PDB: 45176 件ウェブページステータス検索Chemie searchBIRD

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2WPA	Optimisation of 6,6-Dimethyl Pyrrolo 3,4-c pyrazoles: Identification of PHA-793887, a Potent CDK Inhibitor Suitable for Intravenous Dosing 分子名称: CELL DIVISION PROTEIN KINASE 2, CYCLIN A2, N-{6,6-DIMETHYL-5-[(1-METHYLPIPERIDIN-4-YL)CARBONYL]-1,4,5,6-TETRAHYDROPYRROLO[3,4-C]PYRAZOL-3-YL}-3-METHYLBUTANAMIDE, ... 著者 Brasca, M.G, Albanese, C, Alzani, R, Amici, R, Avanzi, N, Ballinari, D, Bischoff, J, Borghi, D, Casale, E, Croci, V, Fiorentini, F, Isacchi, A, Mercurio, C, Nesi, M, Orsini, P, Pastori, W, Pesenti, E, Pevarello, P, Roussel, P, Varasi, M, Volpi, D, Vulpetti, A, Ciomei, M. 登録日 2009-08-03 公開日 2010-02-23 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (2.51 Å) 主引用文献 Optimization of 6,6-Dimethyl Pyrrolo[3,4-C]Pyrazoles: Identification of Pha-793887, a Potent Cdk Inhibitor Suitable for Intravenous Dosing. Bioorg.Med.Chem., 18, 2010
4V48	Real space refined coordinates of the 30S and 50S subunits fitted into the low resolution cryo-EM map of the initiation-like state of E. coli 70S ribosome 分子名称: 16S RIBOSOMAL RNA, 23S ribosomal RNA, 30S RIBOSOMAL PROTEIN S10, ... 著者 Gao, H, Sengupta, J, Valle, M, Korostelev, A, Eswar, N, Stagg, S.M, Van Roey, P, Agrawal, R.K, Harvey, S.T, Sali, A, Chapman, M.S, Frank, J. 登録日 2003-05-06 公開日 2014-07-09 最終更新日 2024-02-28 実験手法 ELECTRON MICROSCOPY (11.5 Å) 主引用文献 Study of the structural dynamics of the E. coli 70S ribosome using real space refinement Cell(Cambridge,Mass.), 113, 2003
4V4G	Crystal structure of five 70s ribosomes from Escherichia Coli in complex with protein Y. 分子名称: 16S ribosomal RNA, 23S RIBOSOMAL RNA, 30S ribosomal protein S10, ... 著者 Vila-Sanjurjo, A, Schuwirth, B.S, Hau, C.W, Cate, J.H. 登録日 2004-10-06 公開日 2014-07-09 最終更新日 2023-12-06 実験手法 X-RAY DIFFRACTION (11.5 Å) 主引用文献 Structural basis for the control of translation initiation during stress. Nat.Struct.Mol.Biol., 11, 2004
3EG6	Structure of WDR5 bound to MLL1 peptide 分子名称: MLL-1 peptide, SULFATE ION, WD repeat-containing protein 5 著者 Patel, A, Dharmarajan, V, Cosgrove, M.S. 登録日 2008-09-10 公開日 2008-09-30 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (1.72 Å) 主引用文献 Structure of WDR5 bound to mixed lineage leukemia protein-1 peptide. J.Biol.Chem., 283, 2008
4V4B	Structure of the ribosomal 80S-eEF2-sordarin complex from yeast obtained by docking atomic models for RNA and protein components into a 11.7 A cryo-EM map. 分子名称: 18S ribosomal RNA, 40S ribosomal protein S0-A, 40S ribosomal protein S11, ... 著者 Spahn, C.M, Gomez-Lorenzo, M.G, Grassucci, R.A, Jorgensen, R, Andersen, G.R, Beckmann, R, Penczek, P.A, Ballesta, J.P.G, Frank, J. 登録日 2004-01-06 公開日 2014-07-09 最終更新日 2024-02-28 実験手法 ELECTRON MICROSCOPY (11.7 Å) 主引用文献 Domain movements of elongation factor eEF2 and the eukaryotic 80S ribosome facilitate tRNA translocation. Embo J., 23, 2004
4V6C	Crystal structure of the E. coli 70S ribosome in an intermediate state of ratcheting 分子名称: 16S rRNA, 23S rRNA, 30S ribosomal protein S10, ... 著者 Zhang, W, Dunkle, J.A, Cate, J.H.D. 登録日 2009-06-27 公開日 2014-07-09 最終更新日 2014-12-10 実験手法 X-RAY DIFFRACTION (3.19 Å) 主引用文献 Structures of the ribosome in intermediate States of ratcheting. Science, 325, 2009
4V6W	Structure of the D. melanogaster 80S ribosome 分子名称: 18S ribosomal RNA, 28S ribosomal RNA, 2S ribosomal RNA, ... 著者 Anger, A.M, Armache, J.-P, Berninghausen, O, Habeck, M, Subklewe, M, Wilson, D.N, Beckmann, R. 登録日 2013-02-27 公開日 2014-07-09 最終更新日 2024-05-15 実験手法 ELECTRON MICROSCOPY (6 Å) 主引用文献 Structures of the human and Drosophila 80S ribosome. Nature, 497, 2013
4V7N	Glycocyamine kinase, beta-beta homodimer from marine worm Namalycastis sp., with transition state analog Mg(II)-ADP-NO3-glycocyamine. 分子名称: ADENOSINE-5'-DIPHOSPHATE, GUANIDINO ACETATE, Glycocyamine kinase beta chain, ... 著者 Lim, K, Pullalarevu, S, Herzberg, O. 登録日 2009-12-15 公開日 2014-07-09 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Structural basis for the mechanism and substrate specificity of glycocyamine kinase, a phosphagen kinase family member. Biochemistry, 49, 2010
4V7V	Crystal structure of the E. coli ribosome bound to clindamycin. 分子名称: 16S rRNA, 23S rRNA, 30S ribosomal protein S10, ... 著者 Dunkle, J.A, Xiong, L, Mankin, A.S, Cate, J.H.D. 登録日 2010-08-16 公開日 2014-07-09 最終更新日 2014-12-10 実験手法 X-RAY DIFFRACTION (3.2891 Å) 主引用文献 Structures of the Escherichia coli ribosome with antibiotics bound near the peptidyl transferase center explain spectra of drug action. Proc.Natl.Acad.Sci.USA, 107, 2010
3TEJ	Crystal structure of a domain fragment involved in peptide natural product biosynthesis 分子名称: Enterobactin synthase component F 著者 Liu, Y, Zheng, T, Bruner, S.D. 登録日 2011-08-15 公開日 2012-01-18 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Structural basis for phosphopantetheinyl carrier domain interactions in the terminal module of nonribosomal peptide synthetases. Chem.Biol., 18, 2011
4V52	Crystal structure of the bacterial ribosome from Escherichia coli in complex with neomycin. 分子名称: 16S rRNA, 23S rRNA, 30S ribosomal protein S10, ... 著者 Borovinskaya, M.A, Pai, R.D, Zhang, W, Schuwirth, B.-S, Holton, J.M, Hirokawa, G, Kaji, H, Kaji, A, Cate, J.H.D. 登録日 2007-06-15 公開日 2014-07-09 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (3.21 Å) 主引用文献 Structural basis for aminoglycoside inhibition of bacterial ribosome recycling. Nat.Struct.Mol.Biol., 14, 2007
4V8G	Crystal structure of RMF bound to the 70S ribosome. 分子名称: 16S Ribosomal RNA, 23S Ribosomal RNA, 30S Ribosomal Protein S10, ... 著者 Polikanov, Y.S, Blaha, G.M, Steitz, T.A. 登録日 2011-12-11 公開日 2014-07-09 最終更新日 2014-12-10 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 How hibernation factors RMF, HPF, and YfiA turn off protein synthesis. Science, 336, 2012
4V5H	E.Coli 70s Ribosome Stalled During Translation Of Tnac Leader Peptide. 分子名称: 16S RIBOSOMAL RNA, 23S RIBOSOMAL RNA, 30S RIBOSOMAL PROTEIN S10, ... 著者 Seidelt, B, Innis, C.A, Wilson, D.N, Gartmann, M, Armache, J, Villa, E, Trabuco, L.G, Becker, T, Mielke, T, Schulten, K, Steitz, T.A, Beckmann, R. 登録日 2009-10-26 公開日 2014-07-09 最終更新日 2024-05-08 実験手法 ELECTRON MICROSCOPY (5.8 Å) 主引用文献 Structural insight into nascent polypeptide chain-mediated translational stalling. Science, 326, 2009
2XA9	Crystal structure of trehalose synthase TreT mutant E326A from P. horikoshii in complex with UDPG 分子名称: TREHALOSE-SYNTHASE TRET, URIDINE-5'-DIPHOSPHATE-GLUCOSE 著者 Song, H.-N, Jung, T.-Y, Yoon, S.-M, Lee, S.-B, Lim, M.-Y, Woo, E.-J. 登録日 2010-03-30 公開日 2011-03-16 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Structural Insights on the New Mechanism of Trehalose Synthesis by Trehalose Synthase Tret from Pyrococcus Horikoshii. J.Mol.Biol., 404, 2010
4V5Z	Structure of a mammalian 80S ribosome obtained by docking homology models of the RNA and proteins into an 8.7 A cryo-EM map 分子名称: 18S Ribosomal RNA, 28S Ribosomal RNA, 40S Ribosomal protein RACK1, ... 著者 Chandramouli, P, Akey, C.W. 登録日 2008-03-27 公開日 2014-07-09 最終更新日 2024-03-20 実験手法 ELECTRON MICROSCOPY (8.7 Å) 主引用文献 Structure of the Mammalian 80S Ribosome at 8.7 A Resolution Structure, 16, 2008
4V9D	Structures of the bacterial ribosome in classical and hybrid states of tRNA binding 分子名称: 16S rRNA, 23S rRNA, 30S ribosomal protein S10, ... 著者 Dunkle, J.A, Wang, L, Feldman, M.B, Pulk, A, Chen, V.B, Kapral, G.J, Noeske, J, Richardson, J.S, Blanchard, S.C, Cate, J.H.D. 登録日 2012-07-31 公開日 2014-07-09 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 Structures of the bacterial ribosome in classical and hybrid states of tRNA binding. Science, 332, 2011
4V68	T. thermophilus 70S ribosome in complex with mRNA, tRNAs and EF-Tu.GDP.kirromycin ternary complex, fitted to a 6.4 A Cryo-EM map. 分子名称: 16S rRNA, 23S rRNA, 30S ribosomal protein S10, ... 著者 Schuette, J.-C, Spahn, C.M.T. 登録日 2008-12-11 公開日 2014-07-09 最終更新日 2019-12-18 実験手法 ELECTRON MICROSCOPY (6.4 Å) 主引用文献 GTPase activation of elongation factor EF-Tu by the ribosome during decoding Embo J., 28, 2009
4V6H	Crystal structure of succinate-semialdehyde dehydrogenase from Burkholderia pseudomallei 分子名称: Succinate-semialdehyde dehydrogenase (NADP+) 著者 Seattle Structural Genomics Center for Infectious Disease (SSGCID) 登録日 2009-07-24 公開日 2014-07-09 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Crystal structure of succinate-semialdehyde dehydrogenase from Burkholderia pseudomallei To be Published
4W2H	Crystal structure of the Thermus thermophilus 70S ribosome in complex with pactamycin (co-crystallized), mRNA and deacylated tRNA in the P site 分子名称: 16S Ribosomal RNA, 23S Ribosomal RNA, 30S Ribosomal Protein S10, ... 著者 Polikanov, Y.S, Osterman, I.A, Szal, T, Tashlitsky, V.N, Serebryakova, M.V, Kusochek, P, Bulkley, D, Malanicheva, I.A, Efimenko, T.A, Efremenkova, O.V, Konevega, A.L, Shaw, K.J, Bogdanov, A.A, Rodnina, M.V, Dontsova, O.A, Mankin, A.S, Steitz, T.A, Sergiev, P.V. 登録日 2014-09-12 公開日 2014-10-15 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Amicoumacin a inhibits translation by stabilizing mRNA interaction with the ribosome. Mol.Cell, 56, 2014
4V6Q	Structural characterization of mRNA-tRNA translocation intermediates (class 5 of the six classes) 分子名称: 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S10, ... 著者 Agirrezabala, X, Liao, H, Schreiner, E, Fu, J, Ortiz-Meoz, R.F, Schulten, K, Green, R, Frank, J. 登録日 2011-12-08 公開日 2014-07-09 最終更新日 2024-05-15 実験手法 ELECTRON MICROSCOPY (11.5 Å) 主引用文献 Structural characterization of mRNA-tRNA translocation intermediates. Proc.Natl.Acad.Sci.USA, 109, 2012
8J07	96nm repeat of human respiratory doublet microtubule and associated axonemal complexes 分子名称: ACTA2, Axonemal dynein light intermediate polypeptide 1, Calaxin, ... 著者 Gui, M, Brown, A. 登録日 2023-04-09 公開日 2023-07-26 最終更新日 2023-08-02 実験手法 ELECTRON MICROSCOPY (4.1 Å) 主引用文献 Axonemal structures reveal mechanoregulatory and disease mechanisms. Nature, 618, 2023
4V73	E. coli 70S-fMetVal-tRNAVal-tRNAfMet complex in hybrid pre-translocation state (pre5a) 分子名称: 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S10, ... 著者 Blau, C, Bock, L.V, Schroder, G.F, Davydov, I, Fischer, N, Stark, H, Rodnina, M.V, Vaiana, A.C, Grubmuller, H. 登録日 2013-10-14 公開日 2014-07-09 最終更新日 2019-12-18 実験手法 ELECTRON MICROSCOPY (15 Å) 主引用文献 Energy barriers and driving forces in tRNA translocation through the ribosome. Nat.Struct.Mol.Biol., 20, 2013
4V7H	Structure of the 80S rRNA and proteins and P/E tRNA for eukaryotic ribosome based on cryo-EM map of Thermomyces lanuginosus ribosome at 8.9A resolution 分子名称: 18S rRNA, 26S ribosomal RNA, 40S ribosomal protein S0(A), ... 著者 Taylor, D.J, Devkota, B, Huang, A.D, Topf, M, Narayanan, E, Sali, A, Harvey, S.C, Frank, J. 登録日 2009-09-22 公開日 2014-07-09 最終更新日 2024-02-28 実験手法 ELECTRON MICROSCOPY (8.9 Å) 主引用文献 Comprehensive molecular structure of the eukaryotic ribosome. Structure, 17, 2009
4WC8	Heterogeneous dodecamer formed from macrocycles containing a sequence from beta-2-microglobulin(63-69). 分子名称: CHLORIDE ION, ORN-TYR-LEU-LEU-PHI-TYR-THR-GLU-ORN-LYS-VAL-ALA-MAA-ALA-VAL-LYS, ORN-TYR-LEU-LEU-PHI-TYR-THR-GLU-ORN-LYS-VAL-ALA-MLE-ALA-VAL-LYS, ... 著者 Spencer, R.K, Nowick, J.S. 登録日 2014-09-04 公開日 2015-05-06 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (1.908 Å) 主引用文献 X-ray Crystallographic Structures of Oligomers of Peptides Derived from beta 2-Microglobulin. J.Am.Chem.Soc., 137, 2015
3ES9	NADPH-Cytochrome P450 Reductase in an Open Conformation 分子名称: FLAVIN MONONUCLEOTIDE, FLAVIN-ADENINE DINUCLEOTIDE, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... 著者 Hamdane, D, Xia, C, Im, S.-C, Zhang, H, Kim, J.-J, Waskell, L. 登録日 2008-10-05 公開日 2009-01-20 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (3.4 Å) 主引用文献 Structure and function of an NADPH-cytochrome P450 oxidoreductase in an open conformation capable of reducing cytochrome P450 J.Biol.Chem., 284, 2009

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