4E7I

PFV intasome freeze-trapped prior to 3'-processing, Mn-bound form (UI-Mn)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003676	molecular_function	nucleic acid binding
A	0015074	biological_process	DNA integration
B	0003676	molecular_function	nucleic acid binding
B	0015074	biological_process	DNA integration

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 401

Chain	Residue
A	HIS62
A	HIS66
A	CYS96
A	CYS99

---

site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MN A 402

Chain	Residue
D	HOH202
A	ASP128
A	ASP185
A	HOH502
A	HOH624
D	DA18

---

site_id	AC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MN A 403

Chain	Residue
A	ASP128
A	GLU221
A	ASN224
A	HOH501
D	DA17
D	DA18

---

site_id	AC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 A 404

Chain	Residue
A	HIS338
A	LYS339
A	HOH530

---

site_id	AC5
Number of Residues	7
Details	BINDING SITE FOR RESIDUE SO4 A 405

Chain	Residue
A	THR158
A	LYS159
A	ALA160
A	ALA165
A	HOH639
A	HOH640
A	HOH647

---

site_id	AC6
Number of Residues	3
Details	BINDING SITE FOR RESIDUE GOL A 406

Chain	Residue
A	SER136
A	GLN137
A	LYS241

---

site_id	AC7
Number of Residues	3
Details	BINDING SITE FOR RESIDUE GOL A 407

Chain	Residue
A	GLN60
A	TYR80
A	PHE278

---

site_id	AC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE GOL A 408

Chain	Residue
A	PRO115
A	ASP116
A	HOH634
C	DT3

---

site_id	AC9
Number of Residues	3
Details	BINDING SITE FOR RESIDUE GOL A 409

Chain	Residue
A	SER162
A	THR163
A	SER164

---

site_id	BC1
Number of Residues	7
Details	BINDING SITE FOR RESIDUE SO4 A 410

Chain	Residue
A	ARG114
A	TYR303
A	PRO305
A	HOH615
A	HOH656
C	DC6
C	GOL101

---

site_id	BC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE GOL A 411

Chain	Residue
A	GLN186
A	THR191
C	DA1

---

site_id	BC3
Number of Residues	9
Details	BINDING SITE FOR RESIDUE MES A 412

Chain	Residue
A	TYR141
A	PRO161
A	GLY187
A	ALA188
A	HOH560
A	HOH624
A	HOH641
A	HOH642
D	HOH202

---

site_id	BC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MN B 401

Chain	Residue
B	ASP128
B	ASP185
B	HOH501
B	HOH502
B	HOH545
C	DA19

---

site_id	BC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 B 402

Chain	Residue
B	LYS219
B	ARG222
B	SER258
B	PRO259
B	VAL260
B	HOH542

---

site_id	BC6
Number of Residues	7
Details	BINDING SITE FOR RESIDUE HEZ B 403

Chain	Residue
A	SER175
A	ILE176
B	TRP154
B	LEU155
B	TYR156
B	TYR243
B	GLN250

---

site_id	BC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE GOL B 404

Chain	Residue
B	TYR263
B	GLN267
B	GLY271
B	ASP273

---

site_id	BC8
Number of Residues	9
Details	BINDING SITE FOR RESIDUE GOL C 101

Chain	Residue
A	VAL260
A	TYR303
A	SO4410
A	HOH659
C	DC6
C	DA7
C	DT8
C	HOH202
D	DC11

---

site_id	BC9
Number of Residues	3
Details	BINDING SITE FOR RESIDUE GOL D 101

Chain	Residue
D	DC16
D	DA17
D	DA18

---

site_id	CC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE GOL D 102

Chain	Residue
A	TRP81
A	MET85
A	HOH600
D	DT8

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	312
Details	Domain: {"description":"Integrase catalytic","evidences":[{"source":"PROSITE-ProRule","id":"PRU00457","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	4
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---