PDB: 367 件ウェブページステータス検索Chemie searchBIRD

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4DMN	HIV-1 Integrase Catalytical Core Domain 分子名称: (2S)-[6-bromo-4-(4-chlorophenyl)-2-methylquinolin-3-yl](methoxy)ethanoic acid, ARSENIC, HIV-1 Integrase, ... 著者 Feng, L, Kvaratskhelia, M. 登録日 2012-02-08 公開日 2012-03-21 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.45 Å) 主引用文献 Multimode, cooperative mechanism of action of allosteric HIV-1 integrase inhibitors. J.Biol.Chem., 287, 2012
4E1N	Crystal Structure of HIV-1 Integrase with a non-catayltic site inhibitor 分子名称: (2S)-tert-butoxy[4-(8-fluoro-5-methyl-3,4-dihydro-2H-chromen-6-yl)-2-methylquinolin-3-yl]ethanoic acid, HIV-1 integrase 著者 Lansdon, E.B. 登録日 2012-03-06 公開日 2012-04-25 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 New Class of HIV-1 Integrase (IN) Inhibitors with a Dual Mode of Action. J.Biol.Chem., 287, 2012
4E1M	Crystal Structure of HIV-1 Integrase with a non-catayltic site inhibitor 分子名称: (2S)-tert-butoxy[4-(3,4-dimethylphenyl)-2-methylquinolin-3-yl]ethanoic acid, HIV-1 Integrase 著者 Lansdon, E.B. 登録日 2012-03-06 公開日 2012-04-25 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 New Class of HIV-1 Integrase (IN) Inhibitors with a Dual Mode of Action. J.Biol.Chem., 287, 2012
4E7I	PFV intasome freeze-trapped prior to 3'-processing, Mn-bound form (UI-Mn) 分子名称: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, DNA (5'-D(*AP*TP*TP*GP*TP*CP*AP*TP*GP*GP*AP*AP*TP*TP*TP*CP*GP*CP*A)-3'), DNA (5'-D(*TP*GP*CP*GP*AP*AP*AP*TP*TP*CP*CP*AP*TP*GP*AP*CP*AP*AP*T)-3'), ... 著者 Hare, S, Cherepanov, P. 登録日 2012-03-17 公開日 2012-05-23 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.5301 Å) 主引用文献 3'-Processing and strand transfer catalysed by retroviral integrase in crystallo. Embo J., 31, 2012
4E7L	PFV integrase Strand Transfer Complex (STC-Mn*) following reaction in crystallo, at 3.0 A resolution. 分子名称: DNA (5'-D(*AP*TP*TP*GP*TP*CP*AP*TP*GP*GP*AP*AP*TP*TP*TP*CP*GP*CP*A)-3'), DNA (5'-D(*CP*CP*CP*GP*AP*GP*GP*CP*AP*CP*GP*TP*G)-3'), DNA (5'-D(*TP*GP*CP*GP*AP*AP*AP*TP*TP*CP*CP*AP*TP*GP*AP*CP*A)-3'), ... 著者 Maertens, G.N, Cherepanov, P. 登録日 2012-03-17 公開日 2012-05-23 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (3.0001 Å) 主引用文献 3'-Processing and strand transfer catalysed by retroviral integrase in crystallo. Embo J., 31, 2012
4E7J	PFV integrase Target Capture Complex, Apo form (TCC-Apo), at 3.15 A resolution 分子名称: DNA (5'-D(*AP*TP*TP*GP*TP*CP*AP*TP*GP*GP*AP*AP*TP*TP*TP*CP*GP*CP*A)-3'), DNA (5'-D(*CP*CP*CP*GP*AP*GP*GP*CP*AP*CP*GP*TP*GP*CP*TP*AP*GP*CP*AP*CP*GP*TP*GP*CP*CP*TP*CP*GP*GP*G)-3'), DNA (5'-D(*TP*GP*CP*GP*AP*AP*AP*TP*TP*CP*CP*AP*TP*GP*AP*CP*A)-3'), ... 著者 Maertens, G.N, Cherepanov, P. 登録日 2012-03-17 公開日 2012-05-23 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (3.1501 Å) 主引用文献 3'-Processing and strand transfer catalysed by retroviral integrase in crystallo. Embo J., 468, 2012
4E7K	PFV integrase Target Capture Complex (TCC-Mn), freeze-trapped prior to strand transfer, at 3.0 A resolution 分子名称: DNA (5'-D(*AP*TP*TP*GP*TP*CP*AP*TP*GP*GP*AP*AP*TP*TP*TP*CP*GP*CP*A)-3'), DNA (5'-D(*CP*CP*CP*GP*AP*GP*GP*CP*AP*CP*GP*TP*GP*CP*TP*AP*GP*CP*AP*CP*GP*TP*GP*CP*CP*TP*CP*GP*GP*G)-3'), DNA (5'-D(*TP*GP*CP*GP*AP*AP*AP*TP*TP*CP*CP*AP*TP*GP*AP*CP*A)-3'), ... 著者 Maertens, G.N, Cherepanov, P. 登録日 2012-03-17 公開日 2012-05-23 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (3.02 Å) 主引用文献 3'-Processing and strand transfer catalysed by retroviral integrase in crystallo. Embo J., 31, 2012
4E7H	PFV intasome prior to 3'-processing, Apo form (UI-Apo) 分子名称: DNA (5'-D(*AP*TP*TP*GP*TP*CP*AP*TP*GP*GP*AP*AP*TP*TP*TP*CP*GP*CP*A)-3'), DNA (5'-D(*TP*GP*CP*GP*AP*AP*AP*TP*TP*CP*CP*AP*TP*GP*AP*CP*AP*AP*T)-3'), GLYCEROL, ... 著者 Hare, S, Cherepanov, P. 登録日 2012-03-17 公開日 2012-05-23 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.5701 Å) 主引用文献 3'-Processing and strand transfer catalysed by retroviral integrase in crystallo. Embo J., 31, 2012
3VQ5	HIV-1 IN core domain in complex with N-METHYL-1-(4-METHYL-2-PHENYL-1,3-THIAZOL-5-YL)METHANAMINE 分子名称: CADMIUM ION, CHLORIDE ION, N-methyl-1-(4-methyl-2-phenyl-1,3-thiazol-5-yl)methanamine, ... 著者 Wielens, J, Chalmers, D.K, Parker, M.W, Scanlon, M.J. 登録日 2012-03-20 公開日 2013-01-30 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Parallel screening of low molecular weight fragment libraries: do differences in methodology affect hit identification? J Biomol Screen, 18, 2013
3VQ4	Fragments bound to HIV-1 integrase 分子名称: (5-phenyl-1,2-oxazol-3-yl)methanol, CADMIUM ION, POL polyprotein, ... 著者 Wielens, J, Chalmers, D.K, Parker, M.W, Scanlon, M.J. 登録日 2012-03-20 公開日 2013-01-30 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Parallel screening of low molecular weight fragment libraries: do differences in methodology affect hit identification? J Biomol Screen, 18, 2013
3VQ6	HIV-1 IN core domain in complex with (1-methyl-5-phenyl-1H-pyrazol-4-yl)methanol 分子名称: (1-methyl-5-phenyl-1H-pyrazol-4-yl)methanol, CADMIUM ION, POL polyprotein, ... 著者 Wielens, J, Chalmers, D.K, Parker, M.W, Scanlon, M.J. 登録日 2012-03-20 公開日 2013-01-30 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Parallel screening of low molecular weight fragment libraries: do differences in methodology affect hit identification? J Biomol Screen, 18, 2013
3VQ9	HIV-1 IN core domain in complex with 6-fluoro-1,3-benzothiazol-2-amine 分子名称: 6-fluoro-1,3-benzothiazol-2-amine, POL polyprotein 著者 Wielens, J, Chalmers, D.K, Parker, M.W, Scanlon, M.J. 登録日 2012-03-20 公開日 2013-01-30 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Parallel screening of low molecular weight fragment libraries: do differences in methodology affect hit identification? J Biomol Screen, 18, 2013
3VQ8	HIV-1 IN core domain in complex with (3R)-3,4-dihydro-2H-chromen-3-ylmethanol 分子名称: (3R)-3,4-dihydro-2H-chromen-3-ylmethanol, CADMIUM ION, CHLORIDE ION, ... 著者 Wielens, J, Chalmers, D.K, Parker, M.W, Scanlon, M.J. 登録日 2012-03-20 公開日 2013-01-30 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Parallel screening of low molecular weight fragment libraries: do differences in methodology affect hit identification? J Biomol Screen, 18, 2013
3VQ7	HIV-1 IN core domain in complex with 4-(1H-pyrrol-1-yl)aniline 分子名称: 4-(1H-pyrrol-1-yl)aniline, CADMIUM ION, POL polyprotein, ... 著者 Wielens, J, Chalmers, D.K, Parker, M.W, Scanlon, M.J. 登録日 2012-03-20 公開日 2013-01-30 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (1.63 Å) 主引用文献 Parallel screening of low molecular weight fragment libraries: do differences in methodology affect hit identification? J Biomol Screen, 18, 2013
3VQA	HIV-1 IN core domain in complex with 1-benzothiophen-6-amine 1,1-dioxide 分子名称: 1-benzothiophen-6-amine 1,1-dioxide, CADMIUM ION, POL polyprotein, ... 著者 Wielens, J, Chalmers, D.K, Parker, M.W, Scanlon, M.J. 登録日 2012-03-20 公開日 2013-01-30 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Parallel screening of low molecular weight fragment libraries: do differences in methodology affect hit identification? J Biomol Screen, 18, 2013
3VQC	HIV-1 IN core domain in complex with (5-METHYL-3-PHENYL-1,2-OXAZOL-4-YL)METHANOL 分子名称: (5-methyl-3-phenyl-1,2-oxazol-4-yl)methanol, CADMIUM ION, POL polyprotein, ... 著者 Wielens, J, Chalmers, D.K, Parker, M.W, Scanlon, M.J. 登録日 2012-03-21 公開日 2013-01-30 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Parallel screening of low molecular weight fragment libraries: do differences in methodology affect hit identification? J Biomol Screen, 18, 2013
3VQE	HIV-1 IN core domain in complex with [1-(4-fluorophenyl)-5-methyl-1H-pyrazol-4-yl]methanol 分子名称: CADMIUM ION, CHLORIDE ION, POL polyprotein, ... 著者 Wielens, J, Chalmers, D.K, Parker, M.W, Scanlon, M.J. 登録日 2012-03-21 公開日 2013-01-30 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Parallel screening of low molecular weight fragment libraries: do differences in methodology affect hit identification? J Biomol Screen, 18, 2013
3VQD	HIV-1 IN core domain in complex with 5-methyl-3-phenyl-1,2-oxazole-4-carboxylic acid 分子名称: 5-methyl-3-phenyl-1,2-oxazole-4-carboxylic acid, CADMIUM ION, POL polyprotein, ... 著者 Wielens, J, Chalmers, D.K, Parker, M.W, Scanlon, M.J. 登録日 2012-03-21 公開日 2013-01-30 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Parallel screening of low molecular weight fragment libraries: do differences in methodology affect hit identification? J Biomol Screen, 18, 2013
3VQB	HIV-1 IN core domain in complex with 6-fluoro-4H-1,3-benzodioxine-8-carboxylic acid 分子名称: 6-fluoro-4H-1,3-benzodioxine-8-carboxylic acid, CADMIUM ION, POL polyprotein, ... 著者 Wielens, J, Chalmers, D.K, Parker, M.W, Scanlon, M.J. 登録日 2012-03-21 公開日 2013-01-30 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Parallel screening of low molecular weight fragment libraries: do differences in methodology affect hit identification? J Biomol Screen, 18, 2013
3VQQ	HIV-1 integrase core domain in complex with 2,1,3-benzothiadiazol-4-amine 分子名称: 2,1,3-benzothiadiazol-4-amine, CADMIUM ION, POL polyprotein, ... 著者 Wielens, J, Chalmers, D.K, Parker, M.W, Scanlon, M.J. 登録日 2012-03-29 公開日 2013-01-30 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Parallel screening of low molecular weight fragment libraries: do differences in methodology affect hit identification? J Biomol Screen, 18, 2013
3VQP	HIV-1 IN core domain in complex with 2,3-dihydro-1,4-benzodioxin-5-ylmethanol 分子名称: 2,3-dihydro-1,4-benzodioxin-5-ylmethanol, CADMIUM ION, CHLORIDE ION, ... 著者 Wielens, J, Chalmers, D.K, Parker, M.W, Scanlon, M.J. 登録日 2012-03-29 公開日 2013-01-30 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Parallel screening of low molecular weight fragment libraries: do differences in methodology affect hit identification? J Biomol Screen, 18, 2013
4FW2	Crystal structure of RSV three-domain integrase with disordered N-terminal domain 分子名称: Integrase 著者 Shi, K, Aihara, H. 登録日 2012-06-29 公開日 2013-05-15 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.65 Å) 主引用文献 A possible role for the asymmetric C-terminal domain dimer of Rous sarcoma virus integrase in viral DNA binding. Plos One, 8, 2013
4FW1	Crystal structure of two-domain RSV INTEGRASE covalently linked with DNA 分子名称: Integrase 著者 Shi, K, Aihara, H. 登録日 2012-06-29 公開日 2013-05-15 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.86 Å) 主引用文献 A possible role for the asymmetric C-terminal domain dimer of Rous sarcoma virus integrase in viral DNA binding. Plos One, 8, 2013
4GVM	HIV-1 Integrase Catalytic Core Domain A128T Mutant Complexed with Allosteric Inhibitor 分子名称: (2S)-[6-bromo-4-(4-chlorophenyl)-2-methylquinolin-3-yl](tert-butoxy)ethanoic acid, ARSENIC, Gag-Pol polyprotein 著者 Feng, L, Kvaratskhelia, M. 登録日 2012-08-30 公開日 2013-05-01 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.16 Å) 主引用文献 The A128T Resistance Mutation Reveals Aberrant Protein Multimerization as the Primary Mechanism of Action of Allosteric HIV-1 Integrase Inhibitors. J.Biol.Chem., 288, 2013
4GW6	HIV-1 Integrase Catalytic Core Domain Complexed with Allosteric Inhibitor 分子名称: (2S)-[6-bromo-4-(4-chlorophenyl)-2-methylquinolin-3-yl](tert-butoxy)ethanoic acid, ARSENIC, Gag-Pol polyprotein 著者 Feng, L, Kvaratskhelia, M. 登録日 2012-08-31 公開日 2013-05-01 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.65 Å) 主引用文献 The A128T Resistance Mutation Reveals Aberrant Protein Multimerization as the Primary Mechanism of Action of Allosteric HIV-1 Integrase Inhibitors. J.Biol.Chem., 288, 2013

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