6I0B
 
 | | Human butyrylcholinesterase in complex with the S enantiomer of a chlorotacrine-tryptophan multi-target inhibitor. | | 分子名称: | (2~{S})-2-azanyl-~{N}-[6-[(6-chloranyl-1,2,3,4-tetrahydroacridin-9-yl)amino]hexyl]-3-(1~{H}-indol-3-yl)propanamide, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Brazzolotto, X, Nachon, F. | | 登録日 | 2018-10-25 | | 公開日 | 2019-03-27 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (2.384 Å) | | 主引用文献 | Novel tacrine-tryptophan hybrids: Multi-target directed ligands as potential treatment for Alzheimer's disease.
Eur.J.Med.Chem., 168, 2019
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6K1B
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6KBN
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4H39
 | | Crystal Structure of JNK3 in Complex with JIP1 Peptide | | 分子名称: | C-Jun-amino-terminal kinase-interacting protein 1, Mitogen-activated protein kinase 10 | | 著者 | Nwachukwu, J.C, Laughlin, J.D, Figuera-Losada, M, Cherry, L, Nettles, K.W, LoGrasso, P.V. | | 登録日 | 2012-09-13 | | 公開日 | 2012-11-21 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (1.992 Å) | | 主引用文献 | Structural Mechanisms of Allostery and Autoinhibition in JNK Family Kinases.
Structure, 20, 2012
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7VWX
 | | CryoEM structure of football-shaped GroEL:ES2 with RuBisCO | | 分子名称: | Chaperonin GroEL, Co-chaperonin GroES, Ribulose bisphosphate carboxylase | | 著者 | Kim, H, Roh, S.H. | | 登録日 | 2021-11-12 | | 公開日 | 2022-01-12 | | 最終更新日 | 2022-02-16 | | 実験手法 | ELECTRON MICROSCOPY (7.6 Å) | | 主引用文献 | Cryo-EM structures of GroEL:ES 2 with RuBisCO visualize molecular contacts of encapsulated substrates in a double-cage chaperonin.
Iscience, 25, 2022
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7X14
 | | Crystal structure of phospho-FFAT motif of MIGA2 bound to VAPB | | 分子名称: | MIGA2 phospho FFAT motif, SULFATE ION, Vesicle-associated membrane protein-associated protein B | | 著者 | Kim, H, Lee, C. | | 登録日 | 2022-02-23 | | 公開日 | 2022-09-14 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (1.675 Å) | | 主引用文献 | Structural basis for mitoguardin-2 mediated lipid transport at ER-mitochondrial membrane contact sites.
Nat Commun, 13, 2022
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7X15
 | | Crystal structure of MIGA2 LD targeting domain | | 分子名称: | DI-PALMITOYL-3-SN-PHOSPHATIDYLETHANOLAMINE, FORMIC ACID, Mitoguardin 2 | | 著者 | Kim, H, Lee, C. | | 登録日 | 2022-02-23 | | 公開日 | 2022-09-14 | | 実験手法 | X-RAY DIFFRACTION (2.852 Å) | | 主引用文献 | Structural basis for mitoguardin-2 mediated lipid transport at ER-mitochondrial membrane contact sites.
Nat Commun, 13, 2022
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7YCJ
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8GW7
 | | AtSLAC1 6D mutant in open state | | 分子名称: | CHLORIDE ION, CHOLESTEROL HEMISUCCINATE, Guard cell S-type anion channel SLAC1,Green fluorescent protein (Fragment) | | 著者 | Lee, Y, Lee, S. | | 登録日 | 2022-09-16 | | 公開日 | 2023-11-15 | | 最終更新日 | 2023-11-29 | | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | | 主引用文献 | Cryo-EM structures of the plant anion channel SLAC1 from Arabidopsis thaliana suggest a combined activation model.
Nat Commun, 14, 2023
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8GW6
 | | AtSLAC1 6D mutant in closed state | | 分子名称: | CHLORIDE ION, CHOLESTEROL HEMISUCCINATE, Guard cell S-type anion channel SLAC1,Green fluorescent protein (Fragment) | | 著者 | Lee, Y, Lee, S. | | 登録日 | 2022-09-16 | | 公開日 | 2023-11-15 | | 最終更新日 | 2023-11-29 | | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | | 主引用文献 | Cryo-EM structures of the plant anion channel SLAC1 from Arabidopsis thaliana suggest a combined activation model.
Nat Commun, 14, 2023
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3O2M
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8J0J
 | | AtSLAC1 8D mutant in closed state | | 分子名称: | CHLORIDE ION, CHOLESTEROL HEMISUCCINATE, Guard cell S-type anion channel SLAC1,Green fluorescent protein | | 著者 | Lee, Y, Lee, S. | | 登録日 | 2023-04-11 | | 公開日 | 2023-11-22 | | 最終更新日 | 2023-11-29 | | 実験手法 | ELECTRON MICROSCOPY (2.7 Å) | | 主引用文献 | Cryo-EM structures of the plant anion channel SLAC1 from Arabidopsis thaliana suggest a combined activation model.
Nat Commun, 14, 2023
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8J1E
 | | AtSLAC1 in open state | | 分子名称: | CHLORIDE ION, CHOLESTEROL HEMISUCCINATE, Guard cell S-type anion channel SLAC1,Green fluorescent protein | | 著者 | Lee, Y, Lee, S. | | 登録日 | 2023-04-12 | | 公開日 | 2023-11-22 | | 最終更新日 | 2023-11-29 | | 実験手法 | ELECTRON MICROSCOPY (3.84 Å) | | 主引用文献 | Cryo-EM structures of the plant anion channel SLAC1 from Arabidopsis thaliana suggest a combined activation model.
Nat Commun, 14, 2023
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4DK1
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4DK0
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3PTG
 | | Design and Synthesis of a Novel, Orally Efficacious Tri-substituted Thiophene Based JNK Inhibitor | | 分子名称: | C-Jun-amino-terminal kinase-interacting protein 1, Mitogen-activated protein kinase 10, N-[4-methyl-3-(1H-1,2,4-triazol-5-yl)thiophen-2-yl]-2-(2-oxo-3,4-dihydroquinolin-1(2H)-yl)acetamide | | 著者 | Bowers, S, Truong, A.P, Neitz, J, Neitzel, M, Probst, G.D, Hom, R.K, Konradi, A.W, Sham, H.L, Toth, G, Pan, H, Yao, N, Artis, D.R, Brigham, E.F, Quinn, K.P, Sauer, J, Powell, K, Ruslim, L, Bard, F, Yednock, T.A, Griswold-Prenner, I. | | 登録日 | 2010-12-02 | | 公開日 | 2011-03-02 | | 最終更新日 | 2024-02-21 | | 実験手法 | X-RAY DIFFRACTION (2.43 Å) | | 主引用文献 | Design and synthesis of a novel, orally active, brain penetrant, tri-substituted thiophene based JNK inhibitor.
Bioorg.Med.Chem.Lett., 21, 2011
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3U86
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3Q8W
 | | A b-aminoacyl containing thiazolidine derivative and DPPIV complex | | 分子名称: | Dipeptidyl peptidase 4, N-(4-{[({(2R)-3-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]-1,3-thiazolidin-2-yl}carbonyl)amino]methyl}phenyl)-D-valine | | 著者 | Lee, J.O, Song, D.H. | | 登録日 | 2011-01-07 | | 公開日 | 2011-03-16 | | 最終更新日 | 2011-07-13 | | 実験手法 | X-RAY DIFFRACTION (3.64 Å) | | 主引用文献 | Discovery of b-aminoacyl containing thiazolidine derivatives as potent and selective dipeptidyl peptidase IV inhibitors
To be Published
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3QQU
 | | Cocrystal structure of unphosphorylated igf with pyrimidine 8 | | 分子名称: | Insulin-like growth factor 1 receptor, N~2~-[3-methoxy-4-(morpholin-4-yl)phenyl]-N~4~-(quinolin-3-yl)pyrimidine-2,4-diamine | | 著者 | Huang, X. | | 登録日 | 2011-02-16 | | 公開日 | 2011-04-20 | | 最終更新日 | 2024-02-21 | | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | | 主引用文献 | Discovery of 2,4-bis-arylamino-1,3-pyrimidines as insulin-like growth factor-1 receptor (IGF-1R) inhibitors.
Bioorg.Med.Chem.Lett., 21, 2011
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2J9F
 | | Human branched-chain alpha-ketoacid dehydrogenase-decarboxylase E1b | | 分子名称: | 2-OXOISOVALERATE DEHYDROGENASE ALPHA SUBUNIT, 2-OXOISOVALERATE DEHYDROGENASE BETA SUBUNIT, C2-1-HYDROXY-3-METHYL-PROPYL-THIAMIN DIPHOSPHATE, ... | | 著者 | Jun, L, Machius, M, Chuang, J.L, Wynn, R.M, Chuang, D.T. | | 登録日 | 2006-11-07 | | 公開日 | 2007-02-27 | | 最終更新日 | 2023-12-13 | | 実験手法 | X-RAY DIFFRACTION (1.88 Å) | | 主引用文献 | The Two Active Sites in Human Branched-Chain Alpha- Keto Acid Dehydrogenase Operate Independently without an Obligatory Alternating-Site Mechanism.
J.Biol.Chem., 282, 2007
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7XMH
 | | Crystal structure of a rice class IIIb chitinase, Oschib2 | | 分子名称: | 1,2-ETHANEDIOL, ACETATE ION, Putative class III chitinase | | 著者 | Jun, T, Tomoya, T, Tomoyuki, N, Takayuki, O. | | 登録日 | 2022-04-25 | | 公開日 | 2023-05-03 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (1.18 Å) | | 主引用文献 | Characterization of two rice GH18 chitinases belonging to family 8 of plant pathogenesis-related proteins.
Plant Sci., 326, 2023
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4W4X
 | | JNK2/3 in complex with 3-(4-{[(4-fluorophenyl)carbamoyl]amino}-1H-pyrazol-1-yl)-N-(2-methylpyridin-4-yl)benzamide | | 分子名称: | 3-(4-{[(4-fluorophenyl)carbamoyl]amino}-1H-pyrazol-1-yl)-N-(2-methylpyridin-4-yl)benzamide, c-jun NH2-terminal kinase 3 | | 著者 | Park, H, Iqbal, S, Hernandez, P, Mora, R, Zheng, K, Feng, Y, LoGrasso, P. | | 登録日 | 2014-08-15 | | 公開日 | 2015-02-11 | | 最終更新日 | 2023-12-27 | | 実験手法 | X-RAY DIFFRACTION (2.65 Å) | | 主引用文献 | Structural Basis and Biological Consequences for JNK2/3 Isoform Selective Aminopyrazoles.
Sci Rep, 5, 2015
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4UX9
 | | Crystal structure of JNK1 bound to a MKK7 docking motif | | 分子名称: | DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 7, MITOGEN-ACTIVATED PROTEIN KINASE 8, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... | | 著者 | Kragelj, J, Palencia, A, Nanao, M.H, Maurin, D, Bouvignies, G, Blackledge, M, Ringkjobing-Jensen, M. | | 登録日 | 2014-08-20 | | 公開日 | 2015-03-25 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (2.34 Å) | | 主引用文献 | Structure and Dynamics of the Mkk7-Jnk Signaling Complex.
Proc.Natl.Acad.Sci.USA, 112, 2015
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4W4Y
 | | JNK2/3 in complex with 3-(4-{[(4-methylphenyl)carbamoyl]amino}-1H-pyrazol-1-yl)-N-(2-methylpyridin-4-yl)benzamide | | 分子名称: | 3-(4-{[(4-methylphenyl)carbamoyl]amino}-1H-pyrazol-1-yl)-N-(2-methylpyridin-4-yl)benzamide, c-jun NH2-terminal kinase 3 | | 著者 | Park, H, Iqbal, S, Hernandez, P, Mora, R, Zheng, K, Feng, Y, LoGrasso, P. | | 登録日 | 2014-08-15 | | 公開日 | 2015-02-11 | | 最終更新日 | 2023-12-27 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Structural Basis and Biological Consequences for JNK2/3 Isoform Selective Aminopyrazoles.
Sci Rep, 5, 2015
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6L6Z
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