7ZKM
| X-ray structure of the complex between human alpha thrombin and a pseudo-cyclic thrombin binding aptamer (TBA-NNp/DDp) - Crystal form beta | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 3-[13-methyl-5,7,12,14-tetrakis(oxidanylidene)-6,13-diazatetracyclo[6.6.2.0^{4,16}.0^{11,15}]hexadeca-1(15),2,4(16),8,10-pentaen-6-yl]propyl 3-[5,7,12,14-tetrakis(oxidanylidene)-13-(3-oxidanylpropyl)-6,13-diazatetracyclo[6.6.2.0^{4,16}.0^{11,15}]hexadeca-1,3,8(16),9,11(15)-pentaen-6-yl]propyl hydrogen phosphate, 3-[5-[3-bis(oxidanyl)phosphanyloxypropoxy]naphthalen-1-yl]oxypropyl 3-(5-oxidanylnaphthalen-1-yl)oxypropyl hydrogen phosphate, ... | 著者 | Troisi, R, Sica, F. | 登録日 | 2022-04-13 | 公開日 | 2022-11-30 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | A terminal functionalization strategy reveals unusual binding abilities of anti-thrombin anticoagulant aptamers. Mol Ther Nucleic Acids, 30, 2022
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7ZKN
| X-ray structure of the complex between human alpha thrombin and a pseudo-cyclic thrombin binding aptamer (TBA-NNp/DDp) - Crystal form gamma | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 3-[13-methyl-5,7,12,14-tetrakis(oxidanylidene)-6,13-diazatetracyclo[6.6.2.0^{4,16}.0^{11,15}]hexadeca-1(15),2,4(16),8,10-pentaen-6-yl]propyl 3-[5,7,12,14-tetrakis(oxidanylidene)-13-(3-oxidanylpropyl)-6,13-diazatetracyclo[6.6.2.0^{4,16}.0^{11,15}]hexadeca-1,3,8(16),9,11(15)-pentaen-6-yl]propyl hydrogen phosphate, 3-[5-[3-bis(oxidanyl)phosphanyloxypropoxy]naphthalen-1-yl]oxypropyl 3-(5-oxidanylnaphthalen-1-yl)oxypropyl hydrogen phosphate, ... | 著者 | Troisi, R, Sica, F. | 登録日 | 2022-04-13 | 公開日 | 2022-11-30 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (3.03 Å) | 主引用文献 | A terminal functionalization strategy reveals unusual binding abilities of anti-thrombin anticoagulant aptamers. Mol Ther Nucleic Acids, 30, 2022
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8FTF
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7ZKL
| X-ray structure of the complex between human alpha thrombin and a pseudo-cyclic thrombin binding aptamer (TBA-NNp/DDp) - Crystal form alpha | 分子名称: | (2S)-2-hydroxybutanedioic acid, 3-[13-methyl-5,7,12,14-tetrakis(oxidanylidene)-6,13-diazatetracyclo[6.6.2.0^{4,16}.0^{11,15}]hexadeca-1(15),2,4(16),8,10-pentaen-6-yl]propyl 3-[5,7,12,14-tetrakis(oxidanylidene)-13-(3-oxidanylpropyl)-6,13-diazatetracyclo[6.6.2.0^{4,16}.0^{11,15}]hexadeca-1,3,8(16),9,11(15)-pentaen-6-yl]propyl hydrogen phosphate, 3-[5-[3-bis(oxidanyl)phosphanyloxypropoxy]naphthalen-1-yl]oxypropyl 3-(5-oxidanylnaphthalen-1-yl)oxypropyl hydrogen phosphate, ... | 著者 | Troisi, R, Sica, F. | 登録日 | 2022-04-13 | 公開日 | 2022-11-30 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (3.18 Å) | 主引用文献 | A terminal functionalization strategy reveals unusual binding abilities of anti-thrombin anticoagulant aptamers. Mol Ther Nucleic Acids, 30, 2022
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8OW2
| Crystal structure of the p110alpha catalytic subunit from homo sapiens in complex with activator 1938 | 分子名称: | 1-[7-[[2-[[4-(4-ethylpiperazin-1-yl)phenyl]amino]pyridin-4-yl]amino]-2,3-dihydroindol-1-yl]ethanone, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform | 著者 | Gong, G.Q, Bellini, D, Vanhaesebroeck, B, Williams, R.L. | 登録日 | 2023-04-26 | 公開日 | 2023-05-24 | 最終更新日 | 2024-06-19 | 実験手法 | X-RAY DIFFRACTION (2.57 Å) | 主引用文献 | A small-molecule PI3K alpha activator for cardioprotection and neuroregeneration. Nature, 618, 2023
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6QPO
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7FW4
| Crystal Structure of human FABP4 soaked with glycerol | 分子名称: | Fatty acid-binding protein, adipocyte, GLYCEROL, ... | 著者 | Ehler, A, Benz, J, Obst, U, Rudolph, M.G. | 登録日 | 2023-04-27 | 公開日 | 2023-06-14 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (1.44 Å) | 主引用文献 | Crystal Structure of a human FABP4 complex To be published
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8OH4
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6QSS
| Crystal Structure of Ignicoccus islandicus malate dehydrogenase co-crystallized with 10 mM Tb-Xo4 | 分子名称: | CHLORIDE ION, Malate dehydrogenase, TERBIUM(III) ION, ... | 著者 | Roche, J, Girard, E, Madern, D. | 登録日 | 2019-02-21 | 公開日 | 2019-07-17 | 最終更新日 | 2024-01-24 | 実験手法 | SOLUTION SCATTERING (1.892 Å), X-RAY DIFFRACTION | 主引用文献 | The archaeal LDH-like malate dehydrogenase from Ignicoccus islandicus displays dual substrate recognition, hidden allostery and a non-canonical tetrameric oligomeric organization. J.Struct.Biol., 208, 2019
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6QTI
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8CPD
| Cryo-EM structure of CRaf dimer with 14:3:3 | 分子名称: | 14-3-3 protein zeta isoform X1, RAF proto-oncogene serine/threonine-protein kinase | 著者 | Dedden, D, Graedler, U, Schwarz, D, Thomsen, M, Leuthner, B, Schneider, E, Nitsche, J. | 登録日 | 2023-03-02 | 公開日 | 2024-02-21 | 最終更新日 | 2024-02-28 | 実験手法 | ELECTRON MICROSCOPY (3.46 Å) | 主引用文献 | Cryo-EM Structures of CRAF 2 /14-3-3 2 and CRAF 2 /14-3-3 2 /MEK1 2 Complexes. J.Mol.Biol., 436, 2024
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8CHF
| cryo-EM Structure of Craf:14-3-3:Mek1 | 分子名称: | 14-3-3 protein zeta isoform X1, 2-{4-[(1E)-1-(hydroxyimino)-2,3-dihydro-1H-inden-5-yl]-3-(pyridin-4-yl)-1H-pyrazol-1-yl}ethanol, Dual specificity mitogen-activated protein kinase kinase 1, ... | 著者 | Dedden, D, Ulrich, G. | 登録日 | 2023-02-07 | 公開日 | 2024-02-21 | 最終更新日 | 2024-02-28 | 実験手法 | ELECTRON MICROSCOPY (4.25 Å) | 主引用文献 | Cryo-EM Structures of CRAF 2 /14-3-3 2 and CRAF 2 /14-3-3 2 /MEK1 2 Complexes. J.Mol.Biol., 436, 2024
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8C0B
| CryoEM structure of Aspergillus nidulans UTP-glucose-1-phosphate uridylyltransferase | 分子名称: | UTP--glucose-1-phosphate uridylyltransferase | 著者 | Han, X, D Angelo, C, Otamendi, A, Cifuente, J.O, de Astigarraga, E, Ochoa-Lizarralde, B, Grininger, M, Routier, F.H, Guerin, M.E, Fuehring, J, Etxebeste, O, Connell, S.R. | 登録日 | 2022-12-16 | 公開日 | 2023-06-28 | 最終更新日 | 2024-07-10 | 実験手法 | ELECTRON MICROSCOPY (3.98 Å) | 主引用文献 | CryoEM analysis of the essential native UDP-glucose pyrophosphorylase from Aspergillus nidulans reveals key conformations for activity regulation and function. Mbio, 14, 2023
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8OI6
| Cryo-EM structure of the undecorated barbed end of filamentous beta/gamma actin | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, Actin, cytoplasmic 1, ... | 著者 | Oosterheert, W, Blanc, F.E.C, Roy, A, Belyy, A, Hofnagel, O, Hummer, G, Bieling, P, Raunser, S. | 登録日 | 2023-03-22 | 公開日 | 2023-08-09 | 最終更新日 | 2023-11-22 | 実験手法 | ELECTRON MICROSCOPY (3.59 Å) | 主引用文献 | Molecular mechanisms of inorganic-phosphate release from the core and barbed end of actin filaments. Nat.Struct.Mol.Biol., 30, 2023
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6QSC
| Crystal Structure of Arg470His mutant of Human Prolidase with Mn ions and GlyPro ligand | 分子名称: | GLYCEROL, GLYCINE, MANGANESE (II) ION, ... | 著者 | Wilk, P, Wator, E, Weiss, M.S. | 登録日 | 2019-02-20 | 公開日 | 2020-03-18 | 最終更新日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (1.569 Å) | 主引用文献 | Structural analysis of new compound heterozygous variants in PEPD gene identified in a patient with Prolidase Deficiency diagnosed by exome sequencing. Genet Mol Biol, 44, 2021
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2X60
| Crystal structure of T. maritima GDP-mannose pyrophosphorylase in complex with GTP. | 分子名称: | GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, MANNOSE-1-PHOSPHATE GUANYLYLTRANSFERASE | 著者 | Pelissier, M.C, Lesley, S, Kuhn, P, Bourne, Y. | 登録日 | 2010-02-12 | 公開日 | 2010-06-23 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Structural Insights Into the Catalytic Mechanism of Bacterial Guanosine-Diphospho-D-Mannose Pyrophosphorylase and its Regulation by Divalent Ions. J.Biol.Chem., 285, 2010
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4OD4
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6QUL
| Structure of a bacterial 50S ribosomal subunit in complex with the novel quinoxolidinone antibiotic cadazolid | 分子名称: | 23S rRNA, 50S ribosomal protein L13, 50S ribosomal protein L14, ... | 著者 | Scaiola, A, Leibundgut, M, Boehringer, D, Ritz, D. | 登録日 | 2019-02-27 | 公開日 | 2019-04-10 | 最終更新日 | 2024-05-15 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Structural basis of translation inhibition by cadazolid, a novel quinoxolidinone antibiotic. Sci Rep, 9, 2019
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7D2O
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7D8K
| Solution structure of the methyl-CpG binding domain of MBD6 from Arabidopsis thaliana | 分子名称: | Methyl-CpG-binding domain-containing protein 6 | 著者 | Mahana, Y, Ohki, I, Walinda, E, Morimoto, D, Sugase, K, Shirakawa, M. | 登録日 | 2020-10-08 | 公開日 | 2021-10-20 | 最終更新日 | 2024-05-15 | 実験手法 | SOLUTION NMR | 主引用文献 | Structural Insights into Methylated DNA Recognition by the Methyl-CpG Binding Domain of MBD6 from Arabidopsis thaliana . Acs Omega, 7, 2022
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8PE4
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7E2M
| Crystal structure of the RWD domain of human GCN2 - 2 | 分子名称: | eIF-2-alpha kinase GCN2 | 著者 | Hei, Z, Zhou, J, Liu, Z, Wang, J, Fang, P. | 登録日 | 2021-02-05 | 公開日 | 2021-03-17 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.35 Å) | 主引用文献 | Crystal structures reveal a novel dimer of the RWD domain of human general control nonderepressible 2. Biochem.Biophys.Res.Commun., 549, 2021
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7DTK
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7E2K
| Crystal structure of the RWD domain of human GCN2 - 1 | 分子名称: | eIF-2-alpha kinase GCN2 | 著者 | Hei, Z, Zhou, J, Liu, Z, Wang, J, Fang, P. | 登録日 | 2021-02-05 | 公開日 | 2021-03-17 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.041 Å) | 主引用文献 | Crystal structures reveal a novel dimer of the RWD domain of human general control nonderepressible 2. Biochem.Biophys.Res.Commun., 549, 2021
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7DTJ
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