Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

4OQA

Structure of Human PARP-1 bound to a DNA double strand break in complex with (2Z)-2-(2,4-dihydroxybenzylidene)-3-oxo-2,3-dihydro-1-benzofuran-7-carboxamide

Summary for 4OQA
Entry DOI10.2210/pdb4oqa/pdb
Related4DQY 4OPX 4OQB
DescriptorPoly [ADP-ribose] polymerase 1, DNA (26-MER), ZINC ION, ... (5 entities in total)
Functional Keywordszinc finger, dna binding, parp, polymerase, dna repair, poly(adp-ribosyl)ation, transferase-dna-transferase inhibitor complex, transferase/dna/transferase inhibitor
Biological sourceHomo sapiens (human)
More
Cellular locationNucleus : P09874 P09874
Total number of polymer chains6
Total formula weight191649.30
Authors
Pascal, J.M.,Steffen, J.D. (deposition date: 2014-02-07, release date: 2014-07-02, Last modification date: 2023-09-20)
Primary citationPatel, M.R.,Bhatt, A.,Steffen, J.D.,Chergui, A.,Murai, J.,Pommier, Y.,Pascal, J.M.,Trombetta, L.D.,Fronczek, F.R.,Talele, T.T.
Discovery and Structure-Activity Relationship of Novel 2,3-Dihydrobenzofuran-7-carboxamide and 2,3-Dihydrobenzofuran-3(2H)-one-7-carboxamide Derivatives as Poly(ADP-ribose)polymerase-1 Inhibitors.
J.Med.Chem., 57:5579-5601, 2014
Cited by
PubMed: 24922587
DOI: 10.1021/jm5002502
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (3.65 Å)
Structure validation

217705

PDB entries from 2024-03-27

PDB statisticsPDBj update infoContact PDBjnumon