2BFD

Reactivity modulation of human branched-chain alpha-ketoacid dehydrogenase by an internal molecular switch

Summary for 2BFD

Related1DTW 1OLS 1OLU 1OLX 1U5B 1V11 1V16 1V1M 1V1R 1WCI 1X7W 1X7X 1X7Y 1X7Z 1X80 2BEU 2BEV 2BEW 2BFB 2BFC 2BFE 2BFF
Descriptor2-OXOISOVALERATE DEHYDROGENASE ALPHA SUBUNIT, 2-OXOISOVALERATE DEHYDROGENASE BETA SUBUNIT, POTASSIUM ION, ... (9 entities in total)
Functional Keywordsoxidoreductase, multi-enzyme complex, acylation, oxidative decarboxylation, maple syrup urine disease, thiamine diphosphate, phosphorylation, conformational switch
Biological sourceHOMO SAPIENS (HUMAN)
Total number of polymer chains2
Total molecular weight84101.36
Authors
Machius, M.,Wynn, R.M.,Chuang, J.L.,Tomchick, D.R.,Brautigam, C.A.,Chuang, D.T. (deposition date: 2004-12-06, release date: 2006-02-16, Last modification date: 2019-05-08)
Primary citation
Machius, M.,Wynn, R.M.,Chuang, J.L.,Li, J.,Kluger, R.,Yu, D.,Tomchick, D.R.,Brautigam, C.A.,Chuang, D.T.
A Versatile Conformational Switch Regulates Reactivity in Human Branched-Chain Alpha-Ketoacid Dehydrogenase.
Structure, 14:287-, 2006
PubMed: 16472748 (PDB entries with the same primary citation)
DOI: 10.1016/J.STR.2005.10.009
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (1.39 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.17412 0.6% 1.4% 8.1%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation reportDownload