5HS1
Saccharomyces cerevisiae CYP51 (Lanosterol 14-alpha demethylase) complexed with Voriconazole
Summary for 5HS1
| Entry DOI | 10.2210/pdb5hs1/pdb |
| Related | 4WMZ 5HQZ |
| Descriptor | Lanosterol 14-alpha demethylase, PROTOPORPHYRIN IX CONTAINING FE, Voriconazole, ... (4 entities in total) |
| Functional Keywords | voriconazole, cyp51, oxidoreductase-oxidoreducatse inhibitor complex, resistance mutation, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor |
| Biological source | Saccharomyces cerevisiae (Baker's yeast) |
| Total number of polymer chains | 1 |
| Total formula weight | 61553.53 |
| Authors | Sabherwal, M.,Sagatova, A.,Keniya, M.V.,Wilson, R.K.,Tyndall, J.D.A.,Monk, B.C. (deposition date: 2016-01-24, release date: 2016-06-01, Last modification date: 2023-09-27) |
| Primary citation | Sagatova, A.A.,Keniya, M.V.,Wilson, R.K.,Sabherwal, M.,Tyndall, J.D.,Monk, B.C. Triazole resistance mediated by mutations of a conserved active site tyrosine in fungal lanosterol 14 alpha-demethylase. Sci Rep, 6:26213-26213, 2016 Cited by PubMed: 27188873DOI: 10.1038/srep26213 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.1 Å) |
Structure validation
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