7RN7
 
 | | Crystal structure of caspase-3 with inhibitor Ac-VD(Aly)VD-CHO | | 分子名称: | Ac-VD(Aly)VD-CHO, Caspase-3 subunit p12, Caspase-3 subunit p17 | | 著者 | McCue, W, Finzel, B.C. | | 登録日 | 2021-07-29 | | 公開日 | 2022-01-05 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Structure-Based Design and Biological Evaluation of Novel Caspase-2 Inhibitors Based on the Peptide AcVDVAD-CHO and the Caspase-2-Mediated Tau Cleavage Sequence YKPVD314.
Acs Pharmacol Transl Sci, 5, 2022
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7RNB
 | | Crystal structure of caspase-3 with inhibitor Ac-VDRVD-CHO | | 分子名称: | Ac-VDRVD-CHO, Caspase-3 subunit p12, Caspase-3 subunit p17 | | 著者 | McCue, W, Finzel, B.C. | | 登録日 | 2021-07-29 | | 公開日 | 2022-01-05 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | | 主引用文献 | Structure-Based Design and Biological Evaluation of Novel Caspase-2 Inhibitors Based on the Peptide AcVDVAD-CHO and the Caspase-2-Mediated Tau Cleavage Sequence YKPVD314.
Acs Pharmacol Transl Sci, 5, 2022
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7RN9
 | | Crystal structure of caspase-3 with inhibitor Ac-VDFVD-CHO | | 分子名称: | Ac-VDFVD-CHO, Caspase-3 subunit p12, Caspase-3 subunit p17 | | 著者 | McCue, W, Finzel, B.C. | | 登録日 | 2021-07-29 | | 公開日 | 2022-01-05 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (1.67 Å) | | 主引用文献 | Structure-Based Design and Biological Evaluation of Novel Caspase-2 Inhibitors Based on the Peptide AcVDVAD-CHO and the Caspase-2-Mediated Tau Cleavage Sequence YKPVD314.
Acs Pharmacol Transl Sci, 5, 2022
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7RNF
 | | Crystal structure of caspase-3 with inhibitor Ac-VDKVD-CHO | | 分子名称: | Ac-VDKVD-CHO, Caspase-3 subunit p12, Caspase-3 subunit p17 | | 著者 | McCue, W, Finzel, B.C. | | 登録日 | 2021-07-29 | | 公開日 | 2022-01-05 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (2.11 Å) | | 主引用文献 | Structure-Based Design and Biological Evaluation of Novel Caspase-2 Inhibitors Based on the Peptide AcVDVAD-CHO and the Caspase-2-Mediated Tau Cleavage Sequence YKPVD314.
Acs Pharmacol Transl Sci, 5, 2022
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7RNA
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7RNG
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7RNC
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4AF8
 | | The structural basis for metacaspase substrate specificity and activation | | 分子名称: | CHLORIDE ION, METACASPASE MCA2, SODIUM ION | | 著者 | McLuskey, K, Rudolf, J, Isaacs, N.W, Coombs, G.H, Moss, C.X, Mottram, J.C. | | 登録日 | 2012-01-18 | | 公開日 | 2012-05-02 | | 最終更新日 | 2024-05-01 | | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | | 主引用文献 | Crystal Structure of a Trypanosoma Brucei Metacaspase.
Proc.Natl.Acad.Sci.USA, 109, 2012
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3V4O
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3V6L
 | | Crystal Structure of caspase-6 inactivation mutation | | 分子名称: | Caspase-6 | | 著者 | Cao, Q, Wang, X.J, Liu, D.F, Li, L.F, Su, X.D. | | 登録日 | 2011-12-20 | | 公開日 | 2012-03-28 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Inhibitory mechanism of caspase-6 phosphorylation revealed by crystal structures, molecular dynamics simulations, and biochemical assays
J.Biol.Chem., 287, 2012
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3V6M
 | | Inhibition of caspase-6 activity by single mutation outside the active site | | 分子名称: | Caspase-6 | | 著者 | Cao, Q, Wang, X.J, Liu, D.F, Li, L.F, Su, X.D. | | 登録日 | 2011-12-20 | | 公開日 | 2012-03-28 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.692 Å) | | 主引用文献 | Inhibitory mechanism of caspase-6 phosphorylation revealed by crystal structures, molecular dynamics simulations, and biochemical assays
J.Biol.Chem., 287, 2012
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4AFV
 | | THE STRUCTURE OF METACASPASE 2 FROM T. BRUCEI DETERMINED IN THE PRESENCE OF CALCIUM CHLORIDE | | 分子名称: | METACASPASE MCA2 | | 著者 | McLuskey, K, Rudolf, J, Isaacs, N.W, Coombs, G.H, Moss, C.X, Mottram, J.C. | | 登録日 | 2012-01-23 | | 公開日 | 2012-05-02 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | | 主引用文献 | Crystal Structure of a Trypanosoma Brucei Metacaspase.
Proc.Natl.Acad.Sci.USA, 109, 2012
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4AFP
 | | The structure of metacaspase 2 from T. brucei determined in the presence of Samarium | | 分子名称: | METACASPASE MCA2, SAMARIUM (III) ION | | 著者 | McLuskey, K, Rudolf, J, Isaacs, N.W, Coombs, G.H, Moss, C.X, Mottram, J.C. | | 登録日 | 2012-01-23 | | 公開日 | 2012-05-02 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Crystal Structure of a Trypanosoma Brucei Metacaspase.
Proc.Natl.Acad.Sci.USA, 109, 2012
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4AFR
 | | THE STRUCTURE OF METACASPASE 2 (C213A MUTANT) FROM T. BRUCEI | | 分子名称: | METACASPASE | | 著者 | McLuskey, K, Rudolf, J, Isaacs, N.W, Coombs, G.H, Moss, C.X, Mottram, J.C. | | 登録日 | 2012-01-23 | | 公開日 | 2012-05-02 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | | 主引用文献 | Crystal Structure of a Trypanosoma Brucei Metacaspase.
Proc.Natl.Acad.Sci.USA, 109, 2012
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3R7N
 | | Caspase-2 bound with two copies of Ac-DVAD-CHO | | 分子名称: | Caspase-2 subunit p12, Caspase-2 subunit p18, Peptide Inhibitor (ACE)DVAD-CHO | | 著者 | Tang, Y, Wells, J, Arkin, M. | | 登録日 | 2011-03-22 | | 公開日 | 2011-07-27 | | 最終更新日 | 2012-12-12 | | 実験手法 | X-RAY DIFFRACTION (2.33 Å) | | 主引用文献 | Structural and enzymatic insights into caspase-2 protein substrate recognition and catalysis.
J.Biol.Chem., 286, 2011
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4DCP
 | | Crystal Structure of caspase 3, L168F mutant | | 分子名称: | Caspase Inhibitor AC-DEVD-CHO, Caspase-3 subunit p12, Caspase-3 subunit p17 | | 著者 | Chung, S.J, Kang, H.J, Kim, S.J. | | 登録日 | 2012-01-18 | | 公開日 | 2012-12-12 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | Molecular insight into the role of the leucine residue on the L2 loop in the catalytic activity of caspases 3 and 7
Biosci.Rep., 32, 2012
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4EHA
 | | Allosteric Modulation of Caspase-3 through Mutagenesis | | 分子名称: | ACE-ASP-GLU-VAL-ASP-CHLOROMETHYLKETONE INHIBITOR, Caspase-3 | | 著者 | Walters, J, Schipper, J.L, Swartz, P.D, Mattos, C, Clark, A.C. | | 登録日 | 2012-04-02 | | 公開日 | 2012-06-06 | | 最終更新日 | 2017-11-15 | | 実験手法 | X-RAY DIFFRACTION (1.696 Å) | | 主引用文献 | Allosteric modulation of caspase 3 through mutagenesis.
Biosci.Rep., 32, 2012
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3R5K
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3RJM
 | | CASPASE2 IN COMPLEX WITH CHDI LIGAND 33c | | 分子名称: | Caspase-2, Peptide inhibitor (ACE)VDV(3PX)D-CHO | | 著者 | Abendroth, J, Lorimer, D, Stewart, L, Maillard, M, Kiselyov, A.S. | | 登録日 | 2011-04-15 | | 公開日 | 2011-09-21 | | 最終更新日 | 2023-12-06 | | 実験手法 | X-RAY DIFFRACTION (2.55 Å) | | 主引用文献 | Exploiting differences in caspase-2 and -3 S(2) subsites for selectivity: Structure-based design, solid-phase synthesis and in vitro activity of novel substrate-based caspase-2 inhibitors.
Bioorg.Med.Chem., 19, 2011
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4EHH
 | | Allosteric Modulation of Caspase-3 through Mutagenesis | | 分子名称: | ACE-ASP-GLU-VAL-ASP-CHLOROMETHYLKETONE INHIBITOR, Caspase-3 | | 著者 | Walters, J, Schipper, J.L, Swartz, P.D, Mattos, C, Clark, A.C. | | 登録日 | 2012-04-02 | | 公開日 | 2012-06-06 | | 最終更新日 | 2017-11-15 | | 実験手法 | X-RAY DIFFRACTION (1.78 Å) | | 主引用文献 | Allosteric modulation of caspase 3 through mutagenesis.
Biosci.Rep., 32, 2012
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3S70
 | | Crystal structure of active caspase-6 bound with Ac-VEID-CHO solved by As-SAD | | 分子名称: | ACETATE ION, CACODYLATE ION, Caspase-6, ... | | 著者 | Su, X.-D, Liu, X, Wang, X.-J. | | 登録日 | 2011-05-26 | | 公開日 | 2012-04-11 | | 最終更新日 | 2012-12-12 | | 実験手法 | X-RAY DIFFRACTION (1.625 Å) | | 主引用文献 | Get phases from arsenic anomalous scattering: de novo SAD phasing of two protein structures crystallized in cacodylate buffer
Plos One, 6, 2011
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3S8E
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4DCJ
 | | Crystal structure of caspase 3, L168D mutant | | 分子名称: | Caspase Inhibitor AC-DEVD-CHO, Caspase-3 subunit p12, Caspase-3 subunit p17 | | 著者 | Chung, S.J, Kang, H.J, Kim, S.J. | | 登録日 | 2012-01-17 | | 公開日 | 2012-12-12 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | Molecular insight into the role of the leucine residue on the L2 loop in the catalytic activity of caspases 3 and 7
Biosci.Rep., 32, 2012
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3R6G
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3R7S
 | | Crystal Structure of Apo Caspase2 | | 分子名称: | Caspase-2 subunit p12, Caspase-2 subunit p18 | | 著者 | Tang, Y, Wells, J, Arkin, M. | | 登録日 | 2011-03-22 | | 公開日 | 2011-07-27 | | 最終更新日 | 2019-07-17 | | 実験手法 | X-RAY DIFFRACTION (2.252 Å) | | 主引用文献 | Structural and enzymatic insights into caspase-2 protein substrate recognition and catalysis.
J.Biol.Chem., 286, 2011
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