1X7Z
Crystal structure of the human mitochondrial branched-chain alpha-ketoacid dehydrogenase
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | 2-oxoisovalerate dehydrogenase alpha subunit | polymer | 400 | 45599.1 | 1 | UniProt (P12694) Pfam (PF00676) | Homo sapiens (human) | Branched-chain alpha-keto acid dehydrogenase E1 component alpha chain, BCKDH E1-alpha, BCKDE1A |
| 2 | B (B) | 2-oxoisovalerate dehydrogenase beta subunit | polymer | 342 | 37902.3 | 1 | UniProt (P21953) Pfam (PF02779) Pfam (PF02780) | Homo sapiens (human) | Branched-chain alpha-keto acid dehydrogenase E1 component beta chain, BCKDH E1-beta |
| 3 | C, G (A, B) | POTASSIUM ION | non-polymer | 39.1 | 2 | Chemie (K) | |||
| 4 | D (A) | MANGANESE (II) ION | non-polymer | 54.9 | 1 | Chemie (MN) | |||
| 5 | E (A) | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) | |||
| 6 | F (A) | THIAMINE DIPHOSPHATE | non-polymer | 425.3 | 1 | Chemie (TPP) | |||
| 7 | H (B) | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
| 8 | I, J (A, B) | water | water | 18.0 | 636 | Chemie (HOH) |
Sequence modifications
A: 1 - 400 (UniProt: P12694)
| PDB | External Database | Details |
|---|---|---|
| Asp 292 | Ser 337 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 83501.4 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 686.0 | |
| All* | Total formula weight | 84187.4 |
