1X7Z

Crystal structure of the human mitochondrial branched-chain alpha-ketoacid dehydrogenase

Summary for 1X7Z

• Entry DOI: 10.2210/pdb1x7z/pdb
• Related: 1U5B 1X7W 1X7X 1X7Y 1X80
• Descriptor: 2-oxoisovalerate dehydrogenase alpha subunit, 2-oxoisovalerate dehydrogenase beta subunit, POTASSIUM ION, ... (8 entities in total)
• Functional Keywords: oxidoreductase, ketoacid dehydrogenase, branched-chain, multi-enzyme complex, acylation, oxidative decarboxylation maple syrup urine disease, thiamin diphosphate, phosphorylation, flavoprotein
• Biological source: Homo sapiens (human); More
• Cellular location: Mitochondrion matrix: P12694 P21953
• Total number of polymer chains: 2
• Total formula weight: 84187.37

Authors

Wynn, R.M.,Kato, M.,Machius, M.,Chuang, J.L.,Li, J.,Tomchick, D.R.,Chuang, D.T. (deposition date: 2004-08-16, release date: 2004-11-23, Last modification date: 2023-08-23)

• Primary citation: Wynn, R.M.,Kato, M.,Machius, M.,Chuang, J.L.,Li, J.,Tomchick, D.R.,Chuang, D.T.; Molecular mechanism for regulation of the human mitochondrial branched-chain alpha-ketoacid dehydrogenase complex by phosphorylation; Structure, 12:2185-2196, 2004; PubMed: 15576032; DOI: 10.1016/j.str.2004.09.013

Experimental method

X-RAY DIFFRACTION (1.72 Å)