PDB: 97310 件ウェブページステータス検索Chemie searchBIRD

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7XHY	Crystal structure of MerTK Kinase domain with BMS794833 分子名称: CHLORIDE ION, DIMETHYL SULFOXIDE, Tyrosine-protein kinase Mer, ... 著者 Kim, J.H, Lee, B.I. 登録日 2022-04-11 公開日 2022-11-30 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2.16 Å) 主引用文献 BMS794833 inhibits macrophage efferocytosis by directly binding to MERTK and inhibiting its activity. Exp.Mol.Med., 54, 2022
7XO2	Minor polymorph in alpha-synuclein fibril seeded by cerebrospinal fluid from a mid-to-late stage (mid-PD-4) Parkinson's disease patient 分子名称: Alpha-synuclein 著者 Fan, Y, Sun, Y.P, Wang, J, Liu, C. 登録日 2022-04-30 公開日 2022-11-30 最終更新日 2024-07-03 実験手法 ELECTRON MICROSCOPY (3 Å) 主引用文献 Conformational change of alpha-synuclein fibrils in cerebrospinal fluid from different clinical phases of Parkinson's disease. Structure, 31, 2023
7XO1	Major polymorph in alpha-synuclein fibril seeded by cerebrospinal fluid from a mid-to-late stage (mid-PD-1) Parkinson's disease patient 分子名称: Alpha-synuclein 著者 Fan, Y, Sun, Y.P, Wang, J, Liu, C. 登録日 2022-04-30 公開日 2022-11-30 最終更新日 2024-07-03 実験手法 ELECTRON MICROSCOPY (3 Å) 主引用文献 Conformational change of alpha-synuclein fibrils in cerebrospinal fluid from different clinical phases of Parkinson's disease. Structure, 31, 2023
8GM6	Structure of apurinic/apyrimidinic DNA lyase TK0353 from Thermococcus kodakarensis (Selenomethionine) 分子名称: GLYCEROL, SULFATE ION, TK0353 著者 Eckenroth, B.E, Gardner, A.F, Doublie, S. 登録日 2023-03-24 公開日 2023-12-06 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (1.98 Å) 主引用文献 Thermococcus kodakarensis TK0353 is a novel AP lyase with a new fold. J.Biol.Chem., 300, 2023
8GM7	Structure of apurinic/apyrimidinic DNA Lyase TK0353 from Thermococcus kodakarensis (Native Crystal Form) 分子名称: GLYCEROL, SULFATE ION, TK0353 著者 Eckenroth, B.E, Gardner, A.F, Doublie, S. 登録日 2023-03-24 公開日 2023-12-06 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (1.75 Å) 主引用文献 Thermococcus kodakarensis TK0353 is a novel AP lyase with a new fold. J.Biol.Chem., 300, 2023
6NAD	Identification and biological evaluation of tertiary ALCOHOL-based inverse agonists of RORgt 分子名称: (S)-(4-chloro-2-methoxy-3-{[4-(trifluoromethyl)piperidin-1-yl]methyl}quinolin-6-yl)(1,2-dimethyl-1H-imidazol-5-yl)[2-(trifluoromethyl)pyridin-4-yl]methanol, Nuclear receptor ROR-gamma 著者 Spurlino, J, Milligan, C. 登録日 2018-12-05 公開日 2019-05-08 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (2.90197086 Å) 主引用文献 3-Substituted Quinolines as ROR gamma t Inverse Agonists. Bioorg.Med.Chem.Lett., 29, 2019
7TTZ	Heterodimeric IgA Fc in complex with Staphylococcus aureus protein SSL7 分子名称: 1,2-ETHANEDIOL, 2-(2-{2-[2-(2-METHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHANOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... 著者 Boulanger, M.J, Verstraete, M, Heinkel, F, Escobar, E, Dixit, S, Von Kreudenstein, T.S. 登録日 2022-02-02 公開日 2023-02-01 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (2.35 Å) 主引用文献 Engineering a pure and stable heterodimeric IgA for the development of multispecific therapeutics. Mabs, 14, 2022
7DWM	Crystal structure of the phage VqmA-DPO complex 分子名称: 3,5-dimethylpyrazin-2-ol, Transcriptional regulator 著者 Gu, Y, Yang, W.S. 登録日 2021-01-17 公開日 2021-05-05 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2.65 Å) 主引用文献 Understanding the mechanism of asymmetric gene regulation determined by the VqmA of vibriophage. Biochem.Biophys.Res.Commun., 558, 2021
7U9E	Pfs230 D1 domain in complex with 230AL-26 分子名称: 230AL-26, Gametocyte surface protein P230, LMIV230-01 著者 Tang, W.K, Tolia, N.H. 登録日 2022-03-10 公開日 2023-02-15 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (2.39 Å) 主引用文献 A human antibody epitope map of Pfs230D1 derived from analysis of individuals vaccinated with a malaria transmission-blocking vaccine. Immunity, 56, 2023
5VGY	Identification of a New Zinc Binding Chemotype by Fragment Screening 分子名称: (5S)-5-[(2,4-dimethoxyphenyl)methyl]-5-hydroxy-2-sulfanylideneimidazolidin-4-one, Carbonic anhydrase 2, SODIUM ION, ... 著者 Peat, T.S. 登録日 2017-04-11 公開日 2017-08-30 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.39 Å) 主引用文献 Identification of a New Zinc Binding Chemotype by Fragment Screening. J. Med. Chem., 60, 2017
7WDA	Crystal structure LpqY in complex with Trehalose from Mycobacterium tuberculosis 分子名称: SULFATE ION, Trehalose-binding lipoprotein LpqY, alpha-D-glucopyranose-(1-1)-alpha-D-glucopyranose 著者 Sharma, D, Das, U. 登録日 2021-12-21 公開日 2022-05-18 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (1.91 Å) 主引用文献 Structural analysis of LpqY, a substrate-binding protein from the SugABC transporter of Mycobacterium tuberculosis, provides insights into its trehalose specificity. Acta Crystallogr D Struct Biol, 78, 2022
7WCJ	Crystal structure LpqY from Mycobacterium tuberculosis 分子名称: SULFATE ION, Trehalose-binding lipoprotein LpqY 著者 Sharma, D, Das, U. 登録日 2021-12-20 公開日 2022-05-18 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2.24 Å) 主引用文献 Structural analysis of LpqY, a substrate-binding protein from the SugABC transporter of Mycobacterium tuberculosis, provides insights into its trehalose specificity. Acta Crystallogr D Struct Biol, 78, 2022
7DA0	High-resolution crystal structure of the chicken MHF complex 分子名称: Centromere protein S, Centromere protein X 著者 Ito, S, Nishino, T. 登録日 2020-10-14 公開日 2021-03-17 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (1.25 Å) 主引用文献 Structural analysis of the chicken FANCM-MHF complex and its stability. Acta Crystallogr.,Sect.F, 77, 2021
7NY4	14-3-3 sigma with RelA/p65 binding site pS45 and covalently bound TCF521-130 分子名称: 14-3-3 protein sigma, 4-(3-oxidanylidenepiperazin-1-yl)sulfonylbenzaldehyde, CHLORIDE ION, ... 著者 Wolter, M, Ottmann, C. 登録日 2021-03-20 公開日 2021-06-09 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.4 Å) 主引用文献 An Exploration of Chemical Properties Required for Cooperative Stabilization of the 14-3-3 Interaction with NF-kappa B-Utilizing a Reversible Covalent Tethering Approach. J.Med.Chem., 64, 2021
7DA1	Crystal structure of the chicken MHF complex 分子名称: Centromere protein S, Centromere protein X 著者 Ito, S, Nishino, T. 登録日 2020-10-14 公開日 2021-03-17 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2.01 Å) 主引用文献 Structural analysis of the chicken FANCM-MHF complex and its stability. Acta Crystallogr.,Sect.F, 77, 2021
7DA2	The crystal structure of the chicken FANCM-MHF complex 分子名称: Centromere protein S, Centromere protein X, Fanconi anemia group M protein 著者 Nishino, T, Ito, S. 登録日 2020-10-14 公開日 2021-03-17 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2.79 Å) 主引用文献 Structural analysis of the chicken FANCM-MHF complex and its stability. Acta Crystallogr.,Sect.F, 77, 2021
7U0R	Crystal structure of Methanomethylophilus alvus PylRS(N166A/V168A) complexed with meta-trifluoromethyl-2-benzylmalonate and AMP-PNP 分子名称: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... 著者 Swenson, C.V, Roe, L.T, Fricke, R.C.B, Smaga, S.S, Gee, C.L, Schepartz, A. 登録日 2022-02-18 公開日 2023-06-14 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Expanding the substrate scope of pyrrolysyl-transfer RNA synthetase enzymes to include non-alpha-amino acids in vitro and in vivo. Nat.Chem., 15, 2023
6NIT	Human Argonaute2-miR-122 bound to a target RNA with four central mismatches (bu4) 分子名称: Protein argonaute-2, RNA (5'-R(P*AP*AP*CP*AP*CP*CP*AP*UP*CP*CP*AP*AP*CP*AP*CP*UP*CP*CP*AP*AP*A)-3'), RNA (5'-R(P*UP*GP*GP*AP*GP*UP*GP*UP*GP*AP*CP*AP*AP*UP*GP*GP*UP*GP*UP*UP*U)-3') 著者 Sheu-Gruttadauria, J, MacRae, I.J. 登録日 2018-12-31 公開日 2019-08-07 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (3.8 Å) 主引用文献 Structural Basis for Target-Directed MicroRNA Degradation. Mol.Cell, 75, 2019
8GMH	Crystal Structure of the ternary complex of TelA-LXG, LapA3, and LapA4 分子名称: 1,2-ETHANEDIOL, LXG domain-containing protein, LapA3, ... 著者 Klein, T.A, Shah, P.Y, Gkragkopoulou, P, Grebenc, D.W, Kim, Y, Whitney, J.C. 登録日 2023-03-25 公開日 2024-01-10 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Structure of a tripartite protein complex that targets toxins to the type VII secretion system. Proc.Natl.Acad.Sci.USA, 121, 2024
7S11	Crystal structure of Fab in complex with mouse CD96 monomer 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Fab heavy chain, Fab light chain, ... 著者 Lee, P.S, Chau, B, Strop, P. 登録日 2021-08-31 公開日 2021-11-03 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.58 Å) 主引用文献 Antibody blockade of CD96 by distinct molecular mechanisms. Mabs, 13, 2021
5FQS	Selective estrogen receptor downregulator antagonists: Tetrahydroisoquinoline phenols 3. 分子名称: (E)-3-[4-(6-HYDROXY-2-ISOBUTYL-1-METHYL-3,4-DIHYDROISOQUINOLIN-1-YL)PHENYL]PROP-2-ENOIC ACID, ESTROGEN RECEPTOR 著者 Scott, J.S, Bailey, A, Davies, R.D.M, Degorce, S.L, MacFaul, P.A, Gingell, H, Moss, T, Norman, R.A, Pink, J.H, Rabow, A.A, Roberts, B, Smith, P.D. 登録日 2015-12-14 公開日 2016-02-10 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (1.94 Å) 主引用文献 Tetrahydroisoquinoline Phenols: Selective Estrogen Receptor Downregulator Antagonists with Oral Bioavailability in Rat. Acs Med.Chem.Lett., 7, 2016
5G4P	Crystal structure of human hippocalcin at 2.4 A resolution 分子名称: CALCIUM ION, Neuron-specific calcium-binding protein hippocalcin 著者 Antonyuk, S.V, Helassa, N, Lian, L.Y, Haynes, L.P, Burgoyne, R.D. 登録日 2016-05-15 公開日 2017-05-03 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.42 Å) 主引用文献 Biophysical and functional characterization of hippocalcin mutants responsible for human dystonia. Hum. Mol. Genet., 26, 2017
8GA6	Geometrically programmable nanomaterial construction using regularized protein building blocks 分子名称: THR6 著者 Huddy, T, Bera, A.K, Baker, D, Kang, A. 登録日 2023-02-22 公開日 2024-03-13 最終更新日 2024-04-10 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Blueprinting extendable nanomaterials with standardized protein blocks. Nature, 627, 2024
5G58	Crystal structure of A190T mutant of human hippocalcin AT 2.5 A resolution 分子名称: CALCIUM ION, Neuron-specific calcium-binding protein hippocalcin 著者 Antonyuk, S.V, Helassa, N, Lian, L.Y, Haynes, L.P, Burgoyne, R.D. 登録日 2016-05-22 公開日 2017-05-03 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (2.54 Å) 主引用文献 Biophysical and functional characterization of hippocalcin mutants responsible for human dystonia. Hum. Mol. Genet., 26, 2017
5GJQ	Structure of the human 26S proteasome bound to USP14-UbAl 分子名称: 26S protease regulatory subunit 10B, 26S protease regulatory subunit 4, 26S protease regulatory subunit 6A, ... 著者 Huang, X.L, Luan, B, Wu, J.P, Shi, Y.G. 登録日 2016-07-01 公開日 2016-08-17 最終更新日 2019-11-06 実験手法 ELECTRON MICROSCOPY (4.5 Å) 主引用文献 An atomic structure of the human 26S proteasome. Nat. Struct. Mol. Biol., 23, 2016

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