4E1N
Crystal Structure of HIV-1 Integrase with a non-catayltic site inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | HIV-1 integrase | polymer | 166 | 18404.7 | 1 | UniProt (P12497) Pfam (PF00665) In PDB | Human immunodeficiency virus type 1 (HIV-1) | |
| 2 | A | (2S)-tert-butoxy[4-(8-fluoro-5-methyl-3,4-dihydro-2H-chromen-6-yl)-2-methylquinolin-3-yl]ethanoic acid | non-polymer | 437.5 | 1 | Chemie (TQX) | |||
| 3 | water | water | 18.0 | 40 | Chemie (HOH) |
Sequence modifications
A: 50 - 212 (UniProt: P12497)
| PDB | External Database | Details |
|---|---|---|
| Gly 47 | - | expression tag |
| Ser 48 | - | expression tag |
| His 49 | - | expression tag |
| Ala 124 | Thr 1271 | conflict |
| Lys 185 | Phe 1332 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 18404.7 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 437.5 | |
| All* | Total formula weight | 18842.2 |
