4E1N

Crystal Structure of HIV-1 Integrase with a non-catayltic site inhibitor

Summary for 4E1N

Entry DOI	10.2210/pdb4e1n/pdb
Related	4E1M
Descriptor	HIV-1 integrase, (2S)-tert-butoxy[4-(8-fluoro-5-methyl-3,4-dihydro-2H-chromen-6-yl)-2-methylquinolin-3-yl]ethanoic acid (3 entities in total)
Functional Keywords	hiv-1, integrase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Human immunodeficiency virus type 1 (HIV-1)
Total number of polymer chains	1
Total formula weight	18842.20
Authors	Lansdon, E.B. (deposition date: 2012-03-06, release date: 2012-04-25, Last modification date: 2023-09-13)
Primary citation	Tsiang, M.,Jones, G.S.,Niedziela-Majka, A.,Kan, E.,Lansdon, E.B.,Huang, W.,Hung, M.,Samuel, D.,Novikov, N.,Xu, Y.,Mitchell, M.,Guo, H.,Babaoglu, K.,Liu, X.,Geleziunas, R.,Sakowicz, R. New Class of HIV-1 Integrase (IN) Inhibitors with a Dual Mode of Action. J.Biol.Chem., 287:21189-21203, 2012 Cited by PubMed: 22535962 DOI: 10.1074/jbc.M112.347534 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation