PDB: 281 件ウェブページステータス検索Chemie searchBIRD

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6P9K	Crystal structure of Mycobacterium tuberculosis KasA in complex with O6G 分子名称: 3-oxoacyl-ACP synthase, GLYCEROL, ISOPROPYL ALCOHOL, ... 著者 Capodagli, G.C, Neiditch, M.B. 登録日 2019-06-10 公開日 2020-04-01 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.703 Å) 主引用文献 A Preclinical Candidate Targeting Mycobacterium tuberculosis KasA. Cell Chem Biol, 27, 2020
6P9M	Crystal structure of Mycobacterium tuberculosis KasA in complex with O6J 分子名称: 3-oxoacyl-[acyl-carrier-protein] synthase 1, GLYCEROL, ISOPROPYL ALCOHOL, ... 著者 Capodagli, G.C, Neiditch, M.B. 登録日 2019-06-10 公開日 2020-04-01 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.256 Å) 主引用文献 A Preclinical Candidate Targeting Mycobacterium tuberculosis KasA. Cell Chem Biol, 27, 2020
6QL5	Structure of fatty acid synthase complex with bound gamma subunit from Saccharomyces cerevisiae at 2.8 angstrom 分子名称: 4'-PHOSPHOPANTETHEINE, FLAVIN MONONUCLEOTIDE, Fatty acid synthase subunit alpha, ... 著者 Singh, K, Graf, B, Linden, A, Sautner, V, Urlaub, H, Tittmann, K, Stark, H, Chari, A. 登録日 2019-01-31 公開日 2020-03-18 最終更新日 2020-04-08 実験手法 ELECTRON MICROSCOPY (2.8 Å) 主引用文献 Discovery of a Regulatory Subunit of the Yeast Fatty Acid Synthase. Cell, 180, 2020
6QL6	Structure of Fatty acid synthase complex from Saccharomyces cerevisiae at 2.9 Angstrom 分子名称: FLAVIN MONONUCLEOTIDE, Fatty acid synthase subunit alpha, Fatty acid synthase subunit beta, ... 著者 Singh, K, Graf, B, Linden, A, Sautner, V, Urlaub, H, Tittmann, K, Stark, H, Chari, A. 登録日 2019-01-31 公開日 2020-03-18 最終更新日 2020-04-08 実験手法 ELECTRON MICROSCOPY (2.9 Å) 主引用文献 Discovery of a Regulatory Subunit of the Yeast Fatty Acid Synthase. Cell, 180, 2020
6QL9	Structure of Fatty acid synthase complex from Saccharomyces cerevisiae at 2.9 Angstrom 分子名称: 1,2-ETHANEDIOL, 4'-PHOSPHOPANTETHEINE, ACETATE ION, ... 著者 Singh, K, Graf, B, Linden, A, Sautner, V, Urlaub, H, Tittmann, K, Stark, H, Chari, A. 登録日 2019-01-31 公開日 2020-03-18 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.82 Å) 主引用文献 Discovery of a Regulatory Subunit of the Yeast Fatty Acid Synthase. Cell, 180, 2020
6QL7	Structure of fatty acid synthase complex with bound gamma subunit from Saccharomyces cerevisiae at 4.6 angstrom 分子名称: Fatty acid synthase subunit alpha, Fatty acid synthase subunit beta, Translation machinery-associated protein 17 著者 Singh, K, Graf, B, Linden, A, Sautner, V, Urlaub, H, Tittmann, K, Stark, H, Chari, A. 登録日 2019-01-31 公開日 2020-03-18 最終更新日 2024-05-15 実験手法 X-RAY DIFFRACTION (4.6 Å) 主引用文献 Discovery of a Regulatory Subunit of the Yeast Fatty Acid Synthase. Cell, 180, 2020
6QSP	Ketosynthase (ApeO) in Complex with its Chain Length Factor (ApeC) from Xenorhabdus doucetiae 分子名称: Beta-ketoacyl synthase, GLYCEROL, PHOSPHATE ION, ... 著者 Grammbitter, G.L.C, Schmalhofer, M, Groll, M, Bode, H. 登録日 2019-02-21 公開日 2019-04-03 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.45 Å) 主引用文献 An Uncommon Type II PKS Catalyzes Biosynthesis of Aryl Polyene Pigments. J.Am.Chem.Soc., 141, 2019
4LS6	Crystal structure of beta-ketoacyl-ACP synthase II (FabF) I108F mutant from Bacillus subtilis 分子名称: 3-oxoacyl-[acyl-carrier-protein] synthase 2, CHLORIDE ION, GLYCEROL, ... 著者 Trajtenberg, F, Larrieux, N, Buschiazzo, A. 登録日 2013-07-22 公開日 2014-04-02 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.56 Å) 主引用文献 Structural insights into bacterial resistance to cerulenin. Febs J., 281, 2014
4LS7	Crystal structure of Bacillus subtilis beta-ketoacyl-ACP synthase II (FabF) in a non-covalent complex with cerulenin 分子名称: 3-oxoacyl-[acyl-carrier-protein] synthase 2, Cerulenin, GLYCEROL, ... 著者 Trajtenberg, F, Larrieux, N, Buschiazzo, A. 登録日 2013-07-22 公開日 2014-04-02 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.674 Å) 主引用文献 Structural insights into bacterial resistance to cerulenin. Febs J., 281, 2014
4LS5	Crystal structure of beta-ketoacyl-ACP synthase II (FabF) from Bacillus subtilis 分子名称: 3-oxoacyl-[acyl-carrier-protein] synthase 2, GLYCEROL, POTASSIUM ION 著者 Trajtenberg, F, Larrieux, N, Buschiazzo, A. 登録日 2013-07-22 公開日 2014-04-02 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.803 Å) 主引用文献 Structural insights into bacterial resistance to cerulenin. Febs J., 281, 2014
4NA2	Crystal Structure of the second ketosynthase from the bacillaene polyketide synthase bound to its natural intermediate 分子名称: Polyketide synthase PksJ 著者 Gay, D.C, Gay, G.R, Keatinge-Clay, A.T. 登録日 2013-10-21 公開日 2014-02-19 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 A close look at a ketosynthase from a trans-acyltransferase modular polyketide synthase. Structure, 22, 2014
4MZ0	Structure of a ketosynthase-acyltransferase di-domain from module CurL of the curacin A polyketide synthase 分子名称: CALCIUM ION, CurL 著者 Whicher, J.R, Smaga, S.S, Smith, J.L. 登録日 2013-09-28 公開日 2014-01-29 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Cyanobacterial polyketide synthase docking domains: a tool for engineering natural product biosynthesis. Chem.Biol., 20, 2013
4NA1	Crystal Structure of the second ketosynthase from the bacillaene polyketide synthase 分子名称: Polyketide synthase PksJ, SULFATE ION 著者 Gay, D.C, Gay, G.R, Keatinge-Clay, A.T. 登録日 2013-10-21 公開日 2014-02-19 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 A close look at a ketosynthase from a trans-acyltransferase modular polyketide synthase. Structure, 22, 2014
4NA3	Crystal Structure of the second ketosynthase from the bacillaene polyketide synthase bound to a hexanoyl substrate mimic 分子名称: Polyketide synthase PksJ, SULFATE ION 著者 Gay, D.C, Gay, G.R, Keatinge-Clay, A.T. 登録日 2013-10-21 公開日 2014-02-19 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.89 Å) 主引用文献 A close look at a ketosynthase from a trans-acyltransferase modular polyketide synthase. Structure, 22, 2014
4OPF	Streptomcyes albus JA3453 oxazolomycin ketosynthase domain OzmH KS8 分子名称: NRPS/PKS 著者 Osipiuk, J, Bigelow, L, Endres, M, Babnigg, G, Bingman, C.A, Yennamalli, R, Lohman, J.R, Ma, M, Shen, B, Phillips Jr, G.N, Joachimiak, A, Midwest Center for Structural Genomics (MCSG), Enzyme Discovery for Natural Product Biosynthesis (NatPro) 登録日 2014-02-05 公開日 2014-02-19 最終更新日 2017-11-22 実験手法 X-RAY DIFFRACTION (2.12 Å) 主引用文献 Structural and evolutionary relationships of "AT-less" type I polyketide synthase ketosynthases. Proc.Natl.Acad.Sci.USA, 112, 2015
4OPE	Streptomcyes albus JA3453 oxazolomycin ketosynthase domain OzmH KS7 分子名称: NITRATE ION, NRPS/PKS 著者 Osipiuk, J, Mack, J, Endres, M, Babnigg, G, Bingman, C.A, Yennamalli, R, Lohman, J.R, Ma, M, Shen, B, Phillips Jr, G.N, Joachimiak, A, Midwest Center for Structural Genomics (MCSG), Enzyme Discovery for Natural Product Biosynthesis (NatPro) 登録日 2014-02-05 公開日 2014-02-19 最終更新日 2018-01-24 実験手法 X-RAY DIFFRACTION (2.58 Å) 主引用文献 Structural and evolutionary relationships of "AT-less" type I polyketide synthase ketosynthases. Proc.Natl.Acad.Sci.USA, 112, 2015
4OQJ	Streptomcyes albus JA3453 oxazolomycin ketosynthase domain OzmQ KS1 分子名称: GLYCEROL, PHOSPHATE ION, PKS, ... 著者 Nocek, B, Mack, J, Endras, M, Babnigg, G, Bingman, C.A, Yennamalli, R, Lohman, J.R, Ma, M, Shen, B, Phillips Jr, G.N, Joachimiak, A, Midwest Center for Structural Genomics (MCSG), Enzyme Discovery for Natural Product Biosynthesis (NatPro) 登録日 2014-02-09 公開日 2014-03-19 最終更新日 2016-11-02 実験手法 X-RAY DIFFRACTION (1.904 Å) 主引用文献 Structural and evolutionary relationships of "AT-less" type I polyketide synthase ketosynthases. Proc.Natl.Acad.Sci.USA, 112, 2015
4QAV	The structure of Beta-ketoacyl -(acyl carrier protein) synthase II (FabF) from Neisseria meningitidis 分子名称: 3-oxoacyl-[acyl-carrier-protein] synthase 2, FORMIC ACID, POTASSIUM ION 著者 Nanson, J.D, Forwood, J.K. 登録日 2014-05-06 公開日 2014-06-04 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 The structure of Beta-ketoacyl -(acyl carrier protein) synthase II (FabF) from Neisseria meningitidis to be published
4QYR	Streptomyces platensis isomigrastatin ketosynthase domain MgsE KS3 分子名称: ACETIC ACID, AT-less polyketide synthase, CHLORIDE ION, ... 著者 Kim, Y, Li, H, Endres, M, Babnigg, J, Bingman, C.A, Yennamalli, R, Lohman, J.R, Ma, M, Shen, B, Phillips Jr, G.N, Joachimiak, A, Midwest Center for Structural Genomics (MCSG), Enzyme Discovery for Natural Product Biosynthesis (NatPro) 登録日 2014-07-25 公開日 2014-08-20 最終更新日 2023-12-06 実験手法 X-RAY DIFFRACTION (2.902 Å) 主引用文献 Structural and evolutionary relationships of "AT-less" type I polyketide synthase ketosynthases. Proc.Natl.Acad.Sci.USA, 112, 2015
4R8E	Crystal structure of beta-ketoacyl-ACP synthase II (FabF) from Yersinia pestis 分子名称: 3-oxoacyl-[acyl-carrier-protein] synthase 2 著者 Himiari, Z, Nanson, J.D, Swarbrick, C.M.D, Forwood, J.K. 登録日 2014-09-02 公開日 2014-12-17 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Structural Characterisation of the Beta-Ketoacyl-Acyl Carrier Protein Synthases, FabF and FabH, of Yersinia pestis. Sci Rep, 5, 2015
2AQ7	Structure-activity relationships at the 5-posiiton of thiolactomycin: an intact 5(R)-isoprene unit is required for activity against the condensing enzymes from Mycobacterium tuberculosis and Escherichia coli 分子名称: (5R)-4-HYDROXY-3,5-DIMETHYL-5-[(1E,3E)-2-METHYLPENTA-1,3-DIENYL]THIOPHEN-2(5H)-ONE, 3-oxoacyl-[acyl-carrier-protein] synthase I 著者 Kim, P, Zhang, Y.M, Shenoy, G, Nguyen, Q.A, Boshoff, H.I, Manjunatha, U.H, Goodwin, M.B, Lonsdale, J, Price, A.C, Miller, D.J. 登録日 2005-08-17 公開日 2006-01-17 最終更新日 2023-08-23 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Structure-Activity Relationships at the 5-Position of Thiolactomycin: An Intact (5R)-Isoprene Unit Is Required for Activity against the Condensing Enzymes from Mycobacterium tuberculosis and Escherichia coli J.Med.Chem., 49, 2006
2AQB	Structure-activity relationships at the 5-position of thiolactomycin: an intact 5(R)-isoprene unit is required for activity against the condensing enzymes from Mycobacterium tuberculosis and Escherchia coli 分子名称: (5R)-5-[(1E)-BUTA-1,3-DIENYL]-4-HYDROXY-3,5-DIMETHYLTHIOPHEN-2(5H)-ONE, 3-oxoacyl-[acyl-carrier-protein] synthase I 著者 Kim, P, Zhang, Y.M, Shenoy, G, Nguyen, Q.A, Boshoff, H.I, Manjunatha, U.H, Goodwin, M.B, Lonsdale, J, Price, A.C, Miller, D.J. 登録日 2005-08-17 公開日 2006-01-17 最終更新日 2023-08-23 実験手法 X-RAY DIFFRACTION (2.19 Å) 主引用文献 Structure-Activity Relationships at the 5-Position of Thiolactomycin: An Intact (5R)-Isoprene Unit Is Required for Activity against the Condensing Enzymes from Mycobacterium tuberculosis and Escherichia coli J.Med.Chem., 49, 2006
2ALM	Crystal structure analysis of a mutant beta-ketoacyl-[acyl carrier protein] synthase II from Streptococcus pneumoniae 分子名称: 3-oxoacyl-(acyl-carrier-protein) synthase II, MAGNESIUM ION 著者 Zhang, Y.M, Hurlbert, J, White, S.W, Rock, C.O. 登録日 2005-08-07 公開日 2005-08-30 最終更新日 2023-08-23 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Roles of the active site water, histidine 303, and phenylalanine 396 in the catalytic mechanism of the elongation condensing enzyme of Streptococcus pneumoniae. J.Biol.Chem., 281, 2006
2BYY	E.coli KAS I H298E Mutation 分子名称: 3-OXOACYL-[ACYL-CARRIER-PROTEIN] SYNTHASE I, AMMONIUM ION 著者 Olsen, J.G, von Wettstein-Knowles, P, Henriksen, A. 登録日 2005-08-09 公開日 2006-02-01 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Fatty acid synthesis. Role of active site histidines and lysine in Cys-His-His-type beta-ketoacyl-acyl carrier protein synthases. FEBS J., 273, 2006
2BUH	E. COLI BETA-KETOACYL (ACYL CARRIER PROTEIN) SYNTHASE I, 120 K 分子名称: 3-OXOACYL-[ACYL-CARRIER-PROTEIN] SYNTHASE I, AMMONIUM ION 著者 Olsen, J.G, Von Wettstein-Knowles, P, Henriksen, A. 登録日 2005-06-13 公開日 2005-06-16 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Fatty acid synthesis. Role of active site histidines and lysine in Cys-His-His-type beta-ketoacyl-acyl carrier protein synthases. FEBS J., 273, 2006

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