8OW2

Crystal structure of the p110alpha catalytic subunit from homo sapiens in complex with activator 1938

Replaces:  8BFV

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	polymer	946	109969.1	1	UniProt (P42336) Pfam (PF00794) Pfam (PF00792) Pfam (PF00613) Pfam (PF00454) In PDB	Homo sapiens (human)	PI3-kinase subunit alpha,PI3K-alpha,PI3Kalpha,PtdIns-3-kinase subunit alpha,Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha,PtdIns-3-kinase subunit p110-alpha,p110alpha,Phosphoinositide 3-kinase alpha,Phosphoinositide-3-kinase catalytic alpha polypeptide,Serine/threonine protein kinase PIK3CA
2	A	1-[7-[[2-[[4-(4-ethylpiperazin-1-yl)phenyl]amino]pyridin-4-yl]amino]-2,3-dihydroindol-1-yl]ethanone	non-polymer		456.6	1	Chemie (QIH)
3		water	water		18.0	36	Chemie (HOH)

Sequence modifications

A: 105 - 1048 (UniProt: P42336)

PDB	External Database	Details
Gly 103	-	expression tag
Ser 104	-	expression tag
Asp 469	Glu 469	conflict

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	109969.1
Non-Polymers*	Number of molecules	1
	Total formula weight	456.6
All*	Total formula weight	110425.6

*Water molecules are not included.