1WCI

Reactivity modulation of human branched-chain alpha-ketoacid dehydrogenase by an internal molecular switch

Summary for 1WCI

Entry DOI	10.2210/pdb1wci/pdb
Related	1DTW 1OLS 1OLU 1OLX 1U5B 1V11 1V16 1V1M 1V1R 1X7W 1X7X 1X7Y 1X7Z 1X80 2BEU 2BEV 2BEW 2BFB 2BFC 2BFD 2BFE 2BFF
Descriptor	2-OXOISOVALERATE DEHYDROGENASE ALPHA SUBUNIT, 2-OXOISOVALERATE DEHYDROGENASE BETA SUBUNIT, CHLORIDE ION, ... (8 entities in total)
Functional Keywords	oxidoreductase, ketoacid dehydrogenase, branched-chain, multi enzyme complex, acylation, oxidative decarboxylation, maple syrup urine disease, thiamine diphosphate, phosphorylation, conformational switch, reactivity, flavoprotein, maple syru urine disease, mitochondrion, thiamine
Biological source	HOMO SAPIENS (HUMAN) More
Total number of polymer chains	2
Total formula weight	84373.04
Authors	Machius, M.,Wynn, R.M.,Chuang, J.L.,Tomchick, D.R.,Brautigam, C.A.,Chuang, D.T. (deposition date: 2004-11-16, release date: 2006-02-16, Last modification date: 2023-12-13)
Primary citation	Machius, M.,Wynn, R.M.,Chuang, J.L.,Li, J.,Kluger, R.,Yu, D.,Tomchick, D.R.,Brautigam, C.A.,Chuang, D.T. A Versatile Conformational Switch Regulates Reactivity in Human Branched-Chain Alpha-Ketoacid Dehydrogenase. Structure, 14:287-, 2006 Cited by PubMed: 16472748 DOI: 10.1016/J.STR.2005.10.009 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.84 Å)

Structure validation