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6E1Z
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Displacement of WDR5 from chromatin by a pharmacological WIN site inhibitor with picomolar affinity
分子名称: 5-[(1H-imidazol-1-yl)methyl]furan-2-carboxylic acid, WD repeat-containing protein 5
著者Phan, J, Fesik, S.W.
登録日2018-07-10
公開日2019-03-13
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (1.1 Å)
主引用文献Displacement of WDR5 from Chromatin by a WIN Site Inhibitor with Picomolar Affinity.
Cell Rep, 26, 2019
1OOA
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CRYSTAL STRUCTURE OF NF-kB(p50)2 COMPLEXED TO A HIGH-AFFINITY RNA APTAMER
分子名称: Nuclear factor NF-kappa-B p105 subunit, RNA aptamer
著者Huang, D.B, Vu, D, Cassiday, L.A, Zimmerman, J.M, Maher III, L.J, Ghosh, G.
登録日2003-03-03
公開日2003-07-22
最終更新日2023-08-16
実験手法X-RAY DIFFRACTION (2.45 Å)
主引用文献Crystal structure of NF-kappaB (p50)2 complexed to a high-affinity RNA aptamer.
Proc.Natl.Acad.Sci.USA, 100, 2003
6E2H
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Crystal structure of human Ash2L (SPRY domain and SDI motif) in complex with full length DPY-30
分子名称: Protein dpy-30 homolog, Set1/Ash2 histone methyltransferase complex subunit ASH2
著者Joshi, M, Brunzelle, J.S, Couture, J.F.
登録日2018-07-11
公開日2018-08-08
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.236 Å)
主引用文献Structural Analysis of the Ash2L/Dpy-30 Complex Reveals a Heterogeneity in H3K4 Methylation.
Structure, 26, 2018
6E23
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Displacement of WDR5 from chromatin by a pharmacological WIN site inhibitor with picomolar affinity
分子名称: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, N-[(3,4-dichlorophenyl)methyl]-3-(6-fluoro-2-methylpyridin-3-yl)-5-{[(2E)-2-imino-3-methyl-2,3-dihydro-1H-imidazol-1-yl]methyl}benzamide, WD repeat-containing protein 5
著者Phan, J, Fesik, S.W.
登録日2018-07-10
公開日2019-03-13
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (1.66 Å)
主引用文献Displacement of WDR5 from Chromatin by a WIN Site Inhibitor with Picomolar Affinity.
Cell Rep, 26, 2019
6E22
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Displacement of WDR5 from chromatin by a pharmacological WIN site inhibitor with picomolar affinity
分子名称: 3-{[(4,5-dihydro-1H-imidazol-2-yl)amino]methyl}-N-[(3,5-dimethoxyphenyl)methyl]-4-fluorobenzamide, SULFATE ION, WD repeat-containing protein 5
著者Phan, J, Fesik, S.W.
登録日2018-07-10
公開日2019-03-13
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Displacement of WDR5 from Chromatin by a WIN Site Inhibitor with Picomolar Affinity.
Cell Rep, 26, 2019
6EOE
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Crystal structure of AMPylated GRP78 with nucleotide
分子名称: 78 kDa glucose-regulated protein, ADENOSINE-5'-DIPHOSPHATE, CITRATE ANION, ...
著者Yan, Y, Preissler, S, Ron, D, Read, R.J.
登録日2017-10-09
公開日2017-11-01
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (1.71 Å)
主引用文献AMPylation targets the rate-limiting step of BiP's ATPase cycle for its functional inactivation.
Elife, 6, 2017
6EOB
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Crystal structure of AMPylated GRP78 in apo form (Crystal form 1)
分子名称: 78 kDa glucose-regulated protein, PHOSPHATE ION
著者Yan, Y, Preissler, S, Ron, D, Read, R.J.
登録日2017-10-09
公開日2017-11-01
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献AMPylation targets the rate-limiting step of BiP's ATPase cycle for its functional inactivation.
Elife, 6, 2017
6ER0
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6th KOW domain of human hSpt5
分子名称: Transcription elongation factor SPT5
著者Hahn, L, Schweimer, K, Roesch, P, Woehrl, B.M.
登録日2017-10-16
公開日2018-10-31
最終更新日2024-05-15
実験手法SOLUTION NMR
主引用文献Structure and nucleic acid binding properties of KOW domains 4 and 6-7 of human transcription elongation factor DSIF.
Sci Rep, 8, 2018
1PCF
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HUMAN TRANSCRIPTIONAL COACTIVATOR PC4 C-TERMINAL DOMAIN
分子名称: TRANSCRIPTIONAL COACTIVATOR PC4
著者Brandsen, J, Gros, P.
登録日1997-09-09
公開日1998-03-18
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (1.74 Å)
主引用文献C-terminal domain of transcription cofactor PC4 reveals dimeric ssDNA binding site.
Nat.Struct.Biol., 4, 1997
1PBU
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Solution structure of the C-terminal domain of the human eEF1Bgamma subunit
分子名称: Elongation factor 1-gamma
著者Vanwetswinkel, S, Kriek, J, Andersen, G.R, Guntert, P, Dijk, J, Canters, G.W, Siegal, G.
登録日2003-05-15
公開日2003-07-15
最終更新日2024-05-22
実験手法SOLUTION NMR
主引用文献1H, (15)N and (13)C resonance assignments of the highly conserved 19 kDa C-terminal domain from human Elongation Factor 1Bgamma.
J.Biomol.Nmr, 26, 2003
1Q02
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NMR structure of the UBA domain of p62 (SQSTM1)
分子名称: sequestosome 1
著者Ciani, B, Layfield, R, Cavey, J.R, Sheppard, P.W, Searle, M.S.
登録日2003-07-15
公開日2003-09-30
最終更新日2024-05-22
実験手法SOLUTION NMR
主引用文献Structure of the Ubiquitin-associated Domain of p62 (SQSTM1) and Implications for Mutations That Cause Paget's Disease of Bone
J.Biol.Chem., 278, 2003
1Q2Z
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The 3D solution structure of the C-terminal region of Ku86
分子名称: ATP-dependent DNA helicase II, 80 kDa subunit
著者Harris, R, Esposito, D, Sankar, A, Maman, J.D, Hinks, J.A, Pearl, L.H, Driscoll, P.C.
登録日2003-07-28
公開日2004-01-13
最終更新日2024-05-22
実験手法SOLUTION NMR
主引用文献The 3D Solution Structure of the C-terminal Region of Ku86 (Ku86CTR)
J.Mol.Biol., 335, 2004
1NF7
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Ternary complex of the human type II Inosine Monophosphate Dedhydrogenase with Ribavirin Monophosphate and C2-Mycophenolic Adenine Dinucleotide
分子名称: Inosine-5'-monophosphate dehydrogenase 2, POTASSIUM ION, RIBAVIRIN MONOPHOSPHATE, ...
著者Risal, D, Strickler, M.D, Goldstein, B.M.
登録日2002-12-13
公開日2004-01-27
最終更新日2023-08-16
実験手法X-RAY DIFFRACTION (2.65 Å)
主引用文献Crystal Structure of Human Inosine Monophosphate Dehydrogenase type II complexed with the MPA/NAD analog C2-MAD
To be Published
1OL6
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Structure of unphosphorylated D274N mutant of Aurora-A
分子名称: ADENOSINE-5'-TRIPHOSPHATE, SERINE/THREONINE KINASE 6
著者Bayliss, R, Conti, E.
登録日2003-08-06
公開日2003-10-30
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Structural Basis of Aurora-A Activation by Tpx2 at the Mitotic Spindle.
Mol.Cell, 12, 2003
1OL5
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Structure of Aurora-A 122-403, phosphorylated on Thr287, Thr288 and bound to TPX2 1-43
分子名称: ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, RESTRICTED EXPRESSION PROLIFERATION ASSOCIATED PROTEIN 100, ...
著者Bayliss, R, Conti, E.
登録日2003-08-06
公開日2003-10-30
最終更新日2024-05-01
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Structural Basis of Aurora-A Activation by Tpx2 at the Mitotic Spindle
Mol.Cell, 12, 2003
1OL7
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Structure of Human Aurora-A 122-403 phosphorylated on Thr287, Thr288
分子名称: ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, SERINE/THREONINE KINASE 6
著者Bayliss, R, Conti, E.
登録日2003-08-06
公開日2003-10-30
最終更新日2024-05-01
実験手法X-RAY DIFFRACTION (2.75 Å)
主引用文献Structural Basis of Aurora-A Activation by Tpx2 at the Mitotic Spindle
Mol.Cell, 12, 2003
1PQC
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HUMAN LXR BETA HORMONE RECEPTOR COMPLEXED WITH T0901317
分子名称: N-(2,2,2-TRIFLUOROETHYL)-N-{4-[2,2,2-TRIFLUORO-1-HYDROXY-1-(TRIFLUOROMETHYL)ETHYL]PHENYL}BENZENESULFONAMIDE, Oxysterols receptor LXR-beta
著者Farnegardh, M, Bonn, T, Sun, S, Ljunggren, J, Ahola, H, Wilhelmsson, A, Gustafsson, J.-A, Carlquist, M.
登録日2003-06-18
公開日2003-09-09
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献The three-dimensional structure of the liver X receptor beta reveals a flexible ligand-binding pocket that can accommodate fundamentally different ligands.
J.Biol.Chem., 278, 2003
1PQ6
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HUMAN LXR BETA HORMONE RECEPTOR / GW3965 COMPLEX
分子名称: ISOPROPYL ALCOHOL, Oxysterols receptor LXR-beta, [3-(3-{[2-chloro-3-(trifluoromethyl)benzyl](2,2-diphenylethyl)amino}propoxy)phenyl]acetic acid
著者Farnegardh, M, Bonn, T, Sun, S, Ljunggren, J, Ahola, H, Wilhelmsson, A, Gustafsson, J.-A, Carlquist, M.
登録日2003-06-18
公開日2003-09-09
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献The three-dimensional structure of the liver X receptor beta reveals a flexible ligand-binding pocket that can accommodate fundamentally different ligands.
J.Biol.Chem., 278, 2003
1NFK
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STRUCTURE OF THE NUCLEAR FACTOR KAPPA-B (NF-KB) P50 HOMODIMER
分子名称: DNA (5'-D(*TP*GP*GP*GP*AP*AP*TP*TP*CP*CP*C)-3'), PROTEIN (NUCLEAR FACTOR KAPPA-B (NF-KB))
著者Ghosh, G, Van Duyne, G, Ghosh, S, Sigler, P.B.
登録日1995-02-28
公開日1996-12-23
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Structure of NF-kappa B p50 homodimer bound to a kappa B site.
Nature, 373, 1995
1NFB
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Ternary complex of the human type II Inosine Monophosphate Dedhydrogenase with 6Cl-IMP and NAD
分子名称: 6-CHLOROPURINE RIBOSIDE, 5'-MONOPHOSPHATE, Inosine-5'-monophosphate dehydrogenase 2, ...
著者Risal, D, Strickler, M.D, Goldstein, B.M.
登録日2002-12-13
公開日2004-01-27
最終更新日2023-08-16
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献The Conformation of NAD Bound to Human Inosine Monophosphate Dehydrogenase Type II
To be Published
1OCA
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HUMAN CYCLOPHILIN A, UNLIGATED, NMR, 20 STRUCTURES
分子名称: CYCLOPHILIN A
著者Ottiger, M, Zerbe, O, Guntert, P, Wuthrich, K.
登録日1997-07-07
公開日1997-11-19
最終更新日2024-05-22
実験手法SOLUTION NMR
主引用文献The NMR solution conformation of unligated human cyclophilin A.
J.Mol.Biol., 272, 1997
1QBG
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CRYSTAL STRUCTURE OF HUMAN DT-DIAPHORASE (NAD(P)H OXIDOREDUCTASE)
分子名称: FLAVIN-ADENINE DINUCLEOTIDE, NAD(P)H DEHYDROGENASE [QUINONE] 1
著者Skelly, J.V, Sanderson, M.R, Suter, D.A, Baumann, U, Gregory, D.S, Bennett, M, Hobbs, S.M, Neidle, S.
登録日1999-04-20
公開日2000-04-24
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Crystal structure of human DT-diaphorase: a model for interaction with the cytotoxic prodrug 5-(aziridin-1-yl)-2,4-dinitrobenzamide (CB1954).
J.Med.Chem., 42, 1999
1Q8G
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NMR structure of human Cofilin
分子名称: Cofilin, non-muscle isoform
著者Pope, B.J, Zierler-Gould, K.M, Kuhne, R, Weeds, A.G, Ball, L.J.
登録日2003-08-21
公開日2004-07-06
最終更新日2024-05-22
実験手法SOLUTION NMR
主引用文献The solution structure of human cofilin: rationalizing actin binding and pH sensitivity
J.Biol.Chem., 279, 2004
1QG2
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CANINE GDP-RAN R76E MUTANT
分子名称: GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, PROTEIN (RAN)
著者Kent, H.M, Moore, M.S, Quimby, B.B, Baker, A.M.E, McCoy, A.J, Murphy, G.A, Corbett, A.H, Stewart, M.
登録日1999-04-20
公開日1999-06-11
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Engineered mutants in the switch II loop of Ran define the contribution made by key residues to the interaction with nuclear transport factor 2 (NTF2) and the role of this interaction in nuclear protein import.
J.Mol.Biol., 289, 1999
1NMK
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The Sanglifehrin-Cyclophilin Interaction: Degradation Work, Synthetic Macrocyclic Analogues, X-ray Crystal Structure and Binding Data
分子名称: (13E,15E)-(3S,6S,9R,10R,11S,12S,18S,21S)-10,12-DIHYDROXY-3-(3-HYDROXYBEN-ZYL)-18-((E)-3-HYDROXY-1-METHYLPROPENYL)-6-ISOPROPYL-11-METHYL-9-(3-OXO-BUTYL)-19-OXA-1,4,7,25-TETRAAZA-BICYCLO[19.3.1]PENTACOSA-13,15-DIENE-2,5,8,20-TETRAONE, Peptidyl-prolyl cis-trans isomerase A
著者Kallen, J, Sedrani, R, Wagner, J.
登録日2003-01-10
公開日2003-04-01
最終更新日2023-08-16
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Sanglifehrin-Cyclophilin Interaction: Degradation Work, Synthetic Macrocyclic Analogues, X-ray Crystal Structure and Binding Data
J.Am.Chem.Soc., 125, 2003

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