6W4K

Crystal structure of Lysine Specific Demethylase 1 (LSD1) with CC-90011

Summary for 6W4K

Entry DOI	10.2210/pdb6w4k/pdb
Descriptor	Lysine-specific histone demethylase 1A, REST corepressor 1, 4-[2-(4-aminopiperidin-1-yl)-5-(3-fluoro-4-methoxyphenyl)-1-methyl-6-oxo-1,6-dihydropyrimidin-4-yl]-2-fluorobenzonitrile, ... (5 entities in total)
Functional Keywords	human lsd1 inhibitor-complex, flavoprotein
Biological source	Homo sapiens (Human) More
Total number of polymer chains	2
Total formula weight	89774.17
Authors	Hosfield, D.J. (deposition date: 2020-03-11, release date: 2020-10-21, Last modification date: 2023-10-18)
Primary citation	Kanouni, T.,Severin, C.,Cho, R.W.,Yuen, N.Y.,Xu, J.,Shi, L.,Lai, C.,Del Rosario, J.R.,Stansfield, R.K.,Lawton, L.N.,Hosfield, D.,O'Connell, S.,Kreilein, M.M.,Tavares-Greco, P.,Nie, Z.,Kaldor, S.W.,Veal, J.M.,Stafford, J.A.,Chen, Y.K. Discovery of CC-90011: A Potent and Selective Reversible Inhibitor of Lysine Specific Demethylase 1 (LSD1). J.Med.Chem., 63:14522-14529, 2020 Cited by PubMed: 33034194 DOI: 10.1021/acs.jmedchem.0c00978 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.93 Å)

Structure validation