HIV-1 Integrase Catalytical Core Domain

Summary for 4DMN

DescriptorHIV-1 Integrase, ARSENIC, SULFATE ION, ... (5 entities in total)
Functional Keywordsintegrase, ccd, dde motif, dimer interface, viral protein-inhibitor complex, viral protein/inhibitor
Biological sourceHuman immunodeficiency virus type 1 (HIV-1)
Cellular locationGag-Pol polyprotein: Host cell membrane; Lipid-anchor . Matrix protein p17: Virion membrane; Lipid- anchor . Capsid protein p24: Virion . Nucleocapsid protein p7: Virion . Reverse transcriptase/ribonuclease H: Virion . Integrase: Virion  P12497
Total number of polymer chains1
Total molecular weight18675.13
Feng, L.,Kvaratskhelia, M. (deposition date: 2012-02-08, release date: 2012-03-21, Last modification date: 2017-11-15)
Primary citation
Kessl, J.J.,Jena, N.,Koh, Y.,Taskent-Sezgin, H.,Slaughter, A.,Feng, L.,de Silva, S.,Wu, L.,Le Grice, S.F.,Engelman, A.,Fuchs, J.R.,Kvaratskhelia, M.
Multimode, cooperative mechanism of action of allosteric HIV-1 integrase inhibitors.
J.Biol.Chem., 287:16801-16811, 2012
PubMed: 22437836 (PDB entries with the same primary citation)
DOI: 10.1074/jbc.M112.354373
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.26612 2.8% 12.3% 8.3%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation reportDownload
PDB entries from 2020-11-18