5N6W
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5n6w by Molmil](/molmil-images/mine/5n6w) | Retinoschisin R141H Mutant | 分子名称: | Retinoschisin | 著者 | Ramsay, E.P, Collins, R.F, Owens, T.W, Siebert, C.A, Jones, R.P.O, Roseman, A, Wang, T, Baldock, C. | 登録日 | 2017-02-16 | 公開日 | 2017-04-12 | 最終更新日 | 2017-08-30 | 実験手法 | ELECTRON MICROSCOPY (4.2 Å) | 主引用文献 | Structural analysis of X-linked retinoschisis mutations reveals distinct classes which differentially effect retinoschisin function Human Molecular Genetics, 25, 2016
|
|
8P5O
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8p5o by Molmil](/molmil-images/mine/8p5o) | Proline activating adenylation domain of gramicidin S synthetase 2 - GrsB1-Acore | 分子名称: | Gramicidin S synthase 2 | 著者 | Stephan, P, Basquin, J, Caputi, L, O'Connor, S.E, Kries, H. | 登録日 | 2023-05-24 | 公開日 | 2023-07-05 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Directed Evolution of Piperazic Acid Incorporation by a Nonribosomal Peptide Synthetase. Angew.Chem.Int.Ed.Engl., 62, 2023
|
|
6SI8
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6si8 by Molmil](/molmil-images/mine/6si8) | Escherichia coli AGPase in complex with AMP. | 分子名称: | ADENOSINE MONOPHOSPHATE, Glucose-1-phosphate adenylyltransferase | 著者 | Cifuente, J.O, Comino, N, D'Angelo, C, Marina, A, Gil-Carton, D, Albesa-Jove, D, Guerin, M.E. | 登録日 | 2019-08-09 | 公開日 | 2020-02-05 | 最終更新日 | 2024-05-22 | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | 主引用文献 | The allosteric control mechanism of bacterial glycogen biosynthesis disclosed by cryoEM. Curr Res Struct Biol, 2, 2020
|
|
8P06
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8p06 by Molmil](/molmil-images/mine/8p06) | Crystal structure of human Casein Kinase II subunit alpha (CK2a1) in complex with 5-((2-(4H-1,2,4-triazol-4-yl)pyridin-4-yl)amino)-7-(cyclopropylamino)pyrazolo[1,5-a]pyrimidine-3-carbonitrile | 分子名称: | 7-(cyclopropylamino)-5-[[2-(1,2,4-triazol-4-yl)pyridin-4-yl]amino]pyrazolo[1,5-a]pyrimidine-3-carbonitrile, Casein kinase II subunit alpha, SULFATE ION | 著者 | Kraemer, A, Ong, H.W, Yang, X, Brown, J.W, Chang, E, Willson, T, Knapp, S, Structural Genomics Consortium (SGC) | 登録日 | 2023-05-09 | 公開日 | 2023-06-21 | 最終更新日 | 2024-08-07 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | More than an Amide Bioisostere: Discovery of 1,2,4-Triazole-containing Pyrazolo[1,5- a ]pyrimidine Host CSNK2 Inhibitors for Combatting beta-Coronavirus Replication. J.Med.Chem., 67, 2024
|
|
1RZZ
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1rzz by Molmil](/molmil-images/mine/1rzz) | PHOTOSYNTHETIC REACTION CENTER DOUBLE MUTANT FROM RHODOBACTER SPHAEROIDES WITH ASP L213 REPLACED WITH ASN AND ARG M233 REPLACED WITH CYS IN THE CHARGE-NEUTRAL DQAQB STATE (TETRAGONAL FORM) | 分子名称: | BACTERIOCHLOROPHYLL A, BACTERIOPHEOPHYTIN A, FE (II) ION, ... | 著者 | Xu, Q, Axelrod, H.L, Abresch, E.C, Paddock, M.L, Okamura, M.Y, Feher, G. | 登録日 | 2003-12-29 | 公開日 | 2004-04-13 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | X-Ray Structure Determination of Three Mutants of the Bacterial Photosynthetic Reaction Centers from Rb. sphaeroides; Altered Proton Transfer Pathways. STRUCTURE, 12, 2004
|
|
7NUP
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7nup by Molmil](/molmil-images/mine/7nup) | Endoplasmic reticulum aminopeptidase 2 complexed with a mixed hydroxamic and sulfonyl ligand | 分子名称: | (3~{S})-4-(4-hydroxyphenyl)-~{N}-oxidanyl-3-[5-[[(5-phenylthiophen-2-yl)sulfonylamino]methyl]-1,2,3-triazol-1-yl]butanamide, 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Mpakali, A, Giastas, P, Stratikos, E. | 登録日 | 2021-03-12 | 公開日 | 2022-06-22 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (3.1 Å) | 主引用文献 | Endoplasmic reticulum aminopeptidase 2 complexed with a mixed hydroxamic and sulfonyl ligand To Be Published
|
|
8OL9
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8ol9 by Molmil](/molmil-images/mine/8ol9) | |
1CC1
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1cc1 by Molmil](/molmil-images/mine/1cc1) | CRYSTAL STRUCTURE OF A REDUCED, ACTIVE FORM OF THE NI-FE-SE HYDROGENASE FROM DESULFOMICROBIUM BACULATUM | 分子名称: | CARBONMONOXIDE-(DICYANO) IRON, FE (II) ION, HYDROGENASE (LARGE SUBUNIT), ... | 著者 | Garcin, E, Vernede, X, Hatchikian, E.C, Volbeda, A, Frey, M, Fontecilla-Camps, J.C. | 登録日 | 1999-03-03 | 公開日 | 1999-06-01 | 最終更新日 | 2023-08-09 | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | 主引用文献 | The crystal structure of a reduced [NiFeSe] hydrogenase provides an image of the activated catalytic center Structure Fold.Des., 7, 1999
|
|
1GBD
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1gbd by Molmil](/molmil-images/mine/1gbd) | |
7NSK
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7nsk by Molmil](/molmil-images/mine/7nsk) | Endoplasmic reticulum aminopeptidase 2 complexed with a hydroxamic ligand | 分子名称: | (2~{S})-3-(4-hydroxyphenyl)-~{N}-oxidanyl-2-[4-[[(5-pyridin-2-ylthiophen-2-yl)sulfonylamino]methyl]-1,2,3-triazol-1-yl]propanamide, 1,2-ETHANEDIOL, 1-ETHOXY-2-(2-ETHOXYETHOXY)ETHANE, ... | 著者 | Mpakali, A, Giastas, P, Stratikos, E. | 登録日 | 2021-03-08 | 公開日 | 2022-06-22 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (3.1 Å) | 主引用文献 | Endoplasmic reticulum aminopeptidase 2 in complex with a phosphinic ligand To Be Published
|
|
7JSD
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7jsd by Molmil](/molmil-images/mine/7jsd) | Hydroxylase homolog of BesD with Fe(II), alpha-ketoglutarate, and lysine | 分子名称: | 2-OXOGLUTARIC ACID, FE (II) ION, LYSINE, ... | 著者 | Kissman, E.N, Neugebauer, M.E, Chang, M.C.Y. | 登録日 | 2020-08-14 | 公開日 | 2021-08-25 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Reaction pathway engineering converts a radical hydroxylase into a halogenase. Nat.Chem.Biol., 18, 2022
|
|
8OW4
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8ow4 by Molmil](/molmil-images/mine/8ow4) | 2.75 angstrom crystal structure of human NFAT1 with bound DNA | 分子名称: | DNA (5'-D(*AP*AP*CP*TP*AP*TP*TP*TP*TP*TP*CP*CP*AP*GP*C)-3'), DNA (5'-D(*TP*TP*GP*CP*TP*GP*GP*AP*AP*AP*AP*AP*TP*AP*G)-3'), Nuclear factor of activated T-cells, ... | 著者 | Lopez-Sagaseta, J, Erausquin, E, Hernandez-Morales, S, Urdiciain, A, Lasarte, J.J, Lozano, T. | 登録日 | 2023-04-27 | 公開日 | 2023-07-26 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (2.75 Å) | 主引用文献 | 2.75 angstrom crystal structure of human NFAT1 with bound DNA Not published
|
|
8RU1
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8ru1 by Molmil](/molmil-images/mine/8ru1) | Chromatin remodeling regulator CECR2 with in crystallo disulfide bond | 分子名称: | Chromatin remodeling regulator CECR2, GLYCEROL, SODIUM ION | 著者 | Fairhead, M, Strain-Damerell, C, Ye, M, Mackinnon, S.R, Pinkas, D, MacLean, E.M, Koekemoer, L, Damerell, D, Krojer, T, Arrowsmith, C.H, Edwards, A, Bountra, C, Yue, W, Burgess-Brown, N, Marsden, B, von Delft, F, Structural Genomics Consortium (SGC) | 登録日 | 2024-01-29 | 公開日 | 2024-03-06 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (1.66 Å) | 主引用文献 | A fast, parallel method for efficiently exploring crystallization behaviour of large numbers of protein variants To Be Published
|
|
7JQM
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7jqm by Molmil](/molmil-images/mine/7jqm) | Crystal structure of the Thermus thermophilus 70S ribosome in complex with Bac7-002, mRNA, and deacylated P-site tRNA at 3.05A resolution | 分子名称: | 16S Ribosomal RNA, 23S Ribosomal RNA, 30S ribosomal protein S10, ... | 著者 | Mardirossian, M, Sola, R, Beckert, B, Valencic, E, Collis, D.W.P, Borisek, J, Armas, F, Di Stasi, A, Buchmann, J, Syroegin, E.A, Polikanov, Y.S, Magistrato, A, Hilpert, K, Wilson, D.N, Scocchi, M. | 登録日 | 2020-08-11 | 公開日 | 2020-08-26 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (3.05 Å) | 主引用文献 | Peptide Inhibitors of Bacterial Protein Synthesis with Broad Spectrum and SbmA-Independent Bactericidal Activity against Clinical Pathogens. J.Med.Chem., 63, 2020
|
|
5MZZ
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5mzz by Molmil](/molmil-images/mine/5mzz) | Crystal structure of the decarboxylase AibA/AibB in complex with 3-methylglutaconate | 分子名称: | 3-methylpent-2-enedioic acid, ACETATE ION, GLYCEROL, ... | 著者 | Bock, T, Luxenburger, E, Hoffmann, J, Schuetza, V, Feiler, C, Mueller, R, Blankenfeldt, W. | 登録日 | 2017-02-02 | 公開日 | 2017-05-31 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | AibA/AibB Induces an Intramolecular Decarboxylation in Isovalerate Biosynthesis by Myxococcus xanthus. Angew. Chem. Int. Ed. Engl., 56, 2017
|
|
7KC0
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7kc0 by Molmil](/molmil-images/mine/7kc0) | Structure of the Saccharomyces cerevisiae replicative polymerase delta in complex with a primer/template and the PCNA clamp | 分子名称: | 2',3'-DIDEOXY-THYMIDINE-5'-TRIPHOSPHATE, DNA (25-MER), DNA (5'-D(P*AP*TP*GP*AP*CP*CP*AP*TP*GP*AP*TP*TP*AP*CP*GP*AP*AP*TP*TP*GP*C)-3'), ... | 著者 | Zheng, F, Georgescu, R, Li, H, O'Donnell, M.E. | 登録日 | 2020-10-04 | 公開日 | 2020-12-02 | 最終更新日 | 2020-12-16 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Structure of eukaryotic DNA polymerase delta bound to the PCNA clamp while encircling DNA. Proc.Natl.Acad.Sci.USA, 117, 2020
|
|
5NIJ
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5nij by Molmil](/molmil-images/mine/5nij) | |
4PEG
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4peg by Molmil](/molmil-images/mine/4peg) | Dbr1 in complex with guanosine-5'-monophosphate | 分子名称: | GLYCEROL, GUANOSINE-5'-MONOPHOSPHATE, MANGANESE (II) ION, ... | 著者 | Montemayor, E.J, Katolik, A, Clark, N.E, Taylor, A.B, Schuermann, J.P, Combs, D.J, Johnsson, R, Holloway, S.P, Stevens, S.W, Damha, M.J, Hart, P.J. | 登録日 | 2014-04-23 | 公開日 | 2014-08-27 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Structural basis of lariat RNA recognition by the intron debranching enzyme Dbr1. Nucleic Acids Res., 42, 2014
|
|
5AB2
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5ab2 by Molmil](/molmil-images/mine/5ab2) | Crystal structure of aminopeptidase ERAP2 with ligand | 分子名称: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Mpakali, A, Giastas, P, Saridakis, E, Mavridis, I.M, Stratikos, E. | 登録日 | 2015-07-31 | 公開日 | 2015-09-30 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2.729 Å) | 主引用文献 | Structural Basis for Antigenic Peptide Recognition and Processing by Endoplasmic Reticulum (Er) Aminopeptidase 2. J.Biol.Chem., 290, 2015
|
|
8JG2
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8jg2 by Molmil](/molmil-images/mine/8jg2) | |
6B7F
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6b7f by Molmil](/molmil-images/mine/6b7f) | Crystal structure of E.coli Phosphopantetheine Adenylyltransferase (PPAT/CoaD) in complex with (R)-3,3-dimethyl-4-(5-vinyl-1H-imidazol-1-yl)isochroman-1-one | 分子名称: | (4R)-4-(5-ethenyl-1H-imidazol-1-yl)-3,3-dimethyl-3,4-dihydro-1H-2-benzopyran-1-one, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, DIMETHYL SULFOXIDE, ... | 著者 | Proudfoot, A.W, Bussiere, D, Lingel, A. | 登録日 | 2017-10-03 | 公開日 | 2017-12-27 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.562 Å) | 主引用文献 | High-Confidence Protein-Ligand Complex Modeling by NMR-Guided Docking Enables Early Hit Optimization. J. Am. Chem. Soc., 139, 2017
|
|
2VCS
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2vcs by Molmil](/molmil-images/mine/2vcs) | Structure of isoniazid (INH) bound to cytosolic soybean ascorbate peroxidase mutant H42A | 分子名称: | 4-(DIAZENYLCARBONYL)PYRIDINE, ASCORBATE PEROXIDASE, PROTOPORPHYRIN IX CONTAINING FE, ... | 著者 | Metcalfe, C.L, Macdonald, I.K, Brown, K.A, Raven, E.L, Moody, P.C.E. | 登録日 | 2007-09-26 | 公開日 | 2007-12-04 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (1.68 Å) | 主引用文献 | The Tuberculosis Prodrug Isoniazid Bound to Activating Peroxidases. J.Biol.Chem., 283, 2008
|
|
3K2A
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3k2a by Molmil](/molmil-images/mine/3k2a) | Crystal structure of the homeobox domain of human homeobox protein Meis2 | 分子名称: | ACETATE ION, CHLORIDE ION, Homeobox protein Meis2 | 著者 | Lam, R, Soloveychik, M, Battaile, K.P, Romanov, V, Lam, K, Beletskaya, I, Gordon, E, Pai, E.F, Chirgadze, N.Y. | 登録日 | 2009-09-29 | 公開日 | 2010-10-13 | 最終更新日 | 2017-11-01 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | Crystal structure of the homeobox domain of human homeobox protein Meis2 To be Published
|
|
1PHK
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1phk by Molmil](/molmil-images/mine/1phk) | TWO STRUCTURES OF THE CATALYTIC DOMAIN OF PHOSPHORYLASE, KINASE: AN ACTIVE PROTEIN KINASE COMPLEXED WITH NUCLEOTIDE, SUBSTRATE-ANALOGUE AND PRODUCT | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, MANGANESE (II) ION, PHOSPHORYLASE KINASE | 著者 | Owen, D.J, Noble, M.E.M, Garman, E.F, Papageorgiou, A.C, Johnson, L.N. | 登録日 | 1996-03-15 | 公開日 | 1996-08-17 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Two structures of the catalytic domain of phosphorylase kinase: an active protein kinase complexed with substrate analogue and product. Structure, 3, 1995
|
|
5O54
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5o54 by Molmil](/molmil-images/mine/5o54) | Glycogen Phosphorylase b in complex with 29a | 分子名称: | (2~{R},3~{S},4~{R},5~{R},6~{R})-5-azanyl-2-(hydroxymethyl)-6-(5-phenyl-4~{H}-1,2,4-triazol-3-yl)oxane-3,4-diol, Glycogen phosphorylase, muscle form, ... | 著者 | Kyriakis, E, Solovou, T.G.A, Stravodimos, G.A, Kantsadi, A.L, Chatzileontiadou, D.S, Skamnaki, V.T, Leonidas, D.D. | 登録日 | 2017-05-31 | 公開日 | 2017-09-27 | 最終更新日 | 2017-11-29 | 実験手法 | X-RAY DIFFRACTION (2.45 Å) | 主引用文献 | Nanomolar Inhibitors of Glycogen Phosphorylase Based on beta-d-Glucosaminyl Heterocycles: A Combined Synthetic, Enzyme Kinetic, and Protein Crystallography Study. J. Med. Chem., 60, 2017
|
|