8OW2
Crystal structure of the p110alpha catalytic subunit from homo sapiens in complex with activator 1938
Replaces: 8BFVEntity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform | polymer | 946 | 109969.1 | 1 | UniProt (P42336) Pfam (PF00794) Pfam (PF00792) Pfam (PF00613) Pfam (PF00454) | Homo sapiens (human) | PI3-kinase subunit alpha,PI3K-alpha,PI3Kalpha,PtdIns-3-kinase subunit alpha,Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha,PtdIns-3-kinase subunit p110-alpha,p110alpha,Phosphoinositide 3-kinase alpha,Phosphoinositide-3-kinase catalytic alpha polypeptide,Serine/threonine protein kinase PIK3CA |
| 2 | B (A) | 1-[7-[[2-[[4-(4-ethylpiperazin-1-yl)phenyl]amino]pyridin-4-yl]amino]-2,3-dihydroindol-1-yl]ethanone | non-polymer | 456.6 | 1 | Chemie (QIH) | |||
| 3 | C (A) | water | water | 18.0 | 36 | Chemie (HOH) |
Sequence modifications
A: 105 - 1048 (UniProt: P42336)
| PDB | External Database | Details |
|---|---|---|
| Gly 103 | - | expression tag |
| Ser 104 | - | expression tag |
| Asp 469 | Glu 469 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 109969.1 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 456.6 | |
| All* | Total formula weight | 110425.6 |
