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8X15
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BU of 8x15 by Molmil
Structure of nucleosome-bound SRCAP-C in the apo state
分子名称: ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Actin, ...
著者Yu, J, Wang, Q, Yu, Z, Li, W, Wang, L, Xu, Y.
登録日2023-11-06
公開日2024-03-06
最終更新日2024-05-29
実験手法ELECTRON MICROSCOPY (3.2 Å)
主引用文献Structural insights into histone exchange by human SRCAP complex.
Cell Discov, 10, 2024
7ONB
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BU of 7onb by Molmil
Structure of the U2 5' module of the A3'-SSA complex
分子名称: MINX, PHD finger-like domain-containing protein 5A, RNU2, ...
著者Cretu, C, Pena, V.
登録日2021-05-25
公開日2021-08-04
実験手法ELECTRON MICROSCOPY (3.1 Å)
主引用文献Structural basis of intron selection by U2 snRNP in the presence of covalent inhibitors.
Nat Commun, 12, 2021
8Y6O
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BU of 8y6o by Molmil
Cryo-EM Structure of the human minor pre-B complex (pre-precatalytic spliceosome) U11 and tri-snRNP part
分子名称: 116 kDa U5 small nuclear ribonucleoprotein component, Centrosomal AT-AC splicing factor, GUANOSINE-5'-TRIPHOSPHATE, ...
著者Bai, R, Yuan, M, Zhang, P, Luo, T, Shi, Y, Wan, R.
登録日2024-02-02
公開日2024-03-20
最終更新日2024-03-27
実験手法ELECTRON MICROSCOPY (3.38 Å)
主引用文献Structural basis of U12-type intron engagement by the fully assembled human minor spliceosome.
Science, 383, 2024
7Q4O
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BU of 7q4o by Molmil
Substrate-bound A-like U2 snRNP
分子名称: BPS oligo, PHD finger-like domain-containing protein 5A, Splicing factor 3A subunit 2, ...
著者Tholen, J, Galej, W.P.
登録日2021-11-01
公開日2022-03-30
実験手法ELECTRON MICROSCOPY (2.2 Å)
主引用文献Structural basis of branch site recognition by the human spliceosome.
Science, 375, 2022
7Q4P
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BU of 7q4p by Molmil
U2 snRNP after ATP-dependent remodelling
分子名称: PHD finger-like domain-containing protein 5A, Splicing factor 3A subunit 2, Splicing factor 3A subunit 3, ...
著者Tholen, J, Galej, W.P.
登録日2021-11-01
公開日2022-03-30
最終更新日2022-04-06
実験手法ELECTRON MICROSCOPY (2.2 Å)
主引用文献Structural basis of branch site recognition by the human spliceosome.
Science, 375, 2022
8R0B
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BU of 8r0b by Molmil
Cryo-EM structure of the cross-exon pre-B+ATP complex
分子名称: 116 kDa U5 small nuclear ribonucleoprotein component, 5'ss oligo, NHP2-like protein 1, ...
著者Zhang, Z, Kumar, V, Dybkov, O, Will, C.L, Zhong, J, Ludwig, S, Urlaub, H, Kastner, B, Stark, H, Luehrmann, R.
登録日2023-10-31
公開日2024-05-22
最終更新日2024-06-05
実験手法ELECTRON MICROSCOPY (4.4 Å)
主引用文献Structural insights into the cross-exon to cross-intron spliceosome switch.
Nature, 2024
8R0A
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BU of 8r0a by Molmil
Cryo-EM structure of the cross-exon pre-B+5'ss complex
分子名称: 116 kDa U5 small nuclear ribonucleoprotein component, 5'ss oligo, NHP2-like protein 1, ...
著者Zhang, Z, Kumar, V, Dybkov, O, Will, C.L, Zhong, J, Ludwig, S, Urlaub, H, Kastner, B, Stark, H, Luehrmann, R.
登録日2023-10-31
公開日2024-05-22
最終更新日2024-06-05
実験手法ELECTRON MICROSCOPY (5.8 Å)
主引用文献Structural insights into the cross-exon to cross-intron spliceosome switch.
Nature, 2024
5GHD
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BU of 5ghd by Molmil
SOLUTION STRUCTURE OF LYS39 ACETYLATED HUMAN SUMO1
分子名称: Small ubiquitin-related modifier 1
著者Naik, M.T, Naik, N, Shih, H, Huang, T.
登録日2016-06-19
公開日2017-06-07
最終更新日2023-11-15
実験手法SOLUTION NMR
主引用文献Structures of Human Sumo
To Be Published
6JLB
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BU of 6jlb by Molmil
Crystal structure of lamin A/C fragment and assembly mechanisms of intermediate filaments
分子名称: Lamin A/C
著者Ahn, J, Jo, I, Ha, N.C.
登録日2019-03-04
公開日2019-09-11
実験手法X-RAY DIFFRACTION (3.205 Å)
主引用文献Structural basis for lamin assembly at the molecular level.
Nat Commun, 10, 2019
3EAY
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BU of 3eay by Molmil
Crystal structure of the human SENP7 catalytic domain
分子名称: SULFATE ION, Sentrin-specific protease 7
著者Lima, C.D, Reverter, D.
登録日2008-08-26
公開日2008-09-16
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Structure of the Human SENP7 Catalytic Domain and Poly-SUMO Deconjugation Activities for SENP6 and SENP7.
J.Biol.Chem., 283, 2008
5MRG
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BU of 5mrg by Molmil
Solution structure of TDP-43 (residues 1-102)
分子名称: TAR DNA-binding protein 43
著者Mompean, M, Romano, V, Pantoja-Uceda, D, Stuani, C, Baralle, F.E, Laurents, D.V.
登録日2016-12-22
公開日2017-06-07
最終更新日2024-05-15
実験手法SOLUTION NMR
主引用文献Point mutations in the N-terminal domain of transactive response DNA-binding protein 43 kDa (TDP-43) compromise its stability, dimerization, and functions.
J. Biol. Chem., 292, 2017
1K4T
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BU of 1k4t by Molmil
HUMAN DNA TOPOISOMERASE I (70 KDA) IN COMPLEX WITH THE POISON TOPOTECAN AND COVALENT COMPLEX WITH A 22 BASE PAIR DNA DUPLEX
分子名称: (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE, 2-(1-DIMETHYLAMINOMETHYL-2-HYDROXY-8-HYDROXYMETHYL-9-OXO-9,11-DIHYDRO-INDOLIZINO[1,2-B]QUINOLIN-7-YL)-2-HYDROXY-BUTYRIC ACID, 5'-D(*(TGP)P*GP*AP*AP*AP*AP*AP*TP*TP*TP*TP*T)-3', ...
著者Staker, B.L, Hjerrild, K, Feese, M.D, Behnke, C.A, Burgin Jr, A.B, Stewart, L.J.
登録日2001-10-08
公開日2002-12-04
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献The mechanism of topoisomerase I poisoning by a camptothecin analog
Proc.Natl.Acad.Sci.USA, 99, 2002
1K4S
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BU of 1k4s by Molmil
HUMAN DNA TOPOISOMERASE I IN COVALENT COMPLEX WITH A 22 BASE PAIR DNA DUPLEX
分子名称: 5'-D(*(SPT)P*GP*AP*AP*AP*AP*AP*(5IU)P*(5IU)P*(5IU)P*(5IU)P*T)-3', 5'-D(*AP*AP*AP*AP*AP*GP*AP*CP*(5IU)P*(5IU))-3', 5'-D(*AP*AP*AP*AP*AP*TP*(IDO)UP*(IDO)UP*(IDO)UP*(IDO)UP*CP*AP*AP*AP*GP*(IDO)UP*CP*(IDO)UP*(IDO)UP*(IDO)UP*(IDO)UP*T)-3', ...
著者Staker, B.L, Hjerrild, K, Feese, M.D, Behnke, C.A, Burgin Jr, A.B, Stewart, L.J.
登録日2001-10-08
公開日2002-12-04
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (3.2 Å)
主引用文献The mechanism of topoisomerase I poisoning by a camptothecin analog
Proc.Natl.Acad.Sci.USA, 99, 2002
1K5G
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BU of 1k5g by Molmil
Crystal structure of Ran-GDP-AlFx-RanBP1-RanGAP complex
分子名称: ALUMINUM FLUORIDE, GTP-binding nuclear protein RAN, GUANOSINE-5'-DIPHOSPHATE, ...
著者Seewald, M.J, Koerner, C, Wittinghofer, A, Vetter, I.R.
登録日2001-10-10
公開日2002-02-13
最終更新日2023-08-16
実験手法X-RAY DIFFRACTION (3.1 Å)
主引用文献RanGAP mediates GTP hydrolysis without an arginine finger.
Nature, 415, 2002
1K5D
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BU of 1k5d by Molmil
Crystal structure of Ran-GPPNHP-RanBP1-RanGAP complex
分子名称: GTP-binding nuclear protein RAN, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, ...
著者Seewald, M.J, Koerner, C, Wittinghofer, A, Vetter, I.R.
登録日2001-10-10
公開日2002-02-13
最終更新日2023-08-16
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献RanGAP mediates GTP hydrolysis without an arginine finger.
Nature, 415, 2002
8H6K
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BU of 8h6k by Molmil
Cryo-EM structure of human exon-defined spliceosome in the mature B state.
分子名称: 116 kDa U5 small nuclear ribonucleoprotein component, GUANOSINE-5'-TRIPHOSPHATE, INOSITOL HEXAKISPHOSPHATE, ...
著者Zhang, W, Zhan, X, Zhang, X, Bai, R, Lei, J, Yan, C, Shi, Y.
登録日2022-10-18
公開日2024-05-01
最終更新日2024-06-12
実験手法ELECTRON MICROSCOPY (2.7 Å)
主引用文献Structural insights into human exon-defined spliceosome prior to activation.
Cell Res., 34, 2024
8H6J
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BU of 8h6j by Molmil
Cryo-EM structure of human exon-defined spliceosome in the mature pre-B state.
分子名称: 116 kDa U5 small nuclear ribonucleoprotein component, GUANOSINE-5'-TRIPHOSPHATE, INOSITOL HEXAKISPHOSPHATE, ...
著者Zhang, W, Zhan, X, Zhang, X, Lei, J, Yan, C, Shi, Y.
登録日2022-10-18
公開日2024-05-01
最終更新日2024-06-12
実験手法ELECTRON MICROSCOPY (3.25 Å)
主引用文献Structural insights into human exon-defined spliceosome prior to activation.
Cell Res., 34, 2024
8H6E
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BU of 8h6e by Molmil
Cryo-EM structure of human exon-defined spliceosome in the late pre-B state.
分子名称: 116 kDa U5 small nuclear ribonucleoprotein component, GUANOSINE-5'-TRIPHOSPHATE, INOSITOL HEXAKISPHOSPHATE, ...
著者Zhang, W, Zhan, X, Zhang, X, Bai, R, Lei, J, Yan, C, Shi, Y.
登録日2022-10-17
公開日2024-05-01
最終更新日2024-06-12
実験手法ELECTRON MICROSCOPY (3.2 Å)
主引用文献Structural insights into human exon-defined spliceosome prior to activation.
Cell Res., 34, 2024
8H6L
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BU of 8h6l by Molmil
Cryo-EM structure of human exon-defined spliceosome in the early B state.
分子名称: 116 kDa U5 small nuclear ribonucleoprotein component, GUANOSINE-5'-TRIPHOSPHATE, INOSITOL HEXAKISPHOSPHATE, ...
著者Zhang, W, Zhan, X, Zhang, X, Bai, R, Lei, J, Yan, C, Shi, Y.
登録日2022-10-18
公開日2024-05-01
最終更新日2024-06-12
実験手法ELECTRON MICROSCOPY (2.6 Å)
主引用文献Structural insights into human exon-defined spliceosome prior to activation.
Cell Res., 34, 2024
8BD9
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BU of 8bd9 by Molmil
Crystal structure of TRIM33 alpha PHD-Bromo domain in complex with 10
分子名称: 1,3-dimethylbenzimidazol-2-one, CALCIUM ION, E3 ubiquitin-protein ligase TRIM33, ...
著者Tassone, G, Pozzi, C, Palomba, T.
登録日2022-10-18
公開日2022-12-07
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (3.2 Å)
主引用文献Exploiting ELIOT for Scaffold-Repurposing Opportunities: TRIM33 a Possible Novel E3 Ligase to Expand the Toolbox for PROTAC Design.
Int J Mol Sci, 23, 2022
8BDY
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BU of 8bdy by Molmil
Crystal structure of TRIM33 alpha PHD-Bromo domain in complex with 9
分子名称: 1,3-dimethylbenzimidazol-2-one, CALCIUM ION, E3 ubiquitin-protein ligase TRIM33, ...
著者Tassone, G, Pozzi, C, Palomba, T.
登録日2022-10-20
公開日2022-12-07
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (3.05 Å)
主引用文献Exploiting ELIOT for Scaffold-Repurposing Opportunities: TRIM33 a Possible Novel E3 Ligase to Expand the Toolbox for PROTAC Design.
Int J Mol Sci, 23, 2022
8BD8
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BU of 8bd8 by Molmil
Crystal structure of TRIM33 alpha PHD-Bromo domain in complex with 8
分子名称: 1,3-dimethylbenzimidazol-2-one, CALCIUM ION, E3 ubiquitin-protein ligase TRIM33, ...
著者Tassone, G, Pozzi, C, Palomba, T.
登録日2022-10-18
公開日2022-12-07
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (3.1 Å)
主引用文献Exploiting ELIOT for Scaffold-Repurposing Opportunities: TRIM33 a Possible Novel E3 Ligase to Expand the Toolbox for PROTAC Design.
Int J Mol Sci, 23, 2022
6QAJ
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BU of 6qaj by Molmil
Structure of the tripartite motif of KAP1/TRIM28
分子名称: Endolysin,Transcription intermediary factor 1-beta, ZINC ION
著者Stoll, G.A, Oda, S, Yu, M, Modis, Y.
登録日2018-12-19
公開日2019-07-24
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (2.901 Å)
主引用文献Structure of KAP1 tripartite motif identifies molecular interfaces required for retroelement silencing.
Proc.Natl.Acad.Sci.USA, 116, 2019
6QU1
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BU of 6qu1 by Molmil
Crystal structure of the KAP1 RBCC domain in complex with the SMARCAD1 CUE1 domain at 3.7 angstrom resolution.
分子名称: SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1, Transcription intermediary factor 1-beta,Transcription intermediary factor 1-beta, ZINC ION
著者Newman, J.A, Aitkenhead, H, Gavard, A, Lim, M, Williams, H.L, Svejstrup, J.Q, von Delft, F, Arrowsmith, C.H, Edwards, A, Bountra, C, Gileadi, O.
登録日2019-02-26
公開日2019-07-17
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (3.7 Å)
主引用文献A Ubiquitin-Binding Domain that Binds a Structural Fold Distinct from that of Ubiquitin.
Structure, 2019
8QO9
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BU of 8qo9 by Molmil
Cryo-EM structure of a human spliceosomal B complex protomer
分子名称: 116 kDa U5 small nuclear ribonucleoprotein component, MINX pre-mRNA, Microfibrillar-associated protein 1, ...
著者Zhang, Z, Kumar, V, Dybkov, O, Will, C.L, Urlaub, H, Stark, H, Luehrmann, R.
登録日2023-09-28
公開日2024-01-24
実験手法ELECTRON MICROSCOPY (5.29 Å)
主引用文献New insights into the functions of B complex proteins revealed by cryo-EM of dimerized spliceosomes
To Be Published

221716

件を2024-06-26に公開中

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