PDB: 341 件ウェブページステータス検索Chemie searchBIRD

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3S7B	Structural Basis of Substrate Methylation and Inhibition of SMYD2 分子名称: (R,R)-2,3-BUTANEDIOL, N-cyclohexyl-N~3~-[2-(3,4-dichlorophenyl)ethyl]-N-(2-{[2-(5-hydroxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-8-yl)ethyl]amino}ethyl)-beta-alaninamide, N-lysine methyltransferase SMYD2, ... 著者 Ferguson, A.D. 登録日 2011-05-26 公開日 2011-08-10 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.42 Å) 主引用文献 Structural Basis of Substrate Methylation and Inhibition of SMYD2. Structure, 19, 2011
5XXD	Crystal structure of SmyD3 in complex with covalent inhibitor 1 分子名称: S-ADENOSYLMETHIONINE, Smyd3 methyltransferase, ZINC ION, ... 著者 Baburajendran, N, Anna E, J. 登録日 2017-07-03 公開日 2018-08-29 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.314 Å) 主引用文献 Crystal structure of SmyD3 in complex with covalent inhibitor 1 To Be Published
3SW9	GLP (G9a-like protein) SET domain in complex with Dnmt3aK44me0 peptide 分子名称: DNA (cytosine-5)-methyltransferase 3A, Histone-lysine N-methyltransferase EHMT1, SINEFUNGIN, ... 著者 Chang, Y, Horton, J.R, Zhang, X, Cheng, X. 登録日 2011-07-13 公開日 2011-12-07 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (3.05 Å) 主引用文献 MPP8 mediates the interactions between DNA methyltransferase Dnmt3a and H3K9 methyltransferase GLP/G9a. Nat Commun, 2, 2011
5XXJ	Crystal structure of SmyD3 in complex with covalent inhibitor 3 分子名称: S-ADENOSYLMETHIONINE, SMYD3, ZINC ION, ... 著者 Baburajendran, N, Jansson, A.E. 登録日 2017-07-04 公開日 2018-08-08 実験手法 X-RAY DIFFRACTION (1.689 Å) 主引用文献 Crystal structure of SmyD3 in complex with covalent inhibitor 3 To Be Published
5XXG	Crystal structure of SmyD3 in complex with covalent inhibitor 2 分子名称: S-ADENOSYLMETHIONINE, SMYD3, ZINC ION, ... 著者 Baburajendran, N, Jansson, E.A. 登録日 2017-07-03 公開日 2018-08-08 実験手法 X-RAY DIFFRACTION (2.14 Å) 主引用文献 Crystal structure of SmyD3 in complex with covalent inhibitor 2 To Be Published
3S7F	Structural Basis of Substrate Methylation and Inhibition of SMYD2 分子名称: (R,R)-2,3-BUTANEDIOL, N-lysine methyltransferase SMYD2, S-ADENOSYLMETHIONINE, ... 著者 Ferguson, A.D. 登録日 2011-05-26 公開日 2011-08-10 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.85 Å) 主引用文献 Structural Basis of Substrate Methylation and Inhibition of SMYD2. Structure, 19, 2011
3S7J	Structural Basis of Substrate Methylation and Inhibition of SMYD2 分子名称: N-lysine methyltransferase SMYD2, S-ADENOSYLMETHIONINE, ZINC ION 著者 Ferguson, A.D. 登録日 2011-05-26 公開日 2011-08-10 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (3.04 Å) 主引用文献 Structural Basis of Substrate Methylation and Inhibition of SMYD2. Structure, 19, 2011
5YJO	Crystal structure of SmyD3 in complex with covalent inhibitor 4 分子名称: Histone-lysine N-methyltransferase SMYD3, S-ADENOSYLMETHIONINE, ZINC ION, ... 著者 Baburajendran, N, Anna E, J. 登録日 2017-10-11 公開日 2018-10-17 最終更新日 2019-07-10 実験手法 X-RAY DIFFRACTION (2.135 Å) 主引用文献 Discovery of Irreversible Inhibitors Targeting Histone Methyltransferase, SMYD3. Acs Med.Chem.Lett., 10, 2019
5YLT	Crystal structure of SET7/9 in complex with a cyproheptadine derivative 分子名称: 2-(1-methylpiperidin-4-ylidene)tricyclo[9.4.0.0^{3,8}]pentadeca-1(11),3(8),4,6,9,12,14-heptaen-6-ol, GLYCEROL, Histone-lysine N-methyltransferase SETD7, ... 著者 Hirano, T, Fujiwara, T, Niwa, H, Hirano, M, Ohira, K, Okazaki, Y, Sato, S, Umehara, T, Maemoto, Y, Ito, A, Yoshida, M, Kagechika, H. 登録日 2017-10-19 公開日 2018-06-20 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (1.69 Å) 主引用文献 Development of Novel Inhibitors for Histone Methyltransferase SET7/9 based on Cyproheptadine. ChemMedChem, 13, 2018
3TG4	Structure of SMYD2 in complex with SAM 分子名称: GLYCEROL, N-lysine methyltransferase SMYD2, S-ADENOSYLMETHIONINE, ... 著者 Zhao, K, Wang, L. 登録日 2011-08-17 公開日 2011-08-31 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Structure of human SMYD2 reveals the basis of p53 tumor suppressor methylation J.Biol.Chem., 2011
3VUZ	Crystal structure of histone methyltransferase SET7/9 in complex with AAM-1 分子名称: 5'-{[(3S)-3-amino-3-carboxypropyl](hexyl)amino}-5'-deoxyadenosine, Histone-lysine N-methyltransferase SETD7 著者 Niwa, H, Handa, N, Tomabechi, Y, Honda, K, Toyama, M, Ohsawa, N, Shirouzu, M, Kagechika, H, Hirano, T, Umehara, T, Yokoyama, S. 登録日 2012-07-10 公開日 2013-03-27 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Structures of histone methyltransferase SET7/9 in complexes with adenosylmethionine derivatives Acta Crystallogr.,Sect.D, 69, 2013
3VV0	Crystal structure of histone methyltransferase SET7/9 in complex with DAAM-3 分子名称: 5'-{[(3S)-3-amino-3-carboxypropyl][2-(hexylamino)ethyl]amino}-5'-deoxyadenosine, Histone-lysine N-methyltransferase SETD7 著者 Niwa, H, Handa, N, Tomabechi, Y, Honda, K, Toyama, M, Ohsawa, N, Shirouzu, M, Kagechika, H, Hirano, T, Umehara, T, Yokoyama, S. 登録日 2012-07-10 公開日 2013-03-27 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.001 Å) 主引用文献 Structures of histone methyltransferase SET7/9 in complexes with adenosylmethionine derivatives Acta Crystallogr.,Sect.D, 69, 2013
5EX0	Crystal structure of human SMYD3 in complex with a MAP3K2 peptide 分子名称: ACETIC ACID, Histone-lysine N-methyltransferase SMYD3, MAP3K2 peptide, ... 著者 Fu, W, Liu, N, Qiao, Q, Wang, M, Min, J, Zhu, B, Xu, R.M, Yang, N. 登録日 2015-11-23 公開日 2016-03-09 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Structural Basis for Substrate Preference of SMYD3, a SET Domain-containing Protein Lysine Methyltransferase J.Biol.Chem., 291, 2016
5EX3	Crystal structure of human SMYD3 in complex with a VEGFR1 peptide 分子名称: ACETIC ACID, Histone-lysine N-methyltransferase SMYD3, S-ADENOSYL-L-HOMOCYSTEINE, ... 著者 Qiao, Q, Fu, W, Liu, N, Wang, M, Min, J, Zhu, B, Xu, R.M, Yang, N. 登録日 2015-11-23 公開日 2016-03-09 最終更新日 2017-10-18 実験手法 X-RAY DIFFRACTION (2.408 Å) 主引用文献 Structural Basis for Substrate Preference of SMYD3, a SET Domain-containing Protein Lysine Methyltransferase J.Biol.Chem., 291, 2016
6OX0	SETD3 in Complex with an Actin Peptide with Sinefungin Replacing SAH as Cofactor 分子名称: 1,2-ETHANEDIOL, Actin Peptide, Histone-lysine N-methyltransferase setd3, ... 著者 Horton, J.R, Dai, S, Cheng, X. 登録日 2019-05-13 公開日 2019-08-21 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.755 Å) 主引用文献 Structural basis for the target specificity of actin histidine methyltransferase SETD3. Nat Commun, 10, 2019
7W29	Crystal Structure of SETD3-SAH in complex with betaA-Orn73 peptide 分子名称: Actin, cytoplasmic 1, N-terminally processed, ... 著者 Li, H, Ma, H. 登録日 2021-11-23 公開日 2022-10-05 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 Histidine methyltransferase SETD3 methylates structurally diverse histidine mimics in actin. Protein Sci., 31, 2022
6O9O	Crystal Structure of SMYD3 with Potent and Selective Isoxazole Amide Inhibitor 1 分子名称: 5-cyclopropyl-N-{1-[({trans-4-[(4,4,4-trifluorobutyl)amino]cyclohexyl}methyl)sulfonyl]piperidin-4-yl}-1,2-oxazole-3-carboxamide, GLYCEROL, Histone-lysine N-methyltransferase SMYD3, ... 著者 Elkins, P.A, Wang, L. 登録日 2019-03-14 公開日 2020-03-18 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (1.586 Å) 主引用文献 Discovery of Isoxazole Amides as Potent and Selective SMYD3 Inhibitors To be published
7W28	Crystal Structure of SETD3-SAH in complex with betaA-4PyrAla73 peptide 分子名称: Actin, cytoplasmic 1, Histone-lysine N-methyltransferase setd3, ... 著者 Li, H, Ma, H. 登録日 2021-11-22 公開日 2022-10-05 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (1.79 Å) 主引用文献 Histidine methyltransferase SETD3 methylates structurally diverse histidine mimics in actin. Protein Sci., 31, 2022
6OX3	SETD3 in Complex with an Actin Peptide with His73 Replaced with Lysine 分子名称: 1,2-ETHANEDIOL, ACETATE ION, Actin Peptide, ... 著者 Horton, J.R, Dai, S, Cheng, X. 登録日 2019-05-13 公開日 2019-08-21 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.785 Å) 主引用文献 Structural basis for the target specificity of actin histidine methyltransferase SETD3. Nat Commun, 10, 2019
6OX1	SETD3 in Complex with an Actin Peptide with Target Histidine Partially Methylated 分子名称: 1,2-ETHANEDIOL, Actin, cytoplasmic 1, ... 著者 Horton, J.R, Dai, S, Cheng, X. 登録日 2019-05-13 公開日 2019-08-21 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.949 Å) 主引用文献 Structural basis for the target specificity of actin histidine methyltransferase SETD3. Nat Commun, 10, 2019
6OX4	A SETD3 Mutant (N255A) in Complex with an Actin Peptide 分子名称: 1,2-ETHANEDIOL, ACETATE ION, Actin Peptide, ... 著者 Horton, J.R, Dai, S, Cheng, X. 登録日 2019-05-13 公開日 2019-08-21 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.294 Å) 主引用文献 Structural basis for the target specificity of actin histidine methyltransferase SETD3. Nat Commun, 10, 2019
6OX5	A SETD3 Mutant (N255A) in Complex with an Actin Peptide with His73 Replaced with Lysine 分子名称: 1,2-ETHANEDIOL, Actin Peptide, Actin-histidine N-methyltransferase, ... 著者 Horton, J.R, Dai, S, Cheng, X. 登録日 2019-05-13 公開日 2019-08-21 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.098 Å) 主引用文献 Structural basis for the target specificity of actin histidine methyltransferase SETD3. Nat Commun, 10, 2019
6OX2	SETD3in Complex with an Actin Peptide with the Target Histidine Fully Methylated 分子名称: 1,2-ETHANEDIOL, Actin Peptide, GLYCEROL, ... 著者 Horton, J.R, Dai, S, Cheng, X. 登録日 2019-05-13 公開日 2019-08-21 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.089 Å) 主引用文献 Structural basis for the target specificity of actin histidine methyltransferase SETD3. Nat Commun, 10, 2019
6P6G	Co-crystal Structure of human SMYD3 with Isoxazole Amides Inhibitors 分子名称: 5-cyclopropyl-N-{1-[({trans-4-[(4,4,4-trifluorobutyl)amino]cyclohexyl}methyl)sulfonyl]piperidin-4-yl}-1,2-oxazole-3-carboxamide, GLYCEROL, Histone-lysine N-methyltransferase SMYD3, ... 著者 Elkins, P.A, Wang, L. 登録日 2019-06-03 公開日 2020-01-15 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (1.59 Å) 主引用文献 Discovery of Isoxazole Amides as Potent and Selective SMYD3 Inhibitors. Acs Med.Chem.Lett., 11, 2020
6P6K	Co-crystal Structure of human SMYD3 with Isoxazole Amides Inhibitors 分子名称: 1,2-ETHANEDIOL, Histone-lysine N-methyltransferase SMYD3, MAGNESIUM ION, ... 著者 Elkins, P.A, Wang, L. 登録日 2019-06-04 公開日 2020-01-15 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (1.55 Å) 主引用文献 Discovery of Isoxazole Amides as Potent and Selective SMYD3 Inhibitors. Acs Med.Chem.Lett., 11, 2020

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