4E7I
PFV intasome freeze-trapped prior to 3'-processing, Mn-bound form (UI-Mn)
Summary for 4E7I
Entry DOI | 10.2210/pdb4e7i/pdb |
Related | 3DLR 3OY9 3OYA |
Descriptor | Pro-Pol polyprotein, DNA (5'-D(*AP*TP*TP*GP*TP*CP*AP*TP*GP*GP*AP*AP*TP*TP*TP*CP*GP*CP*A)-3'), DNA (5'-D(*TP*GP*CP*GP*AP*AP*AP*TP*TP*CP*CP*AP*TP*GP*AP*CP*AP*AP*T)-3'), ... (10 entities in total) |
Functional Keywords | protein-dna complex, tetramer, hhcc motif, endonuclease, metal-binding, multifunctional enzyme, nuclease, nucleotidyltransferase, nucleus, transferase, virion, dna-binding, zinc-binding, viral protein, recombination, viral protein-dna complex, recombination-dna complex, recombination/dna |
Biological source | Human spumaretrovirus (SFVcpz(hu)) More |
Cellular location | Integrase: Virion (Potential). Protease/Reverse transcriptase/ribonuclease H: Host nucleus (By similarity): P14350 |
Total number of polymer chains | 4 |
Total formula weight | 102317.71 |
Authors | Hare, S.,Cherepanov, P. (deposition date: 2012-03-17, release date: 2012-05-23, Last modification date: 2024-02-28) |
Primary citation | Hare, S.,Maertens, G.N.,Cherepanov, P. 3'-Processing and strand transfer catalysed by retroviral integrase in crystallo. Embo J., 31:3020-3028, 2012 Cited by PubMed: 22580823DOI: 10.1038/emboj.2012.118 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.5301 Å) |
Structure validation
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