5E9V

Crystal structure of BRD9 bromodomain in complex with an indolizine ligand

Summary for 5E9V

• Entry DOI: 10.2210/pdb5e9v/pdb
• Descriptor: Bromodomain-containing protein 9, 1-[1-(imidazo[1,2-a]pyridin-5-yl)-7-(morpholin-4-yl)indolizin-3-yl]ethanone, 1,2-ETHANEDIOL, ... (4 entities in total)
• Functional Keywords: bromodomain, transcription, chromatin regulation
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 29344.48

Authors

Tallant, C.,Hay, D.A.,Krojer, T.,Nunez-Alonso, G.,Picaud, S.,Fedorov, O.,Schofield, C.J.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Brennan, P.E.,Knapp, S. (deposition date: 2015-10-15, release date: 2015-10-28, Last modification date: 2024-01-10)

• Primary citation: Tallant, C.,Hay, D.A.,Krojer, T.,Nunez-Alonso, G.,Picaud, S.,Fedorov, O.,Schofield, C.J.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Brennan, P.E.,Knapp, S.; Crystal structure of BRD9 bromodomain in complex with an indolizine ligand; To Be Published,

Experimental method

X-RAY DIFFRACTION (1.8 Å)