4E1N
Crystal Structure of HIV-1 Integrase with a non-catayltic site inhibitor
Summary for 4E1N
Entry DOI | 10.2210/pdb4e1n/pdb |
Related | 4E1M |
Descriptor | HIV-1 integrase, (2S)-tert-butoxy[4-(8-fluoro-5-methyl-3,4-dihydro-2H-chromen-6-yl)-2-methylquinolin-3-yl]ethanoic acid (3 entities in total) |
Functional Keywords | hiv-1, integrase, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Human immunodeficiency virus type 1 (HIV-1) |
Total number of polymer chains | 1 |
Total formula weight | 18842.20 |
Authors | Lansdon, E.B. (deposition date: 2012-03-06, release date: 2012-04-25, Last modification date: 2023-09-13) |
Primary citation | Tsiang, M.,Jones, G.S.,Niedziela-Majka, A.,Kan, E.,Lansdon, E.B.,Huang, W.,Hung, M.,Samuel, D.,Novikov, N.,Xu, Y.,Mitchell, M.,Guo, H.,Babaoglu, K.,Liu, X.,Geleziunas, R.,Sakowicz, R. New Class of HIV-1 Integrase (IN) Inhibitors with a Dual Mode of Action. J.Biol.Chem., 287:21189-21203, 2012 Cited by PubMed: 22535962DOI: 10.1074/jbc.M112.347534 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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