7TGM

Crystal structure of HSC-AMS bound DesD, the desferrioxamine synthetase from the Streptomyces griseoflavus ferrimycin biosynthetic pathway

Summary for 7TGM

Entry DOI	10.2210/pdb7tgm/pdb
Descriptor	Desferrioxamine synthetase DesD, GLYCEROL, 4-[(5-aminopentyl)(hydroxy)amino]-4-oxobutanoic acid, ... (8 entities in total)
Functional Keywords	nrps-independent siderophore (nis) synthetase, iterative synthetase, amide ligase, adenylate-forming enzyme, ligase, inhibitor, ligase-inhibitor complex, ligase/inhibitor
Biological source	Streptomyces griseoflavus
Total number of polymer chains	5
Total formula weight	357175.32
Authors	Patel, K.D.,Gulick, A.M. (deposition date: 2022-01-07, release date: 2022-07-06, Last modification date: 2023-10-18)
Primary citation	Yang, J.,Banas, V.S.,Patel, K.D.,Rivera, G.S.M.,Mydy, L.S.,Gulick, A.M.,Wencewicz, T.A. An acyl-adenylate mimic reveals the structural basis for substrate recognition by the iterative siderophore synthetase DesD. J.Biol.Chem., 298:102166-102166, 2022 Cited by PubMed: 35750210 DOI: 10.1016/j.jbc.2022.102166 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.5 Å)

Structure validation