1AM9

HUMAN SREBP-1A BOUND TO LDL RECEPTOR PROMOTER

Summary for 1AM9

• Entry DOI: 10.2210/pdb1am9/pdb
• Descriptor: DNA (5'-D(*TP*TP*GP*CP*AP*GP*TP*GP*GP*GP*GP*TP*GP*AP*TP*CP*T )-3'), DNA (5'-D(*CP*AP*TP*GP*AP*GP*AP*TP*CP*AP*CP*CP*CP*CP*AP*CP*T P*GP*CP*AP*A)-3'), PROTEIN (STEROL REGULATORY ELEMENT BINDING PROTEIN 1A), ... (5 entities in total)
• Functional Keywords: sterol regulatory element binding protein, basic-helix-loop-helix-leucine zipper, srebp, transcription factor, complex (transcription regulation-dna), transcription-dna complex, transcription/dna
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 8
• Total formula weight: 61321.68

Authors

Parraga, A.,Burley, S.K. (deposition date: 1997-06-25, release date: 1998-07-10, Last modification date: 2024-04-03)

Primary citation

Parraga, A.,Bellsolell, L.,Ferre-D'Amare, A.R.,Burley, S.K.
Co-crystal structure of sterol regulatory element binding protein 1a at 2.3 A resolution.
Structure, 6:661-672, 1998

PubMed Abstract: The sterol regulatory element binding proteins (SREBPs) are helix-loop-helix transcriptional activators that control expression of genes encoding proteins essential for cholesterol biosynthesis/uptake and fatty acid biosynthesis. Unlike helix-loop-helix proteins that recognize symmetric E-boxes (5'-CANNTG-3'), the SREBPs have a tyrosine instead of a conserved arginine in their basic regions. This difference allows recognition of an asymmetric sterol regulatory element (StRE, 5'-ATCACCCAC-3').

PubMed: 9634703
DOI: 10.1016/S0969-2126(98)00067-7

Experimental method

X-RAY DIFFRACTION (2.3 Å)