6MH2
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![BU of 6mh2 by Molmil](/molmil-images/mine/6mh2) | Structure of Herceptin Fab without antigen | 分子名称: | Herceptin Fab arm heavy chain, Herceptin Fab arm light chain | 著者 | Luthra, A, Langley, D.B, Christie, M, Christ, D. | 登録日 | 2018-09-17 | 公開日 | 2019-05-29 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Human Antibody Bispecifics through Phage Display Selection. Biochemistry, 58, 2019
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6P4D
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![BU of 6p4d by Molmil](/molmil-images/mine/6p4d) | Hen egg lysozyme (HEL) containing three point mutations (HEL3x): R21Q, R73E, and D101R | 分子名称: | CHLORIDE ION, GLYCEROL, Lysozyme C, ... | 著者 | Langley, D.B, Christ, D. | 登録日 | 2019-05-27 | 公開日 | 2020-05-27 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (1.05 Å) | 主引用文献 | Conformational diversity facilitates antibody mutation trajectories and discrimination between foreign and self-antigens. Proc.Natl.Acad.Sci.USA, 117, 2020
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6MKR
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![BU of 6mkr by Molmil](/molmil-images/mine/6mkr) | 5287 TCR bound to IAb Padi4 | 分子名称: | 5287 TCR alpha chain, 5287 TCR beta chain, H-2 class II histocompatibility antigen, ... | 著者 | Stadinski, B.D, Blevins, S.J, Huseby, E.S. | 登録日 | 2018-09-26 | 公開日 | 2019-07-03 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (3.355 Å) | 主引用文献 | A temporal thymic selection switch and ligand binding kinetics constrain neonatal Foxp3+Tregcell development. Nat.Immunol., 20, 2019
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6MNN
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![BU of 6mnn by Molmil](/molmil-images/mine/6mnn) | 6236 TCR bound to I-Ab Padi4 | 分子名称: | 6236 TCR alpha chain, 6236 TCR beta chain, H-2 class II histocompatibility antigen, ... | 著者 | Blevins, S.J, Stadinski, B.D, Huseby, E.S. | 登録日 | 2018-10-02 | 公開日 | 2019-07-03 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.83 Å) | 主引用文献 | A temporal thymic selection switch and ligand binding kinetics constrain neonatal Foxp3+Tregcell development. Nat.Immunol., 20, 2019
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4LBY
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![BU of 4lby by Molmil](/molmil-images/mine/4lby) | Identifying ligand binding hot spots in proteins using brominated fragments | 分子名称: | AMMONIUM ION, Elongation factor Tu-A, MAGNESIUM ION, ... | 著者 | Groftehauge, M.K, Therkelsen, M, Taaning, R, Skrydstrup, T, Morth, J.P, Nissen, P. | 登録日 | 2013-06-21 | 公開日 | 2013-09-11 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.692 Å) | 主引用文献 | Identifying ligand-binding hot spots in proteins using brominated fragments. Acta Crystallogr.,Sect.F, 69, 2013
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6MT3
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6MV1
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![BU of 6mv1 by Molmil](/molmil-images/mine/6mv1) | 2.15A resolution structure of the CS-b5R domains of human Ncb5or (NAD+ form) | 分子名称: | Cytochrome b5 reductase 4, FLAVIN-ADENINE DINUCLEOTIDE, NICOTINAMIDE-ADENINE-DINUCLEOTIDE | 著者 | Lovell, S, Mehzabeen, N, Battaile, K.P, Benson, D.R, Cooper, A, Gao, P, Zhu, H. | 登録日 | 2018-10-24 | 公開日 | 2019-07-17 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | 主引用文献 | Crystal structures of the naturally fused CS and cytochrome b5reductase (b5R) domains of Ncb5or reveal an expanded CS fold, extensive CS-b5R interactions and productive binding of the NAD(P)+nicotinamide ring. Acta Crystallogr D Struct Biol, 75, 2019
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6MV2
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![BU of 6mv2 by Molmil](/molmil-images/mine/6mv2) | 2.05A resolution structure of the CS-b5R domains of human Ncb5or (NADP+ form) | 分子名称: | Cytochrome b5 reductase 4, FLAVIN-ADENINE DINUCLEOTIDE, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | 著者 | Lovell, S, Mehzabeen, N, Battaile, K.P, Benson, D.R, Cooper, A, Gao, P, Zhu, H. | 登録日 | 2018-10-24 | 公開日 | 2019-07-17 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | 主引用文献 | Crystal structures of the naturally fused CS and cytochrome b5reductase (b5R) domains of Ncb5or reveal an expanded CS fold, extensive CS-b5R interactions and productive binding of the NAD(P)+nicotinamide ring. Acta Crystallogr D Struct Biol, 75, 2019
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7Q8T
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![BU of 7q8t by Molmil](/molmil-images/mine/7q8t) | Crystal structure of NAMPT bound to ligand TSY535(compound 9a) | 分子名称: | Nicotinamide phosphoribosyltransferase, SULFATE ION, [(2~{R},3~{S},4~{R},5~{S})-3,4-bis(oxidanyl)-5-[4-[[[4-(phenylsulfonyl)phenyl]carbamoylamino]methyl]phenyl]oxolan-2-yl]methyl dihydrogen phosphate | 著者 | Kraemer, A, Tang, S, Butterworth, S, Knapp, S, Structural Genomics Consortium (SGC) | 登録日 | 2021-11-11 | 公開日 | 2021-11-24 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | 主引用文献 | Chemistry-led investigations into the mode of action of NAMPT activators, resulting in the discovery of non-pyridyl class NAMPT activators. Acta Pharm Sin B, 13, 2023
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6BA1
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6PK6
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![BU of 6pk6 by Molmil](/molmil-images/mine/6pk6) | Human PRPF4B bound to benzothiophene inhibitor 329 | 分子名称: | 4-(5-{[(2-aminophenyl)methyl]carbamoyl}thiophen-2-yl)-1-benzothiophene-2-carboxamide, SULFATE ION, Serine/threonine-protein kinase PRP4 homolog | 著者 | Godoi, P.H.C, Santiago, A.S, Fala, A.M, Ramos, P.Z, Sriranganadane, D, Mascarello, A, Segretti, N, Azevedo, H, Guimaraes, C.R.W, Arruda, P, Elkins, J.M, Counago, R.M, Structural Genomics Consortium (SGC) | 登録日 | 2019-06-28 | 公開日 | 2019-08-28 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | to be published To Be Published
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6N44
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7QGJ
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![BU of 7qgj by Molmil](/molmil-images/mine/7qgj) | Apo structure of BIR2 Domain of BIRC2 | 分子名称: | 1,2-ETHANEDIOL, Baculoviral IAP repeat-containing protein 2, ZINC ION | 著者 | Kraemer, A, Farges, F, Schwalm, M.P, Saxena, K, Preuss, F, Knapp, S, Structural Genomics Consortium (SGC) | 登録日 | 2021-12-08 | 公開日 | 2022-02-09 | 最終更新日 | 2024-05-01 | 実験手法 | X-RAY DIFFRACTION (1.3 Å) | 主引用文献 | Apo structure BIR2 Domain of BIRC2 To Be Published
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6P05
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![BU of 6p05 by Molmil](/molmil-images/mine/6p05) | Bromodomain-containing protein 4 (BRD4) bromodomain 1 (BD1) complexed with compound 27 | 分子名称: | Bromodomain-containing protein 4, GLYCEROL, N-{1-[1,1-di(pyridin-2-yl)ethyl]-6-(1-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridin-3-yl)-1H-indol-4-yl}ethanesulfonamide | 著者 | Ratia, K.M, Xiong, R, Li, Y, Zhao, J, Gutgesell, L.M, Shen, Z, Dye, K, Dubrovyskyii, O, Zhao, H, Huang, F, Tonetti, D.A, Thatcher, G.R. | 登録日 | 2019-05-16 | 公開日 | 2020-05-20 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (1.54 Å) | 主引用文献 | Novel Pyrrolopyridone Bromodomain and Extra-Terminal Motif (BET) Inhibitors Effective in Endocrine-Resistant ER+ Breast Cancer with Acquired Resistance to Fulvestrant and Palbociclib. J.Med.Chem., 63, 2020
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6MT5
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7QGP
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![BU of 7qgp by Molmil](/molmil-images/mine/7qgp) | STK10 (LOK) bound to Macrocycle CKJB51 | 分子名称: | 1,2-ETHANEDIOL, 1-[(4-chloranyl-2-methyl-phenyl)methyl]-3-(7,10-dioxa-13,17,18,21-tetrazatetracyclo[12.5.2.1^{2,6}.0^{17,20}]docosa-1(20),2(22),3,5,14(21),15,18-heptaen-5-yl)urea, CHLORIDE ION, ... | 著者 | Berger, B.-T, Schroeder, M, Kraemer, A, Schwalm, M.P, Kurz, C.G, Amrhein, J.A, Hanke, T, Knapp, S, Structural Genomics Consortium (SGC) | 登録日 | 2021-12-09 | 公開日 | 2022-01-26 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | STK10 bound to CKJB51 To Be Published
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6PL9
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![BU of 6pl9 by Molmil](/molmil-images/mine/6pl9) | Adduct formed after 1 month in the reaction of dichlorido(1,3-dimethylbenzimidaz ol-2-ylidene)(eta5-pentamethylcyclopentadienyl)rhodium(III) with HEWL | 分子名称: | 2-(1-chloranyl-2,3,4,5,6-pentamethyl-1$l^{7}-rhodapentacyclo[2.2.0.0^{1,3}.0^{1,5}.0^{2,6}]hexan-1-yl)-1,3-dimethyl-benzimidazole, Lysozyme, SODIUM ION, ... | 著者 | Sullivan, M.P, Hartinger, C.G, Goldstone, D.C. | 登録日 | 2019-06-30 | 公開日 | 2020-11-25 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (1.2 Å) | 主引用文献 | Probing the Paradigm of Promiscuity for N-Heterocyclic Carbene Complexes and their Protein Adduct Formation. Angew.Chem.Int.Ed.Engl., 2021
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6N65
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![BU of 6n65 by Molmil](/molmil-images/mine/6n65) | KRAS G-quadruplex G16T mutant. | 分子名称: | KRAS G-quadruplex G16T mutant, POTASSIUM ION | 著者 | Schmidberger, J.W, Ou, A, Smith, N.M, Iyer, K.S, Bond, C.S. | 登録日 | 2018-11-25 | 公開日 | 2020-04-15 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | High resolution crystal structure of a KRAS promoter G-quadruplex reveals a dimer with extensive poly-A pi-stacking interactions for small-molecule recognition. Nucleic Acids Res., 48, 2020
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6MNM
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![BU of 6mnm by Molmil](/molmil-images/mine/6mnm) | 6256 TCR bound to I-Ab Padi4 | 分子名称: | 6256 TCR alpha chain, 6256 TCR beta chain, H-2 class II histocompatibility antigen, ... | 著者 | Blevins, S.J, Stadinski, B.D, Huseby, E.S. | 登録日 | 2018-10-02 | 公開日 | 2019-07-03 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (3.1 Å) | 主引用文献 | A temporal thymic selection switch and ligand binding kinetics constrain neonatal Foxp3+Tregcell development. Nat.Immunol., 20, 2019
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6OZX
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![BU of 6ozx by Molmil](/molmil-images/mine/6ozx) | Wild type GapR crystal structure 1 from C. crescentus | 分子名称: | UPF0335 protein CC_3319 | 著者 | Tarry, M, Harmel, C, Taylor, J.A, Marczynski, G.T, Schmeing, T.M. | 登録日 | 2019-05-16 | 公開日 | 2019-11-27 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (1.851 Å) | 主引用文献 | Structures of GapR reveal a central channel which could accommodate B-DNA. Sci Rep, 9, 2019
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6P4A
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7QGK
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![BU of 7qgk by Molmil](/molmil-images/mine/7qgk) | The mRubyFT protein, Genetically Encoded Blue-to-Red Fluorescent Timer in its red state | 分子名称: | MAGNESIUM ION, The red form of the mRubyFT protein, Genetically Encoded Blue-to-Red Fluorescent Timer | 著者 | Boyko, K.M, Nikolaeva, A.Y, Gaivoronskii, F.A, Vlaskina, A.V, Subach, O.M, Popov, V.O, Subach, F.V. | 登録日 | 2021-12-08 | 公開日 | 2022-03-23 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | The mRubyFT Protein, Genetically Encoded Blue-to-Red Fluorescent Timer. Int J Mol Sci, 23, 2022
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6N3J
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6CUZ
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![BU of 6cuz by Molmil](/molmil-images/mine/6cuz) | Engineered TrpB from Pyrococcus furiosus, PfTrpB7E6 with (2S,3R)-ethylserine bound as the amino-acrylate | 分子名称: | (2E)-2-[(E)-({3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methylidene)amino]pent-2-enoic acid, PHOSPHATE ION, SODIUM ION, ... | 著者 | Scheele, R.A, Buller, A.R, Boville, C.E, Arnold, F.H. | 登録日 | 2018-03-27 | 公開日 | 2018-09-26 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | 主引用文献 | Engineered Biosynthesis of beta-Alkyl Tryptophan Analogues. Angew. Chem. Int. Ed. Engl., 57, 2018
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6MNG
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![BU of 6mng by Molmil](/molmil-images/mine/6mng) | 4738 TCR bound to IAb Padi4 | 分子名称: | 4738 TCR alpha chain, 4738 TCR beta chain, H-2 class II histocompatibility antigen, ... | 著者 | Blevins, S.J, Stadinski, B.D, Huseby, E.S. | 登録日 | 2018-10-01 | 公開日 | 2019-07-03 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.662 Å) | 主引用文献 | A temporal thymic selection switch and ligand binding kinetics constrain neonatal Foxp3+Tregcell development. Nat.Immunol., 20, 2019
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