6N44

Sheep Galectin-11 (LGALS11) complex with glycerol

Summary for 6N44

• Entry DOI: 10.2210/pdb6n44/pdb
• Descriptor: Galectin, GLYCEROL (3 entities in total)
• Functional Keywords: glycan binding, lectin, galectin, sugar binding protein
• Biological source: Ovis aries (Sheep)
• Total number of polymer chains: 8
• Total formula weight: 125107.75

Authors

Beddoe, T.C.,Sakthivel, D. (deposition date: 2018-11-17, release date: 2020-05-20, Last modification date: 2023-10-11)

Primary citation

Sakthivel, D.,Preston, S.,Gasser, R.B.,Costa, T.P.S.D.,Hernandez, J.N.,Shahine, A.,Shakif-Azam, M.D.,Lock, P.,Rossjohn, J.,Perugini, M.A.,Gonzalez, J.F.,Meeusen, E.,Piedrafita, D.,Beddoe, T.
The oligomeric assembly of galectin-11 is critical for anti-parasitic activity in sheep (Ovis aries).
Commun Biol, 3:464-464, 2020

PubMed Abstract: Galectins are a family of glycan-binding molecules with a characteristic affinity for ß-D-glycosides that mediate a variety of important cellular functions, including immune and inflammatory responses. Galectin-11 (LGALS-11) has been recently identified as a mediator induced specifically in animals against gastrointestinal nematodes and can interfere with parasite growth and development. Here, we report that at least two natural genetic variants of LGALS-11 exist in sheep, and demonstrate fundamental differences in anti-parasitic activity, correlated with their ability to dimerise. This study improves our understanding of the role of galectins in the host immune and inflammatory responses against parasitic nematodes and provides a basis for genetic studies toward selective breeding of animals for resistance to parasites.

PubMed: 32826940
DOI: 10.1038/s42003-020-01179-7

Experimental method

X-RAY DIFFRACTION (2 Å)