PDB: 31311 件ウェブページステータス検索Chemie searchBIRD

---

7TW8	Structure of nsp14 N7-MethylTransferase domain fused with TELSAM bound to SAH 分子名称: S-ADENOSYL-L-HOMOCYSTEINE, Transcription factor ETV6,Proofreading exoribonuclease nsp14 chimera, ZINC ION 著者 Kottur, J, Aggarwal, A.K. 登録日 2022-02-06 公開日 2022-09-07 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (1.55 Å) 主引用文献 High-resolution structures of the SARS-CoV-2 N7-methyltransferase inform therapeutic development. Nat.Struct.Mol.Biol., 29, 2022
6NHB	Structure of human neuronal nitric oxide synthase R354A/G357D mutant heme domain in complex with 6-(5-(2-((2S,4R)-4-ethoxy-1-methylpyrrolidin-2-yl)ethyl)-2,3-difluorophenethyl)-4-methylpyridin-2-amine 分子名称: 5,6,7,8-TETRAHYDROBIOPTERIN, 6-[2-(5-{2-[(2S,4R)-4-ethoxy-1-methylpyrrolidin-2-yl]ethyl}-2,3-difluorophenyl)ethyl]-4-methylpyridin-2-amine, GLYCEROL, ... 著者 Li, H, Poulos, T.L. 登録日 2018-12-21 公開日 2019-03-13 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.03 Å) 主引用文献 Optimization of Blood-Brain Barrier Permeability with Potent and Selective Human Neuronal Nitric Oxide Synthase Inhibitors Having a 2-Aminopyridine Scaffold. J. Med. Chem., 62, 2019
7NMO	Crystal structure of beta-2-microglobulin D76A mutant 分子名称: Beta-2-microglobulin 著者 Guthertz, N. 登録日 2021-02-23 公開日 2022-08-03 最終更新日 2024-10-23 実験手法 X-RAY DIFFRACTION (1.2 Å) 主引用文献 The effect of mutation on an aggregation-prone protein: An in vivo, in vitro, and in silico analysis. Proc.Natl.Acad.Sci.USA, 119, 2022
7Q3I	Human Transthyretin expressed in Vibrio natriegens 分子名称: Transthyretin 著者 Hild Walett, O, Hammarstrom, P. 登録日 2021-10-27 公開日 2022-11-16 最終更新日 2024-05-01 実験手法 X-RAY DIFFRACTION (1.55 Å) 主引用文献 Human Transthyretin expressed in Vibrio natriegens To Be Published
5E9V	Crystal structure of BRD9 bromodomain in complex with an indolizine ligand 分子名称: 1,2-ETHANEDIOL, 1-[1-(imidazo[1,2-a]pyridin-5-yl)-7-(morpholin-4-yl)indolizin-3-yl]ethanone, Bromodomain-containing protein 9 著者 Tallant, C, Hay, D.A, Krojer, T, Nunez-Alonso, G, Picaud, S, Fedorov, O, Schofield, C.J, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Brennan, P.E, Knapp, S. 登録日 2015-10-15 公開日 2015-10-28 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Crystal structure of BRD9 bromodomain in complex with an indolizine ligand To Be Published
7TW7	Structure of nsp14 N7-MethylTransferase domain fused with TELSAM bound to SAM 分子名称: S-ADENOSYLMETHIONINE, Transcription factor ETV6,Proofreading exoribonuclease nsp14 chimera, ZINC ION 著者 Kottur, J, Aggarwal, A.K. 登録日 2022-02-06 公開日 2022-09-07 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (1.62 Å) 主引用文献 High-resolution structures of the SARS-CoV-2 N7-methyltransferase inform therapeutic development. Nat.Struct.Mol.Biol., 29, 2022
5HS1	Saccharomyces cerevisiae CYP51 (Lanosterol 14-alpha demethylase) complexed with Voriconazole 分子名称: Lanosterol 14-alpha demethylase, PROTOPORPHYRIN IX CONTAINING FE, Voriconazole 著者 Sabherwal, M, Sagatova, A, Keniya, M.V, Wilson, R.K, Tyndall, J.D.A, Monk, B.C. 登録日 2016-01-24 公開日 2016-06-01 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Triazole resistance mediated by mutations of a conserved active site tyrosine in fungal lanosterol 14 alpha-demethylase. Sci Rep, 6, 2016
5EA1	Crystal Structure of SMARCA4 bromodomain in complex with MPD 分子名称: (4R)-2-METHYLPENTANE-2,4-DIOL, (4S)-2-METHYL-2,4-PENTANEDIOL, Transcription activator BRG1 著者 Lolli, G, Caflisch, A. 登録日 2015-10-15 公開日 2016-03-16 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 High-Throughput Fragment Docking into the BAZ2B Bromodomain: Efficient in Silico Screening for X-Ray Crystallography. Acs Chem.Biol., 11, 2016
7NMR	Crystal structure of beta-2-microglobulin D76S mutant 分子名称: Beta-2-microglobulin, GLYCEROL 著者 Guthertz, N. 登録日 2021-02-23 公開日 2022-08-03 最終更新日 2024-10-16 実験手法 X-RAY DIFFRACTION (1.15 Å) 主引用文献 The effect of mutation on an aggregation-prone protein: An in vivo, in vitro, and in silico analysis. Proc.Natl.Acad.Sci.USA, 119, 2022
5HLB	E. coli PBP1b in complex with acyl-aztreonam and moenomycin 分子名称: 2-({[(1Z)-1-(2-amino-1,3-thiazol-4-yl)-2-oxo-2-{[(2S,3S)-1-oxo-3-(sulfoamino)butan-2-yl]amino}ethylidene]amino}oxy)-2-methylpropanoic acid, MOENOMYCIN, Penicillin-binding protein 1B 著者 King, D.T, Strynadka, N.C.J. 登録日 2016-01-14 公開日 2016-12-14 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.42 Å) 主引用文献 Escherichia coli Penicillin-Binding Protein 1B: Structural Insights into Inhibition. J. Biol. Chem., 2016
7NMT	Crystal structure of beta-2-microglobulin D76G mutant 分子名称: Beta-2-microglobulin 著者 Guthertz, N. 登録日 2021-02-23 公開日 2022-08-03 最終更新日 2024-10-16 実験手法 X-RAY DIFFRACTION (1.2 Å) 主引用文献 The effect of mutation on an aggregation-prone protein: An in vivo, in vitro, and in silico analysis. Proc.Natl.Acad.Sci.USA, 119, 2022
8SKQ	RNA oligonucleotide containing an alpha-(L)-threofuranosyl nucleic acid (TNA) 分子名称: TNA-containing RNA oligonucleotide 著者 Harp, J.M, Egli, M. 登録日 2023-04-20 公開日 2024-02-14 実験手法 X-RAY DIFFRACTION (1.35 Å) 主引用文献 Shorter Is Better: The alpha-(l)-Threofuranosyl Nucleic Acid Modification Improves Stability, Potency, Safety, and Ago2 Binding and Mitigates Off-Target Effects of Small Interfering RNAs. J.Am.Chem.Soc., 145, 2023
6NPS	Crystal structure of GH115 enzyme AxyAgu115A from Amphibacillus xylanus 分子名称: AxyAgu115A, CHLORIDE ION, GLYCEROL 著者 Stogios, P.J, Skarina, T, Di Leo, R, Yan, R, Master, E, Savchenko, A. 登録日 2019-01-18 公開日 2020-07-15 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.99 Å) 主引用文献 Structural characterization of the family GH115 alpha-glucuronidase from Amphibacillus xylanus yields insight into its coordinated action with alpha-arabinofuranosidases. N Biotechnol, 2021
7Q14	Crystal Structure of a Class D Carbapenemase_K73ALY Complexed with Imipenem 分子名称: 1-BUTANOL, BROMIDE ION, Beta-lactamase, ... 著者 Zhou, Q, He, Y, Jin, Y. 登録日 2021-10-18 公開日 2022-11-16 最終更新日 2024-10-23 実験手法 X-RAY DIFFRACTION (2.15 Å) 主引用文献 An Ion-Pair Induced Intermediate Complex Captured in Class D Carbapenemase Reveals Chloride Ion as a Janus Effector Modulating Activity Acs Cent.Sci., 2023
6NQM	Crystal structure of Human LSD1 分子名称: FLAVIN-ADENINE DINUCLEOTIDE, Lysine-specific histone demethylase 1A 著者 Tan, A.H.Y, Tu, W, McCuaig, R, Donovan, T, Tsimbalyuk, S, Forwood, J.K, Rao, S. 登録日 2019-01-21 公開日 2019-02-13 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 Lysine-Specific Histone Demethylase 1A Regulates Macrophage Polarization and Checkpoint Molecules in the Tumor Microenvironment of Triple-Negative Breast Cancer. Front Immunol, 10, 2019
5EA8	Crystal Structure of Prefusion RSV F Glycoprotein Fusion Inhibitor Resistance Mutant D489Y 分子名称: 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID, D(-)-TARTARIC ACID, Fusion glycoprotein F0, ... 著者 Battles, M.B, McLellan, J.S, Arnoult, E, Roymans, D, Langedijk, J.P. 登録日 2015-10-15 公開日 2015-12-09 最終更新日 2024-10-16 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Molecular mechanism of respiratory syncytial virus fusion inhibitors. Nat.Chem.Biol., 12, 2016
7NMC	Crystal structure of beta-2-microglobulin D76E mutant 分子名称: Beta-2-microglobulin, GLYCEROL, TRIETHYLENE GLYCOL 著者 Guthertz, N. 登録日 2021-02-23 公開日 2022-08-03 最終更新日 2024-10-23 実験手法 X-RAY DIFFRACTION (1.2 Å) 主引用文献 The effect of mutation on an aggregation-prone protein: An in vivo, in vitro, and in silico analysis. Proc.Natl.Acad.Sci.USA, 119, 2022
8VRV	GII.4c H2-tri HBGA norovirus protruding domain 分子名称: 1,2-ETHANEDIOL, Capsid protein, FORMIC ACID, ... 著者 Kher, G, Prewitt, A, Pancera, M, Hansman, G. 登録日 2024-01-22 公開日 2024-06-19 実験手法 X-RAY DIFFRACTION (1.61 Å) 主引用文献 Advancement of norovirus therapies To Be Published
7ZN6	Crystal structure of laccase-like multicopper oxidase (LMCO) from Thermothelomyces thermophilus 分子名称: 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... 著者 Kosinas, C, Dimarogona, M, Zerva, A, Topakas, E. 登録日 2022-04-20 公開日 2023-06-28 最終更新日 2024-10-23 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Structure-function studies of a novel laccase-like multicopper oxidase from Thermothelomyces thermophila provide insights into its biological role. Acta Crystallogr D Struct Biol, 79, 2023
7NMV	Crystal structure of beta-2-microglobulin D76Q mutant 分子名称: Beta-2-microglobulin 著者 Guthertz, N. 登録日 2021-02-23 公開日 2022-08-03 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.51 Å) 主引用文献 The effect of mutation on an aggregation-prone protein: An in vivo, in vitro, and in silico analysis. Proc.Natl.Acad.Sci.USA, 119, 2022
5V8I	Thermus thermophilus 70S ribosome lacking ribosomal protein uS17 分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, 16S Ribosomal RNA, 23S Ribosomal RNA, ... 著者 Gregory, S.T, Jogl, G. 登録日 2017-03-22 公開日 2018-03-28 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (3.25 Å) 主引用文献 Structural robustness of the ribosome inferred from X-ray crystal structures of the 30S ribosomal subunit and the 70S ribosome lacking ribosomal protein uS17 To be published
7TGM	Crystal structure of HSC-AMS bound DesD, the desferrioxamine synthetase from the Streptomyces griseoflavus ferrimycin biosynthetic pathway 分子名称: 4-[(5-aminopentyl)(hydroxy)amino]-4-oxobutanoic acid, Desferrioxamine synthetase DesD, GLYCEROL, ... 著者 Patel, K.D, Gulick, A.M. 登録日 2022-01-07 公開日 2022-07-06 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 An acyl-adenylate mimic reveals the structural basis for substrate recognition by the iterative siderophore synthetase DesD. J.Biol.Chem., 298, 2022
8SY3	Copper Complex of Peanut USP-type BURP Domain Peptide Cyclase 分子名称: BURP domain-containing protein, COPPER (II) ION 著者 Mydy, L.S, Kersten, R.D, Smith, J.L. 登録日 2023-05-24 公開日 2024-02-14 最終更新日 2024-10-16 実験手法 X-RAY DIFFRACTION (3.2 Å) 主引用文献 An intramolecular macrocyclase in plant ribosomal peptide biosynthesis. Nat.Chem.Biol., 20, 2024
5V31	Ethylene forming enzyme in complex with manganese and L-arginine 分子名称: 2-oxoglutarate-dependent ethylene/succinate-forming enzyme, ARGININE, MANGANESE (II) ION 著者 Fellner, M, Martinez, S, Hu, J, Hausinger, R.P. 登録日 2017-03-06 公開日 2017-08-16 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.45 Å) 主引用文献 Structures and Mechanisms of the Non-Heme Fe(II)- and 2-Oxoglutarate-Dependent Ethylene-Forming Enzyme: Substrate Binding Creates a Twist. J. Am. Chem. Soc., 139, 2017
8WF5	Horse heart myoglobin reconstituted with an iron complex of porphyrin bearing two CF3 groups (rMb(FePor(CF3)2)) 分子名称: GLYCEROL, Myoglobin, PROTOPORPHYRIN(CF3)2 CONTAINING FE, ... 著者 Kagawa, Y, Oohora, K, Himiyama, T, Suzuki, A, Hayashi, T. 登録日 2023-09-19 公開日 2024-06-12 最終更新日 2024-09-11 実験手法 X-RAY DIFFRACTION (1.72 Å) 主引用文献 Redox Engineering of Myoglobin by Cofactor Substitution to Enhance Cyclopropanation Reactivity. Angew.Chem.Int.Ed.Engl., 63, 2024

<641642643644645646647648649650651652653654655656>