3JA8
 
 | | Cryo-EM structure of the MCM2-7 double hexamer | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, Minichromosome Maintenance 2, Minichromosome Maintenance 3, ... | | 著者 | Li, N, Zhai, Y, Zhang, Y, Li, W, Yang, M, Lei, J, Tye, B.K, Gao, N. | | 登録日 | 2015-05-09 | | 公開日 | 2015-08-05 | | 最終更新日 | 2024-03-20 | | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | | 主引用文献 | Structure of the eukaryotic MCM complex at 3.8 angstrom
Nature, 524, 2015
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8TK7
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1AM9
 | | HUMAN SREBP-1A BOUND TO LDL RECEPTOR PROMOTER | | 分子名称: | DNA (5'-D(*CP*AP*TP*GP*AP*GP*AP*TP*CP*AP*CP*CP*CP*CP*AP*CP*T P*GP*CP*AP*A)-3'), DNA (5'-D(*TP*TP*GP*CP*AP*GP*TP*GP*GP*GP*GP*TP*GP*AP*TP*CP*T )-3'), MAGNESIUM ION, ... | | 著者 | Parraga, A, Burley, S.K. | | 登録日 | 1997-06-25 | | 公開日 | 1998-07-10 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Co-crystal structure of sterol regulatory element binding protein 1a at 2.3 A resolution.
Structure, 6, 1998
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4XZQ
 | | Nucleosome disassembly by RSC and SWI/SNF is enhanced by H3 acetylation near the nucleosome dyad axis | | 分子名称: | DNA (147-MER), Histone H2A, Histone H2B 1.1, ... | | 著者 | Dechassa, M.L, Luger, K, Chatterjee, N, North, J.A, Manohar, M, Prasad, R, Ottessen, J.J, Poirier, M.G, Bartholomew, B. | | 登録日 | 2015-02-04 | | 公開日 | 2015-10-14 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Histone Acetylation near the Nucleosome Dyad Axis Enhances Nucleosome Disassembly by RSC and SWI/SNF.
Mol.Cell.Biol., 35, 2015
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4YS3
 | | Nucleosome disassembly by RSC and SWI/SNF is enhanced by H3 acetylation near the nucleosome dyad axis | | 分子名称: | DNA (147-MER), Histone H2A, Histone H2B 1.1, ... | | 著者 | Dechassa, M.L, Luger, K, Chatterjee, N, North, J.A, Manohar, M, Prasad, R, Ottessen, J.J, Poirier, M.G, Bartholomew, B. | | 登録日 | 2015-03-16 | | 公開日 | 2015-10-14 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (3 Å) | | 主引用文献 | Histone Acetylation near the Nucleosome Dyad Axis Enhances Nucleosome Disassembly by RSC and SWI/SNF.
Mol.Cell.Biol., 35, 2015
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8EVG
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5MKW
 | | Crystal structure of the human ZRANB3 HNH domain | | 分子名称: | DNA annealing helicase and endonuclease ZRANB3, GLYCEROL, ZINC ION | | 著者 | Ariza, A. | | 登録日 | 2016-12-05 | | 公開日 | 2017-06-28 | | 最終更新日 | 2024-05-01 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Structural insights into the function of ZRANB3 in replication stress response.
Nat Commun, 8, 2017
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7O1F
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7O1E
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4Z66
 | | Nucleosome disassembly by RSC and SWI/SNF is enhanced by H3 acetylation near the nucleosome dyad axis | | 分子名称: | DNA (147-MER), Histone H2A, Histone H2B 1.1, ... | | 著者 | Dechassa, M.L, Luger, K, Chatterjee, N, North, J.A, Manohar, M, Prasad, R, Ottessen, J.J, Poirier, M.G, Bartholomew, B. | | 登録日 | 2015-04-03 | | 公開日 | 2015-10-14 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Histone Acetylation near the Nucleosome Dyad Axis Enhances Nucleosome Disassembly by RSC and SWI/SNF.
Mol.Cell.Biol., 35, 2015
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6H0G
 | | Structure of the DDB1-CRBN-pomalidomide complex bound to ZNF692(ZF4) | | 分子名称: | DNA damage-binding protein 1,DNA damage-binding protein 1,DNA damage-binding protein 1,DDB1 (DNA damage binding protein 1),DNA damage-binding protein 1,DNA damage-binding protein 1,DNA damage-binding protein 1, Protein cereblon, S-Pomalidomide, ... | | 著者 | Bunker, R.D, Petzold, G, Thoma, N.H. | | 登録日 | 2018-07-09 | | 公開日 | 2018-11-07 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (4.25 Å) | | 主引用文献 | Defining the human C2H2 zinc finger degrome targeted by thalidomide analogs through CRBN.
Science, 362, 2018
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6A1Q
 | | Crystal structures of disordered Z-type helices | | 分子名称: | DNA (5'-D(P*CP*AP*CP*A)-3'), DNA (5'-D(P*TP*GP*TP*G)-3') | | 著者 | Karthik, S, Mandal, P.K, Thirugnanasambandam, A, Gautham, N. | | 登録日 | 2018-06-07 | | 公開日 | 2019-01-16 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (2.501 Å) | | 主引用文献 | Crystal structures of disordered Z-type helices.
Nucleosides Nucleotides Nucleic Acids, 38, 2019
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5XM0
 | | The mouse nucleosome structure containing H2A, H2B type3-A, H3.3, and H4 | | 分子名称: | DNA (146-MER), Histone H2A type 1-B, Histone H2B type 3-A, ... | | 著者 | Taguchi, H, Horikoshi, N, Kurumizaka, H. | | 登録日 | 2017-05-12 | | 公開日 | 2018-03-07 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (2.874 Å) | | 主引用文献 | Histone H3.3 sub-variant H3mm7 is required for normal skeletal muscle regeneration.
Nat Commun, 9, 2018
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7MCR
 | | Human Apex/Ref1 homodimer formed under oxidative condition | | 分子名称: | DNA-(apurinic or apyrimidinic site) endonuclease, mitochondrial, MAGNESIUM ION | | 著者 | Nam, Y.W, Yang, S. | | 登録日 | 2021-04-02 | | 公開日 | 2022-04-06 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | The Development of Novel Apurinic/Aprymidinic Endonuclease/Redox-factor 1 Inhibitors for the Treatment of Human Melanoma
To Be Published
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7MEV
 | | Human Apex/Ref1 monomer with C138A mutation | | 分子名称: | DNA-(apurinic or apyrimidinic site) endonuclease, mitochondrial, GLYCEROL, ... | | 著者 | Nam, Y.W, Yang, S. | | 登録日 | 2021-04-07 | | 公開日 | 2022-04-13 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | | 主引用文献 | The Development of Novel Apurinic/Aprymidinic Endonuclease/Redox-factor 1 Inhibitors for the Treatment of Human Melanoma
To Be Published
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5XM1
 | | The mouse nucleosome structure containing H2A, H2B type3-A, H3mm7, and H4 | | 分子名称: | DNA (146-MER), Histone H2A type 1-B, Histone H2B type 3-A, ... | | 著者 | Taguchi, H, Horikoshi, N, Kurumizaka, H. | | 登録日 | 2017-05-12 | | 公開日 | 2018-03-07 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (3.45 Å) | | 主引用文献 | Histone H3.3 sub-variant H3mm7 is required for normal skeletal muscle regeneration.
Nat Commun, 9, 2018
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9FCJ
 | | USP1 bound to ML323 and ubiquitin conjugated to FANCD2 (ordered subset, focused refinement) | | 分子名称: | 5-methyl-2-(2-propan-2-ylphenyl)-~{N}-[[4-(1,2,3-triazol-1-yl)phenyl]methyl]pyrimidin-4-amine, Polyubiquitin-C, Ubiquitin carboxyl-terminal hydrolase 1, ... | | 著者 | Rennie, M.L, Gundogdu, M, Walden, H. | | 登録日 | 2024-05-15 | | 公開日 | 2024-09-04 | | 最終更新日 | 2024-09-25 | | 実験手法 | ELECTRON MICROSCOPY (2.7 Å) | | 主引用文献 | Structural and Biochemical Insights into the Mechanism of Action of the Clinical USP1 Inhibitor, KSQ-4279.
J.Med.Chem., 67, 2024
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9FCI
 | | USP1 bound to KSQ-4279 and ubiquitin conjugated to FANCD2 (focused refinement) | | 分子名称: | 6-(4-cyclopropyl-6-methoxy-pyrimidin-5-yl)-1-[[4-[1-propan-2-yl-4-(trifluoromethyl)imidazol-2-yl]phenyl]methyl]pyrazolo[3,4-d]pyrimidine, Polyubiquitin-C, Ubiquitin carboxyl-terminal hydrolase 1, ... | | 著者 | Rennie, M.L, Gundogdu, M, Walden, H. | | 登録日 | 2024-05-15 | | 公開日 | 2024-09-04 | | 最終更新日 | 2024-09-25 | | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | | 主引用文献 | Structural and Biochemical Insights into the Mechanism of Action of the Clinical USP1 Inhibitor, KSQ-4279.
J.Med.Chem., 67, 2024
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6MC6
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2M14
 | | NMR structure of the complex between the PH domain of the Tfb1 subunit from TFIIH and Rad4 | | 分子名称: | DNA repair protein RAD4, RNA polymerase II transcription factor B subunit 1 | | 著者 | Lafrance-Vanasse, J, Arseneault, G, Cappadocia, L, Legault, P, Omichinski, J.G. | | 登録日 | 2012-11-16 | | 公開日 | 2013-01-23 | | 最終更新日 | 2024-05-15 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Structural and functional evidence that Rad4 competes with Rad2 for binding to the Tfb1 subunit of TFIIH in NER.
Nucleic Acids Res., 41, 2013
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6NEO
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2ZQE
 | | Crystal structure of the Smr domain of Thermus thermophilus MutS2 | | 分子名称: | MutS2 protein | | 著者 | Fukui, K, Kitamura, Y, Nakagawa, N, Masui, R, Kuramitsu, S. | | 登録日 | 2008-08-08 | | 公開日 | 2008-09-30 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | Crystal structure of MutS2 endonuclease domain and the mechanism of homologous recombination suppression
J.Biol.Chem., 283, 2008
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8PP7
 | | human RYBP-PRC1 bound to mononucleosome | | 分子名称: | DNA (215-mer), E3 ubiquitin-protein ligase RING2, Histone H2A, ... | | 著者 | Ciapponi, M, Benda, C, Mueller, J. | | 登録日 | 2023-07-06 | | 公開日 | 2024-03-27 | | 最終更新日 | 2024-07-31 | | 実験手法 | ELECTRON MICROSCOPY (2.91 Å) | | 主引用文献 | Structural basis of the histone ubiquitination read-write mechanism of RYBP-PRC1.
Nat.Struct.Mol.Biol., 31, 2024
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1HHT
 | | RNA dependent RNA polymerase from dsRNA bacteriophage phi6 plus template | | 分子名称: | DNA (5'-(*TP*TP*TP*CP*C)-3'), MANGANESE (II) ION, P2 PROTEIN | | 著者 | Grimes, J.M, Butcher, S.J, Makeyev, E.V, Bamford, D.H, Stuart, D.I. | | 登録日 | 2000-12-28 | | 公開日 | 2001-03-27 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | | 主引用文献 | A Mechanism for Initiating RNA-Dependent RNA Polymerization
Nature, 410, 2001
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8HD5
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