PDB: 5425 件ウェブページステータス検索Chemie searchBIRD

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7ONB	Structure of the U2 5' module of the A3'-SSA complex 分子名称: MINX, PHD finger-like domain-containing protein 5A, RNU2, ... 著者 Cretu, C, Pena, V. 登録日 2021-05-25 公開日 2021-08-04 実験手法 ELECTRON MICROSCOPY (3.1 Å) 主引用文献 Structural basis of intron selection by U2 snRNP in the presence of covalent inhibitors. Nat Commun, 12, 2021
7Q4O	Substrate-bound A-like U2 snRNP 分子名称: BPS oligo, PHD finger-like domain-containing protein 5A, Splicing factor 3A subunit 2, ... 著者 Tholen, J, Galej, W.P. 登録日 2021-11-01 公開日 2022-03-30 実験手法 ELECTRON MICROSCOPY (2.2 Å) 主引用文献 Structural basis of branch site recognition by the human spliceosome. Science, 375, 2022
7Q4P	U2 snRNP after ATP-dependent remodelling 分子名称: PHD finger-like domain-containing protein 5A, Splicing factor 3A subunit 2, Splicing factor 3A subunit 3, ... 著者 Tholen, J, Galej, W.P. 登録日 2021-11-01 公開日 2022-03-30 最終更新日 2022-04-06 実験手法 ELECTRON MICROSCOPY (2.2 Å) 主引用文献 Structural basis of branch site recognition by the human spliceosome. Science, 375, 2022
2N1V	Solution structure of human SUMO1 分子名称: Small ubiquitin-related modifier 1 著者 Naik, M.T, Naik, N, Shih, H, Huang, T. 登録日 2015-04-24 公開日 2016-04-20 最終更新日 2024-05-15 実験手法 SOLUTION NMR 主引用文献 Structures of human SUMO To Be Published
2MW5	Backbone fold of Human Small Ubiquitin like Modifier protein-1 (SUMO-1) based on Prot3D-NMR approach. 分子名称: Small ubiquitin-related modifier 1 著者 Kumar, D, Jaiswal, N, Raikwal, N, Shukla, V, Arora, A. 登録日 2014-10-28 公開日 2014-12-03 最終更新日 2024-05-15 実験手法 SOLUTION NMR 主引用文献 Prot3DNMR: A simple and swift NMR strategy for Three-Dimentional structutral determination of proteins. To be Published
2N1A	Docked structure between SUMO1 and ZZ-domain from CBP 分子名称: CREB-binding protein, Small ubiquitin-related modifier 1, ZINC ION 著者 Diehl, C. 登録日 2015-03-26 公開日 2016-05-04 最終更新日 2024-05-01 実験手法 SOLUTION NMR 主引用文献 Structural Analysis of a Complex between Small Ubiquitin-like Modifier 1 (SUMO1) and the ZZ Domain of CREB-binding Protein (CBP/p300) Reveals a New Interaction Surface on SUMO. J.Biol.Chem., 291, 2016
7VPX	The cryo-EM structure of the human pre-A complex 分子名称: 5SS, DnaJ homolog subfamily C member 8, PHD finger-like domain-containing protein 5A, ... 著者 Zhang, X, Zhan, X, Shi, Y. 登録日 2021-10-18 公開日 2023-05-03 最終更新日 2024-05-22 実験手法 ELECTRON MICROSCOPY (3 Å) 主引用文献 Structural insights into branch site proofreading by human spliceosome. Nat.Struct.Mol.Biol., 2024
2PE6	Non-covalent complex between human SUMO-1 and human Ubc9 分子名称: SUMO-conjugating enzyme UBC9, Small ubiquitin-related modifier 1 著者 Capili, A.D, Lima, C.D. 登録日 2007-04-02 公開日 2007-04-17 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Structure and Analysis of a Complex between SUMO and Ubc9 Illustrates Features of a Conserved E2-Ubl Interaction. J.Mol.Biol., 369, 2007
2KQS	Phosphorylation of SUMO-interacting motif by CK2 enhances Daxx SUMO binding activity 分子名称: Death domain-associated protein 6, Small ubiquitin-related modifier 1 著者 Naik, M.T, Huang, T.H, Shih, H. 登録日 2009-11-17 公開日 2010-12-01 最終更新日 2024-05-01 実験手法 SOLUTION NMR 主引用文献 Structural and functional roles of Daxx SIM phosphorylation in SUMO paralog-selective binding and apoptosis modulation. Mol.Cell, 42, 2011
3U5M	Crystal structure of TRIM33 PHD-Bromo in the free state 分子名称: CALCIUM ION, E3 ubiquitin-protein ligase TRIM33, ZINC ION 著者 Wang, Z, Patel, D.J. 登録日 2011-10-11 公開日 2012-01-18 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (3.08 Å) 主引用文献 A poised chromatin platform for TGF-beta access to master regulators Cell(Cambridge,Mass.), 147, 2011
3EAY	Crystal structure of the human SENP7 catalytic domain 分子名称: SULFATE ION, Sentrin-specific protease 7 著者 Lima, C.D, Reverter, D. 登録日 2008-08-26 公開日 2008-09-16 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Structure of the Human SENP7 Catalytic Domain and Poly-SUMO Deconjugation Activities for SENP6 and SENP7. J.Biol.Chem., 283, 2008
7Z36	Crystal structure of the KAP1 tripartite motif in complex with the ZNF93 KRAB domain 分子名称: Endolysin,Transcription intermediary factor 1-beta,Isoform 2 of Transcription intermediary factor 1-beta, SMARCAD1 CUE1 domain, ZINC ION, ... 著者 Stoll, G.A, Modis, Y. 登録日 2022-03-01 公開日 2022-11-02 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Structure and functional mapping of the KRAB-KAP1 repressor complex. Embo J., 41, 2022
7ZZO	HDAC2 in complex with an inhibitor 分子名称: 2-(cyclohexylazaniumyl)ethanesulfonate, CALCIUM ION, DI(HYDROXYETHYL)ETHER, ... 著者 Cleasby, A, Tisi, D. 登録日 2022-05-25 公開日 2022-09-21 最終更新日 2024-06-19 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Fragment-Based Discovery of a Novel, Brain Penetrant, Orally Active HDAC2 Inhibitor. Acs Med.Chem.Lett., 13, 2022
7ZZT	Ligand binding to HDAC2 分子名称: 1,2-ETHANEDIOL, 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID, CALCIUM ION, ... 著者 Cleasby, A, Tisi, D. 登録日 2022-05-26 公開日 2022-09-21 最終更新日 2024-06-19 実験手法 X-RAY DIFFRACTION (1.56 Å) 主引用文献 Fragment-Based Discovery of a Novel, Brain Penetrant, Orally Active HDAC2 Inhibitor. Acs Med.Chem.Lett., 13, 2022
7ZZP	Structure of HDAC2 complexed with an inhibitory ligand 分子名称: (2S)-2-HYDROXYPROPANOIC ACID, 1,2-ETHANEDIOL, 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID, ... 著者 Cleasby, A, Tisi, D. 登録日 2022-05-25 公開日 2022-09-21 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (1.52 Å) 主引用文献 Fragment-Based Discovery of a Novel, Brain Penetrant, Orally Active HDAC2 Inhibitor. Acs Med.Chem.Lett., 13, 2022
7ZZR	HDAC2 in complex with inhibitory ligand 分子名称: 1,2-ETHANEDIOL, 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID, CALCIUM ION, ... 著者 Cleasby, A, Tisi, D. 登録日 2022-05-26 公開日 2022-09-21 最終更新日 2024-06-19 実験手法 X-RAY DIFFRACTION (2.168 Å) 主引用文献 Fragment-Based Discovery of a Novel, Brain Penetrant, Orally Active HDAC2 Inhibitor. Acs Med.Chem.Lett., 13, 2022
7ZZW	Ligand binding to HDAC2 分子名称: 1,2-ETHANEDIOL, 2-(cyclohexylazaniumyl)ethanesulfonate, CALCIUM ION, ... 著者 Cleasby, A, Tisi, D. 登録日 2022-05-26 公開日 2022-09-21 最終更新日 2024-06-19 実験手法 X-RAY DIFFRACTION (1.73 Å) 主引用文献 Fragment-Based Discovery of a Novel, Brain Penetrant, Orally Active HDAC2 Inhibitor. Acs Med.Chem.Lett., 13, 2022
7ZZS	HDAC2 complexed with an inhibitory ligand 分子名称: (5~{S})-5-(4-chlorophenyl)pyrrolidin-2-one, 1,2-ETHANEDIOL, 2-(cyclohexylazaniumyl)ethanesulfonate, ... 著者 Cleasby, A, Tisi, D. 登録日 2022-05-26 公開日 2022-09-21 最終更新日 2024-06-19 実験手法 X-RAY DIFFRACTION (1.88 Å) 主引用文献 Fragment-Based Discovery of a Novel, Brain Penetrant, Orally Active HDAC2 Inhibitor. Acs Med.Chem.Lett., 13, 2022
8A0B	Inhibitor binding to HDAC2 分子名称: 1,2-ETHANEDIOL, 1,3-dihydroisoindol-2-yl-[(2R,4S)-4-phenylpyrrolidin-1-ium-2-yl]methanone, 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID, ... 著者 Cleasby, A, Tisi, D. 登録日 2022-05-27 公開日 2022-09-21 最終更新日 2024-06-19 実験手法 X-RAY DIFFRACTION (1.746 Å) 主引用文献 Fragment-Based Discovery of a Novel, Brain Penetrant, Orally Active HDAC2 Inhibitor. Acs Med.Chem.Lett., 13, 2022
7ZZU	Inhibitory Ligand binding to HDAC2 分子名称: 1,2-ETHANEDIOL, 2-[4-[(2~{R},4~{S})-4-phenylpyrrolidin-2-yl]carbonylpiperazin-1-yl]pyridine-3-carbonitrile, 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID, ... 著者 Cleasby, A, Tisi, D. 登録日 2022-05-26 公開日 2022-09-21 最終更新日 2024-06-19 実験手法 X-RAY DIFFRACTION (1.85 Å) 主引用文献 Fragment-Based Discovery of a Novel, Brain Penetrant, Orally Active HDAC2 Inhibitor. Acs Med.Chem.Lett., 13, 2022
2VRR	Structure of SUMO modified Ubc9 分子名称: FORMIC ACID, SMALL UBIQUITIN-RELATED MODIFIER 1, SODIUM ION, ... 著者 Knipscheer, P, Flotho, A, Klug, H, Olsen, J.V, van Dijk, W.J, Fish, A, Johnson, E.S, Mann, M, Sixma, T.K, Pichler, A. 登録日 2008-04-13 公開日 2008-08-19 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (2.22 Å) 主引用文献 Ubc9 sumoylation regulates SUMO target discrimination. Mol. Cell, 31, 2008
4OQA	Structure of Human PARP-1 bound to a DNA double strand break in complex with (2Z)-2-(2,4-dihydroxybenzylidene)-3-oxo-2,3-dihydro-1-benzofuran-7-carboxamide 分子名称: (2Z)-2-(2,4-dihydroxybenzylidene)-3-oxo-2,3-dihydro-1-benzofuran-7-carboxamide, DNA (26-MER), Poly [ADP-ribose] polymerase 1, ... 著者 Pascal, J.M, Steffen, J.D. 登録日 2014-02-07 公開日 2014-07-02 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (3.65 Å) 主引用文献 Discovery and Structure-Activity Relationship of Novel 2,3-Dihydrobenzofuran-7-carboxamide and 2,3-Dihydrobenzofuran-3(2H)-one-7-carboxamide Derivatives as Poly(ADP-ribose)polymerase-1 Inhibitors. J.Med.Chem., 57, 2014
8H6K	Cryo-EM structure of human exon-defined spliceosome in the mature B state. 分子名称: 116 kDa U5 small nuclear ribonucleoprotein component, GUANOSINE-5'-TRIPHOSPHATE, INOSITOL HEXAKISPHOSPHATE, ... 著者 Zhang, W, Zhan, X, Zhang, X, Bai, R, Lei, J, Yan, C, Shi, Y. 登録日 2022-10-18 公開日 2024-05-01 最終更新日 2024-06-12 実験手法 ELECTRON MICROSCOPY (2.7 Å) 主引用文献 Structural insights into human exon-defined spliceosome prior to activation. Cell Res., 34, 2024
8H6J	Cryo-EM structure of human exon-defined spliceosome in the mature pre-B state. 分子名称: 116 kDa U5 small nuclear ribonucleoprotein component, GUANOSINE-5'-TRIPHOSPHATE, INOSITOL HEXAKISPHOSPHATE, ... 著者 Zhang, W, Zhan, X, Zhang, X, Lei, J, Yan, C, Shi, Y. 登録日 2022-10-18 公開日 2024-05-01 最終更新日 2024-06-12 実験手法 ELECTRON MICROSCOPY (3.25 Å) 主引用文献 Structural insights into human exon-defined spliceosome prior to activation. Cell Res., 34, 2024
8H6E	Cryo-EM structure of human exon-defined spliceosome in the late pre-B state. 分子名称: 116 kDa U5 small nuclear ribonucleoprotein component, GUANOSINE-5'-TRIPHOSPHATE, INOSITOL HEXAKISPHOSPHATE, ... 著者 Zhang, W, Zhan, X, Zhang, X, Bai, R, Lei, J, Yan, C, Shi, Y. 登録日 2022-10-17 公開日 2024-05-01 最終更新日 2024-06-12 実験手法 ELECTRON MICROSCOPY (3.2 Å) 主引用文献 Structural insights into human exon-defined spliceosome prior to activation. Cell Res., 34, 2024

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