8H0J
 
 | | Annexin A5 mutant | | 分子名称: | Annexin A5, CALCIUM ION | | 著者 | Hua, Z.C, Tang, W. | | 登録日 | 2022-09-29 | | 公開日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (2.23 Å) | | 主引用文献 | structure dissection of the membrane aggregation mechanism induced by Annexin A5 mutation
To Be Published
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8HQY
 | | Cryo-EM structure of SSX1 bound to the H2AK119Ub nucleosome at a resolution of 3.05 angstrom | | 分子名称: | DNA (136-MER), DNA (137-MER), Histone H2A type 1-B/E, ... | | 著者 | Zebin, T, Ai, H.S, Ziyu, X, GuoChao, C, Man, P, Liu, L. | | 登録日 | 2022-12-14 | | 公開日 | 2023-09-27 | | 最終更新日 | 2024-03-06 | | 実験手法 | ELECTRON MICROSCOPY (3.05 Å) | | 主引用文献 | Synovial sarcoma X breakpoint 1 protein uses a cryptic groove to selectively recognize H2AK119Ub nucleosomes.
Nat.Struct.Mol.Biol., 31, 2024
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8GYC
 | | Annexin A5 protein dimer mutant | | 分子名称: | Annexin A5, CALCIUM ION | | 著者 | Hua, Z.C, Tang, W. | | 登録日 | 2022-09-22 | | 公開日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | structure dissection of the membrane aggregation mechanism induced by Annexin A5 mutation
To Be Published
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8ROI
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8ROL
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8H3H
 | | Human ATAD2 Walker B mutant, ATP state | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ATPase family AAA domain-containing protein 2 | | 著者 | Cho, C, Song, J. | | 登録日 | 2022-10-08 | | 公開日 | 2023-10-18 | | 実験手法 | ELECTRON MICROSCOPY (3.15 Å) | | 主引用文献 | Structure of the human ATAD2 AAA+ histone chaperone reveals mechanism of regulation and inter-subunit communication.
Commun Biol, 6, 2023
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8ROH
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8ROJ
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8ROK
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8HQ6
 | | KL2 in complex with CRM1-Ran-RanBP1 | | 分子名称: | CHLORIDE ION, CRM1 isoform 1, DIMETHYL SULFOXIDE, ... | | 著者 | Sun, Q, Jian, L. | | 登録日 | 2022-12-13 | | 公開日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (2.03 Å) | | 主引用文献 | Discovery of Aminoratjadone Derivatives as Potent Noncovalent CRM1 Inhibitors.
J.Med.Chem., 66, 2023
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8HQ3
 | | KL1 in complex with CRM1-Ran-RanBP1 | | 分子名称: | CHLORIDE ION, CRM1 isoform 1, DIMETHYL SULFOXIDE, ... | | 著者 | Sun, Q, Jian, L. | | 登録日 | 2022-12-13 | | 公開日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Discovery of Aminoratjadone Derivatives as Potent Noncovalent CRM1 Inhibitors.
J.Med.Chem., 66, 2023
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8S24
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8S0A
 | | H. sapiens MCM2-7 hexamer bound to double stranded DNA | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, DNA (22-mer), ... | | 著者 | Greiwe, J.F, Weissmann, F, Diffley, J.F.X, Costa, A. | | 登録日 | 2024-02-13 | | 公開日 | 2024-10-02 | | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | | 主引用文献 | MCM Double Hexamer Loading Visualised with Human Proteins
Nature, 2024
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8S0F
 | | H. sapiens OC1M bound to double stranded DNA | | 分子名称: | DNA (39-mer), DNA replication factor Cdt1, DNA replication licensing factor MCM2, ... | | 著者 | Greiwe, J.F, Weissmann, F, Diffley, J.F.X, Costa, A. | | 登録日 | 2024-02-13 | | 公開日 | 2024-10-02 | | 実験手法 | ELECTRON MICROSCOPY (4.1 Å) | | 主引用文献 | MCM Double Hexamer Loading Visualised with Human Proteins
Nature, 2024
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8S0D
 | | H. sapiens MCM bound to double stranded DNA and ORC1-6 | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, DNA (58-mer), DNA replication licensing factor MCM2, ... | | 著者 | Greiwe, J.F, Weissmann, F, Diffley, J.F.X, Costa, A. | | 登録日 | 2024-02-13 | | 公開日 | 2024-10-02 | | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | | 主引用文献 | MCM Double Hexamer Loading Visualised with Human Proteins
Nature, 2024
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8S09
 | | H. sapiens MCM2-7 double hexamer bound to double stranded DNA | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, DNA (45-mer), ... | | 著者 | Greiwe, J.F, Weissmann, F, Diffley, J.F.X, Costa, A. | | 登録日 | 2024-02-13 | | 公開日 | 2024-10-02 | | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | | 主引用文献 | MCM Double Hexamer Loading Visualised with Human Proteins
Nature, 2024
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8S0E
 | | H. sapiens OCCM bound to double stranded DNA | | 分子名称: | Cell division control protein 6 homolog, DNA (39-mer), DNA replication factor Cdt1, ... | | 著者 | Greiwe, J.F, Weissmann, F, Diffley, J.F.X, Costa, A. | | 登録日 | 2024-02-13 | | 公開日 | 2024-10-02 | | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | | 主引用文献 | MCM Double Hexamer Loading Visualised with Human Proteins
Nature, 2024
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8S0B
 | | H. sapiens MCM bound to double stranded DNA and ORC6 as part of the MCM-ORC complex | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, DNA (45-mer), DNA replication licensing factor MCM2, ... | | 著者 | Greiwe, J.F, Weissmann, F, Diffley, J.F.X, Costa, A. | | 登録日 | 2024-02-13 | | 公開日 | 2024-10-02 | | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | | 主引用文献 | MCM Double Hexamer Loading Visualised with Human Proteins
Nature, 2024
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8H9Z
 | | Annexin A5 protein mutant | | 分子名称: | Annexin A5, CALCIUM ION | | 著者 | Hua, Z.C, Tang, W. | | 登録日 | 2022-10-26 | | 公開日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (1.42 Å) | | 主引用文献 | structure dissection of the membrane aggregation mechanism induced by Annexin A5 mutation
To Be Published
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8HE7
 | | ADP-ribosyltransferase 1 (PARP1) catalytic domain bound to a quinazoline-2,4(1H,3H)-dione inhibitor | | 分子名称: | 1-[[4-fluoranyl-3-(3-oxidanylidene-4-pentan-3-yl-piperazin-1-yl)carbonyl-phenyl]methyl]quinazoline-2,4-dione, Poly [ADP-ribose] polymerase 1, processed C-terminus, ... | | 著者 | Wang, X.Y, Zhou, J, Xu, B.L. | | 登録日 | 2022-11-07 | | 公開日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Discovery of Quinazoline-2,4(1 H ,3 H )-dione Derivatives Containing a Piperizinone Moiety as Potent PARP-1/2 Inhibitors─Design, Synthesis, In Vivo Antitumor Activity, and X-ray Crystal Structure Analysis.
J.Med.Chem., 66, 2023
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8HQ4
 | | B27 in complex with CRM1-Ran-RanBP1 | | 分子名称: | 3-[(4-fluorophenyl)carbonylamino]-4-[4-[3-(trifluoromethyl)phenyl]piperazin-1-yl]benzoic acid, CHLORIDE ION, CRM1 isoform 1, ... | | 著者 | Lei, Y, Sun, Q. | | 登録日 | 2022-12-13 | | 公開日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (2.12 Å) | | 主引用文献 | B27 in complex with CRM1-Ran-RanBP1
To Be Published
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6JMQ
 | | LAT1-CD98hc complex bound to MEM-108 Fab | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 4F2 cell-surface antigen heavy chain, ... | | 著者 | Lee, Y, Nishizawa, T, Kusakizako, T, Oda, K, Ishitani, R, Nakane, T, Nureki, O. | | 登録日 | 2019-03-13 | | 公開日 | 2019-06-19 | | 最終更新日 | 2020-07-29 | | 実験手法 | ELECTRON MICROSCOPY (3.31 Å) | | 主引用文献 | Cryo-EM structure of the human L-type amino acid transporter 1 in complex with glycoprotein CD98hc.
Nat.Struct.Mol.Biol., 26, 2019
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6JJ5
 | | BRD4 in complex with 259 | | 分子名称: | 3-((1-methyl-2-oxo-1,2,2a1,5a-tetrahydro-6H-pyrido[3',2':6,7]azepino[4,3,2-cd]isoindol-6-yl)methyl)benzamide, Bromodomain-containing protein 4 | | 著者 | Xu, J, Chen, Y, Jiang, F, Zhu, J. | | 登録日 | 2019-02-25 | | 公開日 | 2020-02-26 | | 最終更新日 | 2024-03-27 | | 実験手法 | X-RAY DIFFRACTION (1.2 Å) | | 主引用文献 | BRD4 in complex with ZZM1
To Be Published
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1OOA
 | | CRYSTAL STRUCTURE OF NF-kB(p50)2 COMPLEXED TO A HIGH-AFFINITY RNA APTAMER | | 分子名称: | Nuclear factor NF-kappa-B p105 subunit, RNA aptamer | | 著者 | Huang, D.B, Vu, D, Cassiday, L.A, Zimmerman, J.M, Maher III, L.J, Ghosh, G. | | 登録日 | 2003-03-03 | | 公開日 | 2003-07-22 | | 最終更新日 | 2023-08-16 | | 実験手法 | X-RAY DIFFRACTION (2.45 Å) | | 主引用文献 | Crystal structure of NF-kappaB (p50)2 complexed to a high-affinity RNA aptamer.
Proc.Natl.Acad.Sci.USA, 100, 2003
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6JIB
 | | Human MTHFD2 in complex with DS44960156 | | 分子名称: | 4-(5-oxo-1,5-dihydro-2H-[1]benzopyrano[3,4-c]pyridine-3(4H)-carbonyl)benzoic acid, Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial, ... | | 著者 | Suzuki, M, Matsui, Y, Kawai, J. | | 登録日 | 2019-02-20 | | 公開日 | 2019-06-05 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | | 主引用文献 | Structure-Based Design and Synthesis of an Isozyme-Selective MTHFD2 Inhibitor with a Tricyclic Coumarin Scaffold.
Acs Med.Chem.Lett., 10, 2019
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