2J9F

Human branched-chain alpha-ketoacid dehydrogenase-decarboxylase E1b

Summary for 2J9F

• Entry DOI: 10.2210/pdb2j9f/pdb
• Related: 1DTW 1OLS 1OLU 1OLX 1U5B 1V11 1V16 1V1M 1V1R 1WCI 1X7W 1X7X 1X7Y 1X7Z 1X80 2BEU 2BEV 2BEW 2BFB 2BFC 2BFD 2BFE 2BFF
• Descriptor: 2-OXOISOVALERATE DEHYDROGENASE ALPHA SUBUNIT, 2-OXOISOVALERATE DEHYDROGENASE BETA SUBUNIT, MANGANESE (II) ION, ... (7 entities in total)
• Functional Keywords: oxidoreductase, flavoprotein, mitochondrion, thiamine pyrophosphate, maple syrup urine disease, transit peptide, phosphorylation, disease mutation, metal-binding, multi-enzyme complex
• Biological source: HOMO SAPIENS (HUMAN); More
• Total number of polymer chains: 4
• Total formula weight: 170388.12

Authors

Jun, L.,Machius, M.,Chuang, J.L.,Wynn, R.M.,Chuang, D.T. (deposition date: 2006-11-07, release date: 2007-02-27, Last modification date: 2023-12-13)

• Primary citation: Li, J.,Machius, M.,Chuang, J.L.,Wynn, R.M.,Chuang, D.T.; The Two Active Sites in Human Branched-Chain Alpha- Keto Acid Dehydrogenase Operate Independently without an Obligatory Alternating-Site Mechanism.; J.Biol.Chem., 282:11904-, 2007; PubMed: 17329260; DOI: 10.1074/JBC.M610843200

Experimental method

X-RAY DIFFRACTION (1.88 Å)