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4OLL
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BU of 4oll by Molmil
cAMP-binding acyltransferase from Mycobacterium smegmatis
分子名称: Acetyltransferase Pat, CALCIUM ION, MERCURY (II) ION
著者Podobnik, M, Rebolj, K, Visweswariah, S.S.
登録日2014-01-24
公開日2014-04-30
最終更新日2017-11-22
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Allostery and Conformational Dynamics in cAMP-binding Acyltransferases.
J.Biol.Chem., 289, 2014
6B3A
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BU of 6b3a by Molmil
AprA Methyltransferase 1 - GNAT didomain in complex with Mn2+ and SAM
分子名称: AprA Methyltransferase 1, GLYCEROL, MANGANESE (II) ION, ...
著者Skiba, M.A, Smith, J.L.
登録日2017-09-21
公開日2017-11-15
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (1.784 Å)
主引用文献A Mononuclear Iron-Dependent Methyltransferase Catalyzes Initial Steps in Assembly of the Apratoxin A Polyketide Starter Unit.
ACS Chem. Biol., 12, 2017
6B3B
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BU of 6b3b by Molmil
AprA Methyltransferase 1 - GNAT in complex with Mn2+ , SAM, and Malonate
分子名称: AprA Methyltransferase 1, GLYCEROL, MALONATE ION, ...
著者Skiba, M.A, Smith, J.L.
登録日2017-09-21
公開日2017-11-15
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献A Mononuclear Iron-Dependent Methyltransferase Catalyzes Initial Steps in Assembly of the Apratoxin A Polyketide Starter Unit.
ACS Chem. Biol., 12, 2017
6B39
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AprA Methyltransferase 1 - GNAT in complex with SAH
分子名称: AprA Methyltransferase 1, S-ADENOSYL-L-HOMOCYSTEINE, SULFATE ION
著者Skiba, M.A, Smith, J.L.
登録日2017-09-21
公開日2017-11-15
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (2.392 Å)
主引用文献A Mononuclear Iron-Dependent Methyltransferase Catalyzes Initial Steps in Assembly of the Apratoxin A Polyketide Starter Unit.
ACS Chem. Biol., 12, 2017
4J3G
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BU of 4j3g by Molmil
Crystal structure of Ribosomal-protein-alanine N-acetyltransferase from Brucella melitensis
分子名称: 1,2-ETHANEDIOL, GCN5-related N-acetyltransferase, IMIDAZOLE, ...
著者Seattle Structural Genomics Center for Infectious Disease (SSGCID)
登録日2013-02-05
公開日2013-03-13
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (1.75 Å)
主引用文献Crystal structure of Ribosomal-protein-alanine N-acetyltransferase from Brucella melitensis
TO BE PUBLISHED
4JWP
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BU of 4jwp by Molmil
Crystal structure of Ribosomal-protein-alanine N-acetyltransferase from Brucella melitensis in complex with Acetyl CoA
分子名称: ACETYL COENZYME *A, CALCIUM ION, CHLORIDE ION, ...
著者SSGCID, Seattle Structural Genomics Center for Infectious Disease (SSGCID)
登録日2013-03-27
公開日2013-05-01
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Crystal structure of Ribosomal-protein-alanine N-acetyltransferase from Brucella melitensis in complex with Acetyl CoA
TO BE PUBLISHED
1CM0
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BU of 1cm0 by Molmil
CRYSTAL STRUCTURE OF THE PCAF/COENZYME-A COMPLEX
分子名称: COENZYME A, P300/CBP ASSOCIATING FACTOR
著者Clements, A, Rojas, J.R, Trievel, R.C, Wang, L, Berger, S.L, Marmorstein, R.
登録日1999-05-12
公開日1999-07-06
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Crystal structure of the histone acetyltransferase domain of the human PCAF transcriptional regulator bound to coenzyme A.
EMBO J., 18, 1999
6GTO
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BU of 6gto by Molmil
Structure of the AtaR antitoxin
分子名称: DUF1778 domain-containing protein, SODIUM ION
著者Garcia-Pino, A, Jurenas, D.
登録日2018-06-18
公開日2019-03-06
最終更新日2024-05-15
実験手法X-RAY DIFFRACTION (2.97 Å)
主引用文献Mechanism of regulation and neutralization of the AtaR-AtaT toxin-antitoxin system.
Nat. Chem. Biol., 15, 2019
6GTQ
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BU of 6gtq by Molmil
Structure of the AtaT Y144F mutant toxin bound to the C-terminus of the antitoxin AtaR
分子名称: ACETATE ION, CHLORIDE ION, CITRATE ANION, ...
著者Garcia-Pino, A, Jurenas, D.
登録日2018-06-18
公開日2019-03-06
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (2.49 Å)
主引用文献Mechanism of regulation and neutralization of the AtaR-AtaT toxin-antitoxin system.
Nat. Chem. Biol., 15, 2019
6GTR
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BU of 6gtr by Molmil
Structure of the AtaT Y144F mutant toxin bound to the C-terminus of the antitoxin AtaR and Acetyl-CoA
分子名称: ACETYL COENZYME *A, DUF1778 domain-containing protein, GLYCEROL, ...
著者Garcia-Pino, A, Jurenas, D.
登録日2018-06-18
公開日2019-03-06
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (2.99 Å)
主引用文献Mechanism of regulation and neutralization of the AtaR-AtaT toxin-antitoxin system.
Nat. Chem. Biol., 15, 2019
6GTP
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BU of 6gtp by Molmil
Structure of the AtaT Y144F mutant toxin
分子名称: ACETYL COENZYME *A, CHLORIDE ION, MAGNESIUM ION, ...
著者Garcia-Pino, A, Jurenas, D.
登録日2018-06-18
公開日2019-03-06
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Mechanism of regulation and neutralization of the AtaR-AtaT toxin-antitoxin system.
Nat. Chem. Biol., 15, 2019
3K9U
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BU of 3k9u by Molmil
Crystal structure of paia acetyltransferase (ta0374) from thermoplasma acidophilum
分子名称: ACETYL COENZYME *A, BROMIDE ION, CHLORIDE ION, ...
著者Filippova, E.V, Minasov, G, Shuvalova, L, Kiryukhina, O, Joachimiak, A, Anderson, W.F, Midwest Center for Structural Genomics (MCSG)
登録日2009-10-16
公開日2009-11-17
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Crystal structure of the novel PaiA N-acetyltransferase from Thermoplasma acidophilum involved in the negative control of sporulation and degradative enzyme production.
Proteins, 79, 2011
3F0A
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BU of 3f0a by Molmil
Structure of a putative n-acetyltransferase (ta0374) in complex with acetyl-coa from thermoplasma acidophilum
分子名称: ACETYL COENZYME *A, CHLORIDE ION, N-ACETYLTRANSFERASE, ...
著者Filippova, E.V, Minasov, G, Shuvalova, L, Kiryukhina, O, Clancy, S, Joachimiak, A, Anderson, W.F, Midwest Center for Structural Genomics (MCSG)
登録日2008-10-24
公開日2008-11-11
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Crystal structure of the novel PaiA N-acetyltransferase from Thermoplasma acidophilum involved in the negative control of sporulation and degradative enzyme production.
Proteins, 79, 2011
3FIX
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BU of 3fix by Molmil
Crystal structure of a putative n-acetyltransferase (ta0374) from thermoplasma acidophilum
分子名称: 1,2-ETHANEDIOL, N-ACETYLTRANSFERASE
著者Filippova, E.V, Minasov, G, Shuvalova, L, Kiryukhina, O, Clancy, S, Joachimiak, A, Anderson, W.F, Midwest Center for Structural Genomics (MCSG)
登録日2008-12-12
公開日2009-01-13
最終更新日2017-11-01
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Crystal structure of the novel PaiA N-acetyltransferase from Thermoplasma acidophilum involved in the negative control of sporulation and degradative enzyme production.
Proteins, 79, 2011
3NE7
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BU of 3ne7 by Molmil
Crystal structure of paia n-acetyltransferase from thermoplasma acidophilum in complex with coenzyme a
分子名称: ACETYLTRANSFERASE, BETA-MERCAPTOETHANOL, COENZYME A, ...
著者Filippova, E.V, Minasov, G, Shuvalova, L, Kiryukhina, O, Clancy, S, Joachimiak, A, Anderson, F.W, Midwest Center for Structural Genomics (MCSG)
登録日2010-06-08
公開日2010-07-28
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Crystal structure of the novel PaiA N-acetyltransferase from Thermoplasma acidophilum involved in the negative control of sporulation and degradative enzyme production.
Proteins, 79, 2011
6W9E
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BU of 6w9e by Molmil
Crystal Structure of Human CDK9/cyclinT1 in complex with MC180295
分子名称: (4-amino-2-{[(1R,2R,4S)-bicyclo[2.2.1]heptan-2-yl]amino}-1,3-thiazol-5-yl)(2-nitrophenyl)methanone, (4-amino-2-{[(1S,2S,4R)-bicyclo[2.2.1]heptan-2-yl]amino}-1,3-thiazol-5-yl)(2-nitrophenyl)methanone, Cyclin-T1, ...
著者Zhang, P, Wu, J.
登録日2020-03-22
公開日2021-09-01
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (3.1 Å)
主引用文献Comparative Modeling of CDK9 Inhibitors to Explore Selectivity and Structure-Activity Relationships
To Be Published
3TFY
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BU of 3tfy by Molmil
Naa50p amino-terminal acetyltransferase bound to substrate peptide fragment and CoA
分子名称: COENZYME A, N-alpha-acetyltransferase 50, NatE catalytic subunit, ...
著者Liszczak, G.P, Marmorstein, R.
登録日2011-08-16
公開日2011-09-07
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (2.75 Å)
主引用文献Structure of a Ternary Naa50p (NAT5/SAN) N-terminal Acetyltransferase Complex Reveals the Molecular Basis for Substrate-specific Acetylation.
J.Biol.Chem., 286, 2011
7NWK
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BU of 7nwk by Molmil
Crystal structure of CDK9-Cyclin T1 bound by compound 6
分子名称: Cyclin-T1, Cyclin-dependent kinase 9, N-((1R,3R)-3-(7-(4-fluoro-2-methoxyphenyl)-3H-imidazo[4,5-b]pyridin-2-yl)cyclopentyl)acetamide
著者Collie, G.W, Ferguson, A.D.
登録日2021-03-16
公開日2021-10-27
最終更新日2024-05-01
実験手法X-RAY DIFFRACTION (2.81 Å)
主引用文献Discovery of a Series of 7-Azaindoles as Potent and Highly Selective CDK9 Inhibitors for Transient Target Engagement.
J.Med.Chem., 64, 2021
6Z45
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BU of 6z45 by Molmil
CDK9-Cyclin-T1 complex bound by compound 24
分子名称: (1~{S},3~{R})-3-acetamido-~{N}-[5-chloranyl-4-(5,5-dimethyl-4,6-dihydropyrrolo[1,2-b]pyrazol-3-yl)pyridin-2-yl]cyclohexane-1-carboxamide, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Cyclin-T1, ...
著者Ferguson, A, Collie, G.W.
登録日2020-05-22
公開日2020-12-23
最終更新日2024-05-01
実験手法X-RAY DIFFRACTION (3.37 Å)
主引用文献Discovery of AZD4573, a Potent and Selective Inhibitor of CDK9 That Enables Short Duration of Target Engagement for the Treatment of Hematological Malignancies.
J.Med.Chem., 63, 2020
8K5R
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BU of 8k5r by Molmil
CDK9/cyclin T1 in complex with KB-0742
分子名称: (1S,3S)-N3-(5-pentan-3-ylpyrazolo[1,5-a]pyrimidin-7-yl)cyclopentane-1,3-diamine, Cyclin-T1, Cyclin-dependent kinase 9
著者Zhou, M, Li, H, Gao, H, Trotter, B.W, Freeman, D.
登録日2023-07-24
公開日2023-12-06
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (3.751 Å)
主引用文献Discovery of KB-0742, a Potent, Selective, Orally Bioavailable Small Molecule Inhibitor of CDK9 for MYC-Dependent Cancers.
J.Med.Chem., 66, 2023
1S7F
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BU of 1s7f by Molmil
RimL- Ribosomal L7/L12 alpha-N-protein acetyltransferase crystal form I (apo)
分子名称: CHLORIDE ION, MALONIC ACID, acetyl transferase
著者Vetting, M.W, de Carvalho, L.P, Roderick, S.L, Blanchard, J.S.
登録日2004-01-29
公開日2005-03-15
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献A novel dimeric structure of the RimL Nalpha-acetyltransferase from Salmonella typhimurium.
J.Biol.Chem., 280, 2005
1S7K
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BU of 1s7k by Molmil
RimL- Ribosomal L7/L12 alpha-N-protein acetyltransferase crystal form 2 (apo)
分子名称: acetyl transferase
著者Vetting, M.W, de Carvalho, L.P, Roderick, S.L, Blanchard, J.S.
登録日2004-01-29
公開日2005-03-15
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献A novel dimeric structure of the RimL Nalpha-acetyltransferase from Salmonella typhimurium.
J.Biol.Chem., 280, 2005
1S7L
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BU of 1s7l by Molmil
RimL- Ribosomal L7/L12 alpha-N-protein acetyltransferase in complex with Coenzyme A (CoA-Cys134 Disulfide)
分子名称: COENZYME A, SULFATE ION, acetyl transferase
著者Vetting, M.W, de Carvalho, L.P, Roderick, S.L, Blanchard, J.S.
登録日2004-01-29
公開日2005-03-15
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献A novel dimeric structure of the RimL Nalpha-acetyltransferase from Salmonella typhimurium.
J.Biol.Chem., 280, 2005
1S7N
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BU of 1s7n by Molmil
Ribosomal L7/L12 alpha-N-protein acetyltransferase in complex with Coenzyme A (CoA free sulfhydryl)
分子名称: COENZYME A, acetyl transferase
著者Vetting, M.W, de Carvalho, L.P, Roderick, S.L, Blanchard, J.S.
登録日2004-01-29
公開日2005-03-15
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献A novel dimeric structure of the RimL Nalpha-acetyltransferase from Salmonella typhimurium.
J.Biol.Chem., 280, 2005
3LQ5
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BU of 3lq5 by Molmil
Structure of CDK9/CyclinT in complex with S-CR8
分子名称: (2S)-2-({9-(1-methylethyl)-6-[(4-pyridin-2-ylbenzyl)amino]-9H-purin-2-yl}amino)butan-1-ol, Cell division protein kinase 9, Cyclin-T1
著者Hole, A.J, Endicott, J.A, Baumli, S.
登録日2010-02-08
公開日2011-01-19
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献CDK Inhibitors Roscovitine and CR8 Trigger Mcl-1 Down-Regulation and Apoptotic Cell Death in Neuroblastoma Cells
Genes Cancer, 1, 2010

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件を2024-07-03に公開中

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