PDB: 149 件ウェブページステータス検索Chemie searchBIRD

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7DLI	Crystal structure of mouse CRY1 in complex with KL001 compound 分子名称: 1,2-ETHANEDIOL, Cryptochrome-1, N-[(2R)-3-carbazol-9-yl-2-oxidanyl-propyl]-N-(furan-2-ylmethyl)methanesulfonamide 著者 Miller, S.A, Aikawa, Y, Hirota, T. 登録日 2020-11-27 公開日 2021-06-23 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Structural differences in the FAD-binding pockets and lid loops of mammalian CRY1 and CRY2 for isoform-selective regulation. Proc.Natl.Acad.Sci.USA, 118, 2021
7D0M	Crystal structure of mouse CRY1 with bound cryoprotectant 分子名称: Cryptochrome-1, DI(HYDROXYETHYL)ETHER, TETRAETHYLENE GLYCOL 著者 Miller, S.A, Aikawa, Y, Hirota, T. 登録日 2020-09-11 公開日 2021-06-23 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 Structural differences in the FAD-binding pockets and lid loops of mammalian CRY1 and CRY2 for isoform-selective regulation. Proc.Natl.Acad.Sci.USA, 118, 2021
7D1C	Crystal structure of mouse Cryptochrome 1 in complex with compound TH303 分子名称: Cryptochrome-1, N-[2-(4-methoxyphenyl)-5,5-bis(oxidanylidene)-4,6-dihydrothieno[3,4-c]pyrazol-3-yl]-4-(phenylcarbonyl)benzamide 著者 Miller, S.A, Hirota, T. 登録日 2020-09-14 公開日 2021-01-27 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (1.91 Å) 主引用文献 Photopharmacological Manipulation of Mammalian CRY1 for Regulation of the Circadian Clock. J.Am.Chem.Soc., 143, 2021
7D19	Crystal structure of mouse Cryptochrome 1 in complex with compound TH129 分子名称: Cryptochrome-1, N-[2-(2,4-dimethylphenyl)-4,6-dihydrothieno[3,4-c]pyrazol-3-yl]-4-(phenylcarbonyl)benzamide 著者 Miller, S.A, Hirota, T. 登録日 2020-09-14 公開日 2021-01-27 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2.35 Å) 主引用文献 Photopharmacological Manipulation of Mammalian CRY1 for Regulation of the Circadian Clock. J.Am.Chem.Soc., 143, 2021
7EJ9	Alternative crystal structure of mouse Cryptochrome 2 in complex with TH301 compound 分子名称: 1-(4-chlorophenyl)-N-[2-(4-methoxyphenyl)-5,5-bis(oxidanylidene)-4,6-dihydrothieno[3,4-c]pyrazol-3-yl]cyclopentane-1-carboxamide, Cryptochrome-2 著者 Miller, S.A, Hirota, T. 登録日 2021-04-01 公開日 2021-06-23 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Structural differences in the FAD-binding pockets and lid loops of mammalian CRY1 and CRY2 for isoform-selective regulation. Proc.Natl.Acad.Sci.USA, 118, 2021
6K8I	Crystal structure of Arabidopsis thaliana CRY2 分子名称: Cryptochrome-2, FLAVIN-ADENINE DINUCLEOTIDE 著者 Ma, L, Wang, X, Guan, Z, Yin, P. 登録日 2019-06-12 公開日 2020-05-13 最終更新日 2024-03-27 実験手法 X-RAY DIFFRACTION (2.697 Å) 主引用文献 Structural insights into BIC-mediated inactivation of Arabidopsis cryptochrome 2. Nat.Struct.Mol.Biol., 27, 2020
6KX8	Crystal structure of mouse Cryptochrome 2 in complex with TH301 compound 分子名称: 1-(4-chlorophenyl)-N-[2-(4-methoxyphenyl)-5,5-bis(oxidanylidene)-4,6-dihydrothieno[3,4-c]pyrazol-3-yl]cyclopentane-1-carboxamide, Cryptochrome-2 著者 Miller, S.A, Aikawa, Y, Hirota, T. 登録日 2019-09-10 公開日 2020-04-01 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.25 Å) 主引用文献 Isoform-selective regulation of mammalian cryptochromes. Nat.Chem.Biol., 16, 2020
6KX5	Crystal structure of mouse Cryptochrome 1 in complex with KL044 compound 分子名称: 2-carbazol-9-yl-N-(2-chloranyl-6-cyano-phenyl)ethanamide, Cryptochrome-1 著者 Miller, S.A, Aikawa, Y, Hirota, T. 登録日 2019-09-10 公開日 2020-04-01 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Isoform-selective regulation of mammalian cryptochromes. Nat.Chem.Biol., 16, 2020
6KX7	Crystal structure of mouse Cryptochrome 1 in complex with TH301 compound 分子名称: 1-(4-chlorophenyl)-N-[2-(4-methoxyphenyl)-5,5-bis(oxidanylidene)-4,6-dihydrothieno[3,4-c]pyrazol-3-yl]cyclopentane-1-carboxamide, Cryptochrome-1 著者 Miller, S.A, Aikawa, Y, Hirota, T. 登録日 2019-09-10 公開日 2020-04-01 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Isoform-selective regulation of mammalian cryptochromes. Nat.Chem.Biol., 16, 2020
6KX6	Crystal structure of mouse Cryptochrome 1 in complex with KL101 compound 分子名称: Cryptochrome-1, ~{N}-[2-(2,4-dimethylphenyl)-4,6-dihydrothieno[3,4-c]pyrazol-3-yl]-3,4-dimethyl-benzamide 著者 Miller, S.A, Aikawa, Y, Hirota, T. 登録日 2019-09-10 公開日 2020-04-01 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Isoform-selective regulation of mammalian cryptochromes. Nat.Chem.Biol., 16, 2020
6KX4	Crystal structure of mouse Cryptochrome 1 apo form 分子名称: Cryptochrome-1 著者 Miller, S.A, Aikawa, Y, Hirota, T. 登録日 2019-09-10 公開日 2020-04-01 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Isoform-selective regulation of mammalian cryptochromes. Nat.Chem.Biol., 16, 2020
6LUE	Crystal structure of mouse Cryptochrome 1 in complex with compound KL201 分子名称: 2-bromanyl-N-(5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidin-4-yl)benzamide, Cryptochrome-1 著者 Miller, S, Aikawa, Y, Hirota, T. 登録日 2020-01-27 公開日 2020-06-10 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 An Isoform-Selective Modulator of Cryptochrome 1 Regulates Circadian Rhythms in Mammals. Cell Chem Biol, 27, 2020
6LZ3	Structure of cryptochrome in active conformation 分子名称: Cryptochrome2, FLAVIN-ADENINE DINUCLEOTIDE 著者 Shao, K, Zhang, X, Zhang, P. 登録日 2020-02-18 公開日 2020-04-29 最終更新日 2020-11-11 実験手法 ELECTRON MICROSCOPY (3.2 Å) 主引用文献 The oligomeric structures of plant cryptochromes. Nat.Struct.Mol.Biol., 27, 2020
6M79	Cryo-EM structure of Arabidopsis CRY under blue light-mediated activation 分子名称: ADENOSINE MONOPHOSPHATE, Cryptochrome-2, FLAVIN-ADENINE DINUCLEOTIDE 著者 Ma, L, Guan, Z.Y, Yin, P. 登録日 2020-03-18 公開日 2020-10-14 最終更新日 2021-08-04 実験手法 ELECTRON MICROSCOPY (3.1 Å) 主引用文献 Structural insights into the photoactivation of Arabidopsis CRY2. Nat.Plants, 6, 2020
6LZ7	Tetrameric structure of ZmCRY1a PHR domain 分子名称: Cryptochrome-1, FLAVIN-ADENINE DINUCLEOTIDE 著者 Shao, K, Zhang, X, Zhang, P. 登録日 2020-02-18 公開日 2020-05-13 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (3.59936166 Å) 主引用文献 The oligomeric structures of plant cryptochromes. Nat.Struct.Mol.Biol., 27, 2020
6K8K	Crystal structure of Arabidopsis thaliana BIC2-CRY2 complex 分子名称: ADENOSINE MONOPHOSPHATE, Cryptochrome-2, FLAVIN-ADENINE DINUCLEOTIDE, ... 著者 Wang, X, Ma, L, Guan, Z, Yin, P. 登録日 2019-06-12 公開日 2020-05-13 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Structural insights into BIC-mediated inactivation of Arabidopsis cryptochrome 2. Nat.Struct.Mol.Biol., 27, 2020
8P4X	FAD_ox bound dark state structure of PdLCry 分子名称: FLAVIN-ADENINE DINUCLEOTIDE, MAGNESIUM ION, Putative light-receptive cryptochrome (Fragment) 著者 Behrmann, E, Behrmann, H. 登録日 2023-05-23 公開日 2023-11-08 最終更新日 2024-03-27 実験手法 ELECTRON MICROSCOPY (2.57 Å) 主引用文献 A marine cryptochrome with an inverse photo-oligomerization mechanism. Nat Commun, 14, 2023
7V8Y	Crystal structure of mouse CRY2 in complex with SHP1703 compound 分子名称: 1-[(2R)-3-[3,6-bis(fluoranyl)carbazol-9-yl]-2-oxidanyl-propyl]imidazolidin-2-one, Cryptochrome-2 著者 Miller, S.A, Hirota, T. 登録日 2021-08-23 公開日 2022-08-24 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 CRY2 isoform selectivity of a circadian clock modulator with antiglioblastoma efficacy. Proc.Natl.Acad.Sci.USA, 119, 2022
7V8Z	Crystal structure of mouse CRY2 in complex with SHP656 compound 分子名称: 1-[(2R)-3-[3,6-bis(fluoranyl)carbazol-9-yl]-2-oxidanyl-propyl]imidazolidin-2-one, Cryptochrome-2 著者 Miller, S.A, Hirota, T. 登録日 2021-08-23 公開日 2022-08-24 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 CRY2 isoform selectivity of a circadian clock modulator with antiglioblastoma efficacy. Proc.Natl.Acad.Sci.USA, 119, 2022
7WVA	Crystal structure of mouse Cryptochrome 1 in complex with TH401 compound 分子名称: 2-(1-methylbenzimidazol-2-yl)sulfanyl-N-[(E)-(2,3,4-trimethoxyphenyl)methylideneamino]ethanamide, Cryptochrome-1 著者 Miller, S.A, Hirota, T. 登録日 2022-02-10 公開日 2022-09-07 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2.05 Å) 主引用文献 A methylbenzimidazole derivative regulates mammalian circadian rhythms by targeting Cryptochrome proteins. F1000Res, 11, 2022
7X0Y	Cryo-EM Structure of Arabidopsis CRY2 tetramer in complex with CIB1 fragment 分子名称: CIB1 fragment, Cryptochrome-2, FLAVIN-ADENINE DINUCLEOTIDE 著者 Hao, Y.H, Zhang, X, Zhang, P. 登録日 2022-02-22 公開日 2023-01-04 最終更新日 2024-06-26 実験手法 ELECTRON MICROSCOPY (3.89 Å) 主引用文献 Cryo-EM structure of the CRY2 and CIB1 fragment complex provides insights into CIB1-mediated photosignaling. Plant Commun., 4, 2023
7X0X	Cryo-EM Structure of Arabidopsis CRY2 in active conformation 分子名称: Cryptochrome-2, FLAVIN-ADENINE DINUCLEOTIDE 著者 Hao, Y.H, Zhang, X, Zhang, P. 登録日 2022-02-22 公開日 2023-01-04 最終更新日 2024-06-26 実験手法 ELECTRON MICROSCOPY (2.56 Å) 主引用文献 Cryo-EM structure of the CRY2 and CIB1 fragment complex provides insights into CIB1-mediated photosignaling. Plant Commun., 4, 2023
7PUA	Middle assembly intermediate of the Trypanosoma brucei mitoribosomal small subunit 分子名称: 30S Ribosomal protein S17, putative, 30S ribosomal protein S8, ... 著者 Lenarcic, T, Leibundgut, M, Saurer, M, Ramrath, D.J.F, Fluegel, T, Boehringer, D, Ban, N. 登録日 2021-09-29 公開日 2022-03-02 実験手法 ELECTRON MICROSCOPY (3.6 Å) 主引用文献 Mitoribosomal small subunit maturation involves formation of initiation-like complexes. Proc.Natl.Acad.Sci.USA, 119, 2022
7PUB	Late assembly intermediate of the Trypanosoma brucei mitoribosomal small subunit 分子名称: 30S Ribosomal protein S17, putative, 30S ribosomal protein S8, ... 著者 Lenarcic, T, Leibundgut, M, Saurer, M, Ramrath, D.J.F, Fluegel, T, Boehringer, D, Ban, N. 登録日 2021-09-29 公開日 2022-05-04 実験手法 ELECTRON MICROSCOPY (3.7 Å) 主引用文献 Mitoribosomal small subunit maturation involves formation of initiation-like complexes. Proc.Natl.Acad.Sci.USA, 119, 2022

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