PDB: 13413 件ウェブページステータス検索Chemie searchBIRD

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6DCF	Crystal structure of a Mycobacterium smegmatis transcription initiation complex with Rifampicin-resistant RNA polymerase and bound to kanglemycin A 分子名称: 1,2-ETHANEDIOL, DNA (26-MER), DNA (31-MER), ... 著者 Lilic, M, Darst, S.A, Campbell, E.A. 登録日 2018-05-06 公開日 2018-09-05 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (3.45 Å) 主引用文献 Rifamycin congeners kanglemycins are active against rifampicin-resistant bacteria via a distinct mechanism. Nat Commun, 9, 2018
6IPJ	Binary Complex of Human DNA Polymerase Mu with MndTTP 分子名称: DNA-directed DNA/RNA polymerase mu,DNA-directed DNA/RNA polymerase mu, MANGANESE (II) ION, SULFATE ION, ... 著者 Chang, Y.K, Wu, W.J, Tsai, M.D. 登録日 2018-11-03 公開日 2019-05-29 最終更新日 2024-03-27 実験手法 X-RAY DIFFRACTION (1.98 Å) 主引用文献 Human DNA Polymerase mu Can Use a Noncanonical Mechanism for Multiple Mn2+-Mediated Functions. J.Am.Chem.Soc., 141, 2019
6CCV	Crystal structure of a Mycobacterium smegmatis RNA polymerase transcription initiation complex with inhibitor Rifampicin 分子名称: 1,2-ETHANEDIOL, DNA (26-MER), DNA (31-MER), ... 著者 Lilic, M, Darst, S.A, Campbell, E.A. 登録日 2018-02-07 公開日 2018-08-15 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (3.05 Å) 主引用文献 Rifamycin congeners kanglemycins are active against rifampicin-resistant bacteria via a distinct mechanism. Nat Commun, 9, 2018
4H3K	Crystal structure of a ternary complex of human symplekin NTD, human Ssu72 and a RNA polymerase II CTD peptide phosphorylated at Ser-2, Ser-5 and Ser-7 分子名称: Hexapeptide, PHOSPHATE ION, RNA polymerase II subunit A C-terminal domain phosphatase SSU72, ... 著者 Xiang, K, Tong, L. 登録日 2012-09-13 公開日 2012-10-31 最終更新日 2017-11-15 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 An unexpected binding mode for a Pol II CTD peptide phosphorylated at Ser7 in the active site of the CTD phosphatase Ssu72. Genes Dev., 26, 2012
2A6H	Crystal structure of the T. thermophilus RNA polymerase holoenzyme in complex with antibiotic sterptolydigin 分子名称: DNA-directed RNA polymerase alpha chain, DNA-directed RNA polymerase beta chain, DNA-directed RNA polymerase beta' chain, ... 著者 Temiakov, D, Zenkin, N, Vassylyeva, M.N, Perederina, A, Tahirov, T.H, Savkina, M, Zorov, S, Nikiforov, V, Igarashi, N, Matsugaki, N, Wakatsuki, S, Severinov, K, Vassylyev, D.G, RIKEN Structural Genomics/Proteomics Initiative (RSGI) 登録日 2005-07-02 公開日 2005-09-20 最終更新日 2023-08-23 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Structural basis of transcription inhibition by antibiotic streptolydigin. Mol.Cell, 19, 2005
5YF8	Crystals structure of Classical swine fever virus NS5B (residues 1-672, Y471A-E472A mutant) 分子名称: ACETATE ION, RdRp catalytic 著者 Liu, W, Gong, P. 登録日 2017-09-20 公開日 2018-09-19 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (3.396 Å) 主引用文献 A unique intra-molecular fidelity-modulating mechanism identified in a viral RNA-dependent RNA polymerase. Nucleic Acids Res., 46, 2018
5YF6	Crystals structure of Classical swine fever virus NS5B (residues 1-682) 分子名称: RdRp catalytic 著者 Liu, W, Gong, P. 登録日 2017-09-20 公開日 2018-09-19 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 A unique intra-molecular fidelity-modulating mechanism identified in a viral RNA-dependent RNA polymerase. Nucleic Acids Res., 46, 2018
5YF7	Crystals structure of Classical swine fever virus NS5B (residues 1-672) 分子名称: RdRp catalytic 著者 Liu, W, Gong, P. 登録日 2017-09-20 公開日 2018-09-19 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.27 Å) 主引用文献 A unique intra-molecular fidelity-modulating mechanism identified in a viral RNA-dependent RNA polymerase. Nucleic Acids Res., 46, 2018
5YF5	Crystals structure of Classical swine fever virus NS5B (residues 1-694) 分子名称: RdRp catalytic 著者 Liu, W, Gong, P. 登録日 2017-09-20 公開日 2018-09-19 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.49 Å) 主引用文献 A unique intra-molecular fidelity-modulating mechanism identified in a viral RNA-dependent RNA polymerase. Nucleic Acids Res., 46, 2018
7CTT	Cryo-EM structure of Favipiravir bound to replicating polymerase complex of SARS-CoV-2 in the pre-catalytic state. 分子名称: MAGNESIUM ION, Non-structural protein 7, Non-structural protein 8, ... 著者 Peng, Q, Peng, R, Shi, Y. 登録日 2020-08-20 公開日 2020-09-02 最終更新日 2024-05-29 実験手法 ELECTRON MICROSCOPY (3.2 Å) 主引用文献 Structural Basis of SARS-CoV-2 Polymerase Inhibition by Favipiravir. Innovation (N Y), 2, 2021
5AEM	Structure of t131 N-terminal TPR array 分子名称: TRANSCRIPTION FACTOR TAU 131 KDA SUBUNIT 著者 Taylor, N.M.I, Muller, C.W. 登録日 2015-01-05 公開日 2015-06-24 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (3.4 Å) 主引用文献 Architecture of TFIIIC and its role in RNA polymerase III pre-initiation complex assembly. Nat Commun, 6, 2015
8H02	Crystal structure of Synechococcus elongatus PCC 7942 RNA polymerase SI3-tail 分子名称: DNA-directed RNA polymerase subunit beta' 著者 Shen, L.Q, Zhang, Y. 登録日 2022-09-27 公開日 2023-04-19 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (1.552 Å) 主引用文献 An SI3-sigma arch stabilizes cyanobacteria transcription initiation complex. Proc.Natl.Acad.Sci.USA, 120, 2023
1MFY	SOLUTION STRUCTURE OF INFLUENZA A VIRUS C4 PROMOTER 分子名称: C4 promoter of influneza A virus 著者 Lee, M.-K, Bae, S.-H, Park, C.-J, Cheong, H.-K, Cheong, C, Choi, B.-S. 登録日 2002-08-14 公開日 2002-09-18 最終更新日 2024-05-22 実験手法 SOLUTION NMR 主引用文献 A single-nucleotide natural variation (U4 to C4) in an influenza A virus promoter exhibits a large structural change: implications for differential viral RNA synthesis by RNA-dependent RNA polymerase. Nucleic Acids Res., 31, 2003
6SYI	C-TERMINAL DOMAIN OF INFLUENZA POLYMERASE PA SUBUNIT AND OPTIMIZED SMALL PEPTIDE INHIBITOR 分子名称: 1,2-ETHANEDIOL, PB1-11, Polymerase acidic protein, ... 著者 Hejdanek, J, Pachl, P. 登録日 2019-09-30 公開日 2020-11-25 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 structural characterization of the interaction between the C-terminal domain of the influenza polymerase PA subunit and an optimized small peptide inhibitor. Antiviral Res., 185, 2020
8QH3	5'vRNA-bound Hantaan virus polymerase in monomeric active state 分子名称: MAGNESIUM ION, RNA (5'-R(P*AP*GP*UP*AP*GP*UP*AP*GP*AP*CP*A)-3'), RNA-directed RNA polymerase L 著者 Durieux Trouilleton, Q, Arragain, B, Malet, H. 登録日 2023-09-06 公開日 2024-03-27 実験手法 ELECTRON MICROSCOPY (2.81 Å) 主引用文献 Structural characterization of the oligomerization of full-length Hantaan virus polymerase into symmetric dimers and hexamers. Nat Commun, 15, 2024
8RC4	Structure of Integrator-PP2A complex 分子名称: DSS1, Integrator complex subunit 1, Integrator complex subunit 10, ... 著者 Fianu, I, Ochmann, M, Walshe, J.L, Cramer, P. 登録日 2023-12-06 公開日 2024-02-07 最終更新日 2024-05-15 実験手法 ELECTRON MICROSCOPY (3.1 Å) 主引用文献 Structural basis of Integrator-dependent RNA polymerase II termination. Nature, 629, 2024
8AP1	Cryo-EM structure of yeast mitochondrial RNA polymerase transcription initiation complex with two GTP molecules poised for de novo initiation (IC2) 分子名称: DNA-directed RNA polymerase, mitochondrial, GUANOSINE-5'-TRIPHOSPHATE, ... 著者 Goovaerts, Q, Shen, J, Patel, S.S, Das, K. 登録日 2022-08-09 公開日 2023-08-23 最終更新日 2023-11-01 実験手法 ELECTRON MICROSCOPY (3.47 Å) 主引用文献 Structures illustrate step-by-step mitochondrial transcription initiation. Nature, 622, 2023
8ATV	Cryo-EM structure of yeast mitochondrial RNA polymerase transcription initiation complex with 5-mer RNA, pppGpGpApApA (IC5) 分子名称: DNA (36-MER), DNA-directed RNA polymerase, mitochondrial, ... 著者 Goovaerts, Q, Shen, J, Patel, S.S, Das, K. 登録日 2022-08-24 公開日 2023-08-30 最終更新日 2023-11-01 実験手法 ELECTRON MICROSCOPY (3.39 Å) 主引用文献 Structures illustrate step-by-step mitochondrial transcription initiation. Nature, 622, 2023
8ATW	Cryo-EM structure of yeast mitochondrial RNA polymerase transcription initiation complex with 6-mer RNA, pppGpGpApApApU (IC6) 分子名称: DNA-directed RNA polymerase, mitochondrial, GUANOSINE-5'-TRIPHOSPHATE, ... 著者 Goovaerts, Q, Shen, J, Patel, S.S, Das, K. 登録日 2022-08-24 公開日 2023-08-30 最終更新日 2023-11-01 実験手法 ELECTRON MICROSCOPY (3.62 Å) 主引用文献 Structures illustrate step-by-step mitochondrial transcription initiation. Nature, 622, 2023
8ATT	Cryo-EM structure of yeast mitochondrial RNA polymerase transcription initiation complex with 4-mer RNA, pppGpGpUpA (IC4) 分子名称: DNA-directed RNA polymerase, mitochondrial, GUANOSINE-5'-TRIPHOSPHATE, ... 著者 Goovaerts, Q, Shen, J, Patel, S.S, Das, K. 登録日 2022-08-24 公開日 2023-08-30 最終更新日 2023-11-01 実験手法 ELECTRON MICROSCOPY (3.44 Å) 主引用文献 Structures illustrate step-by-step mitochondrial transcription initiation. Nature, 622, 2023
2HHP	Structure of yeast poly(A) polymerase in a closed conformation. 分子名称: CITRATE ANION, MAGNESIUM ION, Poly(A) polymerase 著者 Bohm, A, Toth, J. 登録日 2006-06-28 公開日 2007-01-23 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 X-ray crystallographic and steady state fluorescence characterization of the protein dynamics of yeast polyadenylate polymerase. J.Mol.Biol., 366, 2007
6CUX	Escherichia coli RpoB S531L mutant RNA polymerase holoenzyme in complex with Kanglemycin A 分子名称: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... 著者 Molodtsov, V, Murakami, K.S. 登録日 2018-03-26 公開日 2018-07-25 最終更新日 2020-01-01 実験手法 X-RAY DIFFRACTION (4.104 Å) 主引用文献 Mode of Action of Kanglemycin A, an Ansamycin Natural Product that Is Active against Rifampicin-Resistant Mycobacterium tuberculosis. Mol. Cell, 72, 2018
1VFG	Crystal structure of tRNA nucleotidyltransferase complexed with a primer tRNA and an incoming ATP analog 分子名称: DIPHOSPHOMETHYLPHOSPHONIC ACID ADENOSYL ESTER, RNA (75-MER), poly A polymerase 著者 Tomita, K, Fukai, S, Ishitani, R, Ueda, T, Takeuchi, N, Vassylyev, D.G, Nureki, O, RIKEN Structural Genomics/Proteomics Initiative (RSGI) 登録日 2004-04-13 公開日 2004-08-10 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Structural basis for template-independent RNA polymerization. Nature, 430, 2004
6V85	Parainfluenza virus 5 L-P complex 分子名称: Phosphoprotein, RNA-directed RNA polymerase L, ZINC ION 著者 Abdella, R, He, Y. 登録日 2019-12-10 公開日 2020-02-19 最終更新日 2024-03-06 実験手法 ELECTRON MICROSCOPY (4.38 Å) 主引用文献 Structure of a paramyxovirus polymerase complex reveals a unique methyltransferase-CTD conformation. Proc.Natl.Acad.Sci.USA, 117, 2020
6QLC	The ssDNA-binding RNA polymerase cofactor Drc from Pseudomonas phage LUZ7 分子名称: PHOSPHATE ION, ssDNA binding RNA Polymerase cofactor 著者 De Zitter, E, Boon, M, De Smet, J, Lavigne, R, Van Meervelt, L. 登録日 2019-01-31 公開日 2019-10-30 最終更新日 2024-05-15 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 'Drc', a structurally novel ssDNA-binding transcription regulator of N4-related bacterial viruses. Nucleic Acids Res., 48, 2020

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