8OW2
Crystal structure of the p110alpha catalytic subunit from homo sapiens in complex with activator 1938
Replaces: 8BFVSummary for 8OW2
Entry DOI | 10.2210/pdb8ow2/pdb |
Descriptor | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform, 1-[7-[[2-[[4-(4-ethylpiperazin-1-yl)phenyl]amino]pyridin-4-yl]amino]-2,3-dihydroindol-1-yl]ethanone (3 entities in total) |
Functional Keywords | cardioprotection, neuroregeneration, pi3k, kinase, transferase |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 1 |
Total formula weight | 110425.65 |
Authors | Gong, G.Q.,Bellini, D.,Vanhaesebroeck, B.,Williams, R.L. (deposition date: 2023-04-26, release date: 2023-05-24, Last modification date: 2024-06-19) |
Primary citation | Gong, G.Q.,Bilanges, B.,Allsop, B.,Masson, G.R.,Roberton, V.,Askwith, T.,Oxenford, S.,Madsen, R.R.,Conduit, S.E.,Bellini, D.,Fitzek, M.,Collier, M.,Najam, O.,He, Z.,Wahab, B.,McLaughlin, S.H.,Chan, A.W.E.,Feierberg, I.,Madin, A.,Morelli, D.,Bhamra, A.,Vinciauskaite, V.,Anderson, K.E.,Surinova, S.,Pinotsis, N.,Lopez-Guadamillas, E.,Wilcox, M.,Hooper, A.,Patel, C.,Whitehead, M.A.,Bunney, T.D.,Stephens, L.R.,Hawkins, P.T.,Katan, M.,Yellon, D.M.,Davidson, S.M.,Smith, D.M.,Phillips, J.B.,Angell, R.,Williams, R.L.,Vanhaesebroeck, B. A small-molecule PI3K alpha activator for cardioprotection and neuroregeneration. Nature, 618:159-168, 2023 Cited by PubMed: 37225977DOI: 10.1038/s41586-023-05972-2 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.57 Å) |
Structure validation
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