterium Cell(Cambridge,Mass.), 118, 2004
2WA4	FACTOR INHIBITING HIF-1 ALPHA WITH N,3-dihydroxybenzamide 分子名称: FE (II) ION, HYPOXIA-INDUCIBLE FACTOR 1-ALPHA INHIBITOR, N,3-DIHYDROXYBENZAMIDE, ... 著者 Conejo-Garcia, A, Lienard, B.M.R, Clifton, I.J, McDonough, M.A, Schofield, C.J. 登録日 2009-02-02 公開日 2010-04-21 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Structural basis for binding of cyclic 2-oxoglutarate analogues to factor-inhibiting hypoxia-inducible factor. Bioorg. Med. Chem. Lett., 20, 2010
2WA3	FACTOR INHIBITING HIF-1 ALPHA WITH 2-(3-hydroxyphenyl)-2-oxoacetic acid 分子名称: 2-(3-HYDROXYPHENYL)-2-OXO-ETHANOIC ACID, FE (II) ION, HYPOXIA-INDUCIBLE FACTOR 1-ALPHA INHIBITOR 著者 Conejo-Garcia, A, Lienard, B.M.R, Clifton, I.J, McDonough, M.A, Schofield, C.J. 登録日 2009-02-02 公開日 2010-04-21 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Structural basis for binding of cyclic 2-oxoglutarate analogues to factor-inhibiting hypoxia-inducible factor. Bioorg. Med. Chem. Lett., 20, 2010
2W0X	FACTOR INHIBITING HIF-1 ALPHA WITH PYRIDINE 2,4 DICARBOXYLIC ACID 分子名称: FE (II) ION, GLYCEROL, HYPOXIA-INDUCIBLE FACTOR 1 ALPHA INHIBITOR, ... 著者 Conejo-Garcia, A, Lienard, B.M.R, Clifton, I.J, McDonough, M.A, Schofield, C.J. 登録日 2008-10-10 公開日 2009-11-24 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (2.12 Å) 主引用文献 Structural basis for binding of cyclic 2-oxoglutarate analogues to factor-inhibiting hypoxia-inducible factor. Bioorg. Med. Chem. Lett., 20, 2010
8DSY	PPARg bound to inverse agonist H3B-343 分子名称: Peroxisome proliferator-activated receptor gamma, {5-[(5-{[(4-tert-butylphenyl)methyl]carbamoyl}-2,3-dimethyl-1H-indol-1-yl)methyl]-2-chlorophenoxy}acetic acid 著者 Larsen, N.A. 登録日 2022-07-24 公開日 2022-09-07 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (2.95 Å) 主引用文献 Biochemical and structural basis for the pharmacological inhibition of nuclear hormone receptor PPAR gamma by inverse agonists. J.Biol.Chem., 298, 2022
1H9U	The structure of the human retinoid-X-receptor beta ligand binding domain in complex with the specific synthetic agonist LG100268 分子名称: 6-[1-(3,5,5,8,8-PENTAMETHYL-5,6,7,8-TETRAHYDRONAPHTHALEN-2-YL)CYCLOPROPYL]PYRIDINE-3-CARBOXYLIC ACID, CHLORIDE ION, NICKEL (II) ION, ... 著者 Schwabe, J.W.R, Love, J.D, Gooch, J.T. 登録日 2001-03-21 公開日 2002-04-03 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 The Structural Basis for the Specificity of Retinoid-X Receptor-Selective Agonists: New Insights Into the Role of Helix H12 J.Biol.Chem., 277, 2002

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