5E9V
Crystal structure of BRD9 bromodomain in complex with an indolizine ligand
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Bromodomain-containing protein 9 | polymer | 123 | 14249.8 | 2 | UniProt (Q9H8M2) Pfam (PF00439) | Homo sapiens (Human) | Rhabdomyosarcoma antigen MU-RMS-40.8, BRD9 |
| 2 | C, E (A, B) | 1-[1-(imidazo[1,2-a]pyridin-5-yl)-7-(morpholin-4-yl)indolizin-3-yl]ethanone | non-polymer | 360.4 | 2 | Chemie (5L0) | |||
| 3 | D, F (A, B) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 2 | Chemie (EDO) | |||
| 4 | G, H (A, B) | water | water | 18.0 | 136 | Chemie (HOH) |
Sequence modifications
A, B: 130 - 250 (UniProt: Q9H8M2)
| PDB | External Database | Details |
|---|---|---|
| Ser 128 | - | expression tag |
| Met 129 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 28499.5 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 845.0 | |
| All* | Total formula weight | 29344.5 |
