7AMB
 
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4YR9
 | | mouse TDH with NAD+ bound | | 分子名称: | GLYCEROL, L-threonine 3-dehydrogenase, mitochondrial, ... | | 著者 | He, C, Li, F. | | 登録日 | 2015-03-14 | | 公開日 | 2016-02-03 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | Structural insights on mouse l-threonine dehydrogenase: A regulatory role of Arg180 in catalysis
J.Struct.Biol., 192, 2015
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6TY4
 | | FAK structure with AMP-PNP from single particle analysis of 2D crystals | | 分子名称: | Focal adhesion kinase 1, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER | | 著者 | Acebron, I, Righetto, R, Biyani, N, Chami, M, Boskovic, J, Stahlberg, H, Lietha, D. | | 登録日 | 2020-01-15 | | 公開日 | 2020-08-19 | | 最終更新日 | 2024-05-22 | | 実験手法 | ELECTRON MICROSCOPY (5.96 Å) | | 主引用文献 | Structural basis of Focal Adhesion Kinase activation on lipid membranes.
Embo J., 39, 2020
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7LO1
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7BV8
 | | Mature 50S ribosomal subunit from RrmJ knock out E.coli strain | | 分子名称: | 23S rRNA, 50S ribosomal protein L10, 50S ribosomal protein L11, ... | | 著者 | Wang, W, Li, W.Q, Ge, X.L, Yan, K.G, Mandava, C.S, Sanyal, S, Gao, N. | | 登録日 | 2020-04-09 | | 公開日 | 2020-07-01 | | 最終更新日 | 2024-03-27 | | 実験手法 | ELECTRON MICROSCOPY (3.14 Å) | | 主引用文献 | Loss of a single methylation in 23S rRNA delays 50S assembly at multiple late stages and impairs translation initiation and elongation.
Proc.Natl.Acad.Sci.USA, 117, 2020
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2RU5
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4EHK
 | | Allosteric Modulation of Caspase-3 through Mutagenesis | | 分子名称: | ACE-ASP-GLU-VAL-ASP-CHLOROMETHYLKETONE INHIBITOR, Caspase-3 | | 著者 | Walters, J, Schipper, J.L, Swartz, P.D, Mattos, C, Clark, A.C. | | 登録日 | 2012-04-02 | | 公開日 | 2012-06-06 | | 最終更新日 | 2017-11-15 | | 実験手法 | X-RAY DIFFRACTION (1.668 Å) | | 主引用文献 | Allosteric modulation of caspase 3 through mutagenesis.
Biosci.Rep., 32, 2012
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7B9B
 | | Crystal structure of human 5' exonuclease Appollo APO form | | 分子名称: | 5' exonuclease Apollo, NICKEL (II) ION | | 著者 | Newman, J.A, Baddock, H.T, Mukhopadhyay, S.M.M, Burgess-Brown, N.A, von Delft, F, Arrowshmith, C.H, Edwards, A, Bountra, C, Gileadi, O. | | 登録日 | 2020-12-14 | | 公開日 | 2021-01-20 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | A phosphate binding pocket is a key determinant of exo- versus endo-nucleolytic activity in the SNM1 nuclease family.
Nucleic Acids Res., 49, 2021
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5N2C
 | | Crystal structure of the peptidoglycan-associated lipoprotein from Burkholderia cenocepacia | | 分子名称: | 1,2-ETHANEDIOL, 3-CYCLOHEXYL-1-PROPYLSULFONIC ACID, ACETATE ION, ... | | 著者 | Matterazzo, E, Bolognesi, M, Gourlay, L.J. | | 登録日 | 2017-02-07 | | 公開日 | 2017-07-26 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Designing Probes for Immunodiagnostics: Structural Insights into an Epitope Targeting Burkholderia Infections.
ACS Infect Dis, 3, 2017
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5N6I
 | | Crystal structure of mouse cGAS in complex with 39 bp DNA | | 分子名称: | Cyclic GMP-AMP synthase, DNA (36-MER), DNA (37-MER), ... | | 著者 | Andreeva, L, Kostrewa, D, Hopfner, K.-P. | | 登録日 | 2017-02-15 | | 公開日 | 2017-09-13 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (3.6 Å) | | 主引用文献 | cGAS senses long and HMGB/TFAM-bound U-turn DNA by forming protein-DNA ladders.
Nature, 549, 2017
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5N3D
 | | cAMP-dependent Protein Kinase A from Cricetulus griseus in complex with fragment like molecule 4-(trifluoromethyl)benzenecarboximidamide | | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, [azanyl-[4-(trifluoromethyl)phenyl]methylidene]azanium, cAMP-dependent protein kinase catalytic subunit alpha, ... | | 著者 | Siefker, C, Heine, A, Klebe, G. | | 登録日 | 2017-02-08 | | 公開日 | 2018-02-28 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (1.77 Å) | | 主引用文献 | Fragment Binding to Kinase Hinge: If Charge Distribution and Local pK a Shifts Mislead Popular Bioisosterism Concepts.
Angew.Chem.Int.Ed.Engl., 2020
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6TPV
 | | Crystal structures of FNIII domain one and two of the human leucocyte common antigen-related protein, LAR | | 分子名称: | IMIDAZOLE, Receptor-type tyrosine-protein phosphatase F | | 著者 | Vilstrup, J.P, Thirup, S.S, Simonsen, A, Birkefeldt, T, Strandbygaard, D. | | 登録日 | 2019-12-14 | | 公開日 | 2020-05-13 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Crystal and solution structures of fragments of the human leucocyte common antigen-related protein.
Acta Crystallogr D Struct Biol, 76, 2020
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5N3S
 | | cAMP-dependent Protein Kinase A from Cricetulus griseus in complex with fragment like molecule 4-Hydroxybenzamide | | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, 4-HYDROXYBENZAMIDE, DIMETHYL SULFOXIDE, ... | | 著者 | Siefker, C, Heine, A, Klebe, G. | | 登録日 | 2017-02-08 | | 公開日 | 2018-02-28 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (1.14 Å) | | 主引用文献 | Fragment Binding to Kinase Hinge: If Charge Distribution and Local pK a Shifts Mislead Popular Bioisosterism Concepts.
Angew.Chem.Int.Ed.Engl., 2020
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7W5L
 | | The crystal structure of the oxidized form of Gluconobacter oxydans WSH-004 SNDH | | 分子名称: | L-sorbosone dehydrogenase, NAD(P) dependent | | 著者 | Li, D, Hou, X.D, Rao, Y.J, Zhou, J.W, Chen, J. | | 登録日 | 2021-11-30 | | 公開日 | 2023-01-18 | | 最終更新日 | 2023-12-27 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Structural Insight into the Catalytic Mechanisms of an L-Sorbosone Dehydrogenase.
Adv Sci, 10, 2023
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4H34
 | | Crystal structure of the tyrosine phosphatase SHP-2 with Q506P mutation | | 分子名称: | 1,2-ETHANEDIOL, GLYCEROL, Tyrosine-protein phosphatase non-receptor type 11 | | 著者 | Qiu, W, Lin, A, Hutchinson, A, Romanov, V, Ruzanov, M, Thompson, C, Lam, K, Kisselman, G, Battaile, K, Chirgadze, N.Y. | | 登録日 | 2012-09-13 | | 公開日 | 2013-10-02 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | Crystal structure of the tyrosine phosphatase SHP-2 with Q506P mutation
To be Published
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6TTV
 | | Crystal structure of the human METTL3-METTL14 complex bound to Compound 3 (ASI_M3M_138) | | 分子名称: | (2~{S},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolane-2-carboxamide, ACETATE ION, N6-adenosine-methyltransferase catalytic subunit, ... | | 著者 | Bedi, R.K, Huang, D, Sledz, P, Caflisch, A. | | 登録日 | 2019-12-30 | | 公開日 | 2020-03-04 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (2.14 Å) | | 主引用文献 | Small-Molecule Inhibitors of METTL3, the Major Human Epitranscriptomic Writer.
Chemmedchem, 15, 2020
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7CFM
 | | Cryo-EM structure of the P395-bound GPBAR-Gs complex | | 分子名称: | 2-(ethylamino)-6-[3-(4-propan-2-ylphenyl)propanoyl]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidine-4-carboxamide, CHOLESTEROL, G-protein coupled bile acid receptor 1, ... | | 著者 | Yang, F, Mao, C, Guo, L, Lin, J, Ming, Q, Xiao, P, Wu, X, Shen, Q, Guo, S, Shen, D, Lu, R, Zhang, L, Huang, S, Ping, Y, Zhang, C, Ma, C, Zhang, K, Liang, X, Shen, Y, Nan, F, Yi, F, Luca, V, Zhou, J, Jiang, C, Sun, J, Xie, X, Yu, X, Zhang, Y. | | 登録日 | 2020-06-27 | | 公開日 | 2020-09-09 | | 最終更新日 | 2020-12-02 | | 実験手法 | ELECTRON MICROSCOPY (3 Å) | | 主引用文献 | Structural basis of GPBAR activation and bile acid recognition.
Nature, 587, 2020
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4WJ9
 | | Structure of Human apo ALDH1A1 | | 分子名称: | CHLORIDE ION, Retinal dehydrogenase 1, YTTERBIUM (III) ION | | 著者 | Morgan, C.A, Hurley, T.D. | | 登録日 | 2014-09-29 | | 公開日 | 2014-12-10 | | 最終更新日 | 2023-12-27 | | 実験手法 | X-RAY DIFFRACTION (1.74 Å) | | 主引用文献 | Development of a high-throughput in vitro assay to identify selective inhibitors for human ALDH1A1.
Chem.Biol.Interact., 234, 2015
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4WO1
 | | Crystal structure of the DAP12 transmembrane domain in lipid cubic phase | | 分子名称: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, CALCIUM ION, TYRO protein tyrosine kinase-binding protein | | 著者 | Call, M.J, Call, M.E, Knoblich, K. | | 登録日 | 2014-10-15 | | 公開日 | 2015-06-03 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (2.14 Å) | | 主引用文献 | Transmembrane Complexes of DAP12 Crystallized in Lipid Membranes Provide Insights into Control of Oligomerization in Immunoreceptor Assembly.
Cell Rep, 11, 2015
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4YAK
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4YAJ
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6TDM
 | | Bam_5920cDD 5919nDD docking domains | | 分子名称: | Beta-ketoacyl synthase,Beta-ketoacyl synthase | | 著者 | Risser, F, Chagot, B. | | 登録日 | 2019-11-08 | | 公開日 | 2020-08-12 | | 最終更新日 | 2024-06-19 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Towards improved understanding of intersubunit interactions in modular polyketide biosynthesis: Docking in the enacyloxin IIa polyketide synthase.
J.Struct.Biol., 212, 2020
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6TDD
 | | Bam_5924 docking domain | | 分子名称: | Beta-ketoacyl synthase | | 著者 | Risser, F, Chagot, B. | | 登録日 | 2019-11-08 | | 公開日 | 2020-08-12 | | 最終更新日 | 2024-07-03 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Towards improved understanding of intersubunit interactions in modular polyketide biosynthesis: Docking in the enacyloxin IIa polyketide synthase.
J.Struct.Biol., 212, 2020
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4Y5W
 | | Transcription factor-DNA complex | | 分子名称: | DNA (5'-D(P*AP*TP*GP*GP*AP*TP*TP*TP*CP*CP*TP*AP*GP*GP*AP*AP*GP*AP*CP*AP*A)-3'), DNA (5'-D(P*TP*TP*GP*TP*CP*TP*TP*CP*CP*TP*AP*GP*GP*AP*AP*AP*TP*CP*CP*AP*T)-3'), Signal transducer and activator of transcription 6 | | 著者 | Li, J, Niu, F, Ouyang, S, Liu, Z. | | 登録日 | 2015-02-12 | | 公開日 | 2016-02-17 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (3.104 Å) | | 主引用文献 | Structural basis for DNA recognition by STAT6
Proc.Natl.Acad.Sci.USA, 113, 2016
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6TDN
 | | Bam_5925cDD 5924nDD docking domains | | 分子名称: | Beta-ketoacyl synthase,Beta-ketoacyl synthase | | 著者 | Risser, F, Chagot, B. | | 登録日 | 2019-11-08 | | 公開日 | 2020-08-12 | | 最終更新日 | 2024-06-19 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Towards improved understanding of intersubunit interactions in modular polyketide biosynthesis: Docking in the enacyloxin IIa polyketide synthase.
J.Struct.Biol., 212, 2020
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